GO:0004866

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Name endopeptidase inhibitor activity
Categary Function
Go Slim No
Go Link GO:0004866
Unique Molecular Interactions 321
Total Molecular Interactions 411
Total Single Events 3416
Pain Genes Associated 33

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endopeptidase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for endopeptidase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02
2 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
3 INT275398 Binding of ITIH4 and Htatsf1 1 0.02 5.05 2.24
4 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
5 INT128654 ITIH4 Regulation of Gene_expression of CCL16 1 0.02 2.69 1.79
6 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
7 INT351366 LPA Positive_regulation of Rab38 1 0.00 0.95 1.53
8 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
9 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
10 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
11 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
12 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
13 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
14 INT348398 LPA Positive_regulation of Pik3cb 1 0.04 0.88 1.14
15 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
16 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06
17 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
18 INT106810 ZNF398 Positive_regulation of RECK 1 0.02 0.5 1.01
19 INT106809 ZNF398 Positive_regulation of Transcription of RECK 1 0.02 0.5 1.01
20 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
21 INT275409 Binding of ITIH4 and Cxcr4 1 0.09 2.87 0.97
22 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
23 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92
24 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92
25 INT156989 LPA Positive_regulation of Gene_expression of EFNB1 1 0.00 0.91 0.92
26 INT106808 RECK Negative_regulation of MMP2 1 0.40 0.5 0.83
27 INT164607 Positive_regulation of GSR Positive_regulation of Gpx1 1 0.01 0.33 0.81
28 INT164606 GSR Positive_regulation of Gpx1 1 0.01 0.32 0.8
29 INT16507 Binding of LPA and Crp 1 0.00 0.78 0.78
30 INT16494 Binding of LPA and Serpinf2 1 0.00 0.78 0.78
31 INT351364 LPA Positive_regulation of Trpv1 1 0.02 1.15 0.78
32 INT16492 Positive_regulation of Binding of LPA and Serpinf2 1 0.00 0.78 0.78
33 INT16506 Positive_regulation of Binding of LPA and Crp 1 0.00 0.78 0.78
34 INT16498 Binding of ADRA1D and LPA 1 0.10 0.78 0.78
35 INT16497 Positive_regulation of Binding of ADRA1D and LPA 1 0.10 0.78 0.78
36 INT168507 Binding of SPINK1 and Ctrc 1 0.03 0.93 0.76
37 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
38 INT137139 ITIH4 Positive_regulation of OPRM1 1 0.37 0.67 0.72
39 INT351367 LPA Regulation of Trpv1 1 0.01 0.83 0.69
40 INT120484 ITIH4 Positive_regulation of Il1 1 0.01 0.62 0.68
41 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 0.40 0.71 0.66
42 INT46964 C3 Positive_regulation of Tcm 1 0.00 1.26 0.66
43 INT167795 Negative_regulation of LPA Negative_regulation of Mag 1 0.01 0.84 0.64
44 INT167794 LPA Negative_regulation of Mag 1 0.01 0.77 0.63
