GO:0004857

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Name enzyme inhibitor activity
Categary Function
Go Slim No
Go Link GO:0004857
Unique Molecular Interactions 250
Total Molecular Interactions 326
Total Single Events 2376
Pain Genes Associated 26

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for enzyme inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for enzyme inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169346 Nxn Negative_regulation of Dynll1 1 0.06 1.22 1.87
2 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
3 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35
4 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
5 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31
6 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
7 INT139227 Icam1 Negative_regulation of Timp1 1 0.37 1.13 1.06
8 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
9 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
10 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
11 INT196523 Binding of MMP2 and TIMP1 3 0.43 1.94 0.85
12 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
13 INT104749 Ugt1a1 Regulation of Positive_regulation of G2e3 1 0.00 0.07 0.77
14 INT104748 Ugt1a1 Regulation of Positive_regulation of LOC100359830 1 0.01 0.07 0.77
15 INT176479 IL17A Positive_regulation of Gene_expression of TIMP1 1 0.02 1.33 0.74
16 INT196526 Binding of TIMP1 and TIMP2 1 0.45 1.49 0.71
17 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7
18 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
19 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
20 INT239488 Spna1 Negative_regulation of Gene_expression of Timp1 1 0.00 0.94 0.62
21 INT239489 Spna1 Negative_regulation of Timp1 1 0.00 0.89 0.57
22 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57
23 INT175627 TIMP1 Positive_regulation of MMP2 1 0.03 0.71 0.56
24 INT173555 TIMP1 Negative_regulation of MMP7 1 0.01 0 0.56
25 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56
26 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56
27 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56
28 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
29 INT173554 TIMP1 Negative_regulation of MMP1 1 0.03 0 0.55
30 INT60481 Binding of Ugt1a1 and UGT1A6 1 0.23 0 0.55
31 INT173553 TIMP1 Negative_regulation of MMP2 1 0.05 0 0.55
32 INT285758 RETNLB Positive_regulation of Gene_expression of TIMP1 1 0.01 1.79 0.55
33 INT316736 Il1 Positive_regulation of Timp1 1 0.04 0.63 0.54
34 INT196522 Binding of MMP1 and TIMP1 1 0.39 0.29 0.53
35 INT150795 ZNF398 Positive_regulation of Localization of TIMP2 1 0.06 0.51 0.53
36 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
37 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52
38 INT150798 THBS3 Negative_regulation of TIMP2 1 0.18 0.49 0.52
39 INT196521 Binding of MMP2 and TIMP2 1 0.30 0.68 0.52
40 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51
41 INT93951 Nfkb1 Regulation of Gene_expression of Timp1 1 0.00 0.26 0.51
42 INT150799 ZNF398 Positive_regulation of TIMP2 1 0.09 0.49 0.51
43 INT187108 TIMP1 Negative_regulation of ABCA1 1 0.02 0.28 0.51
44 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
45 INT127430 VEGFA Negative_regulation of Gene_expression of TIMP1 1 0.43 0.6 0.5
46 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
47 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
48 INT277064 CRP Positive_regulation of Gene_expression of TIMP1 1 0.15 1.47 0.45
49 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4
50 INT321860 Timp1 Negative_regulation of Icam1 1 0.22 1.13 0.39
51 INT303444 Timp1 Regulation of Fig4 1 0.15 0.43 0.39
52 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
53 INT335994 Timp1 Regulation of Col7a1 1 0.01 0.36 0.37
