GO:0004867

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Name serine-type endopeptidase inhibitor activity
Categary Function
Go Slim No
Go Link GO:0004867
Unique Molecular Interactions 1116
Total Molecular Interactions 1530
Total Single Events 14281
Pain Genes Associated 75

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for serine-type endopeptidase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported for serine-type endopeptidase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
2 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02
3 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
4 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
5 INT275398 Binding of ITIH4 and Htatsf1 1 0.02 5.05 2.24
6 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
7 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
8 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
9 INT128654 ITIH4 Regulation of Gene_expression of CCL16 1 0.02 2.69 1.79
10 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
11 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
12 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
13 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
14 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
15 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
16 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
17 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
18 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
19 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
20 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
21 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
22 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
23 INT343949 SERPINE2 Positive_regulation of Positive_regulation of Slco1c1 1 0.00 0.59 1.27
24 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
25 INT46022 tp Positive_regulation of SERPINB1 1 0.04 0 1.26
26 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
27 INT123260 Binding of Gabrg2 and Serpini1 1 0.02 0.63 1.16
28 INT123261 Gabrg2 Regulation of Serpini1 1 0.01 0.63 1.16
29 INT25109 Negative_regulation of COL7A1 Positive_regulation of PLEKHM1 1 0.01 0 1.16
30 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
31 INT25114 COL7A1 Positive_regulation of PLEKHM1 1 0.01 0 1.15
32 INT224728 Col7a1 Positive_regulation of Cia1 1 0.00 2.9 1.12
33 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
34 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
35 INT53176 Spink4 Regulation of Localization of Abat 1 0.19 0 1.09
36 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
37 INT343950 SERPINE2 Positive_regulation of Slco1c1 1 0.00 1.63 1.07
38 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
39 INT106810 ZNF398 Positive_regulation of RECK 1 0.02 0.5 1.01
40 INT106809 ZNF398 Positive_regulation of Transcription of RECK 1 0.02 0.5 1.01
41 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
42 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
43 INT275409 Binding of ITIH4 and Cxcr4 1 0.09 2.87 0.97
44 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
45 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
46 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92
47 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
48 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
49 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92
50 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
51 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
52 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
53 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
54 INT169477 TGFB3 Positive_regulation of Spink3 1 0.02 1.83 0.89
55 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84
56 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
57 INT124427 NPEPPS Positive_regulation of Protein_catabolism of COL7A1 1 0.00 0.56 0.84
58 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
59 INT106808 RECK Negative_regulation of MMP2 1 0.40 0.5 0.83
60 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
61 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
62 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
63 INT16488 Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
64 INT16491 Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
65 INT16494 Binding of LPA and Serpinf2 1 0.00 0.78 0.78
66 INT16492 Positive_regulation of Binding of LPA and Serpinf2 1 0.00 0.78 0.78
67 INT16493 Positive_regulation of Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
68 INT16489 Positive_regulation of Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
69 INT168507 Binding of SPINK1 and Ctrc 1 0.03 0.93 0.76
70 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
71 INT53177 Spink4 Positive_regulation of Localization of Abat 1 0.33 0 0.74
72 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73
73 INT162240 Binding of COL7A1 and MMP1 1 0.03 0.86 0.73
74 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
75 INT162239 Binding of COL7A1 and MMP8 1 0.04 0.86 0.73
76 INT117639 Serpini1 Negative_regulation of Cpox 1 0.00 0.64 0.72
77 INT137139 ITIH4 Positive_regulation of OPRM1 1 0.37 0.67 0.72
78 INT177359 Serpinc1 Positive_regulation of CSRP1 1 0.00 0.97 0.72
79 INT224580 Gene_expression of IL18 Positive_regulation of SERPINH1 1 0.00 1.34 0.7
80 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
81 INT126779 Binding of Serpinc1 and F8 1 0.00 1.52 0.69
82 INT126781 Binding of F10 and Serpinc1 1 0.00 1.51 0.69
83 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
84 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
85 INT48032 Binding of Avp and Pebp1 1 0.00 0 0.68
86 INT120484 ITIH4 Positive_regulation of Il1 1 0.01 0.62 0.68
87 INT48031 Binding of Oxt and Pebp1 1 0.01 0 0.68
88 INT169217 Binding of Pebp1 and Coc 1 0.00 0.22 0.67
89 INT130355 spc Regulation of Serpine1 1 0.14 0.2 0.66
90 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 0.40 0.71 0.66
91 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
92 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
93 INT130354 Adcy10 Regulation of Serpine1 1 0.17 0.2 0.66