45 INT30129 Binding of C3 and Gast 1 0.06 0.09 0.62
46 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6
47 INT137138 ITIH4 Positive_regulation of Positive_regulation of OPRM1 1 0.42 0.55 0.59
48 INT149479 CEBPD Positive_regulation of C3 1 0.30 0.14 0.57
49 INT223924 Cux1 Regulation of Gene_expression of Serpina1 1 0.04 0.15 0.57
50 INT137141 Binding of HIVEP1 and ITIH4 2 0.16 1.44 0.56
51 INT139429 LPA Positive_regulation of Negative_regulation of MBP 1 0.00 0.78 0.56
52 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54
53 INT125086 LPA Positive_regulation of Rtn4 1 0.00 0.36 0.54
54 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
55 INT130561 NCKIPSD Regulation of SERPINF2 1 0.22 0 0.52
56 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51
57 INT167583 ENPP2 Positive_regulation of Gene_expression of LPA 1 0.08 0.93 0.51
58 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
59 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48
60 INT229127 SPINK1 Positive_regulation of PRSS1 1 0.53 1.59 0.48
61 INT173293 LPA Positive_regulation of OR1S1 1 0.03 0.15 0.47
62 INT331731 Binding of C3 and CD79A 1 0.02 0.85 0.46
63 INT341625 Binding of SPINK1 and CTRC 1 0.41 1.22 0.46
64 INT54135 Binding of F13A1 and LPA 2 0.00 0.71 0.42
65 INT161654 Gsr Regulation of Gpx1 1 0.14 0.85 0.42
66 INT54136 Negative_regulation of Binding of F13A1 and LPA 1 0.00 0.42 0.42
67 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42
68 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42
69 INT329960 Binding of C5 and TRAF1 1 0.32 1.04 0.42
70 INT329958 Binding of C5 and STAT4 1 0.33 0.93 0.41
71 INT153116 Binding of SPINK1 and Abpa 1 0.01 1.32 0.4
72 INT4975 Binding of ITIH4 and MAG 1 0.44 2.24 0.39
73 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
74 INT281154 ITIH4 Positive_regulation of Cxcr4 1 0.09 0.71 0.37
75 INT281155 Binding of ITIH4 and Ddc 1 0.09 1.27 0.37
76 INT281153 Binding of ITIH4 and Cd4 1 0.10 0.91 0.37
77 INT155166 Binding of C2 and C3 1 0.40 0 0.34
78 INT193784 ITIH4 Positive_regulation of YWHAZ 1 0.04 1.21 0.34
79 INT311265 RENBP Regulation of IL8 1 0.03 1.59 0.33
80 INT311263 RENBP Regulation of TNF 1 0.01 1.59 0.33
81 INT298472 LPA Positive_regulation of Gene_expression of CXCL16 1 0.05 0.41 0.32
82 INT311266 RENBP Regulation of IL6 1 0.02 1.59 0.32
83 INT330182 Binding of ITIH2 and BRD4 1 0.05 0.37 0.32
84 INT284229 Binding of ITIH4 and Ccr5 1 0.10 0.27 0.31
85 INT207434 LPA Regulation of Gene_expression of PLA2G7 1 0.11 0.73 0.31
86 INT116358 Binding of C3 and ELANE 1 0.12 0 0.29
87 INT116356 Positive_regulation of Binding of C3 and ELANE 1 0.16 0 0.29
88 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27
89 INT321602 Binding of C4A and PRTN3 1 0.00 0.99 0.27
90 INT24223 Ifng Negative_regulation of Gene_expression of C3 1 0.01 0 0.26
91 INT167582 ENPP2 Regulation of Gene_expression of LPA 1 0.05 0.61 0.26
92 INT207441 Binding of LPA and PLA2G7 1 0.10 0.56 0.26
93 INT179166 TFPI Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.25
94 INT41950 Ptger1 Positive_regulation of Localization of A2m 1 0.19 0.46 0.24
95 INT41949 Ptger1 Positive_regulation of Gene_expression of A2m 1 0.19 0.46 0.24
