GO:0004890

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Name GABA-A receptor activity
Categary Function
Go Slim No
Go Link GO:0004890
Unique Molecular Interactions 151
Total Molecular Interactions 187
Total Single Events 2200
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for GABA-A receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for GABA-A receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
2 INT249013 Gabrg1 Negative_regulation of Per2 1 0.34 0.07 2.31
3 INT179445 Vta1 Positive_regulation of Gabrd 1 0.09 0 1.98
4 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94
5 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
6 INT249005 Gabrg1 Positive_regulation of Per2 1 0.39 0 1.7
7 INT45816 Binding of Car2 and Gabrg1 2 0.28 0.15 1.63
8 INT356327 Crh Positive_regulation of Localization of Gabrg1 1 0.17 0 1.58
9 INT334347 GRP Positive_regulation of Localization of Gabrg1 1 0.19 0 1.5
10 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
11 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
12 INT356233 Slc32a1 Positive_regulation of Gabrg1 1 0.17 1.6 1.44
13 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33
14 INT14827 Binding of Gabrd and Pag1 1 0.07 0.95 1.33
15 INT69279 Regulation of Binding of TSPO and Gabrg1 1 0.00 2.05 1.26
16 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
17 INT249014 Gabrg1 Regulation of Per2 1 0.31 0 1.24
18 INT197231 Grik1 Regulation of Gabrg1 1 0.19 0.13 1.22
19 INT123260 Binding of Gabrg2 and Serpini1 1 0.02 0.63 1.16
20 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
21 INT144153 Socs6 Positive_regulation of Gene_expression of Gabrg1 1 0.07 0 1.16
22 INT123261 Gabrg2 Regulation of Serpini1 1 0.01 0.63 1.16
23 INT249002 Gabrg1 Positive_regulation of Protein_catabolism of Per1 1 0.35 0.09 1.15
24 INT53847 Pag1 Regulation of Gabrd 1 0.01 1 1.08
25 INT53842 Abat Regulation of Gabrd 1 0.04 1 1.08
26 INT60948 Ltp Negative_regulation of Negative_regulation of Gabrd 1 0.02 0.07 1.03
27 INT197241 Kars Regulation of Localization of Gabrg1 1 0.23 0 1.02
28 INT46645 Binding of Gabrg1 and Chrm5 1 0.29 0.09 1
29 INT81127 Binding of Gabrd and Abat 3 0.25 0 0.96
30 INT215584 P2rx1 Regulation of Localization of Gabrg1 1 0.01 0 0.92
31 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
32 INT292988 Negative_regulation of SGCG Positive_regulation of GABRB3 1 0.01 0.3 0.89
33 INT310348 Binding of Tspo and Gabrd 1 0.00 0.43 0.88
34 INT292990 SGCG Positive_regulation of Gene_expression of GABRB3 1 0.01 0.29 0.87
35 INT292989 SGCG Positive_regulation of GABRB3 1 0.01 0.29 0.87
36 INT317705 Gad2 Regulation of Gene_expression of Gabrg1 1 0.28 0.53 0.8
37 INT13428 Gabrd Regulation of Localization of Sstr2 1 0.31 0 0.79
38 INT356324 ORF61 Regulation of Localization of Gabrg1 1 0.00 0.19 0.76
39 INT137321 Gabrg1 Negative_regulation of Positive_regulation of Gabbr1 1 0.22 0 0.75
40 INT19577 Gabrg1 Negative_regulation of Got1 1 0.04 0.16 0.74
41 INT244062 Gabrg1 Regulation of Gabbr1 1 0.01 0.09 0.74
42 INT111904 Binding of Gabrg1 and Insrr 1 0.02 0 0.74
43 INT249023 Gabrg1 Positive_regulation of Csn2 1 0.02 0 0.74
44 INT103985 Binding of Gabrg1 and Cea 1 0.01 0 0.72
45 INT244025 Prkaca Regulation of Phosphorylation of Gabrg1 1 0.08 0.18 0.72
