GO:0004842

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Name ubiquitin-protein ligase activity
Categary Function
Go Slim No
Go Link GO:0004842
Unique Molecular Interactions 464
Total Molecular Interactions 621
Total Single Events 2806
Pain Genes Associated 92

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ubiquitin-protein ligase activity. They are ordered first by their pain relevance and then by number of times they were reported for ubiquitin-protein ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
2 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
3 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93
4 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
5 INT159837 Trim2 Negative_regulation of Transcription of Fos 1 0.10 1.92 1.22
6 INT57824 Binding of Trim13 and Slc25a2 1 0.01 0.08 1.19
7 INT20929 Binding of Trim13 and Vas1 1 0.10 0 1.18
8 INT57823 Binding of Trim13 and Atxn2l 1 0.00 0.08 1.17
9 INT59203 ecs Positive_regulation of Negative_regulation of Ube2d3 1 0.00 1.93 1.15
10 INT12684 Binding of Bcar3 and Trim13 1 0.03 0 1.08
11 INT153039 Binding of G2e3 and LOC100360318 1 0.00 0 1.01
12 INT61698 G2e3 Regulation of Localization of Abat 1 0.05 0 0.88
13 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
14 INT46540 TRIM13 Positive_regulation of GPANK1 1 0.05 0 0.83
15 INT104749 Ugt1a1 Regulation of Positive_regulation of G2e3 1 0.00 0.07 0.77
16 INT141911 Arih2 Regulation of Positive_regulation of Cpox 1 0.01 1.19 0.76
17 INT141910 Arih2 Regulation of Cpox 1 0.01 1.19 0.76
18 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
19 INT221938 Binding of TRPA1 and Tceb1 1 0.02 0 0.71
20 INT192332 UBR7 Negative_regulation of TXK 1 0.00 1.38 0.63
21 INT59202 ecs Positive_regulation of Ube2d3 1 0.00 0.98 0.59
22 INT72387 Trim13 Regulation of Phosphorylation of Shc1 1 0.32 0.09 0.54
23 INT240192 RBX1 Negative_regulation of BDNF 1 0.08 0.13 0.52
24 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
25 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
26 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
27 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
28 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
29 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
30 INT240193 RBX1 Positive_regulation of Gene_expression of BDNF 1 0.10 0 0.43
31 INT20221 Binding of Grcc10 and Fbxo6 1 0.00 0 0.42
32 INT121378 Fancl Positive_regulation of MIF 1 0.01 0.92 0.42
33 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 0.01 1.28 0.42
34 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
35 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
36 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4
37 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
38 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
39 INT38274 Binding of TCN1 and Cbl 1 0.11 0.24 0.38
40 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
41 INT151698 Binding of RNF130 and Vwf 1 0.04 0.29 0.37
42 INT151694 Binding of FBL and RNF130 1 0.40 0.23 0.36
43 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
44 INT97043 Binding of G2e3 and Hist1h3g 1 0.01 0.5 0.36
45 INT107726 BIRC2 Regulation of ASIP 1 0.03 0.24 0.35
46 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
47 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
48 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
49 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
50 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
51 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
52 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
53 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
54 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
55 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
56 INT145284 Msr1 Negative_regulation of FEM1B 1 0.01 0 0.29
57 INT31507 FEM1B Positive_regulation of Localization of POMC 1 0.51 0 0.29
58 INT31508 FEM1B Positive_regulation of Gene_expression of CRH 1 0.54 0 0.28
59 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
60 INT31505 CRH Positive_regulation of Gene_expression of FEM1B 1 0.54 0 0.28
61 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
