GO:0004889

From wiki-pain
Jump to: navigation, search
Name acetylcholine-activated cation-selective channel activity
Categary Function
Go Slim No
Go Link GO:0004889
Unique Molecular Interactions 137
Total Molecular Interactions 153
Total Single Events 1483
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for acetylcholine-activated cation-selective channel activity. They are ordered first by their pain relevance and then by number of times they were reported for acetylcholine-activated cation-selective channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 0.01 0 2.44
2 INT124435 Gene_expression of Chrna9 Positive_regulation of Phosphorylation of Creb1 1 0.11 0.6 1.17
3 INT60794 Binding of TREH and Chrna9 1 0.00 0 1.04
4 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
5 INT23681 Negative_regulation of Binding of Stx3 and Chrna7 1 0.00 0 0.75
6 INT23680 Binding of Stx3 and Chrna7 1 0.00 0 0.75
7 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
8 INT43663 Binding of Chrna7 and Rac2 1 0.01 0 0.72
9 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
10 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
11 INT23679 Chrna7 Regulation of Binding of Stx3 1 0.00 0 0.56
12 INT60793 Negative_regulation of Binding of TREH and Chrna9 1 0.00 0 0.53
13 INT167484 Binding of CHRNE and GGNBP2 1 0.02 0 0.5
14 INT146306 Binding of Chrna9 and Myo5c 1 0.01 0.27 0.48
15 INT88080 Binding of Chrna4 and Psmb6 1 0.03 0.56 0.46
16 INT83111 LIAS Negative_regulation of Binding of Chrna7 1 0.02 0 0.45
17 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
18 INT5531 Binding of Acot1 and Chrna2 1 0.12 0 0.42
19 INT274781 Agrn Positive_regulation of Chrna2 1 0.08 0.18 0.41
20 INT85037 Binding of Cct2 and Chrna3 1 0.00 0.15 0.38
21 INT46788 Chrna7 Positive_regulation of G6pd 1 0.50 0 0.33
22 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3
23 INT159179 Mmp3 Regulation of Chrng 1 0.01 0.32 0.29
24 INT59682 Hps6 Positive_regulation of Binding of Chrna7 1 0.02 0 0.29
25 INT54460 Binding of Abt1 and Chrna9 1 0.03 0.31 0.26
26 INT59683 Binding of Chrna7 and Evi2a 1 0.03 0 0.25
27 INT143972 Chrna7 Negative_regulation of Gene_expression of Trpv1 1 0.01 0.18 0.24
28 INT281798 CFD Regulation of Positive_regulation of Chrna4 1 0.01 0.24 0.24
29 INT97868 Binding of Chrna2 and Regulation of Acot1 1 0.09 0 0.23
30 INT143974 Chrna7 Positive_regulation of Vti1b 1 0.17 0.16 0.2
31 INT47426 Chrna7 Positive_regulation of Localization of Ldha 1 0.05 0 0.18
32 INT47427 Chrna7 Positive_regulation of Ldha 1 0.05 0 0.18
33 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17
34 INT261626 Binding of CHRNA5 and MAOA 1 0.22 1.6 0.17
35 INT101725 Binding of ITGA4 and Chrna7 1 0.00 0 0.16
36 INT340111 Chrna7 Regulation of CYSLTR1 1 0.00 0.25 0.15
37 INT132253 Tm2d1 Regulation of Chrna9 1 0.02 0.09 0.14
38 INT207683 Chrnb4 Positive_regulation of Htr3b 1 0.26 0.31 0.1
39 INT139558 Chrna4 Regulation of Neurod1 1 0.17 0 0.1
40 INT207682 Chrnb4 Positive_regulation of Hcn4 1 0.35 0.29 0.1
41 INT207681 Chrnb4 Positive_regulation of Scn2b 1 0.02 0.32 0.1
42 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 1 0.17 0 0.1
43 INT207684 Chrnb4 Positive_regulation of Htr3a 1 0.22 0.3 0.1