46 INT197234 Grik1 Positive_regulation of Localization of Gabrg1 1 0.15 0.82 0.71
47 INT356235 SLC32A1 Regulation of Localization of Gabrg1 1 0.10 1.21 0.7
48 INT356232 Slc32a1 Regulation of Localization of Gabrg1 1 0.10 1.21 0.7
49 INT248998 Gabrg1 Regulation of Luc7l3 1 0.05 0 0.69
50 INT249018 Gabrg1 Regulation of Localization of Per2 1 0.35 0 0.69
51 INT249010 Gabrg1 Regulation of Positive_regulation of Per1 1 0.33 0 0.67
52 INT152926 Aanat Regulation of Localization of Gabrg1 1 0.01 0.42 0.67
53 INT249008 Gabrg1 Regulation of Per1 1 0.33 0 0.67
54 INT197240 Grik2 Regulation of Gene_expression of Gabrg1 1 0.08 0.13 0.64
55 INT197238 Grik1 Regulation of Gene_expression of Gabrg1 1 0.17 0.13 0.64
56 INT197236 Grik2 Regulation of Gabrg1 1 0.08 0.13 0.64
57 INT69280 Negative_regulation of Binding of TSPO and Gabrg1 1 0.00 1.03 0.63
58 INT69278 Binding of TSPO and Gabrg1 1 0.00 1.01 0.62
59 INT25957 Gabrg1 Regulation of Localization of AVP 1 0.01 0 0.62
60 INT128869 Gabrg1 Positive_regulation of Transcription of Jun 1 0.09 0.55 0.62
61 INT197239 Grik1 Regulation of Localization of Gabrg1 1 0.10 0.56 0.61
62 INT343365 Acsf2 Negative_regulation of Gabrd 1 0.04 0 0.61
63 INT310712 Gabrg1 Positive_regulation of Gene_expression of PMP22 1 0.35 0.56 0.61
64 INT201294 Negative_regulation of Grik1 Negative_regulation of Gabrg1 1 0.30 0 0.6
65 INT249027 Gabrg1 Negative_regulation of Luc7l3 1 0.05 0.07 0.59
66 INT32755 Binding of Gabrg1 and Abat 1 0.10 0 0.59
67 INT244043 Binding of Gabrg1 and Ubqln1 1 0.03 0.26 0.59
68 INT244055 Prkaca Regulation of Gabrg1 1 0.08 0 0.58
69 INT356311 Crh Regulation of Gabrg1 1 0.08 0.08 0.57
70 INT249009 Gabrg1 Regulation of Gene_expression of Per2 1 0.40 0 0.56
71 INT249022 Gabrg1 Regulation of Gene_expression of Luc7l3 1 0.07 0 0.56
72 INT249001 Gabrg1 Positive_regulation of Arntl 1 0.29 0 0.55
73 INT249006 Gabrg1 Positive_regulation of Transcription of Arntl 1 0.31 0 0.55
74 INT97207 Binding of Gabrg1 and Ptar1 1 0.00 0.07 0.55
75 INT163469 Binding of Gabrg1 and Sst 1 0.15 0.3 0.55
76 INT160183 Fbxo23 Regulation of Gabrg1 1 0.02 0.07 0.55
77 INT249024 Gabrg1 Positive_regulation of Transcription of Per1 1 0.59 0 0.55
78 INT249020 Gabrg1 Positive_regulation of Per1 1 0.40 0 0.55
79 INT248997 Gabrg1 Positive_regulation of Clock 1 0.37 0 0.54
80 INT248995 Gabrg1 Regulation of Transcription of Clock 1 0.36 0 0.54
81 INT13349 Binding of Gabrg1 and Mastl 1 0.08 0.24 0.54
82 INT249007 Gabrg1 Regulation of Transcription of Per2 1 0.35 0 0.54
83 INT249016 Gabrg1 Positive_regulation of Transcription of Clock 1 0.37 0 0.54
84 INT160184 Fbxo23 Positive_regulation of Gabrg1 1 0.04 0.06 0.52
85 INT177504 Gabrg1 Positive_regulation of PCNA 1 0.07 0.22 0.52
86 INT248996 Gabrg1 Negative_regulation of Gene_expression of Per2 1 0.33 0 0.51
87 INT249025 Gabrg1 Negative_regulation of Gene_expression of Luc7l3 1 0.07 0 0.51
88 INT249026 Gabrg1 Positive_regulation of Luc7l3 1 0.06 0 0.51
89 INT205733 Gphn Regulation of Gene_expression of Gabrd 1 0.03 0.18 0.51
90 INT154014 Binding of Esr1 and Gabrg1 1 0.07 0.07 0.5
91 INT96282 Cav2 Regulation of Positive_regulation of Gabrg1 1 0.25 0 0.48
92 INT58356 Gabrg1 Regulation of Localization of Lhb 1 0.01 0 0.48