62 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
63 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
64 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
65 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
66 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
67 INT221939 Tceb1 Negative_regulation of Positive_regulation of TRPA1 1 0.02 0 0.26
68 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
69 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
70 INT192331 UBR7 Negative_regulation of INSRR 1 0.00 0.54 0.23
71 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
72 INT171250 Binding of BMI1 and OAP 1 0.13 1.02 0.22
73 INT329530 Malt1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.48 0.22
74 INT224431 TNF Positive_regulation of Gene_expression of FBXO2 1 0.47 0.35 0.22
75 INT223570 Binding of Mri1 and Uhrf2 1 0.02 0.56 0.22
76 INT224452 Il1 Positive_regulation of Gene_expression of FBXO2 1 0.37 0.35 0.22
77 INT163863 Binding of MIB1 and Vim 1 0.02 1.06 0.21
78 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
79 INT116469 VEGFA Positive_regulation of Amfr 1 0.01 1.39 0.21
80 INT323884 BMI1 Regulation of Gene_expression of TIMP2 1 0.01 0.64 0.21
81 INT163864 Binding of MIB1 and Ema 1 0.04 1.07 0.21
82 INT116466 Vegfa Positive_regulation of Amfr 1 0.07 1.41 0.21
83 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
84 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19
85 INT170721 Siah1a Regulation of Negative_regulation of Grm2 1 0.22 0 0.18
86 INT334267 Mul1 Positive_regulation of Protein_catabolism of Tlr4 1 0.01 0.18 0.18
87 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
88 INT190637 Negative_regulation of Binding of Rab7 and Rnf115 1 0.25 0.68 0.17
89 INT176134 AKT1 Regulation of Gene_expression of BIRC3 1 0.08 1.09 0.17
90 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
91 INT316132 IL10 Regulation of MARCH1 1 0.11 2.12 0.17
92 INT316122 IL10 Regulation of Gene_expression of MARCH1 1 0.19 2.12 0.17
93 INT343850 Binding of TRAF4 and TICAM1 1 0.03 0.19 0.17
94 INT190630 Binding of Rab7 and Rnf115 1 0.22 0.68 0.17
95 INT168700 Positive_regulation of Binding of Nedd4 and Tyr 1 0.03 0.19 0.17
96 INT170724 Binding of Grm8 and Siah1a 1 0.19 0.11 0.15
97 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
98 INT226204 Nfkb1 Positive_regulation of Gene_expression of Trim63 1 0.04 0.65 0.14
99 INT221937 Negative_regulation of Binding of TRPA1 and Tceb1 1 0.02 0 0.14
100 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14
101 INT117913 CREM Positive_regulation of Negative_regulation of BIRC2 1 0.15 0.81 0.14
102 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
103 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
104 INT226208 Nfkb1 Positive_regulation of Protein_catabolism of Trim63 1 0.04 0.66 0.14
105 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
106 INT192330 UBR7 Negative_regulation of Positive_regulation of PDGFRB 1 0.01 0.54 0.12
107 INT324831 Binding of TRIM63 and Ticam1 1 0.01 0.09 0.12
108 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12
109 INT117911 MAPK1 Regulation of Positive_regulation of BIRC2 1 0.04 0.9 0.12
110 INT334254 Binding of Traf6 and Gtf3a 1 0.00 0.18 0.11
111 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
112 INT328143 Gabrb3 Positive_regulation of Ube3a 1 0.56 0.99 0.11
113 INT231118 Tlr4 Positive_regulation of Gene_expression of Trim63 1 0.20 0.67 0.11
114 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
115 INT323882 Binding of BMI1 and MMP13 1 0.01 1.26 0.11
116 INT323869 Binding of BMI1 and COL1A2 1 0.00 1.21 0.11
117 INT328146 Gabrb3 Negative_regulation of Ube3a 1 0.48 0.99 0.11
118 INT168827 Binding of TRPC4AP and UBR1 1 0.00 0.34 0.1
119 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1
120 INT226210 Akt1 Regulation of Mul1 1 0.04 0.6 0.1
121 INT350011 Binding of BMI1 and IL6 1 0.01 0.58 0.1
122 INT154711 Binding of SGCG and Rnf13 1 0.36 0.76 0.1
123 INT44591 PLAT Negative_regulation of CNOT4 1 0.10 0.33 0.1
124 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
125 INT111866 Binding of LNPEP and CNOT4 1 0.02 0 0.09
126 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