54 INT336339 Glp2r Positive_regulation of Timp1 1 0.16 1.82 0.36
55 INT198969 GAPDH Negative_regulation of TIMP1 1 0.47 0 0.35
56 INT179845 Il11 Positive_regulation of Negative_regulation of Timp1 1 0.14 0 0.35
57 INT97328 Ptger2 Regulation of Transcription of Timp1 1 0.00 0.48 0.34
58 INT224701 Timp3 Negative_regulation of TNF 1 0.01 0.65 0.34
59 INT97357 IL1A Positive_regulation of Transcription of Timp1 1 0.06 0.47 0.34
60 INT311265 RENBP Regulation of IL8 1 0.03 1.59 0.33
61 INT311263 RENBP Regulation of TNF 1 0.01 1.59 0.33
62 INT311266 RENBP Regulation of IL6 1 0.02 1.59 0.32
63 INT303446 Timp1 Negative_regulation of Mmp2 1 0.19 0.33 0.31
64 INT97327 Ptger2 Positive_regulation of Gene_expression of Timp1 1 0.00 0.46 0.31
65 INT97358 IL1A Regulation of Timp1 1 0.04 0.51 0.31
66 INT97326 Ptger2 Positive_regulation of Transcription of Timp1 1 0.00 0.49 0.31
67 INT187102 Negative_regulation of Binding of MMP9 and TIMP2 1 0.36 0.69 0.3
68 INT187106 Binding of MMP9 and TIMP2 1 0.30 0.69 0.3
69 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29
70 INT187105 TIMP2 Negative_regulation of Positive_regulation of MMP9 1 0.36 0.36 0.29
71 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29
72 INT335307 SLC15A4 Regulation of TIMP1 1 0.01 0.69 0.29
73 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29
74 INT319753 Mpo Positive_regulation of Timp1 1 0.14 2.13 0.29
75 INT55682 IL1B Positive_regulation of TIMP1 2 0.46 0.17 0.28
76 INT218709 Mmp1a Negative_regulation of TIMP1 1 0.00 1.84 0.28
77 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
78 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
79 INT55683 IL1B Positive_regulation of Gene_expression of TIMP1 1 0.64 0.17 0.28
80 INT55681 IL1B Regulation of Gene_expression of TIMP1 1 0.56 0.18 0.28
81 INT275556 Il10 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28
82 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28
83 INT218660 Mmp1a Negative_regulation of Timp1 1 0.02 1.84 0.28
84 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28
85 INT220870 Timp3 Negative_regulation of Adamts4 1 0.03 0.15 0.27
86 INT172140 CSF2 Positive_regulation of Gene_expression of TIMP1 1 0.07 0.72 0.27
87 INT220871 Timp3 Negative_regulation of Adamts1 1 0.01 0.15 0.27
88 INT170560 Binding of Renbp and Narf 1 0.01 1.69 0.27
89 INT34231 PTGER2 Positive_regulation of Gene_expression of TIMP1 1 0.13 0.23 0.27
90 INT348924 Mmp1 Regulation of Gene_expression of Renbp 1 0.03 0.95 0.26
91 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
92 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
93 INT277066 MMP1 Positive_regulation of Gene_expression of TIMP1 1 0.16 0.76 0.24
94 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
95 INT311268 RENBP Regulation of Gene_expression of IL8 1 0.02 1.05 0.24
96 INT210794 Timp4 Positive_regulation of Itgbl1 1 0.40 0 0.23
97 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22
98 INT227905 IL10 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.48 0.22
99 INT218675 Olr811 Negative_regulation of Gene_expression of Timp1 1 0.00 0.22 0.22
100 INT187117 Negative_regulation of TIMP2 Negative_regulation of MMP9 1 0.36 0.6 0.22
101 INT218664 Olr811 Regulation of Timp1 1 0.00 0.9 0.22
102 INT220192 PTGER2 Negative_regulation of Positive_regulation of TIMP1 1 0.04 0.99 0.22
103 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
104 INT323884 BMI1 Regulation of Gene_expression of TIMP2 1 0.01 0.64 0.21
105 INT205051 MMP3 Negative_regulation of TIMP1 1 0.36 3.02 0.2
106 INT336379 TIMP1 Negative_regulation of FADS1 1 0.01 0.52 0.2
107 INT21576 NT5C3 Negative_regulation of Gene_expression of TIMP1 1 0.03 0.25 0.2
108 INT214590 TIMP1 Regulation of ICAM1 1 0.10 0.29 0.19
109 INT21577 IL4I1 Positive_regulation of Gene_expression of TIMP1 1 0.11 0.24 0.19