93 INT75679 Gabrg1 Regulation of Gene_expression of Gnrh1 1 0.18 0 0.48
94 INT190144 Binding of ABAT and Gabrg1 1 0.01 0 0.47
95 INT214162 Gabrg1 Negative_regulation of Pomc 1 0.05 0.65 0.46
96 INT310711 Binding of RPLP0 and Gabrg1 1 0.04 0.37 0.45
97 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
98 INT249011 Gabrg1 Regulation of Clock 1 0.19 0 0.43
99 INT67633 Binding of DST and Gabrd 1 0.03 0 0.41
100 INT214151 Gabrg1 Negative_regulation of Gene_expression of Agrp 1 0.04 0.52 0.4
101 INT214147 Gabrg1 Negative_regulation of Gene_expression of Npy 1 0.03 0.52 0.4
102 INT334763 Ednra Positive_regulation of Gabrg1 1 0.01 0 0.4
103 INT103346 Abat Positive_regulation of Gabrd 1 0.20 0.08 0.4
104 INT244046 Binding of Gabrg1 and Prkca 1 0.06 0 0.39
105 INT75680 Gabrg1 Regulation of Gnrh1 1 0.09 0 0.38
106 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
107 INT330794 Positive_regulation of Gabrd Positive_regulation of Localization of Bdnf 1 0.02 0.78 0.33
108 INT295539 Gabrg1 Positive_regulation of Gene_expression of Ghrh 1 0.30 0 0.33
109 INT187361 Binding of Gabrg1 and Kcnn3 1 0.36 0.13 0.3
110 INT89013 Positive_regulation of Gabrd Positive_regulation of Pomc 1 0.21 0.18 0.29
111 INT244034 Binding of Gabrg2 and Ubqln1 1 0.01 0.09 0.26
112 INT295535 Gabrg1 Regulation of Ghrh 1 0.16 0.08 0.26
113 INT177502 Binding of Gabrg1 and Gad2 1 0.14 0.07 0.25
114 INT317704 Binding of Gabrg1 and Tst 1 0.20 0.37 0.24
115 INT244047 Binding of Gabrg2 and Myoz1 1 0.00 0.19 0.23
116 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23
117 INT73969 Positive_regulation of Gabbr1 Regulation of Gabrd 1 0.01 0 0.23
118 INT244058 Binding of Gabrg1 and Myoz1 1 0.01 0.19 0.23
119 INT287014 Gabrd Regulation of Ptn 1 0.10 0 0.18
120 INT244038 Binding of Gabrg2 and Gabarap 1 0.08 0.24 0.18
121 INT307650 Gabrg1 Regulation of Bdnf 1 0.06 0 0.15
122 INT244052 Ppp1ca Regulation of Phosphorylation of Gabrg1 1 0.00 0.18 0.14
123 INT156057 UMOD Regulation of GABRG3 1 0.01 0.54 0.14
124 INT244017 Prkaca Positive_regulation of Phosphorylation of Gabrg1 1 0.09 0.17 0.13
125 INT334759 Ednra Regulation of Gabrg1 1 0.01 0 0.13
126 INT244040 Binding of Gabrg1 and Gabarap 1 0.15 0.05 0.13
127 INT244053 Bdnf Regulation of Phosphorylation of Gabrg1 1 0.10 0.11 0.13
128 INT244033 Binding of Gabrg1 and Ppp1ca 1 0.00 0.16 0.12
129 INT328143 Gabrb3 Positive_regulation of Ube3a 1 0.56 0.99 0.11
130 INT244013 Gphn Positive_regulation of Gabrg1 1 0.07 0 0.11
131 INT328146 Gabrb3 Negative_regulation of Ube3a 1 0.48 0.99 0.11
132 INT244039 Binding of Gabrg1 and Gphn 1 0.09 0.16 0.1
133 INT73968 Gabbr1 Regulation of Gabrd 1 0.01 0 0.09
134 INT273947 Binding of Gabra1 and Mrvi1 1 0.00 0.94 0.07
135 INT195482 Dcn Regulation of Binding of Gabrg1 1 0.18 0.09 0.07
136 INT273937 Binding of Crem and Gabra1 1 0.30 0.94 0.07
137 INT244041 Binding of Cacnb3 and Gabrg1 1 0.03 0 0.05
138 INT244048 Binding of Gabrg2 and Gabarapl1 1 0.02 0.19 0.05
139 INT244031 Binding of Gabrg2 and Nsf 1 0.04 0.19 0.05
140 INT244019 Gene_expression of Gabarap Positive_regulation of Gene_expression of Gabrg1 1 0.16 0.08 0.04
141 INT317035 UBQLN1 Regulation of Localization of Gabrg1 1 0.12 0 0.03
