GO:0004897

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Name ciliary neurotrophic factor receptor activity
Categary Function
Go Slim No
Go Link GO:0004897
Unique Molecular Interactions 29
Total Molecular Interactions 58
Total Single Events 262
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ciliary neurotrophic factor receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for ciliary neurotrophic factor receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
2 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
3 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
4 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
5 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
6 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
7 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
8 INT328821 Binding of Il6st and Jak1 1 0.05 0 0.38
9 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
10 INT328824 Binding of Il6st and TYK2 1 0.02 0 0.38
11 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24
12 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23
13 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
14 INT294694 REM1 Positive_regulation of LIFR 1 0.01 0.24 0.18
15 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18
16 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17
17 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17
18 INT349860 Binding of Cntf and Lifr 1 0.39 0.22 0.1
19 INT299538 Lifr Positive_regulation of Ak5 1 0.07 0.23 0.09
20 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
21 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08
22 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08
23 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05
24 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03
25 INT235594 Binding of LIFR and Rem1 1 0.02 0.36 0
26 INT294316 IL6ST Positive_regulation of Gene_expression of IL11 1 0.22 0 0
27 INT294693 LPA Regulation of LIFR 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ciliary neurotrophic factor receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in ciliary neurotrophic factor receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
2 INT174816 Binding of IL6R 14 0.09 11.26 3.63
3 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
4 INT126716 Positive_regulation of Il6r 8 0.42 4.31 3.1
5 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9
6 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
7 INT178458 Negative_regulation of LIFR 13 0.47 8.75 2.48
8 INT333961 Binding of Il6r 1 0.07 3.67 2.29
9 INT114317 Gene_expression of Il6r 9 0.54 3.4 1.89
10 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83
11 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
12 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
13 INT159009 Regulation of Il6st 2 0.18 2 1.41
14 INT131255 Positive_regulation of Transcription of Lifr 1 0.01 0.99 1.28
15 INT131252 Transcription of Lifr 1 0.02 0.99 1.28
16 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
17 INT114318 Positive_regulation of Gene_expression of Il6r 2 0.28 1.84 1.09
18 INT85963 Gene_expression of LIFR 23 0.75 9 0.98
19 INT162783 Binding of LIFR 1 0.36 1.52 0.86
20 INT178455 Localization of LIFR 6 0.61 2.24 0.83
21 INT333963 Localization of Il6r 1 0.10 0.75 0.83
22 INT102311 Regulation of IL6R 4 0.12 2.37 0.74
23 INT294699 Negative_regulation of Localization of LIFR 2 0.04 1.52 0.67
24 INT333965 Binding of Il6st 1 0.08 0.9 0.65
25 INT178456 Positive_regulation of Gene_expression of LIFR 7 0.50 2.74 0.54
26 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49
27 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
28 INT260859 Negative_regulation of Binding of IL6R 1 0.06 1.08 0.38
29 INT130943 Regulation of Il6r 3 0.40 0.36 0.37
30 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
31 INT90405 Positive_regulation of Gene_expression of IL6R 3 0.03 1.85 0.31
32 INT173941 Negative_regulation of Gene_expression of IL6R 2 0.04 0.48 0.29
33 INT126195 Transcription of Il6st 1 0.39 0.2 0.28
34 INT130944 Regulation of Gene_expression of Il6r 1 0.00 0.21 0.25
35 INT280656 Protein_catabolism of Il6r 1 0.69 0 0.22
36 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21
37 INT148637 Gene_expression of Lifr 5 0.75 0.92 0.18
38 INT136520 Positive_regulation of Regulation of IL6ST 1 0.09 0.08 0.13
39 INT280688 Regulation of Regulation of Il6r 1 0.40 0 0.12
40 INT299517 Positive_regulation of Gene_expression of Il6st 1 0.06 0.23 0.09
41 INT299520 Positive_regulation of Gene_expression of Lifr 1 0.18 0.23 0.09
42 INT298670 Regulation of Gene_expression of IL6R 1 0.01 0.43 0.07
43 INT206151 Positive_regulation of Gene_expression of IL6ST 2 0.24 0.35 0.06
44 INT294329 Regulation of Gene_expression of IL6ST 1 0.22 0 0.05
45 INT253389 Positive_regulation of Positive_regulation of Il6st 1 0.28 0.07 0.05
46 INT280648 Negative_regulation of Transcription of Il6r 1 0.38 0 0.05
47 INT280667 Transcription of Il6r 1 0.62 0 0.05
48 INT294344 Localization of IL6ST 1 0.39 0 0.04
49 INT188226 Regulation of Gene_expression of LIFR 1 0.44 0.73 0.04
50 INT178453 Regulation of LIFR 3 0.50 0.31 0.03
51 INT235585 Negative_regulation of Negative_regulation of LIFR 1 0.16 0.35 0
52 INT178454 Regulation of Positive_regulation of LIFR 1 0.37 0.19 0
53 INT148636 Regulation of Lifr 1 0.20 0.27 0
54 INT299513 Regulation of Gene_expression of Lifr 1 0.23 0.14 0
55 INT206153 Phosphorylation of IL6ST 1 0.22 0.05 0
56 INT178452 Negative_regulation of Positive_regulation of LIFR 1 0.35 0.19 0
57 INT206156 Positive_regulation of Phosphorylation of IL6ST 1 0.14 0.05 0
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