94 INT329589 Serpina5 Positive_regulation of PTX3 1 0.03 1.52 0.66
95 INT92045 Binding of ALB and SERPINA1 1 0.30 1.37 0.64
96 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
97 INT65256 Pebp1 Regulation of Gene_expression of Basp1 1 0.00 0.05 0.64
98 INT333165 Binding of asa and Col7a1 1 0.03 0.94 0.63
99 INT2700 Binding of App and Cpe 1 0.00 0 0.63
100 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
101 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
102 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
103 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
104 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
105 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
106 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6
107 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
108 INT137138 ITIH4 Positive_regulation of Positive_regulation of OPRM1 1 0.42 0.55 0.59
109 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
110 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
111 INT142990 Serpinc1 Positive_regulation of Phosphorylation of S1pr1 1 0.03 0.05 0.59
112 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
113 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
114 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
115 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
116 INT75490 LEPRE1 Positive_regulation of Gene_expression of COL7A1 1 0.03 0.52 0.57
117 INT223924 Cux1 Regulation of Gene_expression of Serpina1 1 0.04 0.15 0.57
118 INT137141 Binding of HIVEP1 and ITIH4 2 0.16 1.44 0.56
119 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
120 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
121 INT137897 Binding of SERPINH1 and IL36B 1 0.00 0.64 0.55
122 INT129640 Binding of Ambp and Oprd1 1 0.22 0.19 0.55
123 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
124 INT129639 Regulation of Binding of Ambp and Oprd1 1 0.17 0.19 0.55
125 INT99736 Binding of PLG and Serpinf2 1 0.01 0.73 0.55
126 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
127 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
128 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
129 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
130 INT129869 SERPINA6 Regulation of AVP 1 0.25 2.33 0.54
131 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
132 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54
133 INT227908 Binding of COL7A1 and MMRN1 1 0.00 1.11 0.53
134 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
135 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
136 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
137 INT130561 NCKIPSD Regulation of SERPINF2 1 0.22 0 0.52
138 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51
139 INT63512 Vip Positive_regulation of Localization of SERPINE2 1 0.63 1.84 0.5
140 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
141 INT322048 Prkdc Negative_regulation of Col7a1 1 0.00 0.45 0.5
142 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
143 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
144 INT55553 Avp Regulation of Serpina6 1 0.02 0 0.49
145 INT36143 Binding of SERPINH1 and HLA-B 1 0.00 0.66 0.49
146 INT175326 SERPINH1 Regulation of Pnlip 1 0.00 0.53 0.49
147 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
148 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49
149 INT224729 Negative_regulation of Col7a1 Positive_regulation of Cia1 1 0.00 1.02 0.48
150 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
151 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
152 INT229127 SPINK1 Positive_regulation of PRSS1 1 0.53 1.59 0.48
153 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
154 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
155 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
156 INT341625 Binding of SPINK1 and CTRC 1 0.41 1.22 0.46
157 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
158 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
159 INT159538 SERPINB1 Regulation of Gene_expression of CALCA 1 0.01 0.8 0.45
160 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
161 INT262815 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.39 2.73 0.44
162 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
163 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
164 INT48715 PTGER2 Regulation of Gene_expression of SERPINE1 1 0.21 0.6 0.44
165 INT48716 IL1B Regulation of Gene_expression of SERPINE1 1 0.42 0.59 0.44
166 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
167 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
168 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
169 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
170 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
171 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
172 INT262819 Gene_expression of Serpinf1 Negative_regulation of Binding of 1190002H23Rik 1 0.05 2.66 0.43
173 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
174 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
175 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
176 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42
177 INT299040 Binding of COL7A1 and SPARC 1 0.02 0.7 0.42
178 INT248242 Binding of COL7A1 and SDC1 1 0.00 0.76 0.41
179 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
180 INT83915 Il1b Positive_regulation of SERPINA3 1 0.02 0.5 0.41
181 INT248243 Binding of COL7A1 and SDC3 1 0.00 0.76 0.41
182 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
183 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
184 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
185 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
186 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
187 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
188 INT153116 Binding of SPINK1 and Abpa 1 0.01 1.32 0.4
189 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
190 INT4975 Binding of ITIH4 and MAG 1 0.44 2.24 0.39
191 INT64384 Agt Negative_regulation of Son 1 0.26 0 0.39
192 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38
193 INT50624 Binding of Pebp1 and Opcml 2 0.13 0 0.38