142 INT244030 Binding of Gabrg1 and Trak2 1 0.03 0 0.03
143 INT328141 Binding of Chrne and Gabrb3 1 0.41 0.08 0
144 INT244020 Ppp1cc Negative_regulation of Gabrg1 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for GABA-A receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in GABA-A receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74
2 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16
3 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34
4 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02
5 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52
6 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92
7 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89
8 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21
9 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25
10 INT51801 Gene_expression of Gabrd 64 0.72 19.17 22.61
11 INT16851 Regulation of Localization of Gabrg1 34 0.39 4.34 22.29
12 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82
13 INT11524 Negative_regulation of Gabrd 39 0.58 6.25 18.8
14 INT6807 Regulation of Gabrd 39 0.62 9.22 18.74
15 INT21132 Gene_expression of GABRB3 36 0.33 11.32 17.61
16 INT28314 Negative_regulation of Gene_expression of Gabrg1 29 0.44 12.56 13.8
17 INT12444 Binding of Gabrd 26 0.48 4.7 11.23
18 INT34474 Negative_regulation of Positive_regulation of Gabrg1 10 0.57 1.28 9
19 INT45812 Protein_catabolism of Gabrg1 12 0.79 1.93 8.76
20 INT49315 Localization of Gabrd 17 0.63 2.32 7.95
21 INT28315 Regulation of Gene_expression of Gabrg1 20 0.60 4.78 7
22 INT6941 Positive_regulation of Positive_regulation of Gabrd 6 0.50 1.29 4.6
23 INT45813 Negative_regulation of Negative_regulation of Gabrg1 10 0.46 0.66 4.51
24 INT70739 Gene_expression of Gabrg2 11 0.75 4.15 4.18
25 INT41635 Positive_regulation of Negative_regulation of Gabrg1 2 0.45 0.28 4.18
26 INT63840 Positive_regulation of Positive_regulation of Gabrg1 9 0.49 0.9 4.11
27 INT28062 Regulation of Negative_regulation of Gabrg1 3 0.47 0 3.87
28 INT183560 Binding of GABRB3 12 0.23 2.59 3.77
29 INT68791 Positive_regulation of Gene_expression of Gabrd 10 0.47 2.89 3.48
30 INT91418 Transcription of Gabrg1 11 0.62 1.12 3.16
31 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14
32 INT244388 Regulation of Gene_expression of Gabrd 8 0.38 3.27 3.08
33 INT70738 Negative_regulation of Gabrg2 7 0.57 4 2.96
34 INT55824 Negative_regulation of Positive_regulation of Gabrd 5 0.59 1.56 2.88
35 INT163528 Gene_expression of Gabra1 3 0.74 0.75 2.73
36 INT243927 Phosphorylation of Gabrg1 1 0.52 1.1 2.67
37 INT292993 Positive_regulation of Gene_expression of GABRB3 4 0.17 0.9 2.63
38 INT292992 Negative_regulation of Gene_expression of GABRB3 3 0.15 0.78 2.41
39 INT74361 Negative_regulation of Gabrb3 4 0.58 0.73 2.28
40 INT21130 Positive_regulation of GABRB3 4 0.27 1.88 2.21
41 INT14523 Positive_regulation of Binding of Gabrg1 5 0.50 0.25 2.17
42 INT112980 Regulation of Positive_regulation of Gabrg1 5 0.26 0.62 1.94
43 INT215636 Regulation of Localization of Gabrd 2 0.18 0.18 1.71
44 INT70705 Regulation of Regulation of Gabrg1 3 0.15 0.29 1.69
45 INT45814 Negative_regulation of Protein_catabolism of Gabrg1 2 0.34 0.09 1.62
46 INT13176 Positive_regulation of Binding of Gabrd 3 0.38 0.73 1.55