96 INT229129 SPINK1 Negative_regulation of PRSS1 1 0.49 0.79 0.24
97 INT64789 ITIH4 Positive_regulation of Positive_regulation of Pla2g1b 1 0.19 0.55 0.24
98 INT311268 RENBP Regulation of Gene_expression of IL8 1 0.02 1.05 0.24
99 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23
100 INT238260 Positive_regulation of pma Negative_regulation of Transcription of C3 1 0.02 0.12 0.23
101 INT173294 LPA Positive_regulation of EGF 1 0.01 0.07 0.23
102 INT128986 Binding of CST3 and Phdlc1 1 0.01 1.96 0.22
103 INT275404 ITIH4 Regulation of Positive_regulation of Htatsf1 1 0.02 0.91 0.22
104 INT58306 C4A Regulation of Gene_expression of IL1B 1 0.00 0.15 0.21
105 INT332013 Hc Regulation of Binding of C3ar1 1 0.12 1.11 0.21
106 INT58304 C4A Regulation of Localization of TNF 1 0.00 0.15 0.21
107 INT332016 C3ar1 Regulation of Binding of Hc 1 0.12 1.11 0.21
108 INT218510 Binding of C3 and Cfb 1 0.02 0.53 0.2
109 INT257844 STS Positive_regulation of Negative_regulation of CST7 1 0.01 0.24 0.19
110 INT181082 Binding of C3 and C3ar1 1 0.03 1.31 0.19
111 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19
112 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19
113 INT308533 ITIH4 Positive_regulation of Protein_catabolism of Tjp2 1 0.01 1.28 0.18
114 INT229928 Binding of C3 and CFH 1 0.07 1.35 0.17
115 INT334423 Binding of SPINK1 and Cea 1 0.02 2.53 0.17
116 INT284230 Positive_regulation of Binding of ITIH4 and Ccr5 1 0.10 0 0.17
117 INT229931 Negative_regulation of Binding of C3 and CFH 1 0.08 1.35 0.17
118 INT344590 Binding of IFN1@ and C3 1 0.32 0.3 0.16
119 INT88311 ITIH4 Positive_regulation of CCR5 1 0.49 1.57 0.16
120 INT111802 Binding of CD40LG and TFPI 1 0.14 0.62 0.16
121 INT298475 LPA Positive_regulation of Gene_expression of IL8 1 0.07 0.38 0.15
122 INT116359 Positive_regulation of Binding of C4A and ELANE 1 0.14 0 0.15
123 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15
124 INT275375 Binding of ITIH4 and NDRG1 1 0.00 0.65 0.14
125 INT116357 Binding of C4A and ELANE 1 0.11 0 0.14
126 INT84050 IL6 Positive_regulation of ITIH4 1 0.49 0.18 0.13
127 INT275401 Binding of ITIH4 and Atf3 1 0.12 0.64 0.13
128 INT275408 Binding of ITIH4 and Gap43 1 0.03 0.64 0.13
129 INT252573 Rpe Negative_regulation of Gpx1 1 0.07 2.34 0.13
130 INT311262 RENBP Regulation of Regulation of TNF 1 0.02 0.33 0.13
131 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
132 INT330156 Scn2a1 Regulation of Transcription of Pcsk1n 1 0.13 0 0.13
133 INT223040 AR Positive_regulation of Negative_regulation of TFPI 1 0.03 0 0.13
134 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
135 INT155388 Binding of LPA and Lipg 1 0.00 1.22 0.12
136 INT155387 Binding of LPA and RT1-A 1 0.00 1.22 0.12
137 INT270355 Vcsa1 Positive_regulation of Negative_regulation of Mme 1 0.13 0.52 0.12
138 INT284228 Binding of ITIH4 and Eclc 1 0.02 0.29 0.12
139 INT289404 Mthfd1 Positive_regulation of Hc 1 0.04 0.58 0.12
140 INT143662 Rere Regulation of Gpx1 1 0.69 0.56 0.12
141 INT251295 Binding of CD4 and Regulation of ITIH4 1 0.11 0.24 0.11
142 INT334870 Binding of C4b and Mpz 1 0.10 0 0.11