194 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
195 INT220052 Binding of Col7a1 and Cia1 1 0.01 1.11 0.38
196 INT182052 Il18 Positive_regulation of Col7a1 1 0.03 0.74 0.38
197 INT48714 PTGER2 Negative_regulation of Gene_expression of SERPINE1 1 0.15 0.28 0.38
198 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
199 INT200469 Binding of COL7A1 and COMP 1 0.04 0.91 0.38
200 INT281154 ITIH4 Positive_regulation of Cxcr4 1 0.09 0.71 0.37

Single Events

The table below shows the top 100 pain related interactions that have been reported for serine-type endopeptidase inhibitor activity. They are ordered first by their pain relevance and then by number of times they were reported in serine-type endopeptidase inhibitor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73
3 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
4 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
5 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2
6 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
7 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
8 INT1158 Regulation of Agt 106 0.61 29.4 30.29
9 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
10 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
11 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05
12 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
13 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
14 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
15 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
16 INT11625 Localization of App 98 0.78 55.46 20.86
17 INT16794 Binding of App 103 0.48 64.87 19.79
18 INT65502 Regulation of App 77 0.62 52.05 19.44
19 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42
20 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
21 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
22 INT2066 Localization of Agt 56 0.80 9.95 16.25
23 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78
24 INT4977 Binding of ITIH4 60 0.46 42.48 15.65
25 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
26 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78
27 INT54052 Gene_expression of App 33 0.78 25.08 14.7
28 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18
29 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67
30 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
31 INT3962 Regulation of AGT 50 0.62 20.96 13.01
32 INT4199 Binding of Agt 76 0.48 21.06 12.66
33 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61
34 INT29745 Binding of APP 47 0.48 26.49 12.4
35 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
36 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09
37 INT398 Localization of AGT 45 0.78 16.97 11.54
38 INT23654 Binding of SPINK1 27 0.48 30.85 11.53
39 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
40 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
41 INT8065 Binding of AGT 54 0.48 20.54 10.85
42 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93
43 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
44 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7
45 INT41569 Regulation of APP 32 0.62 17.15 9.4
46 INT88559 Negative_regulation of Spink1 25 0.56 21.81 9.28
47 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04
48 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82
49 INT82743 Gene_expression of SPINK1 48 0.78 44.28 8.77
50 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
51 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44
52 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35
53 INT10065 Positive_regulation of Serpina6 12 0.70 1.48 8.22
54 INT44816 Regulation of Serpina6 16 0.62 3.63 8.02
55 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
56 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
57 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24
58 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
59 INT85764 Binding of PEBP1 9 0.44 4.52 7.2
60 INT15490 Negative_regulation of Gene_expression of COL7A1 40 0.58 25.97 7.18
61 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17
62 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88
63 INT22781 Binding of COL7A1 76 0.48 41.59 6.66
64 INT33781 Binding of Pebp1 11 0.44 1.76 6.61
65 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56
66 INT1280 Negative_regulation of Pebp1 7 0.28 2.12 6.45
67 INT10131 Gene_expression of Serpinf1 53 0.76 35.57 6.42
68 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39
69 INT60713 Binding of Col7a1 47 0.43 22.52 6.29
70 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25
71 INT103378 Binding of Spink1 24 0.40 15.3 6.19
72 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16
73 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
74 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96
75 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92
76 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
77 INT10147 Gene_expression of Serpinc1 28 0.76 17.73 5.77
78 INT29821 Gene_expression of Serpina1 18 0.60 2.98 5.75
79 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61
80 INT63507 Gene_expression of SERPINE2 8 0.70 8.35 5.56
81 INT106813 Positive_regulation of RECK 1 0.69 2.39 5.38
82 INT12039 Localization of TFPI 22 0.68 9.88 5.35
83 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
84 INT134966 Localization of Col7a1 23 0.42 16.4 5.24
85 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
86 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
87 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05
88 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98
89 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95
90 INT28703 Negative_regulation of TFPI 29 0.38 19.81 4.93
91 INT84057 Positive_regulation of Gene_expression of ITIH4 12 0.50 10.5 4.92
92 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
93 INT9095 Regulation of Gene_expression of COL7A1 24 0.57 10.55 4.88
94 INT2947 Regulation of TFPI 10 0.44 5.81 4.86
95 INT2072 Localization of AMBP 33 0.65 37.58 4.84
96 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
97 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77