110 INT335299 IRF6 Positive_regulation of TIMP1 1 0.03 0.21 0.19
111 INT181996 TNFRSF11B Positive_regulation of Gene_expression of TIMP1 1 0.00 0.67 0.18
112 INT181928 RLN1 Positive_regulation of TIMP1 1 0.00 0.1 0.17
113 INT339252 Positive_regulation of GNRH1 Positive_regulation of Localization of SCG5 1 0.51 0 0.17
114 INT155233 TXNIP Regulation of BCL2 1 0.23 0.15 0.17
115 INT97820 Serpine1 Negative_regulation of TIMP1 1 0.00 0.29 0.17
116 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
117 INT185808 SPP1 Positive_regulation of TIMP1 1 0.64 0.33 0.16
118 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16
119 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
120 INT207253 INS Negative_regulation of TXNIP 1 0.45 1.2 0.15
121 INT328793 Binding of Mmp7 and Timp2 1 0.00 0.72 0.15
122 INT328794 Binding of Timp2 and Mmp3 1 0.00 0.72 0.15
123 INT279102 Renbp Regulation of Hand1 1 0.02 0.27 0.14
124 INT246018 Timp1 Negative_regulation of Localization of Il1 1 0.01 1.05 0.14
125 INT246019 Timp1 Negative_regulation of Localization of TNF 1 0.23 1.05 0.14
126 INT290444 S100A4 Regulation of TIMP1 1 0.00 1.3 0.14
127 INT185455 MUC1 Negative_regulation of Timp1 1 0.06 0.84 0.13
128 INT311262 RENBP Regulation of Regulation of TNF 1 0.02 0.33 0.13
129 INT281267 Binding of CRP and TIMP1 1 0.06 0.82 0.13
130 INT305287 Renbp Regulation of FRTS 1 0.02 0.06 0.13
131 INT246016 Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
132 INT170991 FGF2 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.72 0.13
133 INT337676 Binding of TIMP1 and Scrib 1 0.01 1.24 0.13
134 INT185454 IGHG1 Negative_regulation of Timp1 1 0.04 0.85 0.13
135 INT290443 Gene_expression of TIMP2 Negative_regulation of MMP2 1 0.06 1.56 0.13
136 INT185416 MUC1 Negative_regulation of TIMP1 1 0.18 0.84 0.13
137 INT246017 Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
138 INT185418 IGHG1 Negative_regulation of TIMP1 1 0.11 0.84 0.13
139 INT126882 Negative_regulation of TIMP1 Regulation of NA 1 0.28 0 0.12
140 INT289402 Negative_regulation of Cd55 Positive_regulation of Gene_expression of Ik 1 0.00 0.58 0.12
141 INT289407 Mthfd1 Negative_regulation of Cd55 1 0.01 0.6 0.12
142 INT289403 Cd55 Positive_regulation of Gene_expression of Ik 1 0.00 0.58 0.12
143 INT213144 TIMP1 Negative_regulation of THBD 1 0.04 1.16 0.12
144 INT220197 PTGER2 Negative_regulation of TIMP1 1 0.03 0.23 0.12
145 INT207254 ZNF236 Positive_regulation of TXNIP 1 0.03 0.68 0.12
146 INT181929 GOPC Regulation of Gene_expression of TIMP1 1 0.00 0 0.12
147 INT126883 TIMP1 Regulation of NA 1 0.17 0 0.12
148 INT245313 Negative_regulation of Binding of MMP2 and TIMP1 1 0.01 0.45 0.11
149 INT321863 Timp1 Negative_regulation of Gene_expression of Mcpt1 1 0.25 0.79 0.11
150 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
151 INT299158 Binding of Lgals3 and Renbp 1 0.00 0.64 0.11
152 INT321861 Timp1 Negative_regulation of Mcpt1 1 0.25 0.79 0.11
153 INT321862 Timp1 Negative_regulation of Il6 1 0.12 0.79 0.11
154 INT203629 IL8 Negative_regulation of Timp1 1 0.05 0 0.1
155 INT203628 Cxcl1 Negative_regulation of TIMP2 1 0.01 0 0.1
156 INT203583 IL8 Negative_regulation of TIMP2 1 0.03 0 0.1
157 INT187112 Binding of TIMP2 and Positive_regulation of TIMP1 1 0.32 0.26 0.1
158 INT218713 Mmp1a Negative_regulation of Gene_expression of TIMP1 1 0.00 0.18 0.1
159 INT203590 Negative_regulation of IL6 Negative_regulation of TIMP2 1 0.07 0 0.1
160 INT203626 IL6 Negative_regulation of Timp1 1 0.12 0 0.1
161 INT203586 IL6 Negative_regulation of TIMP2 1 0.07 0 0.1
162 INT203623 Cxcl1 Negative_regulation of Timp1 1 0.01 0 0.1
163 INT311267 RENBP Regulation of Gene_expression of TNF 1 0.02 0.54 0.09
164 INT213145 DAK Positive_regulation of TIMP1 1 0.02 0.36 0.09
