GO:0004861

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Name cyclin-dependent protein kinase inhibitor activity
Categary Function
Go Slim No
Go Link GO:0004861
Unique Molecular Interactions 342
Total Molecular Interactions 436
Total Single Events 5207
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for cyclin-dependent protein kinase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
3 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
4 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
5 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
6 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
7 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
8 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
9 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
10 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
11 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
12 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
13 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
14 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
15 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
16 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
17 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
18 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
19 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
20 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
21 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
22 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
23 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
24 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
25 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
26 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
27 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
28 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
29 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
30 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
31 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
32 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
33 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
34 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
35 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
36 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
37 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
38 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
39 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
40 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
41 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
42 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
43 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
44 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
45 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
46 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
47 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
48 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
49 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
50 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
51 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
52 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
53 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
54 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
55 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
56 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
57 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
58 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
59 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
60 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
61 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
62 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
63 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
64 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
65 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
66 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
67 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
68 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
69 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
70 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
71 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34
72 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
73 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
74 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
75 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
76 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
77 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
78 INT220521 Ugt1a6b Positive_regulation of Cdkn1b 1 0.01 2.38 0.31
79 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
80 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
81 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
82 INT237380 Binding of Cdkn2d and Il12b 1 0.01 0.45 0.26
83 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
84 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
85 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
86 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
87 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
88 INT121249 Binding of ANXA5 and CASP3 1 0.36 0.67 0.25
89 INT149713 Binding of Casp3 and Fas 1 0.40 1.09 0.25
90 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
91 INT210785 Cdkn1c Positive_regulation of Itgbl1 1 0.38 0 0.23
92 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
93 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
94 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
95 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
96 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
97 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
98 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
99 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
100 INT322543 Binding of FOXO3 and Cdkn1b 1 0.08 0.84 0.19
101 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
102 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
103 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
104 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
105 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
106 INT275400 Casp3 Positive_regulation of NDRG1 1 0.00 1.36 0.18
107 INT96416 CYC1 Positive_regulation of Casp3 1 0.02 0.96 0.17
108 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
109 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15
110 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
111 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
112 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
113 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
114 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
115 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
116 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
117 INT314867 Binding of Cdc7 and Cdkn2b 1 0.25 1.16 0.14
118 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
119 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
120 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
121 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
122 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
123 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
124 INT275389 Binding of Casp3 and Htatsf1 1 0.00 0.64 0.13
125 INT252632 Binding of Casp3 and Tradd 1 0.11 0.68 0.12
126 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12
127 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
128 INT315391 IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
129 INT315390 Positive_regulation of IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
130 INT142961 Binding of Nfkb1 and Casp3 1 0.00 1.02 0.11
131 INT234062 Nes Positive_regulation of Casp3 1 0.18 0.08 0.11
132 INT285023 Casp3 Negative_regulation of Casp7 1 0.07 0.44 0.1
133 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
134 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
135 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
136 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