127 INT87037 Binding of FBXO6 and Col5a3 1 0.00 0.48 0.09
128 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
129 INT335771 MIR155 Regulation of IRAK1 1 0.04 0.29 0.09
130 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
131 INT262939 PAX6 Regulation of CDH4 1 0.02 0.97 0.08
132 INT190529 IFNA1 Positive_regulation of Transcription of TRIM63 1 0.00 0.39 0.08
133 INT262937 PAX6 Regulation of CDH8 1 0.03 0.98 0.08
134 INT316127 IL10 Regulation of UBR1 1 0.00 1.06 0.08
135 INT190636 Nr1h2 Positive_regulation of Rnf115 1 0.20 0.71 0.08
136 INT224985 Binding of Ube3a and Snord116 1 0.34 0.45 0.08
137 INT323881 BMI1 Regulation of Gene_expression of LEP 1 0.03 1.09 0.08
138 INT321597 Binding of MUC1 and MIB1 1 0.19 0.98 0.08
139 INT262944 PAX6 Regulation of CDH6 1 0.03 0.97 0.08
140 INT243309 TNFAIP1 Positive_regulation of Localization of TNF 1 0.07 0.71 0.08
141 INT243313 TNFAIP1 Positive_regulation of TNF 1 0.31 0.71 0.08
142 INT328150 H2-Q13 Positive_regulation of Gene_expression of Ube3a 1 0.55 1.23 0.07
143 INT268673 Binding of NCOR2 and BCOR 1 0.01 2.54 0.07
144 INT170722 Siah1a Regulation of Gene_expression of Grm8 1 0.24 0 0.07
145 INT192329 UBR7 Negative_regulation of Phosphorylation of PDGFRB 1 0.01 0.06 0.07
146 INT328148 H2-Q13 Positive_regulation of Ube3a 1 0.55 1.23 0.07
147 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
148 INT298258 Binding of Runx3 and Stub1 1 0.11 0.18 0.06
149 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05
150 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05
151 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
152 INT334265 Binding of Traf6 and Irak4 1 0.19 0.24 0.05
153 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05
154 INT231834 Trip12 Positive_regulation of Positive_regulation of Cel 1 0.00 0.75 0.05
155 INT332795 Negative_regulation of Vhl Positive_regulation of Positive_regulation of Cxcr4 1 0.02 1.64 0.05
156 INT201729 Traf6 Positive_regulation of Phosphorylation of Nfkb1 1 0.00 0.45 0.04
157 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04
158 INT201733 Traf6 Positive_regulation of Protein_catabolism of Nfkbib 1 0.00 0.44 0.04
159 INT190095 Negative_regulation of Binding of Hivep3 and Traf2 1 0.15 0.08 0.04
160 INT201750 Traf6 Positive_regulation of Cib1 1 0.00 0.37 0.04
161 INT210466 Negative_regulation of Binding of Gopc and Uhrf2 1 0.10 0.07 0.04
162 INT238803 Ager Positive_regulation of Cbl 1 0.01 1.57 0.04
163 INT342726 Binding of Laptm5 and Park2 1 0.03 0.64 0.04
164 INT190096 Binding of Hivep3 and Traf2 1 0.17 0.08 0.04
165 INT210465 Binding of Gopc and Uhrf2 1 0.09 0.07 0.04
166 INT201746 Traf6 Positive_regulation of Map4k4 1 0.00 0.37 0.04
167 INT348024 Binding of Chuk and Traf3 1 0.13 0.65 0.04
168 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04
169 INT201739 Traf6 Positive_regulation of Localization of Nfkb1 1 0.00 0.45 0.04
170 INT288369 Binding of Laptm5 and Mgrn1 1 0.05 0 0.04
171 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
172 INT348526 Binding of TRAF2 and EDAR 1 0.15 0.52 0.03
173 INT348538 Binding of TRAF2 and EDARADD 1 0.06 0.53 0.03
174 INT173199 CNOT4 Regulation of Regulation of Myc 1 0.01 0.66 0.03
175 INT184134 Binding of Cish and Rbx1 1 0.10 0 0.03
176 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
177 INT348028 Binding of Traf3 and Ticam1 1 0.01 0.56 0.03
178 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 0.03 0.15 0.03
179 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
180 INT304190 Binding of HP and ZFP91 1 0.00 2.74 0.03
181 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
182 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
183 INT292553 Binding of TRAF2 and TRADD 1 0.09 0.1 0
184 INT317301 Binding of Park2 and Park7 1 0.36 0.62 0
185 INT342725 Pink1 Positive_regulation of Phosphorylation of Park2 1 0.29 0.62 0
186 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
187 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
188 INT292560 Binding of TNFRSF1A and TRAF2 1 0.08 0.09 0
189 INT318081 Binding of RPL5 and UBC 1 0.02 0.52 0
190 INT247846 Positive_regulation of Narfl Positive_regulation of Positive_regulation of Ube4a 1 0.00 0.82 0
191 INT219256 Binding of Ddx41 and G2e3 1 0.01 1.63 0
192 INT281609 Foxo3 Positive_regulation of Transcription of Trim63 1 0.29 0 0
193 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
194 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0
195 INT313117 Binding of Stub1 and Carf 1 0.10 0 0
196 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0
197 INT262938 Binding of PAX6 and SIX3 1 0.13 0.9 0
198 INT268515 MIR221 Positive_regulation of BCOR 1 0.09 1.36 0
199 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0
200 INT267261 GOPC Regulation of BMI1 1 0.06 0.75 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ubiquitin-protein ligase activity. They are ordered first by their pain relevance and then by number of times they were reported in ubiquitin-protein ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15102 Gene_expression of Trim13 18 0.67 0.43 15.49
2 INT60865 Gene_expression of G2e3 20 0.73 2.1 12.76
3 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
4 INT58775 Binding of G2e3 10 0.33 0.19 11.52
5 INT171253 Positive_regulation of BMI1 23 0.53 39.41 11.23
6 INT1567 Binding of TRIM13 10 0.47 0.24 9.16
7 INT21438 Binding of Trim13 10 0.47 0.26 8.76
8 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36
9 INT165228 Binding of BMI1 13 0.47 25.36 7.97
10 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
11 INT58774 Negative_regulation of G2e3 8 0.38 0.22 7.75
12 INT48270 Negative_regulation of RNF130 44 0.57 21.31 6.14
13 INT51494 Localization of Trim13 1 0.60 0 4.36
14 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
15 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11
16 INT2677 Regulation of Trim13 3 0.44 0.5 3.91
17 INT51495 Positive_regulation of Trim13 3 0.41 0.08 3.81
18 INT50022 Positive_regulation of G2e3 10 0.42 0.47 3.72
19 INT24160 Gene_expression of TRIM13 7 0.65 1.42 3.46
20 INT54749 Binding of BTRC 7 0.09 0.88 2.9
21 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
22 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
23 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
24 INT60864 Regulation of G2e3 4 0.21 0.64 2.54
25 INT32923 Negative_regulation of Binding of TRIM13 2 0.57 0 2.38
26 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
27 INT52785 Localization of G2e3 5 0.66 0.33 2.26
28 INT30385 Protein_catabolism of Trim13 2 0.97 0 2.22
29 INT51496 Negative_regulation of Localization of Trim13 1 0.32 0 2.18
30 INT171251 Regulation of BMI1 8 0.20 10.46 2.01
31 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
32 INT275860 Negative_regulation of Localization of TNFAIP1 1 0.03 4.41 1.91
33 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85
34 INT45064 Protein_catabolism of TRIM13 6 0.86 0 1.8
35 INT100563 Regulation of Binding of G2e3 1 0.24 0 1.79
36 INT104745 Positive_regulation of Binding of G2e3 1 0.05 0.07 1.77
37 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69
38 INT224975 Gene_expression of Ube3a 5 0.76 7.18 1.69
39 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
40 INT41820 Positive_regulation of TRIM13 3 0.49 0.46 1.65
41 INT85955 Negative_regulation of Localization of G2e3 2 0.48 0.05 1.63
42 INT117915 Gene_expression of BIRC2 8 0.63 6.74 1.59
43 INT66942 Negative_regulation of Protein_catabolism of Trim13 1 0.50 0 1.58
44 INT72377 Phosphorylation of Trim13 1 0.79 0.27 1.57
45 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
46 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
47 INT81222 Binding of RNF130 9 0.47 5.38 1.54
48 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
49 INT100376 Positive_regulation of Gene_expression of Vhl 4 0.10 6.47 1.47
50 INT243339 Localization of TNFAIP1 4 0.41 3.7 1.39
51 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
52 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
53 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
54 INT224447 Gene_expression of FBXO2 7 0.75 7.33 1.31
55 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
56 INT263523 Regulation of Binding of BMI1 1 0.34 3.01 1.3
57 INT190067 Binding of Traf2 5 0.20 3.28 1.27
58 INT59200 Negative_regulation of Ube2d3 3 0.13 2.37 1.23
59 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22
60 INT23525 Regulation of FEM1B 5 0.44 1.26 1.22