165 INT154914 UGT1A9 Regulation of IGHD6-6 1 0.05 0 0.09
166 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09
167 INT334786 Bbaa12 Positive_regulation of Positive_regulation of Angptl4 1 0.13 0.21 0.08
168 INT270682 Binding of OLR1 and RENBP 1 0.00 0.76 0.08
169 INT277053 Protein_catabolism of TIMP1 Positive_regulation of COL5A2 1 0.01 0.14 0.07
170 INT336383 TIMP1 Positive_regulation of Ppara 1 0.08 0.77 0.07
171 INT187104 Binding of IGHG3 and TIMP1 1 0.01 0.22 0.07
172 INT218671 Mmp1a Negative_regulation of Gene_expression of Timp1 1 0.02 0.6 0.06
173 INT145626 Binding of PKLR and UGT1A1 1 0.02 0 0.06
174 INT266655 TIMP1 Regulation of Gene_expression of MMP9 1 0.18 0.11 0.06
175 INT145624 Binding of PKLR and UGT1A9 1 0.02 0 0.06
176 INT76862 Dynll1 Positive_regulation of Rb1 1 0.37 0.1 0.06
177 INT266662 TIMP1 Regulation of Gene_expression of GOPC 1 0.06 0.11 0.06
178 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05
179 INT355586 Binding of LTBP1 and ANGPTL4 1 0.10 2.15 0.05
180 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05
181 INT209155 MMP9 Negative_regulation of TIMP1 1 0.01 0.17 0.05
182 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05
183 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05
184 INT209156 MMP2 Negative_regulation of TIMP1 1 0.00 0.17 0.05
185 INT299954 Negative_regulation of LXN Negative_regulation of FTSJ3 1 0.00 0.75 0.05
186 INT192263 LTC4S Positive_regulation of Gene_expression of TIMP1 1 0.00 0.28 0.04
187 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04
188 INT180955 PLG Regulation of Positive_regulation of TIMP1 1 0.21 0.38 0.04
189 INT328301 GHRH Positive_regulation of SCG5 1 0.24 0.13 0.04
190 INT270330 Binding of HYAL1 and TIMP1 1 0.00 0.2 0.04
191 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04
192 INT274715 TBL1XR1 Positive_regulation of TIMP1 1 0.00 0.26 0.04
193 INT335289 IRF6 Positive_regulation of Gene_expression of TIMP1 1 0.03 0.16 0.04
194 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04
195 INT172832 Binding of ROS1 and Renbp 1 0.00 0.83 0.03
196 INT289250 Il6 Positive_regulation of Gene_expression of Timp1 1 0.11 0.64 0.03
197 INT278608 PPARA Positive_regulation of UGT1A9 1 0.25 0.29 0.03
198 INT342936 Renbp Positive_regulation of Ros1 1 0.02 1.56 0.03
199 INT218712 Timp1 Regulation of MMP1 1 0.00 0.41 0.03
200 INT94426 CTS Positive_regulation of Gene_expression of TIMP2 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for enzyme inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in enzyme inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29
2 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54
3 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99
4 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16
5 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86
6 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98
7 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85
8 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
9 INT55687 Localization of TIMP1 47 0.74 30.24 12.31
10 INT111397 Localization of Timp1 17 0.70 11.67 8.76
11 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57
12 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17
13 INT36678 Binding of TIMP1 33 0.36 14.99 7.87
14 INT57176 Positive_regulation of Dynll1 9 0.49 4.76 7.71
15 INT74099 Negative_regulation of Dynll1 8 0.56 3.43 7.25
16 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
17 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14
18 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94
19 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
20 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48
21 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05