143 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11
144 INT334861 Positive_regulation of Binding of C4b and Mpz 1 0.13 0 0.11
145 INT153815 LPA Positive_regulation of Gene_expression of Gtf3a 1 0.00 0.16 0.1
146 INT143423 Binding of SPINK1 and Thim 1 0.00 0.1 0.1
147 INT273892 LPA Positive_regulation of ALB 1 0.01 0.95 0.1
148 INT245182 Binding of SPINK1 and TCF7L2 1 0.39 2.05 0.1
149 INT281029 MASP2 Positive_regulation of C4A 1 0.00 0.72 0.1
150 INT311267 RENBP Regulation of Gene_expression of TNF 1 0.02 0.54 0.09
151 INT294692 LPA Positive_regulation of BATF 1 0.00 0 0.09
152 INT205204 LPA Positive_regulation of Positive_regulation of Pik3c3 1 0.02 0.22 0.09
153 INT189195 Binding of C4A and C4B 1 0.14 2.45 0.09
154 INT251292 Binding of ITIH4 and ERVW-1 1 0.22 0.07 0.08
155 INT45452 Binding of C2 and C3 1 0.34 0.08 0.08
156 INT251293 Regulation of Binding of ITIH4 and ERVW-1 1 0.27 0.07 0.08
157 INT41832 Binding of ALB and C5 1 0.41 0.07 0.08
158 INT41831 Binding of ALB and C3 1 0.22 0.07 0.08
159 INT270682 Binding of OLR1 and RENBP 1 0.00 0.76 0.08
160 INT279502 Binding of C2 and Hc 1 0.01 0.2 0.07
161 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
162 INT223039 Gene_expression of TFPI Positive_regulation of Gene_expression of ADRBK1 1 0.11 0 0.07
163 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
164 INT223043 Gene_expression of TFPI Positive_regulation of Gene_expression of ADRBK2 1 0.12 0 0.07
165 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
166 INT218511 Cfb Positive_regulation of C5 1 0.01 0.29 0.06
167 INT218503 Cfb Positive_regulation of C3 1 0.01 0.29 0.06
168 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
169 INT299703 ECB2 Negative_regulation of Binding of C5 1 0.00 0.39 0.06
170 INT334868 Binding of C4b and Nfatc1 1 0.01 0 0.06
171 INT229982 Binding of C3 and amd 1 0.02 1.14 0.06
172 INT28705 F7 Negative_regulation of TFPI 1 0.02 0.66 0.06
173 INT275126 Binding of CSTB and IGHG3 1 0.00 0.49 0.05
174 INT320402 Binding of Usp14 and Psmb10 1 0.00 0 0.05
175 INT208432 Sms Negative_regulation of Negative_regulation of Gpx1 1 0.14 0.61 0.05
176 INT189202 Binding of C4B and HAS2 1 0.02 1.25 0.05
177 INT171543 IL4 Positive_regulation of Transcription of C3 1 0.28 0 0.05
178 INT171542 IL4 Positive_regulation of Gene_expression of C3 1 0.19 0 0.05
179 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05
180 INT356238 Binding of HLA-E and PI3 1 0.02 0 0.05
181 INT349665 Positive_regulation of Binding of AR and TFPI 1 0.02 0 0.05
182 INT208433 Sms Positive_regulation of Gene_expression of Gpx1 1 0.25 0.53 0.05
183 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
184 INT349667 Binding of AR and TFPI 1 0.02 0 0.05
185 INT343498 Binding of ITIH4 and TPPP 1 0.06 0.64 0.05
186 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 0.18 1.07 0.04
187 INT245218 Binding of C3 and C5AR1 2 0.29 2.94 0.04
188 INT185756 Binding of ITIH4 and Cd4 2 0.05 1.22 0.04
189 INT209644 Binding of AR and C4B 1 0.00 0.32 0.04
190 INT349663 Binding of TFPI and PYCARD 1 0.04 0 0.04
191 INT241752 ITIH4 Negative_regulation of Binding of CXCR4 1 0.08 0.71 0.04
192 INT320439 Binding of Uchl5 and Psmb10 1 0.00 0 0.04
