GO:0004887

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Name thyroid hormone receptor activity
Categary Function
Go Slim No
Go Link GO:0004887
Unique Molecular Interactions 82
Total Molecular Interactions 122
Total Single Events 485
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thyroid hormone receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for thyroid hormone receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
2 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 0.43 0.1 0.62
3 INT2686 Binding of Thra and SGSM3 1 0.36 0.1 0.61
4 INT2685 S100A6 Positive_regulation of Regulation of Thra 1 0.47 0.09 0.58
5 INT2684 S100A6 Regulation of Regulation of Thra 1 0.45 0.09 0.58
6 INT177269 Binding of CXADR and NR1H4 1 0.04 0 0.58
7 INT263975 NR4A3 Negative_regulation of Positive_regulation of TBK1 1 0.02 1.2 0.57
8 INT117482 CFTR Negative_regulation of THRB 1 0.01 0.15 0.51
9 INT117483 SFXN3 Negative_regulation of THRB 1 0.15 0.15 0.51
10 INT321293 Binding of Nr1h4 and Nr0b2 1 0.18 0.31 0.43
11 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36
12 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34
13 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
14 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27
15 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
16 INT262180 Nr1h4 Regulation of Sult2a1 1 0.11 0.11 0.25
17 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25
18 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23
19 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
20 INT344714 Nr1h4 Negative_regulation of Gene_expression of Lipg 1 0.02 0.77 0.23
21 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
22 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
23 INT321290 Positive_regulation of Nr1h4 Positive_regulation of Nr0b2 1 0.20 0.2 0.18
24 INT193562 Nr1i3 Positive_regulation of Hspg2 1 0.00 0 0.17
25 INT145055 Pebp1 Negative_regulation of Localization of Nr1i3 1 0.14 0.33 0.14
26 INT145058 Nr1i3 Regulation of Transcription of Ppara 1 0.28 0.23 0.13
27 INT278610 CDCA2 Negative_regulation of NR1H4 1 0.01 0.62 0.13
28 INT264403 NR1H4 Negative_regulation of IL1R2 1 0.04 0.09 0.12
29 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11
30 INT177263 Binding of NR1H4 and FAUP1 1 0.00 0 0.09
31 INT177278 Binding of HLA-DRB4 and NR1H4 1 0.02 0 0.08
32 INT279416 NR1H4 Regulation of PPARA 1 0.01 0.13 0.08
33 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
34 INT278602 Binding of SULT2A1 and NR1I3 1 0.04 0 0.07
35 INT279421 Binding of NR1H4 and MLXIPL 1 0.00 0.27 0.07
36 INT177255 Binding of SV2A and NR1H4 1 0.04 0 0.07
37 INT278684 Binding of NR1I3 and Rxra 1 0.00 0 0.07
38 INT4580 Positive_regulation of Thra Positive_regulation of Babr 1 0.00 0 0.07
39 INT182943 Binding of DR1 and NR1H4 3 0.03 0.14 0.06
40 INT113862 Binding of CA2 and NR1H4 1 0.00 0 0.06
41 INT113861 Binding of CA3 and NR1H4 1 0.00 0 0.06
42 INT107724 ASIP Negative_regulation of NR4A3 1 0.15 0.43 0.06
43 INT145059 Binding of PPARA and Nr1i3 1 0.06 0.26 0.05
44 INT145056 Binding of Nr1i3 and Plcl1 1 0.21 0.26 0.05
45 INT177276 Positive_regulation of Binding of CXADR and NR1H4 1 0.04 0 0.05
46 INT177282 Regulation of Binding of CXADR and NR1H4 1 0.02 0 0.05
47 INT125570 Ncoa6 Positive_regulation of Nr1i3 1 0.12 0 0.05