44 INT5529 Acot1 Positive_regulation of Chrna2 1 0.17 0 0.09
45 INT261625 Binding of CHRNA3 and CPD 1 0.07 0.35 0.08
46 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08
47 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
48 INT5530 Positive_regulation of Binding of Acot1 and Chrna2 1 0.15 0 0.07
49 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06
50 INT352062 Binding of SV2A and Chrna7 1 0.00 0.7 0.04
51 INT126110 Chrng Positive_regulation of Chrm1 1 0.00 0.1 0
52 INT126111 Chrm1 Positive_regulation of Chrng 1 0.00 0.1 0
53 INT328141 Binding of Chrne and Gabrb3 1 0.41 0.08 0
54 INT312646 Agrn Positive_regulation of Phosphorylation of CHRNE 1 0.02 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for acetylcholine-activated cation-selective channel activity. They are ordered first by their pain relevance and then by number of times they were reported in acetylcholine-activated cation-selective channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
2 INT12269 Gene_expression of Chrna9 39 0.73 6.98 18.44
3 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
4 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
5 INT59333 Positive_regulation of Chrna9 14 0.64 3.23 7.64
6 INT88079 Gene_expression of Chrna4 20 0.76 8.52 6.98
7 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
8 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
9 INT59331 Positive_regulation of Gene_expression of Chrna9 6 0.62 1.91 4.63
10 INT5527 Binding of Chrna2 11 0.47 1.42 4.01
11 INT60789 Negative_regulation of Chrna9 9 0.34 0.91 3.95
12 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92
13 INT54458 Binding of Chrna9 10 0.36 0.88 3.57
14 INT59334 Regulation of Chrna9 6 0.44 0.62 3.26
15 INT12273 Regulation of Chrna2 8 0.59 0.4 3.21
16 INT12270 Gene_expression of Chrna2 11 0.67 5.47 3.06
17 INT39367 Negative_regulation of Chrna2 5 0.42 0.53 2.57
18 INT135866 Positive_regulation of Positive_regulation of Chrne 1 0.12 0 2.43
19 INT139556 Positive_regulation of Chrna4 10 0.25 4.52 2.36
20 INT135862 Positive_regulation of Chrne 1 0.17 0 2.36
21 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13
22 INT25739 Negative_regulation of Chrng 8 0.50 1.34 2.11
23 INT123253 Localization of Chrna4 4 0.44 1.31 1.99
24 INT47425 Localization of Chrna7 11 0.81 6.7 1.86
25 INT25738 Positive_regulation of Chrng 7 0.43 0.99 1.69
26 INT169387 Regulation of Gene_expression of Chrna7 4 0.36 2.19 1.63
27 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57
28 INT135864 Gene_expression of Chrne 6 0.65 0.76 1.47
29 INT119789 Localization of Chrna9 4 0.20 0.32 1.44
30 INT22426 Positive_regulation of Regulation of Chrna2 2 0.48 0.33 1.31
31 INT25741 Regulation of Chrng 4 0.52 0.89 1.22
32 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2
33 INT18724 Binding of Chrng 4 0.47 0.37 1.18
34 INT24197 Regulation of Binding of Chrna7 2 0.11 0 1.14
35 INT57773 Gene_expression of Chrng 4 0.08 0.23 0.99
36 INT12271 Negative_regulation of Gene_expression of Chrna9 6 0.52 0.62 0.88
37 INT37107 Negative_regulation of CHRNE 4 0.43 2.25 0.87
38 INT37105 Binding of CHRNE 3 0.31 6.88 0.87
