GO:0004888

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Name transmembrane signaling receptor activity
Categary Function
Go Slim No
Go Link GO:0004888
Unique Molecular Interactions 1610
Total Molecular Interactions 2517
Total Single Events 17246
Pain Genes Associated 101

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transmembrane signaling receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for transmembrane signaling receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
2 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
3 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
4 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
5 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
6 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
7 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
8 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
9 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
10 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
11 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
12 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
13 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
14 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
15 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83
16 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
17 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
18 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
19 INT14910 Binding of GPR182 and SIT1 1 0.02 1.87 1.73
20 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
21 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
22 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
23 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
24 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
25 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
26 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
27 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
28 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
29 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
30 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
31 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
32 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
33 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
34 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
35 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
36 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
37 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
38 INT131949 ANTXR1 Positive_regulation of NAV1 1 0.03 0.23 1.38
39 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
40 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
41 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
42 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
43 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
44 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
45 INT177232 ICAM1 Regulation of Gene_expression of Vcam1 1 0.03 5.52 1.28
46 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
47 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
48 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
49 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
50 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
51 INT151657 Vcam1 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
52 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
53 INT139191 Binding of Fas and RFFL 1 0.00 0.61 1.22
54 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
55 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
56 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
57 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
58 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
59 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14
60 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
61 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
62 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
63 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
64 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07
65 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
66 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
67 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
68 INT122429 Prkci Regulation of Gene_expression of Ighm 1 0.00 0 1.02
69 INT122431 Prkci Negative_regulation of Negative_regulation of Ighm 1 0.00 0 1.02
70 INT122433 Prkci Negative_regulation of Ighm 1 0.00 0 1.02
71 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
72 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98
73 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
74 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
75 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
76 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
77 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
78 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
79 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
80 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
81 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
82 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91
83 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
84 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
85 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
86 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
87 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
88 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
89 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
90 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
91 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
92 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
93 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
94 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
95 INT96008 Binding of KNG1 and EBP 1 0.01 0.15 0.88
96 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
97 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 0.27 1.92 0.87
98 INT130769 FASLG Negative_regulation of Binding of FAS 1 0.10 0.66 0.86
99 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
100 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
101 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85
102 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
103 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
104 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
105 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
106 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
107 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
108 INT237204 Binding of LGALS4 and Cd3e 1 0.15 2.61 0.8
109 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
110 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
111 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
112 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77
113 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
114 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
115 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
116 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
117 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
118 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
119 INT152948 Homer1 Regulation of Gpr88 1 0.36 0.18 0.75
120 INT152944 Dlg4 Regulation of Gpr88 1 0.12 0.18 0.75
121 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
122 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
123 INT228499 Binding of FAS and Fasl 1 0.15 2.75 0.73
124 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
125 INT290548 Positive_regulation of Crhr1 Positive_regulation of Etf1 1 0.01 0.38 0.72
126 INT146460 IFNG Positive_regulation of Gene_expression of TNFRSF10D 1 0.03 1.46 0.72
127 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
128 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
129 INT146462 TNFSF10 Positive_regulation of Gene_expression of TNFRSF10D 1 0.27 1.45 0.71