48 INT337693 Cyp3a62 Positive_regulation of Nr1i3 1 0.01 0.31 0.05
49 INT337692 Cyp2b2 Positive_regulation of Nr1i3 1 0.00 0.31 0.05
50 INT177270 Binding of TNFRSF25 and NR1H4 2 0.02 0.21 0.04
51 INT177272 Binding of ABCB1 and NR1H4 1 0.02 0 0.04
52 INT206896 ESR1 Positive_regulation of Gene_expression of Nr1i3 1 0.00 0.36 0.04
53 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04
54 INT248706 Mapk8 Positive_regulation of Nr1i3 1 0.00 0.3 0.03
55 INT264382 NR1H4 Positive_regulation of VDR 1 0.04 0.09 0.03
56 INT264396 NR1H4 Positive_regulation of THRA 1 0.01 0.09 0.03
57 INT182950 Binding of VDR and NR1H4 5 0.03 1.16 0
58 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
59 INT290033 Binding of PPARD and NR1H4 1 0.01 0.39 0
60 INT290027 Binding of PPARG and NR1H4 1 0.03 0.39 0
61 INT290029 Binding of INS and NR1H4 1 0.01 0.47 0
62 INT300664 Binding of Gla and Thra 1 0.08 0 0
63 INT98353 THRB Negative_regulation of Positive_regulation of ESR1 1 0.00 0.09 0
64 INT183014 Binding of NR1H4 and Dre 1 0.00 0.06 0
65 INT182955 Positive_regulation of Binding of VDR and NR1H4 1 0.03 0 0
66 INT302303 Binding of NR1H4 and Rdh5 1 0.02 0.11 0
67 INT244029 Binding of Nr1i3 and Zdhhc3 1 0.00 0 0
68 INT330956 Binding of TEP1 and NR1H4 1 0.00 1.07 0
69 INT244061 Binding of Nr1i3 and Gabarap 1 0.00 0 0
70 INT234439 Binding of NR1H4 and HCC 1 0.06 0.82 0
71 INT278605 CDCA2 Positive_regulation of NR1H4 1 0.01 0.36 0
72 INT182930 Binding of TNFRSF10B and NR1H4 1 0.02 0 0
73 INT135128 Binding of NR1I2 and NR1H4 1 0.09 0.57 0
74 INT182963 Binding of NR1H4 and KCNIP3 1 0.03 0.45 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thyroid hormone receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in thyroid hormone receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73
2 INT39691 Positive_regulation of NR1I3 2 0.59 1.46 3.88
3 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01
4 INT132575 Binding of NR1H4 57 0.20 22.06 2.82
5 INT321310 Positive_regulation of Nr1h4 1 0.49 1.75 2.75
6 INT169073 Positive_regulation of Nr1h4 8 0.47 2.44 2.45
7 INT169072 Gene_expression of Nr1h4 7 0.60 6.23 2.18
8 INT114953 Gene_expression of NR1H4 23 0.29 16.58 2.02
9 INT135132 Positive_regulation of NR1H4 17 0.30 8.63 1.38
10 INT2681 Binding of Thra 11 0.32 5.98 1.27
11 INT124835 Positive_regulation of Nr1i3 7 0.28 2.87 1.23
12 INT114961 Positive_regulation of Gene_expression of NR1H4 6 0.16 3.55 1.23
13 INT2682 Regulation of Thra 4 0.55 0.49 1.21
14 INT19277 Gene_expression of Thra 4 0.58 0.68 1.1
15 INT321329 Positive_regulation of Positive_regulation of Nr1h4 1 0.35 0.43 1.07
16 INT253957 Gene_expression of THRA 14 0.58 7.07 0.97
17 INT219980 Positive_regulation of THRA 4 0.49 1.17 0.96
18 INT120232 Gene_expression of Nr1i3 4 0.75 1.08 0.84
19 INT219983 Binding of THRA 1 0.08 1.08 0.82
20 INT107063 Gene_expression of Nr1i3 5 0.67 0.72 0.76
21 INT262091 Negative_regulation of Nr1h4 1 0.15 0.76 0.68
22 INT264000 Positive_regulation of Transcription of NR4A3 1 0.28 1.01 0.65
23 INT263999 Transcription of NR4A3 1 0.40 0.98 0.63
24 INT320854 Localization of NR4A3 1 0.28 0.2 0.56
25 INT219981 Negative_regulation of THRA 3 0.09 0.46 0.49
26 INT219982 Transcription of THRA 1 0.15 0.72 0.45
27 INT262102 Binding of Nr1h4 1 0.13 0.34 0.43