193 INT251296 Binding of CCR5 and ITIH4 1 0.16 0.08 0.04
194 INT241749 ITIH4 Negative_regulation of Binding of CCR5 1 0.16 0.71 0.04
195 INT347414 Tlr4 Negative_regulation of Gpx1 1 0.01 0.36 0.04
196 INT189198 Binding of C4A and SERPINF1 1 0.12 1.17 0.04
197 INT279531 Binding of LPA and MBL2 1 0.02 0.54 0.04
198 INT323674 Binding of TFPI and THBD 1 0.02 2.45 0.04
199 INT245216 Binding of C3 and C3AR1 1 0.19 1.21 0.04
200 INT252767 CAT Regulation of Gpx1 1 0.00 0.25 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for endopeptidase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in endopeptidase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9650 Gene_expression of LPA 141 0.75 104.57 29
2 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05
3 INT756 Gene_expression of C3 138 0.75 100.6 19.2
4 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
5 INT4977 Binding of ITIH4 60 0.46 42.48 15.65
6 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78
7 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18
8 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89
9 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63
10 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
11 INT23654 Binding of SPINK1 27 0.48 30.85 11.53
12 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05
13 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
14 INT82743 Gene_expression of SPINK1 48 0.78 44.28 8.77
15 INT32579 Binding of C4B 14 0.36 14.99 7.79
16 INT573 Negative_regulation of C3 60 0.59 41.37 7.78
17 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75
18 INT178198 Gene_expression of C3 62 0.78 39.5 7.69
19 INT153814 Localization of LPA 19 0.65 18.25 7.68
20 INT1120 Gene_expression of C3 33 0.67 22.86 7.56
21 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84
22 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48
23 INT195 Gene_expression of C4a 16 0.48 15.55 6.1
24 INT677 Positive_regulation of CST3 20 0.67 17.47 6
25 INT29821 Gene_expression of Serpina1 18 0.60 2.98 5.75
26 INT106813 Positive_regulation of RECK 1 0.69 2.39 5.38
27 INT12039 Localization of TFPI 22 0.68 9.88 5.35
28 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16
29 INT28703 Negative_regulation of TFPI 29 0.38 19.81 4.93
30 INT84057 Positive_regulation of Gene_expression of ITIH4 12 0.50 10.5 4.92
31 INT2947 Regulation of TFPI 10 0.44 5.81 4.86
32 INT11030 Binding of LPA 70 0.48 40.35 4.81
33 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64
34 INT210885 Regulation of SLPI 8 0.44 7.15 4.61
35 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43
36 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
37 INT6507 Binding of C5 23 0.48 15.35 3.91
38 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83
39 INT55093 Negative_regulation of SPINK1 13 0.42 15.11 3.8
40 INT181922 Binding of RENBP 16 0.36 13.92 3.71
41 INT69904 Binding of Hc 11 0.35 7.79 3.69
42 INT182676 Transcription of C4B 1 0.31 4.82 3.66
43 INT57644 Regulation of SPINK1 7 0.47 15.19 3.64
44 INT135963 Negative_regulation of Hc 19 0.42 12.36 3.63
45 INT106817 Gene_expression of RECK 8 0.77 2.78 3.62