130 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
131 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
132 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
133 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68
134 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
135 INT122190 Binding of Crhr1 and Ucn 4 0.49 0.65 0.67
136 INT81631 Selenbp2 Negative_regulation of Fas 1 0.03 0.77 0.67
137 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
138 INT81630 Selenbp2 Negative_regulation of Positive_regulation of Fas 1 0.03 0.77 0.67
139 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
140 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
141 INT334128 Acsm3 Positive_regulation of Sele 1 0.16 1.6 0.66
142 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
143 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
144 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
145 INT32719 ENG Regulation of LH 2 0.00 0 0.64
146 INT66603 TFF2 Positive_regulation of Gene_expression of ICAM1 1 0.02 0 0.64
147 INT356329 Crhr1 Regulation of Cea 1 0.09 0.31 0.64
148 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
149 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63
150 INT356314 Binding of Crhr1 and ORF61 1 0.00 0 0.63
151 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
152 INT346141 ADM Positive_regulation of Gene_expression of ICAM1 1 0.19 1.75 0.63
153 INT66601 WDR87 Positive_regulation of Gene_expression of ICAM1 1 0.00 0 0.63
154 INT66604 SARDH Positive_regulation of Gene_expression of ICAM1 1 0.01 0 0.63
155 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
156 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
157 INT139192 RFFL Positive_regulation of Fas 1 0.00 0.3 0.61
158 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
159 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61
160 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
161 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
162 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
163 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
164 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
165 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
166 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
167 INT73073 Binding of Cd3e and Oprk1 1 0.28 0.06 0.59
168 INT121288 Binding of TAC1 and Cd79a 1 0.12 0.32 0.58
169 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
170 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57
171 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
172 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
173 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
174 INT85487 IL1RN Negative_regulation of IL1R1 1 0.02 0 0.57
175 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
176 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
177 INT80030 Binding of FAS and TNF 3 0.27 2.54 0.56
178 INT187222 Binding of Vip and Vipr2 2 0.19 1.82 0.56
179 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
180 INT195666 Binding of PROC and THBD 2 0.40 2.42 0.56
181 INT129271 Binding of ANTXR1 and Efs 1 0.00 0 0.56
182 INT66600 TFF2 Regulation of Positive_regulation of ICAM1 1 0.01 0 0.56
183 INT182348 Binding of Cd3e and Crp 1 0.15 2.33 0.56
184 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
185 INT122427 Ighm Positive_regulation of Positive_regulation of P9Ehs1 1 0.00 0 0.56
186 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
187 INT356321 Positive_regulation of Crhr1 Positive_regulation of Cea 1 0.19 0.37 0.56
188 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
189 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
190 INT91428 CD44 Positive_regulation of Binding of MMRN1 1 0.24 0.85 0.55
191 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
192 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
193 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
194 INT133049 TNF Positive_regulation of ICAM1 4 0.47 2.49 0.54
195 INT356322 Positive_regulation of Crhr1 Positive_regulation of ORF61 1 0.00 0 0.54
196 INT54304 Il1rl1 Regulation of Regulation of Pdyn 1 0.04 0.23 0.54
197 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
198 INT18115 Binding of NPC1 and Oprd1 1 0.11 0 0.54
199 INT210934 Gene_expression of Tlr4 Negative_regulation of Ccl2 1 0.47 0.69 0.54
200 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53

Single Events

The table below shows the top 100 pain related interactions that have been reported for transmembrane signaling receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in transmembrane signaling receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
2 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6
3 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
4 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
5 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
6 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25
7 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28
8 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
9 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
10 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
11 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
12 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
13 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
14 INT10799 Localization of ENG 63 0.78 18.67 27.28
15 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
16 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
17 INT134651 Binding of TLR4 89 0.48 66.96 23.19
18 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92
19 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
20 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
21 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
22 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
23 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61
24 INT49487 Gene_expression of Sele 65 0.76 68.11 19.41
25 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
26 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78
27 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72
28 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
29 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16
30 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
31 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61
32 INT139830 Gene_expression of AGER 47 0.75 41.71 16.53
33 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
34 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36
35 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
36 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
37 INT11855 Positive_regulation of Gene_expression of Il1rl1 19 0.69 12.22 14.57
38 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
39 INT7674 Regulation of ENG 42 0.30 11.41 14.44
40 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21
41 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78
42 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
43 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
44 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96
45 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94
46 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
47 INT36287 Binding of CD4 96 0.47 58.93 11.88
48 INT65638 Negative_regulation of Gene_expression of Il1rl1 12 0.58 7.86 11.7
49 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
50 INT65713 Localization of ICAM1 42 0.81 39.55 11.49
51 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
52 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
53 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96
54 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
55 INT150540 Binding of TLR2 50 0.45 35.86 10.43
56 INT16404 Regulation of CD4 54 0.61 33.05 10.29
57 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97
58 INT80549 Binding of ICAM1 53 0.47 42.76 9.72
59 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5
60 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4