47 INT74360 Gene_expression of Gabrb3 2 0.77 3.85 1.49
48 INT121605 Transcription of Gabrd 2 0.19 0.37 1.46
49 INT248967 Negative_regulation of Transcription of Gabrg1 2 0.38 0 1.43
50 INT183557 Localization of GABRB3 3 0.46 1.01 1.34
51 INT13530 Negative_regulation of GABRB3 4 0.17 1.48 1.31
52 INT244274 Regulation of Binding of Gabrg1 2 0.43 0.73 1.31
53 INT236435 Negative_regulation of Gene_expression of Gabrd 4 0.17 0.91 1.19
54 INT292991 Negative_regulation of Localization of GABRB3 2 0.13 0.44 1.18
55 INT95370 Phosphorylation of Gabrd 3 0.78 0.46 1.15
56 INT163527 Positive_regulation of Gene_expression of Gabra1 1 0.31 0.16 1.15
57 INT215642 Regulation of Negative_regulation of Gabrd 2 0.07 0 1.14
58 INT215638 Negative_regulation of Localization of Gabrd 2 0.36 0.36 1.12
59 INT54505 Binding of Gabra1 2 0.35 0.45 1.1
60 INT244276 Regulation of Protein_catabolism of Gabrg1 1 0.23 0.29 0.99
61 INT243931 Positive_regulation of Phosphorylation of Gabrg1 1 0.29 0.42 0.97
62 INT95372 Regulation of Phosphorylation of Gabrd 1 0.24 0.21 0.9
63 INT322477 Negative_regulation of Binding of Gabrg1 2 0.41 0.47 0.87
64 INT131757 Positive_regulation of Transcription of Gabrd 1 0.07 0.29 0.83
65 INT318278 Regulation of Gene_expression of GABRB3 1 0.14 0.47 0.77
66 INT121610 Regulation of Transcription of Gabrd 1 0.10 0.08 0.64
67 INT344760 Gene_expression of GABRG3 1 0.36 0.41 0.62
68 INT74362 Regulation of Gabrb3 1 0.28 0 0.58
69 INT243940 Binding of Gabrg2 2 0.47 0.88 0.56
70 INT39251 Negative_regulation of Gabrg1 1 0.06 0 0.53
71 INT163526 Regulation of Gene_expression of Gabra1 1 0.16 0.16 0.52
72 INT86339 Positive_regulation of Gabrb3 1 0.14 0.14 0.51
73 INT148391 Positive_regulation of Gabrg2 3 0.45 0.31 0.5
74 INT245016 Transcription of GABRB3 1 0.17 0 0.47
75 INT292608 Positive_regulation of Regulation of GABRB3 1 0.05 1.58 0.45
76 INT161878 Negative_regulation of Gene_expression of Gabrg2 2 0.57 0.75 0.4
77 INT318270 Positive_regulation of Negative_regulation of GABRB3 1 0.11 0.09 0.36
78 INT70737 Transcription of Gabrg2 3 0.52 0.67 0.31
79 INT328133 Localization of Gabrb3 1 0.75 1.35 0.27
80 INT318277 Phosphorylation of GABRB3 1 0.19 0.45 0.25
81 INT247915 Regulation of Positive_regulation of Gabrg2 1 0.26 0.08 0.25
82 INT216403 Positive_regulation of Negative_regulation of Gabrd 1 0.20 0.47 0.24
83 INT356219 Binding of Gabrb3 1 0.29 1.25 0.23
84 INT260854 Negative_regulation of Binding of Gabrd 1 0.10 0.06 0.22
85 INT318139 Regulation of Gene_expression of Gabrg2 1 0.44 0.87 0.16
86 INT328139 Negative_regulation of Gene_expression of Gabrb3 1 0.43 0.1 0.15
87 INT195481 Regulation of Transcription of Gabrg1 1 0.18 0 0.11
88 INT195480 Positive_regulation of Protein_catabolism of Gabrg1 1 0.35 0 0.09
89 INT243921 Regulation of Gabrg2 1 0.08 0.18 0.03
90 INT328126 Positive_regulation of Gene_expression of Gabrb3 1 0.50 1.08 0
91 INT328138 Protein_catabolism of Gabrb3 1 0.88 0 0
92 INT63293 Negative_regulation of Negative_regulation of Gabrd 1 0.18 0 0
93 INT182517 Negative_regulation of Regulation of Gabrg1 1 0.18 0 0
94 INT261772 Regulation of Positive_regulation of Gabrd 1 0.11 0.42 0
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