137 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
138 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
139 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
140 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
141 INT245118 RBM45 Negative_regulation of CDKN2B 1 0.01 1.41 0.08
142 INT220514 Ppara Positive_regulation of Gene_expression of Cdkn1b 1 0.08 1 0.08
143 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
144 INT245119 Negative_regulation of RBM45 Negative_regulation of CDKN2B 1 0.01 1.43 0.08
145 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
146 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
147 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
148 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
149 INT203849 Ass1 Positive_regulation of Casp3 1 0.00 0.71 0.07
150 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
151 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
152 INT175966 Kctd1 Negative_regulation of Positive_regulation of CASP3 1 0.09 0.82 0.06
153 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
154 INT302129 BAX Regulation of Positive_regulation of CASP3 1 0.02 0.69 0.06
155 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
156 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
157 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
158 INT257879 Negative_regulation of Eif4e Positive_regulation of Cdkn1b 1 0.28 0.54 0.06
159 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
160 INT211347 Binding of Sigmar1 and Positive_regulation of Casp3 1 0.12 0.92 0.06
161 INT204079 HP Positive_regulation of Gene_expression of Cdkn1b 1 0.00 0.6 0.05
162 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
163 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
164 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
165 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
166 INT302141 CDKN1C Regulation of CDKN1B 1 0.09 0.26 0.05
167 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
168 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
169 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
170 INT242411 Mch Positive_regulation of Casp3 1 0.09 0.15 0.04
171 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04
172 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04
173 INT242413 Regulation of Mch Positive_regulation of Casp3 1 0.05 0.16 0.04
174 INT267217 Gene_expression of Hspb8 Negative_regulation of Positive_regulation of Casp3 1 0.14 2.8 0.04
175 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
176 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
177 INT193778 ITIH4 Positive_regulation of CASP3 1 0.03 0.98 0.03
178 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
179 INT283720 Id2 Negative_regulation of Transcription of Cdkn2b 1 0.18 0.11 0.03
180 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
181 INT175946 RSF1 Positive_regulation of Positive_regulation of CASP3 1 0.01 0.41 0.03
182 INT220512 Cav1 Regulation of Positive_regulation of Cdkn1b 1 0.06 0.85 0.03
183 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
184 INT172897 Negative_regulation of Lox Positive_regulation of Positive_regulation of Casp3 1 0.04 1.19 0.03
185 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
186 INT172910 Lox Positive_regulation of Positive_regulation of Casp3 1 0.03 1.19 0.03
187 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
188 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
189 INT345350 Casp3 Positive_regulation of Prkcd 1 0.05 0.79 0.03
190 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
191 INT327981 CASP9 Positive_regulation of CASP3 2 0.29 1.34 0
192 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
193 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0
194 INT325154 CDKN1B Negative_regulation of CCNE2 1 0.07 0.1 0
195 INT333772 Positive_regulation of Casp3 Positive_regulation of Gga3 1 0.05 0.5 0
196 INT348532 TP63 Positive_regulation of CASP3 1 0.04 0.55 0
197 INT233276 Cdkn1a Regulation of Hoxa10 1 0.12 0.26 0
198 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
199 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
200 INT247847 Narfl Positive_regulation of Positive_regulation of Casp3 1 0.02 0.79 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cyclin-dependent protein kinase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in cyclin-dependent protein kinase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
5 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
6 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
7 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
8 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
9 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
10 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
11 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
12 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
13 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
14 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
15 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
16 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
17 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
18 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
19 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
20 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
21 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
22 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
23 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
24 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
25 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
26 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
27 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
28 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
29 INT98178 Localization of Casp3 32 0.65 21.01 7.77
30 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
31 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
32 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
33 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
34 INT57232 Binding of Casp3 22 0.36 9.42 6.2
35 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
36 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
37 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
38 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
39 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
40 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
41 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
42 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
43 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
44 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
45 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
46 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
47 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
48 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
49 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
50 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
51 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
52 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
53 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
54 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
55 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
56 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
57 INT31118 Localization of Casp3 17 0.73 11.55 2.3
58 INT111038 Gene_expression of Cdkn1b 23 0.75 25.35 2.22
59 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
60 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
61 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
62 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
63 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9
64 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
65 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
66 INT137505 Positive_regulation of Cdkn1b 18 0.67 10.55 1.54
67 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
68 INT54996 Regulation of KAT2B 1 0.19 0.38 1.45
69 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
70 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