28 INT234463 Phosphorylation of NR1H4 23 0.34 14.56 0.39
29 INT9746 Regulation of NR1I3 2 0.36 0 0.35
30 INT193558 Negative_regulation of Nr1i3 2 0.03 0.5 0.34
31 INT234456 Negative_regulation of Gene_expression of NR1H4 2 0.18 1.05 0.32
32 INT120225 Positive_regulation of Gene_expression of Nr1i3 1 0.67 0.16 0.28
33 INT262108 Negative_regulation of Positive_regulation of Nr1h4 1 0.15 0.14 0.22
34 INT304404 Localization of THRA 1 0.12 0.68 0.22
35 INT136869 Localization of Nr1i3 2 0.43 0.31 0.19
36 INT120233 Binding of Nr1i3 1 0.47 0.09 0.19
37 INT172530 Gene_expression of THRB 5 0.04 4.62 0.18
38 INT304406 Positive_regulation of Localization of THRA 1 0.07 0.25 0.17
39 INT321313 Regulation of Nr1h4 1 0.32 0.37 0.17
40 INT136426 Positive_regulation of Gene_expression of NR4A3 1 0.49 0.23 0.17
41 INT136427 Gene_expression of NR4A3 1 0.75 0.23 0.17
42 INT234469 Negative_regulation of Phosphorylation of NR1H4 2 0.14 1.25 0.16
43 INT234464 Negative_regulation of NR1H4 6 0.19 3.54 0.12
44 INT125560 Positive_regulation of Nr1i3 3 0.40 0.35 0.12
45 INT234468 Protein_catabolism of NR1H4 2 0.32 0.87 0.09
46 INT177318 Negative_regulation of Binding of NR1H4 5 0.14 3.39 0.08
47 INT234477 Localization of NR1H4 3 0.24 2.23 0.07
48 INT321327 Transcription of Nr1h4 1 0.50 0.15 0.07
49 INT321330 Negative_regulation of Transcription of Nr1h4 1 0.30 0.15 0.07
50 INT145047 Transcription of Nr1i3 1 0.39 0.26 0.05
51 INT136868 Positive_regulation of Localization of Nr1i3 1 0.28 0 0.05
52 INT206889 Positive_regulation of Gene_expression of Nr1i3 1 0.01 0.36 0.04
53 INT242712 Localization of Nr1i3 1 0.01 0.09 0.04
54 INT206951 Gene_expression of Nr1h4 2 0.56 0.68 0.03
55 INT175765 Positive_regulation of NR4A3 2 0.45 0.11 0.03
56 INT321312 Phosphorylation of Nr1h4 1 0.58 0.23 0.03
57 INT321351 Positive_regulation of Gene_expression of Nr1h4 1 0.49 0.12 0.03
58 INT177301 Positive_regulation of Binding of NR1H4 3 0.29 0.45 0
59 INT177309 Gene_expression of NR1I3 2 0.44 0 0
60 INT234451 Positive_regulation of Phosphorylation of NR1H4 1 0.22 5.15 0
61 INT145054 Positive_regulation of Regulation of Nr1i3 1 0.23 0.18 0
62 INT210870 Gene_expression of Thra 1 0.35 0.23 0
63 INT241974 Binding of NR4A3 1 0.04 0 0
64 INT304412 Regulation of Localization of THRA 1 0.06 0 0
65 INT293537 Negative_regulation of Gene_expression of Thra 1 0.24 0.11 0
66 INT234475 Transcription of NR1H4 1 0.17 1.62 0
67 INT206948 Positive_regulation of Negative_regulation of Nr1i3 1 0.03 0.51 0
68 INT46503 Positive_regulation of Negative_regulation of Thra 1 0.07 0 0
69 INT145050 Regulation of Nr1i3 1 0.15 0.35 0
70 INT145046 Positive_regulation of Positive_regulation of Nr1i3 1 0.26 0.18 0
71 INT293535 Regulation of Gene_expression of Thra 1 0.26 0.28 0
72 INT304407 Regulation of Gene_expression of THRA 1 0.06 0.07 0
73 INT234470 Positive_regulation of Protein_catabolism of NR1H4 1 0.22 0.93 0
74 INT145048 Regulation of Positive_regulation of Nr1i3 1 0.15 0.18 0
75 INT178975 Transcription of Nr1i3 1 0.36 0 0
76 INT276809 Binding of NR1I3 1 0.14 0 0
77 INT264439 Regulation of Binding of NR1H4 1 0.19 0 0
78 INT177334 Regulation of Gene_expression of NR1I3 1 0.20 0 0
79 INT276799 Localization of NR1I3 1 0.29 0 0
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