46 INT54102 Positive_regulation of Gene_expression of TFPI 14 0.49 6.67 3.54
47 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52
48 INT53584 Regulation of Gpx1 19 0.62 14.38 3.48
49 INT8539 Negative_regulation of Serpina1a 21 0.58 12.65 3.39
50 INT43985 Regulation of LPA 29 0.62 20.79 3.29
51 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05
52 INT27243 Positive_regulation of SPINK1 13 0.68 26.71 2.92
53 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89
54 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85
55 INT9460 Positive_regulation of C3 6 0.69 3.96 2.81
56 INT64147 Gene_expression of C5 15 0.60 16.8 2.78
57 INT121683 Gene_expression of Hc 23 0.75 7.15 2.7
58 INT76099 Positive_regulation of ITIH4 8 0.69 5.71 2.66
59 INT127552 Gene_expression of Pcsk1n 8 0.78 1.11 2.66
60 INT103977 Positive_regulation of Gene_expression of SPINK1 7 0.50 7.38 2.66
61 INT29818 Regulation of Serpina1 8 0.27 0.08 2.64
62 INT155160 Binding of C3 20 0.47 7.77 2.61
63 INT61904 Gene_expression of CST7 3 0.53 3.22 2.53
64 INT120483 Localization of ITIH4 11 0.69 12.05 2.51
65 INT10044 Positive_regulation of Serpina1 5 0.69 0.99 2.45
66 INT38871 Binding of TFPI 12 0.32 5.9 2.36
67 INT75756 Phosphorylation of LPA 5 0.68 0.67 2.35
68 INT12384 Positive_regulation of PI3 7 0.38 5.73 2.33
69 INT29094 Binding of C3 39 0.37 12.65 2.27
70 INT640 Regulation of CST3 9 0.60 4.04 2.26
71 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23
72 INT40565 Gene_expression of SLPI 15 0.75 7.25 2.21
73 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17
74 INT106814 Positive_regulation of Gene_expression of RECK 2 0.69 1.04 2.1
75 INT55897 Positive_regulation of C4a 8 0.29 3.81 2.07
76 INT10045 Negative_regulation of Serpina1 7 0.43 1.01 2.07
77 INT46109 Binding of SERPINF2 6 0.37 1.08 2.06
78 INT216065 Localization of C4B 2 0.21 2.86 2.01
79 INT35689 Localization of C3 17 0.75 5.3 1.98
80 INT16385 Regulation of C3 20 0.41 9.98 1.92
81 INT14500 Positive_regulation of Gene_expression of CST3 9 0.67 7.46 1.87
82 INT135961 Positive_regulation of Hc 8 0.67 3.67 1.87
83 INT68522 Localization of Pcsk1n 2 0.56 1.19 1.85
84 INT64787 Regulation of ITIH4 7 0.38 5.61 1.82
85 INT96797 Negative_regulation of ITIH4 5 0.42 3.21 1.8
86 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74
87 INT9648 Positive_regulation of Gene_expression of LPA 15 0.59 11.31 1.72
88 INT94848 Negative_regulation of Gene_expression of Gpx1 11 0.30 4.91 1.7
89 INT156671 Gene_expression of Vcsa1 22 0.75 23.32 1.69
90 INT223923 Positive_regulation of Gene_expression of Serpina1 1 0.08 0.27 1.67
91 INT14405 Gene_expression of SERPINF2 14 0.65 3 1.64
92 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62
93 INT212790 Regulation of C5 6 0.24 6.04 1.59
94 INT193809 Regulation of Binding of ITIH4 2 0.31 1.82 1.59
95 INT60975 Localization of CST3 6 0.78 2.4 1.58
96 INT223920 Regulation of Gene_expression of Serpina1 1 0.05 0.4 1.57
97 INT67869 Transcription of Gpx1 3 0.68 0.67 1.56
98 INT182037 Localization of C3 10 0.68 6.69 1.54
99 INT64821 Positive_regulation of SLPI 11 0.67 5.08 1.48
100 INT14404 Negative_regulation of SERPINF2 11 0.47 3.15 1.47