61 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06
62 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
63 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
64 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
65 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51
66 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84
67 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
68 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47
69 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
70 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
71 INT184281 Binding of AGER 25 0.37 23.06 7.32
72 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14
73 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
74 INT81880 Positive_regulation of Gene_expression of Sele 30 0.48 27.54 7.05
75 INT206518 Gene_expression of Trem2 1 0.78 16.79 6.92
76 INT17049 Localization of CD4 57 0.75 35.33 6.89
77 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
78 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
79 INT87432 Regulation of Gene_expression of Il1rl1 6 0.58 4.5 6.62
80 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47
81 INT23375 Binding of ENG 17 0.47 6.02 6.46
82 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4
83 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4
84 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
85 INT11154 Binding of EGFR 149 0.48 96.23 6.29
86 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08
87 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6
88 INT97797 Localization of TLR4 18 0.77 13.78 6
89 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96
90 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
91 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84
92 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
93 INT80033 Binding of FAS 37 0.48 41.19 5.67
94 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
95 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
96 INT65712 Positive_regulation of Localization of ICAM1 14 0.70 16.72 5.5
97 INT51411 Negative_regulation of EDAR 8 0.41 1.05 5.49
98 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
99 INT113516 Negative_regulation of Fas 16 0.51 8.37 5.32
100 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
101 INT62525 Positive_regulation of SELE 38 0.70 46 5.25
102 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
103 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
104 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12
105 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
106 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09
107 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97
108 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
109 INT32256 Gene_expression of PLXNA3 11 0.75 7.8 4.92
110 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87
111 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75
112 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73
113 INT113517 Binding of Fas 16 0.37 15.86 4.62
114 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59
115 INT63651 Gene_expression of Adcyap1r1 17 0.77 2.57 4.58
116 INT67144 Gene_expression of Cd44 17 0.76 8.94 4.48
117 INT125447 Positive_regulation of CLDN4 14 0.70 4.71 4.45
118 INT137178 Gene_expression of TLR3 46 0.72 24.97 4.33
119 INT89963 Regulation of Fas 15 0.59 8.25 4.32
120 INT181596 Binding of IL1R1 9 0.36 7.99 4.32
121 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
122 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29
123 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23
124 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19
125 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17
126 INT63977 Positive_regulation of Sele 28 0.68 18.49 4.17
127 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
128 INT115889 Binding of Fas 27 0.36 28.87 4.08
129 INT76227 Binding of NPC1 30 0.41 32.31 4.05
130 INT20925 Binding of ANTXR1 15 0.01 4.2 3.8
131 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
132 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
133 INT81188 Gene_expression of Vipr2 16 0.78 4.38 3.7
134 INT63979 Regulation of Sele 13 0.54 10.64 3.7
135 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
136 INT36799 Negative_regulation of Ighm 21 0.41 17.47 3.65
137 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6
138 INT61253 Negative_regulation of Sele 13 0.57 11.68 3.56
139 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
140 INT32905 Gene_expression of Mrc1 18 0.58 11.07 3.54
141 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
142 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5
143 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
144 INT12385 Localization of NGFR 6 0.81 3.05 3.47
145 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
146 INT184270 Negative_regulation of AGER 8 0.32 10.48 3.45
147 INT25386 Positive_regulation of Cd3e 30 0.62 13.91 3.41
148 INT264970 Positive_regulation of Localization of TLR2 1 0.11 4.21 3.37
149 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33
150 INT21156 Binding of PLXNA3 21 0.36 7.95 3.3
151 INT36286 Binding of Cd3e 33 0.36 10.11 3.21
152 INT76680 Positive_regulation of Il1rap 5 0.24 4.5 3.21
153 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
154 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13
155 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
156 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
157 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
158 INT9884 Localization of CD79A 41 0.78 21.75 3.06
159 INT43907 Binding of CD79A 28 0.48 28.11 3.04
160 INT186805 Transcription of TLR2 12 0.63 9.66 3.04
161 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02
162 INT184286 Regulation of AGER 1 0.46 6.7 3
163 INT64437 Gene_expression of IL1R1 9 0.65 6.22 2.99
164 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
165 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
166 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9
167 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
168 INT51460 Negative_regulation of Gene_expression of Sele 8 0.52 10.18 2.89
169 INT126966 Positive_regulation of IL1R1 8 0.67 6.93 2.84
170 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
171 INT59342 Negative_regulation of NPC1 20 0.44 20.21 2.79
172 INT170557 Gene_expression of Lepr 16 0.67 17.26 2.78
173 INT5460 Positive_regulation of EDAR 10 0.23 8.18 2.71
174 INT81411 Negative_regulation of Sele 8 0.38 7 2.7
175 INT98226 Negative_regulation of Cd79a 5 0.49 3.99 2.66
176 INT129722 Gene_expression of TNFRSF10D 4 0.58 6.75 2.66
177 INT63869 Positive_regulation of IL1RAP 8 0.45 3.84 2.63
178 INT133029 Regulation of TLR2 18 0.56 11.31 2.62
179 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
180 INT12619 Positive_regulation of ANTXR1 7 0.49 3.17 2.61
181 INT186799 Localization of TLR2 5 0.68 2.51 2.58
182 INT191017 Localization of Cd79a 28 0.56 13.94 2.55
183 INT11052 Positive_regulation of Gene_expression of CD69 23 0.43 16.66 2.54
184 INT91429 Binding of CD44 34 0.41 17.67 2.51
185 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
186 INT80329 Positive_regulation of THBD 12 0.47 20.96 2.45
187 INT82347 Regulation of PLXNA3 5 0.60 4.59 2.45
188 INT184280 Positive_regulation of AGER 8 0.52 9.05 2.43
189 INT258581 Gene_expression of Il1rap 3 0.14 2.59 2.43
190 INT73671 Regulation of Gene_expression of Sele 8 0.45 7.01 2.39
191 INT19646 Binding of KLRD1 9 0.04 4.27 2.35
192 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
193 INT36029 Negative_regulation of Il1r1 9 0.41 4.64 2.3
194 INT88017 Regulation of Fas 12 0.62 8.27 2.29
195 INT172078 Localization of Cd3e 22 0.37 9.88 2.27
196 INT190028 Positive_regulation of Mrc1 10 0.22 2.94 2.26
197 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
198 INT52601 Positive_regulation of Il1rl1 12 0.66 1.34 2.22
199 INT98983 Gene_expression of IL18R1 6 0.13 2.35 2.22
200 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
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