GO:0004872

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Name receptor activity
Categary Function
Go Slim No
Go Link GO:0004872
Unique Molecular Interactions 12968
Total Molecular Interactions 18819
Total Single Events 142085
Pain Genes Associated 1334

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
3 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
4 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
5 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
6 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
7 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
8 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
9 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
10 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
11 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
12 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
13 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
14 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
15 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
16 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
17 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
18 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
19 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
20 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
21 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
22 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
23 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
24 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
25 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
26 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
27 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
28 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
29 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
30 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
31 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
32 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58
33 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
34 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
35 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
36 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
37 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
38 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
39 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
40 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
41 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
42 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
43 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
44 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
45 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
46 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
47 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97
48 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
49 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
50 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
51 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
52 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
53 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
54 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
55 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
56 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
57 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
58 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
59 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
60 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
61 INT64883 Ptger2 Positive_regulation of Ina 1 0.03 1.26 3.64
62 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
63 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
64 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
65 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
66 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
67 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
68 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
69 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
70 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
71 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
72 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
73 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
74 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
75 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
76 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
77 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
78 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
79 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
80 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
81 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
82 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
83 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
84 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
85 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
86 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
87 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
88 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
89 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
90 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
91 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
92 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
93 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
94 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
95 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
96 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
97 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
98 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
99 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
100 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
101 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
102 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
103 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
104 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
105 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
106 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
107 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
108 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
109 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
110 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76
111 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
112 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
113 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
114 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
115 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
116 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
117 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
118 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
119 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
120 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
121 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
122 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
123 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
124 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
125 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
126 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
127 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
128 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
129 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
130 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
131 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
132 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
133 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
134 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
135 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
136 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
137 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
138 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
139 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
140 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
141 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
142 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
143 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
144 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48
145 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
146 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
147 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 0.01 0 2.44
148 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
149 INT143272 Binding of CNR1 and Gprasp1 1 0.01 0.17 2.42
150 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
151 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
152 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
153 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
154 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
155 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
156 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
157 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
158 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
159 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
160 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
161 INT249013 Gabrg1 Negative_regulation of Per2 1 0.34 0.07 2.31
162 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
163 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
164 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
165 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
166 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
167 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
168 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
169 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
170 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
171 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
172 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
173 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
174 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
175 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
176 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
177 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
178 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
179 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
180 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
181 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
182 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
183 INT273120 NOVA2 Regulation of Gene_expression of MET 1 0.23 1.17 2.11
184 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
185 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
186 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
187 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
188 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
189 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
190 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
191 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
192 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
193 INT107268 Binding of ITGAL and NCR3 1 0.01 2.76 2.07
194 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
195 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
196 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
197 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
198 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
199 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
200 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02

Single Events

The table below shows the top 100 pain related interactions that have been reported for receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
3 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
4 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
5 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
6 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
7 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
8 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
9 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
10 INT1212 Binding of Oprl1 312 0.48 28.6 225.15
11 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
12 INT767 Localization of Gnrhr 565 0.80 106.68 214.57
13 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
14 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
15 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74
16 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
17 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
18 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
19 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
20 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
21 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93
22 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
23 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
24 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61
25 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99
26 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24
27 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16
28 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
29 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36
30 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74
31 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
32 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34
33 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
34 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
35 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
36 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38
37 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
38 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
39 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
40 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
41 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
42 INT114 Binding of Oprl1 139 0.48 23 103.35
43 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
44 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
45 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4
46 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
47 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
48 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49
49 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14
50 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02
51 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
52 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
53 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7
54 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
55 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6
56 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
57 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
58 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45
59 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56
60 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
61 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
62 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
63 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
64 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64
65 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
66 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13
67 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
68 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
69 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
70 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68
71 INT4153 Binding of Insrr 109 0.40 17.99 72.15
72 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06
73 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
74 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
75 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17
76 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
77 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
78 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61
79 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1
80 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84
81 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
82 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42
83 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
84 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52
85 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98
86 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26
87 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
88 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
89 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23
90 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
91 INT7340 Regulation of Grin1 87 0.62 30.37 57.93
92 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
93 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
94 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59
95 INT21737 Binding of MC1R 129 0.48 45.45 56.54
96 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
97 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66
98 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
99 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
100 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16
101 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
102 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
103 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
104 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
105 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
106 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
107 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
108 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
109 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
110 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92
111 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
112 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
113 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51
114 INT122041 Binding of Ppara 308 0.48 189.17 51.48
115 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
116 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14
117 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
118 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24
119 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
120 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
121 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
122 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
123 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
124 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89
125 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85
126 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
127 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
128 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31
129 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
130 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
131 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
132 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
133 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
134 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
135 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
136 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
137 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
138 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84
139 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
140 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
141 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21
142 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
143 INT16194 Binding of CNR1 82 0.48 20.75 39.59
144 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
145 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
146 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21
147 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
148 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
149 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
150 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
151 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
152 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25
153 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
154 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
155 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
156 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
157 INT11246 Binding of Grin1 65 0.48 14.53 36.93
158 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
159 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
160 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28
161 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
162 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
163 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
164 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
165 INT12608 Regulation of CNR1 62 0.60 24.36 36.02
166 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
167 INT13501 Binding of Drd2 65 0.48 23.76 35.6
168 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54
169 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
170 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
171 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
172 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
173 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93
174 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
175 INT103094 Binding of PPARA 308 0.47 177.26 34.75
176 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
177 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
178 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52
179 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
180 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
181 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
182 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24
183 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
184 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08
185 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
186 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
187 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
188 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52
189 INT50308 Binding of Cnr1 61 0.48 14.41 33.52
190 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
191 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
192 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23
193 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
194 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
195 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
196 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6
197 INT14823 Gene_expression of MET 103 0.75 51.92 32.48
198 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
199 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89
200 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
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