22 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72
23 INT60475 Gene_expression of Ugt1a1 17 0.77 4.26 5.62
24 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51
25 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78
26 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77
27 INT74393 Gene_expression of Dynll1 8 0.65 2.64 4.39
28 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
29 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
30 INT97334 Positive_regulation of Gene_expression of Timp1 11 0.49 7.44 4.14
31 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09
32 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91
33 INT181922 Binding of RENBP 16 0.36 13.92 3.71
34 INT39199 Positive_regulation of Ugt1a1 9 0.45 1.78 3.69
35 INT169344 Positive_regulation of Gene_expression of Dynll1 3 0.49 2.34 3.48
36 INT93947 Regulation of Gene_expression of Timp1 5 0.25 5.04 3.42
37 INT65120 Regulation of Ugt1a1 3 0.45 1.07 3.29
38 INT55690 Positive_regulation of Localization of TIMP1 8 0.50 4.77 3.28
39 INT230060 Binding of Timp1 7 0.47 5.61 3.2
40 INT130603 Binding of Timp1 9 0.35 8.52 3.04
41 INT55739 Transcription of Timp1 7 0.67 4.72 3
42 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
43 INT104476 Protein_catabolism of Timp1 6 0.41 5.75 2.61
44 INT175685 Positive_regulation of Gene_expression of Timp1 11 0.57 8.18 2.58
45 INT88225 Transcription of Ugt1a1 5 0.61 1.51 2.4
46 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
47 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
48 INT158459 Negative_regulation of Gene_expression of Timp1 8 0.40 4.21 2.16
49 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07
50 INT155234 Gene_expression of TXNIP 48 0.77 24.4 2.05
51 INT173509 Positive_regulation of Localization of Timp1 5 0.41 2.99 2.04
52 INT101912 Regulation of TIMP2 8 0.44 5.55 2
53 INT79198 Positive_regulation of Positive_regulation of Dynll1 2 0.42 0.99 1.99
54 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
55 INT52508 Positive_regulation of TIMP2 7 0.43 8.1 1.96
56 INT169352 Negative_regulation of Timp3 10 0.58 6.94 1.92
57 INT187128 Binding of TIMP2 11 0.41 6.43 1.9
58 INT148944 Transcription of UGT1A1 3 0.59 0.07 1.84
59 INT102825 Regulation of Timp1 10 0.38 5.49 1.79
60 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
61 INT97333 Regulation of Gene_expression of Timp1 6 0.54 4.8 1.71
62 INT108252 Positive_regulation of Renbp 16 0.24 11.66 1.68
63 INT98469 Positive_regulation of Transcription of Timp1 4 0.45 3.2 1.68
64 INT167288 Regulation of Dynll1 3 0.45 1.22 1.56
65 INT77314 Gene_expression of Lxn 3 0.76 5.67 1.55
66 INT269828 Transcription of Timp1 3 0.38 5.2 1.53
67 INT53131 Transcription of TIMP1 8 0.68 3.89 1.5
68 INT44288 Binding of Ugt1a1 7 0.45 0.54 1.48
69 INT88224 Positive_regulation of Transcription of Ugt1a1 1 0.29 0.54 1.48
70 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47
71 INT168863 Regulation of Wdtc1 3 0.08 1.88 1.45
72 INT150809 Localization of TIMP2 7 0.65 2.6 1.43
73 INT113268 Positive_regulation of Positive_regulation of Timp1 3 0.15 3.23 1.43
74 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38
75 INT97332 Regulation of Timp1 4 0.44 3.6 1.38
76 INT197143 Positive_regulation of Renbp 15 0.33 9.41 1.31
77 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
78 INT345377 Positive_regulation of Positive_regulation of TIMP3 1 0.37 0.09 1.29
79 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
80 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21
81 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
82 INT108246 Regulation of Renbp 5 0.21 4.66 1.12
83 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
84 INT233286 Positive_regulation of Timp3 1 0.02 1.46 1.1
85 INT159775 Negative_regulation of Gene_expression of Timp1 9 0.37 4.36 1.08