101 INT263023 Gene_expression of PI3 6 0.75 2.68 1.39
102 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38
103 INT10885 Negative_regulation of C3 9 0.38 11.86 1.35
104 INT179539 Positive_regulation of Gene_expression of C3 9 0.70 5.98 1.32
105 INT35728 Positive_regulation of Vcsa1 4 0.48 0.87 1.3
106 INT41944 Positive_regulation of Gene_expression of A2m 2 0.23 2.56 1.29
107 INT148212 Negative_regulation of Gene_expression of C3 2 0.43 5.47 1.24
108 INT35729 Positive_regulation of Positive_regulation of Vcsa1 1 0.31 0.3 1.23
109 INT679 Negative_regulation of CST3 7 0.57 4.63 1.22
110 INT107942 Positive_regulation of C5 9 0.50 6.86 1.19
111 INT25492 Positive_regulation of Positive_regulation of TFPI 4 0.50 1.44 1.16
112 INT160553 Regulation of C4B 3 0.14 1.54 1.16
113 INT41947 Regulation of A2m 2 0.29 1.08 1.14
114 INT36064 Binding of CST3 14 0.47 16.38 1.12
115 INT11109 Positive_regulation of Serpina1a 5 0.68 4.97 1.12
116 INT93055 Regulation of C3 4 0.40 1.81 1.12
117 INT153115 Protein_catabolism of SPINK1 2 0.90 2.46 1.11
118 INT5643 Positive_regulation of SERPINF2 3 0.35 0.94 1.09
119 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06
120 INT86931 Gene_expression of A2m 3 0.16 4.81 1.04
121 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03
122 INT206140 Negative_regulation of Gene_expression of LPA 5 0.43 3.71 1.03
123 INT89887 Regulation of Gene_expression of Gpx1 3 0.32 0.8 1.02
124 INT101841 Localization of SERPINF2 4 0.68 1.27 1.01
125 INT106816 Negative_regulation of RECK 1 0.37 0.34 1.01
126 INT116360 Protein_catabolism of C3 19 0.64 4.4 1
127 INT106812 Transcription of RECK 2 0.68 0.76 1
128 INT238250 Regulation of Gene_expression of C3 2 0.27 2.16 0.98
129 INT330142 Positive_regulation of Pcsk1n 1 0.28 0.3 0.95
130 INT335454 Negative_regulation of Localization of TFPI 1 0.25 3.24 0.93
131 INT145772 Regulation of C4a 3 0.38 1.99 0.92
132 INT184665 Positive_regulation of C4b 7 0.28 5.84 0.9
133 INT41946 Localization of A2m 1 0.38 1.81 0.89
134 INT111668 Binding of C3 4 0.36 3.84 0.87
135 INT35292 Negative_regulation of C5 7 0.43 5.3 0.86
136 INT79956 Positive_regulation of Positive_regulation of C3 4 0.35 4.17 0.86
137 INT28689 Negative_regulation of Positive_regulation of C3 4 0.23 1.28 0.85
138 INT23621 Regulation of C4A 10 0.44 5.07 0.84
139 INT184351 Localization of Hc 2 0.20 2.33 0.83
140 INT191528 Positive_regulation of Localization of LPA 1 0.05 3.59 0.83
141 INT269693 Regulation of Negative_regulation of Hc 1 0.00 0.09 0.83
142 INT329967 Positive_regulation of Gene_expression of C5 1 0.42 1.63 0.81
143 INT73030 Regulation of SERPINF2 10 0.39 5.69 0.8
144 INT121858 Negative_regulation of PI3 7 0.43 3.16 0.8
145 INT16482 Regulation of Positive_regulation of LPA 1 0.08 0.79 0.79
146 INT193805 Negative_regulation of Gene_expression of ITIH4 3 0.42 3.98 0.76
147 INT184341 Negative_regulation of C4b 12 0.50 7.66 0.75
148 INT149485 Regulation of Gene_expression of C3 5 0.60 3.39 0.75
149 INT168432 Negative_regulation of Positive_regulation of Gpx1 4 0.40 2.89 0.75
150 INT41943 Positive_regulation of Positive_regulation of A2m 2 0.22 1.19 0.74
151 INT39819 Localization of C4A 4 0.62 3.1 0.72
