GO:0004812

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Name aminoacyl-tRNA ligase activity
Categary Function
Go Slim No
Go Link GO:0004812
Unique Molecular Interactions 22
Total Molecular Interactions 23
Total Single Events 195
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for aminoacyl-tRNA ligase activity. They are ordered first by their pain relevance and then by number of times they were reported for aminoacyl-tRNA ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT197241 Kars Regulation of Localization of Gabrg1 1 0.23 0 1.02
2 INT118396 Nfe2l2 Positive_regulation of Gene_expression of Cars 1 0.05 0.26 0.47
3 INT346913 Binding of Kars and Positive_regulation of Gene_expression of Ros1 1 0.03 1.25 0.46
4 INT135389 4930519F16Rik Positive_regulation of Pars2 1 0.01 0.78 0.45
5 INT346914 Binding of Kars and Positive_regulation of Gene_expression of Car2 1 0.05 1.24 0.45
6 INT197235 Binding of Grik1 and Kars 1 0.32 0.1 0.25
7 INT197237 Binding of Kars and Grik4 1 0.17 0.1 0.25
8 INT197232 Binding of Grik5 and Kars 1 0.17 0.1 0.25
9 INT334256 Binding of Tlr9 and Iars 1 0.02 0.68 0.24
10 INT334269 Iars Negative_regulation of Gene_expression of IFNA1 1 0.03 0.62 0.23
11 INT213814 F3 Positive_regulation of Pars2 1 0.01 0.58 0.21
12 INT285383 Cars Regulation of Regulation of Sult1a1 1 0.01 0 0.06
13 INT353912 Binding of ACLY and LARS 1 0.25 0.28 0.06
14 INT308649 Binding of Ppp1r13b and Iars 1 0.01 0.29 0.04
15 INT246838 Iars Positive_regulation of Phosphorylation of Ins1 1 0.05 0.86 0.03
16 INT246835 Iars Positive_regulation of Ins1 1 0.06 0.86 0.03
17 INT235626 Binding of IARS and INS 1 0.08 0.15 0
18 INT225548 Asc2 Positive_regulation of Positive_regulation of Rars 1 0.08 0 0
19 INT225586 Rbm39 Positive_regulation of Rars 1 0.08 0 0
20 INT225594 Ncoa6 Positive_regulation of Positive_regulation of Rars 1 0.28 0 0
21 INT231521 Binding of IARS and POMT1 1 0.03 0.72 0
22 INT235625 INS Positive_regulation of Positive_regulation of IARS 1 0.10 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for aminoacyl-tRNA ligase activity. They are ordered first by their pain relevance and then by number of times they were reported in aminoacyl-tRNA ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86792 Gene_expression of Kars 17 0.77 4.24 8.58
2 INT197229 Positive_regulation of Kars 5 0.54 1.89 4.81
3 INT117495 Gene_expression of Pars2 13 0.38 7.93 4.24
4 INT197220 Positive_regulation of Gene_expression of Kars 3 0.39 0.29 3.15
5 INT40772 Localization of Iars 7 0.25 0.49 2.75
6 INT197225 Regulation of Positive_regulation of Kars 1 0.35 0 2.56
7 INT207082 Positive_regulation of Pars2 10 0.14 5.45 2.22
8 INT40775 Positive_regulation of Localization of Iars 1 0.14 0 1.5
9 INT40771 Positive_regulation of Iars 6 0.36 2.1 1.33
10 INT131816 Negative_regulation of Pars2 1 0.19 1.05 1.31
11 INT31397 Gene_expression of Iars 7 0.51 4.16 1.24
12 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93
13 INT197223 Localization of Kars 3 0.58 0.73 0.89
14 INT197221 Negative_regulation of Kars 2 0.33 0.69 0.87
15 INT11779 Binding of Iars 4 0.26 1.38 0.78
16 INT197211 Binding of Kars 2 0.29 1.3 0.78
17 INT118389 Gene_expression of Cars 2 0.13 0.68 0.72
18 INT116249 Positive_regulation of LARS 6 0.39 4.16 0.71
19 INT195984 Localization of LARS 3 0.42 0.93 0.53
20 INT40774 Negative_regulation of Localization of Iars 1 0.12 0 0.51
21 INT67783 Negative_regulation of LARS 3 0.37 1.23 0.5
22 INT213778 Positive_regulation of Positive_regulation of Pars2 1 0.10 1.4 0.5
23 INT40773 Regulation of Localization of Iars 1 0.07 0 0.49
24 INT135387 Localization of Pars2 1 0.58 0.79 0.46
25 INT118391 Positive_regulation of Gene_expression of Cars 1 0.05 0.26 0.46
26 INT197212 Regulation of Kars 1 0.35 0.1 0.43
27 INT207101 Regulation of Pars2 1 0.10 0.76 0.43
28 INT135385 Binding of Pars2 1 0.24 0.73 0.41
29 INT143299 Transcription of Pars2 2 0.21 0.79 0.4
30 INT213775 Regulation of Gene_expression of Pars2 1 0.13 0.88 0.4
31 INT246823 Phosphorylation of Iars 7 0.31 2.77 0.38
32 INT216267 Binding of IARS 4 0.32 5.34 0.37
33 INT148527 Positive_regulation of Cars 1 0.49 0.18 0.37
34 INT153494 Regulation of Gene_expression of Cars 1 0.09 0.43 0.27
35 INT511 Positive_regulation of IARS 7 0.45 3.58 0.26
36 INT47648 Negative_regulation of Iars 3 0.16 1.42 0.24
37 INT308616 Positive_regulation of Phosphorylation of Iars 1 0.15 0.63 0.24
38 INT346909 Positive_regulation of Positive_regulation of Kars 1 0.35 1.39 0.24
39 INT323921 Positive_regulation of Gene_expression of IARS 1 0.25 0.83 0.21
40 INT213768 Positive_regulation of Gene_expression of Pars2 1 0.10 0.55 0.19
41 INT308611 Negative_regulation of Gene_expression of Iars 1 0.14 1.78 0.13
42 INT9219 Gene_expression of LARS 3 0.59 0.87 0.12
43 INT195087 Protein_catabolism of Pars2 1 0.12 0.83 0.09
44 INT291272 Negative_regulation of Positive_regulation of IARS 1 0.04 0.46 0.07
45 INT285351 Binding of Cars 1 0.21 0 0.06
46 INT89402 Phosphorylation of IARS 1 0.61 0.6 0.04
47 INT206466 Regulation of IARS 2 0.17 0.56 0
48 INT310752 Binding of LARS 2 0.42 1.15 0
49 INT235631 Negative_regulation of IARS 1 0.11 0.33 0
50 INT225417 Positive_regulation of Rars 1 0.34 0 0
51 INT353914 Positive_regulation of Gene_expression of LARS 1 0.44 0.22 0
52 INT323093 Regulation of Phosphorylation of Iars 1 0.13 0.17 0
53 INT308348 Positive_regulation of Gene_expression of Iars 1 0.23 0.25 0
54 INT256514 Localization of Rars 1 0.26 0.11 0
55 INT152687 Regulation of LARS 1 0.23 0 0
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