86 INT205618 Gene_expression of Renbp 15 0.26 9.26 1.04
87 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
88 INT172176 Regulation of Regulation of TIMP1 1 0.20 2.33 0.97
89 INT187026 Positive_regulation of Gene_expression of TIMP2 3 0.47 2.05 0.96
90 INT77054 Regulation of Gene_expression of Timp2 2 0.05 0.7 0.96
91 INT110739 Negative_regulation of Negative_regulation of TIMP1 4 0.41 3.29 0.95
92 INT101913 Regulation of Gene_expression of TIMP2 2 0.44 1.2 0.93
93 INT295679 Regulation of Localization of TIMP1 1 0.17 2.7 0.93
94 INT39198 Negative_regulation of Ugt1a1 7 0.52 1.35 0.92
95 INT316726 Regulation of Localization of Timp1 1 0.15 0.81 0.92
96 INT203323 Gene_expression of Angptl4 3 0.77 8.45 0.89
97 INT129850 Binding of Lxn 1 0.37 0 0.89
98 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88
99 INT137857 Positive_regulation of SCG5 3 0.49 1.01 0.88
100 INT99411 Positive_regulation of UGT1A9 2 0.39 0.65 0.88
101 INT178987 Positive_regulation of Positive_regulation of TIMP1 5 0.20 2.81 0.83
102 INT93665 Negative_regulation of Gene_expression of TIMP2 4 0.37 2.47 0.82
103 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82
104 INT104475 Regulation of Protein_catabolism of Timp1 1 0.00 0.61 0.79
105 INT34233 Regulation of Negative_regulation of TIMP1 3 0.27 0.48 0.77
106 INT134752 Negative_regulation of Gene_expression of TIMP3 5 0.37 2.25 0.73
107 INT207285 Positive_regulation of Gene_expression of TXNIP 1 0.69 9.53 0.73
108 INT170546 Gene_expression of Renbp 15 0.32 14.33 0.72
109 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
110 INT179481 Positive_regulation of Wdtc1 8 0.67 7.11 0.71
111 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
112 INT51053 Negative_regulation of Positive_regulation of TIMP1 6 0.35 1.67 0.69
113 INT77401 Regulation of Regulation of ARRB1 1 0.25 0 0.69
114 INT55689 Positive_regulation of Transcription of TIMP1 3 0.46 1.02 0.67
115 INT94429 Transcription of TIMP2 3 0.61 4.05 0.67
116 INT190229 Gene_expression of Cd55 7 0.64 5 0.64
117 INT319540 Regulation of Angptl4 2 0.49 2.94 0.64
118 INT317874 Positive_regulation of Angptl4 4 0.69 6.72 0.63
119 INT159283 Negative_regulation of Transcription of Ugt1a1 1 0.38 0.15 0.62
120 INT187050 Localization of RENBP 8 0.35 6.92 0.61
121 INT219793 Negative_regulation of Renbp 5 0.13 3.42 0.61
122 INT174106 Binding of Renbp 18 0.24 15.82 0.58
123 INT127878 Negative_regulation of Positive_regulation of Timp2 1 0.07 1.12 0.57
124 INT205619 Regulation of Renbp 6 0.17 1.91 0.55
125 INT153940 Localization of Timp1 3 0.78 0.63 0.55
126 INT213154 Positive_regulation of Binding of TIMP1 2 0.41 1.33 0.55
127 INT235515 Positive_regulation of Gene_expression of Renbp 5 0.24 5.19 0.54
128 INT139666 Binding of Timp2 3 0.13 0.55 0.5
129 INT303453 Negative_regulation of Binding of Timp1 1 0.41 1.44 0.49
130 INT303455 Regulation of Binding of Timp1 1 0.44 1.21 0.48
131 INT173583 Negative_regulation of Binding of TIMP1 1 0.13 0 0.48
132 INT216519 Gene_expression of Wdtc1 4 0.65 4.02 0.47
133 INT180920 Positive_regulation of Positive_regulation of Timp1 2 0.38 1.59 0.46
134 INT170554 Binding of Renbp 17 0.17 12.36 0.45
135 INT110738 Positive_regulation of Negative_regulation of TIMP1 4 0.44 0.44 0.45
136 INT311099 Positive_regulation of Negative_regulation of TIMP3 2 0.22 0.78 0.45
137 INT133783 Positive_regulation of Gene_expression of Ugt1a1 5 0.46 0.94 0.44
138 INT139667 Transcription of Timp2 2 0.17 0.45 0.43
139 INT197561 Localization of ANGPTL4 6 0.42 1.19 0.42
140 INT210769 Gene_expression of Timp4 1 0.53 0 0.42
141 INT184444 Binding of Timp3 3 0.47 0.25 0.41
142 INT150095 Regulation of Positive_regulation of TIMP1 2 0.44 0.76 0.41
143 INT181987 Negative_regulation of Negative_regulation of Timp1 1 0.23 1.39 0.41