71 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
72 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
73 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
74 INT114220 Negative_regulation of Gene_expression of Cdkn1b 4 0.33 4.11 1.23
75 INT93625 Gene_expression of Cdkn1c 2 0.75 0.42 1.2
76 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
77 INT111036 Positive_regulation of Cdkn1b 16 0.45 9 1.06
78 INT102845 Localization of CASP3 7 0.81 2.81 1.06
79 INT111037 Positive_regulation of Gene_expression of Cdkn1b 5 0.39 11.17 1.06
80 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
81 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
82 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
83 INT31117 Binding of Casp3 14 0.23 5.27 0.93
84 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
85 INT220498 Negative_regulation of Gene_expression of Cdkn1b 9 0.21 7.48 0.8
86 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
87 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
88 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
89 INT93621 Positive_regulation of Gene_expression of Cdkn1c 1 0.67 0.42 0.77
90 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
91 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
92 INT224579 Gene_expression of Cdkn2d 6 0.41 4.23 0.68
93 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
94 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64
95 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
96 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
97 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
98 INT241621 Regulation of Cdkn1b 2 0.06 0.36 0.62
99 INT113850 Negative_regulation of Cdkn1b 4 0.42 3.45 0.6
100 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
101 INT242061 Positive_regulation of Negative_regulation of Casp3 3 0.09 1.7 0.58
102 INT98786 Positive_regulation of Gene_expression of Cdkn1b 21 0.67 8.7 0.56
103 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
104 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
105 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
106 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
107 INT100191 Gene_expression of Cdkn2b 1 0.65 0.06 0.51
108 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
109 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
110 INT163828 Localization of Cdkn1b 4 0.66 5.2 0.48
111 INT137504 Positive_regulation of Positive_regulation of Cdkn1b 2 0.45 1.71 0.45
112 INT163829 Positive_regulation of Localization of Cdkn1b 2 0.17 0.96 0.45
113 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
114 INT129144 Regulation of Localization of Casp3 1 0.26 0.84 0.44
115 INT153436 Positive_regulation of Localization of Casp3 3 0.49 2.12 0.43
116 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
117 INT132496 Regulation of Gene_expression of CASP3 6 0.20 4.59 0.42
118 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
119 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
120 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
121 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
122 INT155293 Positive_regulation of Protein_catabolism of Casp3 3 0.45 1.7 0.4
123 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
124 INT225223 Localization of Cdkn2b 2 0.62 1.29 0.37
125 INT239084 Localization of KAT2B 4 0.73 3.08 0.36
126 INT165916 Negative_regulation of Localization of Casp3 2 0.41 2.41 0.34
127 INT285500 Binding of Cdkn1c 1 0.18 0.76 0.34
128 INT204065 Regulation of Gene_expression of Cdkn1b 1 0.06 3.49 0.34
129 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
130 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
131 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
132 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
133 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
134 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
135 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
136 INT196426 Gene_expression of Cdkn2b 6 0.67 4.29 0.29
137 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
138 INT266973 Negative_regulation of KAT2B 1 0.01 0.99 0.29
139 INT203616 Positive_regulation of CDKN1C 2 0.60 12.62 0.27
140 INT159320 Negative_regulation of Protein_catabolism of CASP3 1 0.21 0.59 0.27
141 INT123541 Regulation of Gene_expression of Cdkn2b 1 0.26 0.06 0.26
142 INT164728 Positive_regulation of Cdkn1c 1 0.36 0.3 0.26
143 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
144 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
145 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
146 INT141820 Positive_regulation of Binding of Casp3 1 0.12 0.55 0.24
147 INT248401 Gene_expression of CDKN1C 21 0.67 14.52 0.23
148 INT179043 Negative_regulation of Cdkn1b 7 0.36 5.99 0.22
149 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
150 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
151 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
152 INT195018 Regulation of Negative_regulation of Casp3 1 0.21 0.48 0.2
153 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
154 INT179044 Regulation of Cdkn1b 4 0.22 2.64 0.18
155 INT248400 Regulation of CDKN1C 1 0.45 2.92 0.17
156 INT178607 Binding of CASP3 5 0.19 1.06 0.16
157 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
158 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
159 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
160 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
161 INT123522 Phosphorylation of Casp3 3 0.80 1.36 0.14
162 INT257863 Positive_regulation of Protein_catabolism of Cdkn1b 1 0.45 0.43 0.14
163 INT248403 Positive_regulation of Gene_expression of CDKN1C 1 0.40 7.77 0.14
164 INT257865 Negative_regulation of Protein_catabolism of Cdkn1b 1 0.42 0.43 0.14
165 INT257858 Protein_catabolism of Cdkn1b 1 0.64 0.43 0.14
166 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
167 INT61789 Negative_regulation of Cdkn1a 2 0.41 1.35 0.13
168 INT179034 Binding of Cdkn1b 7 0.31 5.12 0.12
169 INT226041 Positive_regulation of Binding of Casp3 1 0.12 0.82 0.12
170 INT148991 Gene_expression of Cdkn1a 1 0.44 0.46 0.11
171 INT190821 Positive_regulation of Negative_regulation of CASP3 1 0.06 0.51 0.1
172 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
173 INT220494 Negative_regulation of Positive_regulation of Cdkn1b 1 0.14 0.35 0.1
174 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09
175 INT233868 Localization of CDKN1B 2 0.73 0.37 0.09
176 INT101082 Positive_regulation of KAT2B 1 0.38 0.76 0.09
177 INT239085 Binding of KAT2B 1 0.18 2.04 0.09
178 INT346497 Negative_regulation of Phosphorylation of Cdkn1a 1 0.41 0.83 0.09
179 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
180 INT171688 Positive_regulation of Transcription of Casp3 3 0.28 1.16 0.08
181 INT210778 Negative_regulation of Cdkn1c 1 0.36 0 0.08
182 INT233871 Negative_regulation of Protein_catabolism of CDKN1B 1 0.57 0.27 0.08
183 INT245123 Gene_expression of CDKN2B 6 0.68 3.62 0.07
184 INT184989 Positive_regulation of CDKN2B 3 0.47 2.77 0.07
185 INT185030 Binding of CDKN2B 3 0.35 2.6 0.07
186 INT288609 Regulation of Regulation of Casp3 1 0.05 0.69 0.07
187 INT328542 Regulation of Positive_regulation of Cdkn1a 1 0.03 0.79 0.07
188 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06
189 INT333205 Negative_regulation of Protein_catabolism of Casp3 1 0.04 0.6 0.05
190 INT179033 Negative_regulation of Regulation of Cdkn1b 1 0.36 1.34 0.05
191 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
192 INT220489 Regulation of Gene_expression of Cdkn1b 1 0.20 1.57 0.04
193 INT265483 Phosphorylation of CASP3 1 0.22 0.25 0.04
194 INT316430 Positive_regulation of Negative_regulation of Cdkn1a 1 0.19 1.24 0.04
195 INT224295 Protein_catabolism of CDKN1A 1 0.12 0.55 0.03
196 INT203619 Positive_regulation of Positive_regulation of CDKN1C 1 0.13 0.34 0.03
197 INT314842 Phosphorylation of Cdkn2b 1 0.71 0.61 0.03
198 INT283688 Transcription of Cdkn2b 1 0.28 0.11 0.03
199 INT123524 Phosphorylation of Cdkn1b 4 0.29 2.29 0
200 INT172965 Negative_regulation of Positive_regulation of Cdkn1a 4 0.41 1.84 0
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