152 INT179530 Transcription of C3 4 0.69 2.59 0.7
153 INT116361 Positive_regulation of Protein_catabolism of C3 6 0.45 1.86 0.69
154 INT88317 Negative_regulation of Binding of ITIH4 6 0.36 4.46 0.69
155 INT121684 Positive_regulation of Gene_expression of Hc 3 0.67 1.56 0.69
156 INT161201 Localization of C5 2 0.75 0.93 0.69
157 INT41945 Negative_regulation of A2m 2 0.27 0.35 0.68
158 INT109603 Positive_regulation of Localization of CST3 1 0.45 0.61 0.67
159 INT157225 Negative_regulation of Gene_expression of Hc 2 0.12 1.12 0.66
160 INT75755 Positive_regulation of Phosphorylation of LPA 1 0.02 0 0.65
161 INT137146 Positive_regulation of Binding of ITIH4 1 0.41 0.7 0.64
162 INT299325 Negative_regulation of Gene_expression of PI3 1 0.24 0.35 0.63
163 INT156960 Localization of Vcsa1 2 0.77 1.46 0.62
164 INT158193 Regulation of Negative_regulation of Serpina1 1 0.18 0 0.62
165 INT187050 Localization of RENBP 8 0.35 6.92 0.61
166 INT43984 Regulation of Gene_expression of LPA 7 0.49 6.3 0.61
167 INT184367 Protein_catabolism of Hc 4 0.26 2.66 0.6
168 INT77443 Binding of ITIH2 1 0.00 0.2 0.6
169 INT148230 Positive_regulation of Regulation of Gpx1 1 0.31 0.58 0.6
170 INT142625 Negative_regulation of Localization of SERPINF2 1 0.31 0.16 0.59
171 INT46173 Transcription of C3 4 0.61 3.54 0.53
172 INT156959 Regulation of Localization of Vcsa1 1 0.21 0.9 0.51
173 INT85081 Protein_catabolism of C5 5 0.19 1.34 0.5
174 INT275395 Regulation of Gene_expression of ITIH4 4 0.26 2.26 0.5
175 INT179549 Positive_regulation of Gene_expression of C4b 2 0.19 1.36 0.49
176 INT45447 Positive_regulation of Gene_expression of C3 2 0.42 0.9 0.49
177 INT167366 Positive_regulation of A2m 1 0.02 0.43 0.49
178 INT335451 Positive_regulation of Localization of TFPI 1 0.29 1.65 0.48
179 INT167584 Protein_catabolism of LPA 2 0.83 1.76 0.46
180 INT46045 Negative_regulation of Gene_expression of C3 5 0.30 3.15 0.45
181 INT115612 Regulation of Gene_expression of TFPI 2 0.17 0.27 0.44
182 INT257849 Binding of CST7 2 0.18 0 0.44
183 INT330154 Regulation of Pcsk1n 1 0.25 0.45 0.44
184 INT193812 Negative_regulation of Localization of ITIH4 1 0.30 1.15 0.44
185 INT220886 Regulation of C3 2 0.36 1.04 0.43
186 INT223057 Negative_regulation of Gene_expression of TFPI 1 0.16 0.25 0.43
187 INT241407 Phosphorylation of C3 2 0.24 0.16 0.42
188 INT77028 Transcription of LPA 4 0.50 0.64 0.41
189 INT55898 Localization of C4a 2 0.40 1.29 0.41
190 INT223910 Protein_catabolism of Serpina1 1 0.08 0.09 0.41
191 INT64788 Negative_regulation of Regulation of ITIH4 1 0.34 0.71 0.41
192 INT238253 Localization of C3 1 0.37 1.76 0.41
193 INT211361 Regulation of RENBP 5 0.08 2.8 0.38
194 INT288336 Positive_regulation of Gene_expression of A2m 1 0.12 1.73 0.37
195 INT68523 Negative_regulation of Pcsk1n 2 0.35 0 0.36
196 INT54100 Phosphorylation of TFPI 1 0.00 1.09 0.36
197 INT179545 Transcription of C4b 2 0.40 0.59 0.35
198 INT179541 Positive_regulation of Transcription of C4b 1 0.10 0.59 0.35
199 INT8540 Gene_expression of Serpina1a 5 0.66 3.99 0.34
200 INT179532 Protein_catabolism of C3 5 0.26 1.61 0.34
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