98 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75
99 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75
100 INT6005 Gene_expression of Serpini1 5 0.58 1.62 4.74
101 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72
102 INT35254 Negative_regulation of SERPINB1 22 0.48 11.42 4.7
103 INT2144 Localization of COL7A1 36 0.74 20.92 4.67
104 INT210885 Regulation of SLPI 8 0.44 7.15 4.61
105 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
106 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43
107 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42
108 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41
109 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
110 INT24439 Gene_expression of Spink1 19 0.63 10.05 4.35
111 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26
112 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26
113 INT58003 Localization of APP 32 0.80 13.75 4.2
114 INT3826 Positive_regulation of Tfpi 10 0.61 2.26 4.16
115 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12
116 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
117 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
118 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
119 INT51312 Positive_regulation of Gene_expression of SERPINA1 4 0.46 9.41 3.84
120 INT179261 Gene_expression of SERPINA6 12 0.14 3.53 3.82
121 INT55093 Negative_regulation of SPINK1 13 0.42 15.11 3.8
122 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
123 INT57644 Regulation of SPINK1 7 0.47 15.19 3.64
124 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
125 INT106817 Gene_expression of RECK 8 0.77 2.78 3.62
126 INT24231 Localization of SERPINB1 13 0.61 3.1 3.61
127 INT16263 Regulation of Serpine1 13 0.45 5.24 3.6
128 INT54102 Positive_regulation of Gene_expression of TFPI 14 0.49 6.67 3.54
129 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51
130 INT3889 Regulation of Serpinc1 13 0.61 8.6 3.46
131 INT76399 Binding of Serpina6 4 0.34 3.81 3.46
132 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
133 INT8539 Negative_regulation of Serpina1a 21 0.58 12.65 3.39
134 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32
135 INT21572 Gene_expression of Pebp1 9 0.71 2.52 3.3
136 INT7773 Localization of SERPINF1 18 0.55 8.54 3.25
137 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16
138 INT37811 Negative_regulation of SERPINB6 8 0.47 4.65 3.15
139 INT10132 Negative_regulation of Serpinf1 14 0.58 11.72 3.14
140 INT14086 Binding of SERPINB1 18 0.34 4.32 3.13
141 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12
142 INT20146 Localization of Tfpi 5 0.81 1.21 3.11
143 INT103246 Positive_regulation of Protein_catabolism of COL7A1 8 0.34 8.67 3.03
144 INT14960 Positive_regulation of Serpinc1 17 0.68 12.71 3.02
145 INT45673 Gene_expression of Serpina6 10 0.53 3.47 3
146 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
147 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
148 INT27243 Positive_regulation of SPINK1 13 0.68 26.71 2.92
149 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87
150 INT178772 Transcription of App 17 0.70 10.79 2.79
151 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
152 INT54054 Binding of App 4 0.48 10.89 2.78
153 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75
154 INT64843 Gene_expression of Serping1 19 0.67 8.88 2.72
155 INT120372 Positive_regulation of Ambp 21 0.21 21.1 2.66
156 INT76099 Positive_regulation of ITIH4 8 0.69 5.71 2.66
157 INT127552 Gene_expression of Pcsk1n 8 0.78 1.11 2.66
158 INT103977 Positive_regulation of Gene_expression of SPINK1 7 0.50 7.38 2.66
159 INT71794 Binding of SERPINC1 17 0.39 10.5 2.64
160 INT29818 Regulation of Serpina1 8 0.27 0.08 2.64
161 INT6928 Regulation of Tfpi 4 0.26 1.06 2.61
162 INT56376 Negative_regulation of AMBP 29 0.35 21.49 2.59
163 INT65258 Regulation of Gene_expression of Col7a1 17 0.55 8.26 2.57
164 INT156130 Binding of SERPING1 29 0.42 26.16 2.52
165 INT120483 Localization of ITIH4 11 0.69 12.05 2.51
166 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51
167 INT699 Positive_regulation of A2M 16 0.66 10.49 2.5
168 INT42039 Positive_regulation of Spink1 11 0.67 8.4 2.48
169 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47
170 INT181986 Negative_regulation of Positive_regulation of Col7a1 6 0.08 7.4 2.46
171 INT60142 Negative_regulation of Serpinb1a 2 0.42 0.59 2.46
172 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
173 INT10044 Positive_regulation of Serpina1 5 0.69 0.99 2.45
174 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
175 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43
176 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
177 INT25121 Negative_regulation of Positive_regulation of COL7A1 5 0.24 1.32 2.37
178 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36
179 INT38871 Binding of TFPI 12 0.32 5.9 2.36
180 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
181 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35
182 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
183 INT12384 Positive_regulation of PI3 7 0.38 5.73 2.33
184 INT56030 Regulation of App 8 0.62 4.06 2.32
185 INT160673 Gene_expression of Ambp 16 0.49 19.49 2.3
186 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
187 INT71490 Positive_regulation of Positive_regulation of Serpina6 3 0.70 0.16 2.27
188 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22
189 INT40565 Gene_expression of SLPI 15 0.75 7.25 2.21
190 INT43612 Regulation of SERPINB1 12 0.11 3.26 2.21
191 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
192 INT227153 Negative_regulation of PEBP1 1 0.12 0.51 2.17
193 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16
194 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16
195 INT70962 Positive_regulation of SERPING1 33 0.69 27.32 2.14
196 INT37809 Gene_expression of SERPINB6 7 0.77 6.58 2.12
197 INT106814 Positive_regulation of Gene_expression of RECK 2 0.69 1.04 2.1
198 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
199 INT45672 Negative_regulation of Serpina6 5 0.43 1.66 2.08
200 INT10045 Negative_regulation of Serpina1 7 0.43 1.01 2.07
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