61 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
62 INT207183 Binding of Bmi1 1 0.01 16.24 1.14
63 INT159835 Negative_regulation of Trim2 1 0.09 1.81 1.14
64 INT91610 Binding of ZFP91 4 0.31 2.86 1.11
65 INT60135 Negative_regulation of Protein_catabolism of TRIM13 1 0.30 0 1.1
66 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
67 INT223563 Gene_expression of Uhrf2 4 0.48 1.15 1.04
68 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03
69 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
70 INT27314 Negative_regulation of CNOT4 4 0.00 1.64 0.98
71 INT121422 Gene_expression of BIRC3 7 0.75 6.24 0.96
72 INT70248 Positive_regulation of Positive_regulation of G2e3 1 0.13 0.17 0.94
73 INT60140 Localization of TRIM13 1 0.53 0 0.94
74 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
75 INT53930 Positive_regulation of ZFP91 2 0.02 0.8 0.93
76 INT351587 Positive_regulation of Gene_expression of Uhrf2 1 0.29 0.81 0.92
77 INT156641 Positive_regulation of CNOT4 4 0.07 3.19 0.9
78 INT113121 Negative_regulation of Binding of G2e3 1 0.07 0 0.88
79 INT217683 Localization of BMI1 7 0.68 6.28 0.87
80 INT32948 Negative_regulation of Binding of Trim13 1 0.41 0 0.86
81 INT278709 Gene_expression of CBL 4 0.14 3.91 0.85
82 INT41819 Regulation of TRIM13 2 0.44 0.2 0.85
83 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
84 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84
85 INT68665 Binding of Vhl 9 0.48 10.3 0.82
86 INT217685 Negative_regulation of BMI1 7 0.18 6.01 0.82
87 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
88 INT128143 Negative_regulation of Gene_expression of G2e3 4 0.09 0 0.82
89 INT38272 Positive_regulation of Cbl 1 0.27 0.82 0.82
90 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
91 INT221926 Regulation of Tceb1 1 0.02 0.72 0.79
92 INT316151 Gene_expression of MARCH1 1 0.55 2.32 0.78
93 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
94 INT181326 Binding of TNFAIP1 2 0.29 0.81 0.74
95 INT29924 Negative_regulation of Gene_expression of Trim13 1 0.34 0 0.74
96 INT161471 Gene_expression of Bmi1 9 0.76 11.47 0.72
97 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71
98 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
99 INT80025 Positive_regulation of MIB1 5 0.40 5.41 0.64
100 INT122497 Gene_expression of UBE2S 2 0.58 0.8 0.64
101 INT263996 Transcription of TNFAIP3 1 0.39 0.99 0.64
102 INT209898 Gene_expression of TRAF4 1 0.52 2.11 0.64
103 INT38270 Binding of Cbl 1 0.26 0.52 0.64
104 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63
105 INT166015 Regulation of Gene_expression of BIRC3 1 0.31 0.63 0.63
106 INT106608 Regulation of Gene_expression of SKP2 1 0.50 0.26 0.63
107 INT106603 Gene_expression of SKP2 5 0.63 6.99 0.62
108 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
109 INT100370 Negative_regulation of Gene_expression of Vhl 1 0.06 0.9 0.62
110 INT112665 Gene_expression of TRAF2 3 0.29 3.97 0.61
111 INT31512 Gene_expression of FEM1B 3 0.65 0.43 0.6
112 INT323751 Gene_expression of IRAK1 3 0.44 1.33 0.6
113 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
114 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
115 INT170695 Binding of Siah1a 1 0.48 1.19 0.59
116 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
117 INT288354 Gene_expression of Mgrn1 1 0.60 0 0.58
118 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
119 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
120 INT221928 Gene_expression of Tceb1 1 0.04 0 0.57
121 INT79870 Regulation of RNF130 3 0.44 1.12 0.56
122 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
123 INT346819 Negative_regulation of ZFP91 1 0.36 0.97 0.55
124 INT33731 Negative_regulation of TRIM13 1 0.41 0.26 0.55
125 INT60752 Gene_expression of ZFP91 6 0.58 2.55 0.53
126 INT149394 Positive_regulation of Mul1 4 0.12 1.89 0.53
127 INT214855 Regulation of Positive_regulation of CNOT4 1 0.02 0.66 0.53
128 INT181325 Positive_regulation of TNFAIP1 4 0.36 4.64 0.52
129 INT117926 Positive_regulation of Gene_expression of BIRC2 1 0.48 3.25 0.52
130 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
131 INT288355 Localization of Mgrn1 1 0.67 0 0.52
132 INT240206 Negative_regulation of RBX1 1 0.08 0.15 0.51