144 INT109486 Positive_regulation of Negative_regulation of Dynll1 1 0.48 0 0.41
145 INT94430 Positive_regulation of Transcription of TIMP2 2 0.24 2.25 0.39
146 INT211361 Regulation of RENBP 5 0.08 2.8 0.38
147 INT60477 Gene_expression of UGT1A9 2 0.24 0 0.34
148 INT139941 Localization of Ugt1a1 2 0.70 0.21 0.33
149 INT19783 Localization of Wdtc1 2 0.13 1.89 0.33
150 INT204941 Protein_catabolism of Timp2 1 0.03 0.35 0.32
151 INT321592 Localization of Lxn 1 0.79 1.11 0.32
152 INT187136 Negative_regulation of Localization of TIMP2 1 0.37 0.69 0.3
153 INT187130 Positive_regulation of Negative_regulation of TIMP2 1 0.43 0.78 0.29
154 INT147521 Regulation of Gene_expression of Ugt1a1 2 0.23 0.39 0.26
155 INT233398 Localization of TIMP3 2 0.45 1.31 0.26
156 INT193545 Binding of Dynll1 2 0.36 0.39 0.25
157 INT142864 Positive_regulation of Phosphorylation of ARRB1 1 0.01 0 0.25
158 INT142865 Phosphorylation of ARRB1 1 0.01 0 0.25
159 INT24734 Positive_regulation of LXN 1 0.21 0.7 0.23
160 INT323894 Negative_regulation of Regulation of TIMP2 1 0.20 1.04 0.23
161 INT156686 Negative_regulation of Localization of TIMP1 2 0.35 1.29 0.22
162 INT278672 Positive_regulation of Transcription of UGT1A1 1 0.27 0.07 0.22
163 INT234683 Protein_catabolism of Renbp 2 0.26 0.33 0.21
164 INT341658 Negative_regulation of Regulation of TIMP1 1 0.33 0.91 0.21
165 INT205617 Negative_regulation of Positive_regulation of Renbp 1 0.16 1.04 0.21
166 INT321587 Positive_regulation of Lxn 1 0.68 0.9 0.21
167 INT327477 Localization of Angptl4 1 0.10 1.28 0.19
168 INT327470 Negative_regulation of Localization of Angptl4 1 0.06 1.35 0.19
169 INT334776 Positive_regulation of Gene_expression of Angptl4 1 0.69 3.67 0.19
170 INT327479 Negative_regulation of Gene_expression of Angptl4 1 0.06 1.35 0.19
171 INT133784 Protein_catabolism of Ugt1a1 1 0.26 0.49 0.19
172 INT122740 Positive_regulation of Cd55 4 0.58 2.68 0.18
173 INT187051 Positive_regulation of Gene_expression of RENBP 3 0.09 2.04 0.18
174 INT189564 Binding of TIMP3 4 0.31 2.45 0.17
175 INT246462 Gene_expression of SCG5 3 0.65 0.78 0.17
176 INT210765 Negative_regulation of Timp4 1 0.38 0 0.16
177 INT342932 Positive_regulation of Gene_expression of Renbp 2 0.10 1.09 0.15
178 INT321593 Regulation of Lxn 1 0.23 0.93 0.15
179 INT310587 Positive_regulation of Negative_regulation of Timp1 1 0.44 0.81 0.14
180 INT105897 Regulation of UGT1A1 3 0.60 1.6 0.13
181 INT276149 Localization of SCG5 3 0.78 0.56 0.13
182 INT155235 Negative_regulation of TXNIP 2 0.58 2.44 0.13
183 INT334780 Regulation of Gene_expression of Angptl4 1 0.61 0.3 0.13
184 INT335098 Positive_regulation of Gene_expression of ANGPTL4 2 0.44 0.45 0.12
185 INT289388 Negative_regulation of Cd55 1 0.15 0.57 0.12
186 INT192591 Protein_catabolism of RENBP 1 0.02 0.94 0.12
187 INT335109 Gene_expression of ANGPTL4 2 0.68 0.53 0.11
188 INT207291 Negative_regulation of Gene_expression of TXNIP 1 0.58 3.47 0.11
189 INT187124 Positive_regulation of Positive_regulation of TIMP2 1 0.40 0.22 0.11
190 INT153941 Localization of Timp2 2 0.58 0.07 0.1
191 INT321857 Phosphorylation of Timp1 1 0.61 0.76 0.1
192 INT180707 Regulation of Localization of Timp2 1 0.35 0 0.1
193 INT321859 Negative_regulation of Phosphorylation of Timp1 1 0.32 0.76 0.1
194 INT121346 Binding of UGT1A9 1 0.24 0 0.1
195 INT235508 Localization of Renbp 3 0.36 2.02 0.09
196 INT351074 Negative_regulation of Binding of Timp1 1 0.04 1.14 0.09
197 INT342933 Negative_regulation of Gene_expression of Renbp 4 0.09 2.42 0.08
198 INT339259 Positive_regulation of Localization of SCG5 1 0.49 0 0.08
199 INT323892 Regulation of Transcription of TIMP2 1 0.21 0.9 0.08
200 INT193543 Localization of Dynll1 1 0.68 0.17 0.07
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