39 INT12272 Negative_regulation of Gene_expression of Chrna2 3 0.33 2.04 0.82
40 INT123254 Regulation of Chrna4 3 0.27 0.84 0.76
41 INT57842 Positive_regulation of Binding of Chrng 2 0.03 0.25 0.75
42 INT214467 Regulation of Positive_regulation of Chrna9 1 0.06 0.64 0.7
43 INT85033 Positive_regulation of Chrna3 2 0.06 0.35 0.67
44 INT123251 Regulation of Gene_expression of Chrna4 2 0.27 0.36 0.67
45 INT133004 Gene_expression of Chrna3 2 0.58 0.63 0.66
46 INT99329 Binding of Chrna4 3 0.37 0.45 0.6
47 INT5525 Positive_regulation of Chrna2 3 0.66 0.44 0.59
48 INT59332 Regulation of Gene_expression of Chrna9 3 0.55 0 0.58
49 INT123256 Regulation of Localization of Chrna4 1 0.27 0.28 0.58
50 INT68027 Localization of Chrna2 1 0.44 0 0.57
51 INT59335 Regulation of Gene_expression of Chrna2 3 0.30 0.81 0.55
52 INT163185 Negative_regulation of Transcription of Chrng 1 0.39 0.62 0.49
53 INT163186 Transcription of Chrng 1 0.48 0.6 0.49
54 INT119609 Regulation of CHRNE 1 0.05 0.36 0.46
55 INT57772 Negative_regulation of Gene_expression of Chrng 1 0.04 0 0.44
56 INT57774 Negative_regulation of Negative_regulation of Chrng 1 0.04 0 0.44
57 INT281775 Regulation of Positive_regulation of Chrna4 1 0.02 0.98 0.41
58 INT60790 Positive_regulation of Negative_regulation of Chrna9 1 0.03 0 0.37
59 INT169388 Transcription of Chrna7 2 0.69 0.27 0.36
60 INT169386 Regulation of Transcription of Chrna7 1 0.45 0.05 0.36
61 INT119788 Positive_regulation of Localization of Chrna9 1 0.13 0 0.35
62 INT25740 Positive_regulation of Negative_regulation of Chrng 1 0.35 0.24 0.35
63 INT94219 Regulation of Binding of Chrna9 1 0.09 0 0.32
64 INT18725 Negative_regulation of Binding of Chrng 1 0.13 0 0.3
65 INT94220 Positive_regulation of Binding of Chrna9 1 0.13 0 0.27
66 INT220699 Positive_regulation of CHRNE 5 0.32 2.26 0.26
67 INT120590 Transcription of Chrna9 3 0.39 0.48 0.25
68 INT334903 Positive_regulation of Localization of Chrna7 2 0.04 0.83 0.23
69 INT73451 Positive_regulation of Positive_regulation of Chrna2 1 0.48 0 0.22
70 INT538 Protein_catabolism of Chrna7 2 0.57 1.01 0.19
71 INT95662 Binding of Chrna3 1 0.00 0.17 0.17
72 INT261645 Positive_regulation of CHRNA5 1 0.37 0.69 0.14
73 INT261639 Positive_regulation of CHRNA3 1 0.38 0.68 0.14
74 INT37103 Gene_expression of CHRNE 5 0.67 4.32 0.12
75 INT1796 Phosphorylation of Chrna7 1 0.82 0 0.12
76 INT43207 Regulation of Positive_regulation of Chrna7 1 0.01 0 0.11
77 INT139554 Positive_regulation of Gene_expression of Chrna4 2 0.25 0 0.1
78 INT139553 Transcription of Chrna4 1 0.27 0 0.1
79 INT139555 Positive_regulation of Positive_regulation of Chrna4 1 0.25 0 0.1
80 INT136073 Regulation of Positive_regulation of Chrna2 1 0.26 0.35 0.1
81 INT261641 Localization of CHRNA5 1 0.64 0.91 0.09
82 INT261646 Localization of CHRNA3 1 0.65 0.91 0.09
83 INT257606 Regulation of Chrne 1 0.44 1.09 0.08
84 INT220702 Protein_catabolism of CHRNE 1 0.64 1.22 0.08
85 INT343361 Positive_regulation of Transcription of Chrna9 1 0.09 0 0.07
86 INT207668 Binding of Chrnb4 1 0.27 0 0.05
87 INT312617 Phosphorylation of CHRNE 1 0.02 0.7 0
88 INT312615 Negative_regulation of Phosphorylation of CHRNE 1 0.02 0.77 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox