GO:0004864

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Name protein phosphatase inhibitor activity
Categary Function
Go Slim No
Go Link GO:0004864
Unique Molecular Interactions 65
Total Molecular Interactions 83
Total Single Events 606
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein phosphatase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for protein phosphatase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 0.00 0.74 1.25
2 INT196812 Ppp1r1b Negative_regulation of Ppp1cc 3 0.07 0.13 1.12
3 INT196834 Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 2 0.15 0 0.87
4 INT112914 Ppp1r1b Negative_regulation of Prkaca 3 0.22 0.13 0.86
5 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75
6 INT82039 Akr1d1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.02 0 0.74
7 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72
8 INT161297 Ppp1r1b Negative_regulation of Prkaca 1 0.10 0.16 0.7
9 INT161298 Ppp1r1b Negative_regulation of Trib3 1 0.05 0.16 0.7
10 INT100806 Ppp1r14a Regulation of Ppp1cc 1 0.05 0 0.65
11 INT82038 Positive_regulation of Akr1d1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.02 0 0.64
12 INT112916 Nts Regulation of Phosphorylation of Ppp1r1b 1 0.47 0 0.55
13 INT79593 Binding of Reg1 and LMTK2 1 0.00 0.32 0.53
14 INT196824 Ppp1r1b Regulation of Prkaca 1 0.10 0 0.51
15 INT196826 Ppp1r1b Regulation of Ppp1cc 1 0.10 0 0.51
16 INT228850 Dio1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.06 0 0.44
17 INT196821 Phosphorylation of Ppp1r1b Positive_regulation of Prkaca 1 0.09 0 0.41
18 INT112919 Nts Negative_regulation of Phosphorylation of Ppp1r1b 1 0.28 0 0.4
19 INT135015 MGP Negative_regulation of Cabin1 1 0.01 0.26 0.4
20 INT133708 Npff Negative_regulation of Phosphorylation of Ppp1r1b 1 0.30 0.41 0.4
21 INT196829 Ppp1r1b Negative_regulation of Phosphorylation of Ppp1cc 1 0.07 0 0.39
22 INT196796 Ppp1r1b Negative_regulation of Phosphorylation of Trh 1 0.01 0 0.39
23 INT183645 Ppp1r14b Positive_regulation of Macf1 1 0.00 1.23 0.38
24 INT183646 Negative_regulation of Ppp1r14b Positive_regulation of Macf1 1 0.00 1.29 0.38
25 INT196798 Trh Positive_regulation of Phosphorylation of Ppp1r1b 1 0.01 0 0.3
26 INT135014 Binding of Ephb1 and Cabin1 1 0.09 0.32 0.3
27 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27
28 INT305623 Ca2 Positive_regulation of Cabin1 1 0.00 0.27 0.27
29 INT276046 Negative_regulation of Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 1 0.15 0.11 0.23
30 INT164517 CABIN1 Positive_regulation of Transcription of IL2 1 0.13 0.35 0.22
31 INT112912 Nts Positive_regulation of Phosphorylation of Arpp19 1 0.18 0 0.21
32 INT99733 Binding of F13A1 and Ppp1r1a 1 0.00 0.25 0.19
33 INT99735 Binding of PLG and Ppp1r1a 1 0.00 0.24 0.19
34 INT99731 Binding of Serpinf2 and Ppp1r1a 1 0.00 0.24 0.19
35 INT193081 PRKCA Positive_regulation of Ppp1r14a 1 0.01 0.13 0.18
36 INT193080 ROCK1 Positive_regulation of Ppp1r14a 1 0.00 0.13 0.18
37 INT112913 Nts Positive_regulation of Phosphorylation of Ppp1r1b 1 0.53 0 0.18
38 INT276069 Binding of Camk2a and Ppp1r1b 1 0.18 0 0.12
39 INT276057 Binding of Prkaca and Ppp1r1b 1 0.10 0 0.12
40 INT213421 Binding of CXCL2 and SET 1 0.11 0.17 0.1
41 INT213417 Binding of CCL7 and SET 1 0.11 0.17 0.1
42 INT213414 Binding of CXCL1 and SET 1 0.10 0.17 0.1
43 INT213415 Binding of CCL8 and SET 1 0.11 0.17 0.1
44 INT213420 Binding of IL6 and SET 1 0.10 0.17 0.1
45 INT213416 Binding of CCL2 and SET 1 0.11 0.17 0.1
46 INT146590 Positive_regulation of Ppp1r1b Regulation of Pdyn 1 0.45 0.43 0.09
47 INT274156 Negative_regulation of Cabin1 Negative_regulation of Gene_expression of Vegfa 1 0.08 0.28 0.09
48 INT146589 Ppp1r1b Regulation of Pdyn 1 0.26 0.43 0.09
49 INT261892 Creb1 Regulation of Gene_expression of Ppp1r1b 1 0.31 1.46 0.09
50 INT146591 Negative_regulation of Ppp1r1b Regulation of Pdyn 1 0.42 0.43 0.09
51 INT276033 Binding of Ppp1cc and Ppp1r1b 1 0.06 0 0.09
52 INT310113 Binding of SET and TP53INP2 1 0.15 0.05 0.08
53 INT310110 SET Positive_regulation of Localization of POMT1 1 0.08 0 0.05
54 INT270664 Ensa Positive_regulation of Localization of Ins1 1 0.02 0.89 0.05
55 INT293367 Binding of CABIN1 and Ppia 1 0.00 0.19 0.03
56 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
57 INT177352 Binding of CEL and PTN 1 0.01 0 0.03
58 INT294293 Binding of RCAN1 and CABIN1 1 0.03 0 0.03
59 INT276070 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Ppp1r1b 1 0.24 0 0.03
60 INT308329 Binding of F5 and PTN 1 0.04 0 0
61 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0
62 INT310115 Binding of NOVA2 and SET 1 0.12 0 0
63 INT293366 Binding of CABIN1 and Fkbp1a 1 0.00 0.05 0
64 INT318683 ARPP21 Negative_regulation of SET 1 0.00 0.1 0
65 INT294313 Gene_expression of CABIN1 Positive_regulation of IL11 1 0.03 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein phosphatase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in protein phosphatase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10481 Phosphorylation of Ppp1r1b 29 0.82 2.46 21.59
2 INT112908 Phosphorylation of Ppp1r1b 65 0.77 1.27 16.42
3 INT10480 Positive_regulation of Ppp1r1b 15 0.70 2.82 9.97
4 INT4737 Gene_expression of Ppp1r1b 29 0.67 5.73 9.83
5 INT82005 Positive_regulation of Phosphorylation of Ppp1r1b 10 0.69 0 9.51
6 INT66460 Negative_regulation of Cabin1 15 0.43 8.98 8.03
7 INT4738 Regulation of Ppp1r1b 14 0.49 2.41 7.08
8 INT120468 Negative_regulation of Ppp1r1b 10 0.50 2.55 6.56
9 INT10483 Regulation of Phosphorylation of Ppp1r1b 8 0.62 0.73 5.8
10 INT82009 Negative_regulation of Phosphorylation of Ppp1r1b 7 0.58 0.85 4.94
11 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73
12 INT138348 Positive_regulation of Phosphorylation of Ppp1r1b 16 0.56 1.4 4.63
13 INT120469 Positive_regulation of Negative_regulation of Ppp1r1b 5 0.39 0.76 4.59
14 INT113137 Positive_regulation of Ppp1r1b 14 0.65 0.89 4.21
15 INT196736 Gene_expression of Ppp1r1b 24 0.55 2.01 3.99
16 INT10484 Positive_regulation of Gene_expression of Ppp1r1b 6 0.47 1.05 3.51
17 INT112907 Regulation of Phosphorylation of Ppp1r1b 11 0.21 0.06 3.15
18 INT48539 Positive_regulation of Cabin1 8 0.32 0.63 2.68
19 INT202051 Negative_regulation of PPP1R11 1 0.01 1.6 2.51
20 INT24887 Localization of CABIN1 1 0.71 1.19 2.39
21 INT156694 Binding of SET 10 0.36 3.77 2.21
22 INT161296 Positive_regulation of Positive_regulation of Ppp1r1b 1 0.35 0.17 2.07
23 INT196784 Regulation of Ppp1r1b 8 0.32 0.3 1.78
24 INT24888 Gene_expression of CABIN1 3 0.56 0.91 1.71
25 INT127145 Gene_expression of SET 46 0.65 10.39 1.7
26 INT112904 Negative_regulation of Ppp1r1b 3 0.34 0.1 1.29
27 INT132191 Regulation of Cabin1 6 0.45 2.96 1.28
28 INT113136 Positive_regulation of Positive_regulation of Ppp1r1b 2 0.47 0 1.25
29 INT121792 Gene_expression of PTN 13 0.75 2.81 1.07
30 INT126876 Gene_expression of Cabin1 6 0.63 2.81 0.92
31 INT112906 Negative_regulation of Phosphorylation of Ppp1r1b 5 0.55 0 0.86
32 INT82008 Negative_regulation of Positive_regulation of Ppp1r1b 1 0.28 0 0.83
33 INT228844 Regulation of Gene_expression of Ppp1r1b 3 0.32 0.17 0.77
34 INT16611 Localization of Ppp1r1b 1 0.79 0 0.74
35 INT100802 Binding of Ppp1r14a 1 0.08 0 0.7
36 INT134276 Positive_regulation of Positive_regulation of Cabin1 1 0.03 0.13 0.65
37 INT79584 Localization of LMTK2 1 0.01 0.51 0.61
38 INT126877 Positive_regulation of Gene_expression of Cabin1 3 0.56 1.97 0.57
39 INT235840 Negative_regulation of Gene_expression of Ppp1r1b 1 0.09 0.19 0.57
40 INT196774 Positive_regulation of Gene_expression of Ppp1r1b 4 0.31 0.29 0.56
41 INT37359 Negative_regulation of PTN 4 0.32 1.58 0.53
42 INT196738 Binding of Ppp1r1b 3 0.26 0.27 0.53
43 INT277472 Positive_regulation of PTN 4 0.49 1.14 0.46
44 INT135013 Binding of Cabin1 2 0.32 0.72 0.46
45 INT79585 Negative_regulation of LMTK2 1 0.01 0.32 0.44
46 INT69808 Gene_expression of PPP1R11 1 0.02 0.32 0.42
47 INT183627 Negative_regulation of Ppp1r14b 2 0.02 1.98 0.38
48 INT183624 Binding of Ppp1r14b 1 0.02 1.06 0.38
49 INT121794 Regulation of PTN 2 0.44 0.91 0.31
50 INT121791 Regulation of Regulation of PTN 1 0.27 0.84 0.31
51 INT48538 Regulation of Positive_regulation of Cabin1 1 0.01 0.28 0.29
52 INT139645 Positive_regulation of Negative_regulation of Ppp1r1b 1 0.17 0.1 0.27
53 INT79583 Gene_expression of LMTK2 1 0.01 0.15 0.27
54 INT156707 Positive_regulation of SET 6 0.49 1.14 0.26
55 INT10479 Positive_regulation of Regulation of Ppp1r1b 1 0.47 0.3 0.26
56 INT50175 Regulation of Gene_expression of Ppp1r1b 1 0.01 0 0.26
57 INT139652 Negative_regulation of Arpp19 1 0.12 0.1 0.26
58 INT88004 Binding of CABIN1 2 0.03 0.11 0.25
59 INT79580 Regulation of Negative_regulation of LMTK2 1 0.01 0.14 0.25
60 INT79586 Regulation of LMTK2 1 0.01 0.33 0.24
61 INT112901 Phosphorylation of Arpp19 1 0.34 0 0.21
62 INT193076 Gene_expression of Ppp1r14a 1 0.08 0.28 0.2
63 INT193075 Positive_regulation of Gene_expression of Ppp1r14a 1 0.05 0.28 0.2
64 INT146588 Negative_regulation of Regulation of Ppp1r1b 1 0.36 0.85 0.18
65 INT193074 Binding of Ppp1r14a 1 0.04 0.12 0.18
66 INT248768 Localization of SET 3 0.44 2.38 0.17
67 INT121793 Localization of PTN 3 0.61 0.67 0.16
68 INT126875 Negative_regulation of Gene_expression of Cabin1 2 0.47 1.04 0.16
69 INT164520 Regulation of CABIN1 2 0.26 0.1 0.13
70 INT108971 Gene_expression of Ppp1r1a 1 0.01 0.63 0.12
71 INT261888 Negative_regulation of Gene_expression of Ppp1r1b 1 0.41 2.77 0.11
72 INT294331 Positive_regulation of CABIN1 1 0.03 0 0.11
73 INT183637 Gene_expression of Ppp1r14b 3 0.04 1.42 0.1
74 INT274155 Localization of Cabin1 1 0.57 0.55 0.1
75 INT274153 Negative_regulation of Binding of Cabin1 1 0.28 0.2 0.08
76 INT228847 Localization of Ppp1r1b 2 0.53 0.25 0.07
77 INT294336 Negative_regulation of Binding of CABIN1 1 0.03 0 0.07
78 INT25177 Regulation of Ppp1r1a 1 0.01 0.27 0.07
79 INT310119 Regulation of Gene_expression of SET 5 0.32 0.49 0.05
80 INT310118 Negative_regulation of SET 1 0.30 0.15 0.04
81 INT268605 Binding of Ppp1r1b 1 0.08 0 0.03
82 INT268604 Negative_regulation of Binding of Ppp1r1b 1 0.10 0 0.03
83 INT308336 Transcription of PTN 1 0.67 0 0.03
84 INT294360 Negative_regulation of Gene_expression of CABIN1 1 0.03 0.06 0.03
85 INT300524 Regulation of SET 4 0.28 1.19 0
86 INT126208 Binding of PTN 2 0.36 0 0
87 INT308332 Negative_regulation of Localization of PTN 2 0.17 0.09 0
88 INT257434 Positive_regulation of Gene_expression of PTN 1 0.45 0.07 0
89 INT259253 Positive_regulation of Gene_expression of SET 1 0.05 0.6 0
90 INT294330 Positive_regulation of Gene_expression of CABIN1 1 0.03 0.06 0
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