133 INT72378 Positive_regulation of Phosphorylation of Trim13 1 0.49 0.08 0.51
134 INT319248 Positive_regulation of Positive_regulation of Cbl 1 0.08 0.94 0.51
135 INT71157 Positive_regulation of RNF130 7 0.67 2.77 0.5
136 INT315427 Positive_regulation of Uhrf2 2 0.38 0.33 0.5
137 INT226164 Gene_expression of Trim63 5 0.68 4.77 0.49
138 INT89258 Localization of STUB1 3 0.14 0.67 0.49
139 INT319278 Positive_regulation of Cbl 1 0.08 0.92 0.49
140 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
141 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
142 INT117919 Negative_regulation of BIRC2 4 0.30 3.72 0.45
143 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
144 INT306885 Positive_regulation of SKP2 1 0.21 0.6 0.45
145 INT154708 Gene_expression of Rnf13 1 0.67 3.27 0.45
146 INT238793 Gene_expression of Cbl 6 0.03 3.01 0.43
147 INT323739 Regulation of IRAK1 3 0.23 1.73 0.43
148 INT270000 Localization of IRAK1 3 0.73 0.82 0.43
149 INT44600 Gene_expression of MALT1 6 0.75 6.14 0.42
150 INT67098 Regulation of MIB1 3 0.24 4.23 0.42
151 INT343940 Binding of Uhrf2 2 0.30 0.06 0.42
152 INT343891 Positive_regulation of Gene_expression of IRAK1 1 0.23 0.3 0.42
153 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
154 INT38271 Positive_regulation of Positive_regulation of Cbl 1 0.27 0.41 0.41
155 INT40183 Regulation of Binding of Trim13 1 0.44 0 0.41
156 INT207182 Positive_regulation of Bmi1 1 0.02 6.81 0.41
157 INT167084 Binding of Cbl 3 0.10 1.34 0.39
158 INT203081 Gene_expression of Trim63 2 0.56 1.53 0.39
159 INT156643 Positive_regulation of Positive_regulation of CNOT4 2 0.05 1.64 0.39
160 INT203568 Regulation of SKP2 3 0.26 1.61 0.38
161 INT117923 Positive_regulation of BIRC2 1 0.48 2.5 0.38
162 INT168697 Binding of Nedd4 1 0.26 0.48 0.38
163 INT111872 Binding of CNOT4 4 0.02 1.11 0.37
164 INT231102 Gene_expression of Mul1 8 0.21 1.66 0.35
165 INT217464 Binding of Traf6 5 0.29 1.28 0.35
166 INT50848 Regulation of ZFP91 5 0.38 2.45 0.35
167 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
168 INT221930 Binding of Tceb1 1 0.02 0 0.33
169 INT316165 Positive_regulation of Gene_expression of MARCH1 1 0.33 0.12 0.33
170 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
171 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
172 INT156647 Transcription of CNOT4 1 0.07 0.79 0.32
173 INT156650 Positive_regulation of Transcription of CNOT4 1 0.05 0.79 0.32
174 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
175 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
176 INT226170 Positive_regulation of Gene_expression of Trim63 5 0.44 3.96 0.31
177 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
178 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
179 INT224979 Negative_regulation of Ube3a 2 0.57 3.18 0.29
180 INT288356 Positive_regulation of Mgrn1 1 0.45 0.07 0.29
181 INT203067 Positive_regulation of Gene_expression of Trim63 2 0.50 0.92 0.28
182 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28
183 INT315428 Transcription of Uhrf2 1 0.38 0 0.28
184 INT209903 Positive_regulation of TRAF4 1 0.41 1.27 0.28
185 INT118490 Regulation of CNOT4 2 0.02 1.18 0.27
186 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
187 INT221927 Regulation of Gene_expression of Tceb1 1 0.02 0 0.26
188 INT323753 Negative_regulation of Gene_expression of TRAF6 1 0.21 0.52 0.26
189 INT161464 Regulation of Gene_expression of Bmi1 1 0.44 3.01 0.26
190 INT44599 Gene_expression of CNOT4 4 0.40 3.09 0.25
191 INT170714 Regulation of Gene_expression of Siah1a 1 0.61 0.71 0.25
192 INT224449 Positive_regulation of Gene_expression of FBXO2 3 0.49 1.72 0.24
193 INT72235 Negative_regulation of BTRC 3 0.02 0 0.24
194 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
195 INT221929 Positive_regulation of Tceb1 1 0.02 0 0.24
196 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
197 INT26381 Positive_regulation of Fbxo6 1 0.04 0 0.22
198 INT154709 Positive_regulation of Gene_expression of Rnf13 1 0.35 1.65 0.22
199 INT92101 Regulation of Negative_regulation of RNF130 1 0.44 0.83 0.22
200 INT203471 Localization of Stub1 1 0.23 0.5 0.21
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