GO:0004908

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Name interleukin-1 receptor activity
Categary Function
Go Slim No
Go Link GO:0004908
Unique Molecular Interactions 70
Total Molecular Interactions 94
Total Single Events 540
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-1 receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-1 receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
2 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
3 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
4 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
5 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68
6 INT85487 IL1RN Negative_regulation of IL1R1 1 0.02 0 0.57
7 INT54304 Il1rl1 Regulation of Regulation of Pdyn 1 0.04 0.23 0.54
8 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53
9 INT229095 Binding of IL1R1 and Il1r1 1 0.00 0.64 0.5
10 INT307675 Binding of IL1R1 and SNRNP70 1 0.02 1.05 0.45
11 INT114599 Positive_regulation of Il1rap Positive_regulation of Trib3 1 0.03 0.07 0.43
12 INT114600 Positive_regulation of Il1b Positive_regulation of Il1rap 1 0.19 0.09 0.4
13 INT114592 Il1b Positive_regulation of Il1rap 1 0.27 0.09 0.4
14 INT164890 Binding of IL1RAP and IL33 1 0.09 0.2 0.36
15 INT229087 IL1R1 Negative_regulation of ACCS 1 0.03 0.86 0.33
16 INT226512 Il1rl1 Positive_regulation of Jun 1 0.12 0.34 0.29
17 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
18 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
19 INT328621 Gene_expression of Il1rl1 Positive_regulation of Cfp 1 0.00 0.06 0.23
20 INT164892 IL33 Regulation of Gene_expression of IL1RAP 1 0.06 0.2 0.18
21 INT164894 Binding of IL1A and IL1RAP 1 0.08 0.1 0.18
22 INT63443 Binding of Pomc and Il1rl1 1 0.04 0.06 0.18
23 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
24 INT164908 Binding of IL1RAP and IL1RL1 1 0.08 0.1 0.18
25 INT159596 Binding of IL18 and IL18R1 1 0.08 0.17 0.17
26 INT355566 IL1RL1 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17
27 INT226527 Il1rl1 Positive_regulation of Gene_expression of IK 1 0.00 0.42 0.15
28 INT226507 Il1rl1 Positive_regulation of Gene_expression of Jun 1 0.13 0.2 0.15
29 INT226518 Il1rl1 Positive_regulation of MAPK14 1 0.04 0.2 0.15
30 INT305371 Binding of IL1RL1 and MRI1 1 0.09 0.95 0.15
31 INT226520 Il1rl1 Positive_regulation of Gene_expression of MAPK14 1 0.03 0.2 0.15
32 INT229088 IL1R1 Positive_regulation of Gene_expression of IL6 1 0.04 0.45 0.14
33 INT226516 Il1rl1 Positive_regulation of Phosphorylation of Jun 1 0.02 0.19 0.14
34 INT325272 Il1rl1 Positive_regulation of Gene_expression of TNF 1 0.02 0.41 0.12
35 INT264403 NR1H4 Negative_regulation of IL1R2 1 0.04 0.09 0.12
36 INT325268 Il1rl1 Positive_regulation of Gene_expression of Spg21 1 0.05 0.41 0.12
37 INT264391 RXRG Negative_regulation of IL1R2 1 0.02 0.09 0.12
38 INT229089 IL1R1 Positive_regulation of IL6 1 0.03 0.45 0.12
39 INT300545 Il6 Positive_regulation of Gene_expression of Il1r1 1 0.02 0.42 0.11
40 INT195121 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gopc 1 0.17 0.26 0.11
41 INT195119 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of Gfap 1 0.38 0.26 0.11
42 INT339498 Binding of Il1rap and Positive_regulation of Irak1 1 0.01 0 0.1
43 INT25285 CBS Negative_regulation of Localization of IL1RL1 1 0.05 0 0.09
44 INT226515 Binding of Il1rl1 and Il33 1 0.02 0.36 0.08
45 INT325274 IL1RAP Positive_regulation of Mapk8 1 0.14 0 0.07
46 INT325264 Il1rap Positive_regulation of Mapk1 1 0.08 0 0.07
47 INT220629 Gene_expression of Bace1 Positive_regulation of Localization of Il1r2 1 0.17 0.19 0.07
48 INT325275 IL1RAP Positive_regulation of Mapk14 1 0.13 0 0.07
49 INT303997 IL1RL1 Positive_regulation of Lep 1 0.01 0.2 0.07
50 INT325262 Il1rap Positive_regulation of Mapk8 1 0.09 0 0.07
51 INT325258 Il1rap Positive_regulation of Mapk14 1 0.08 0 0.07
52 INT325273 IL1RAP Positive_regulation of Mapk1 1 0.13 0 0.07
53 INT220638 Gene_expression of Bace2 Positive_regulation of Localization of Il1r2 1 0.13 0.19 0.07
54 INT325256 Chchd8 Regulation of Il1rl1 1 0.00 0.33 0.05
55 INT285996 Binding of ACAT1 and IL1RL1 1 0.00 0 0
56 INT164907 IFNG Positive_regulation of Gene_expression of IL1RL1 1 0.31 0.11 0
57 INT164896 Binding of IL1RAP and ITS 1 0.11 0 0
58 INT164900 STAT6 Positive_regulation of Gene_expression of IL1RL1 1 0.42 0.06 0
59 INT164891 STAT1 Positive_regulation of Gene_expression of IL1RL1 1 0.41 0.06 0
60 INT164911 Binding of IL1RL1 and ITS 1 0.48 0 0
61 INT164897 IL4 Positive_regulation of Gene_expression of IL1RL1 1 0.54 0.06 0
62 INT325271 Positive_regulation of Il33 Regulation of Gene_expression of Il1rl1 1 0.22 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-1 receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-1 receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25
2 INT11855 Positive_regulation of Gene_expression of Il1rl1 19 0.69 12.22 14.57
3 INT65638 Negative_regulation of Gene_expression of Il1rl1 12 0.58 7.86 11.7
4 INT87432 Regulation of Gene_expression of Il1rl1 6 0.58 4.5 6.62
5 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09
6 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87
7 INT181596 Binding of IL1R1 9 0.36 7.99 4.32
8 INT15299 Gene_expression of IL1RL1 37 0.69 10.09 3.43
9 INT76680 Positive_regulation of Il1rap 5 0.24 4.5 3.21
10 INT64437 Gene_expression of IL1R1 9 0.65 6.22 2.99
11 INT126966 Positive_regulation of IL1R1 8 0.67 6.93 2.84
12 INT45014 Regulation of IL1RL1 12 0.14 1.87 2.67
13 INT63869 Positive_regulation of IL1RAP 8 0.45 3.84 2.63
14 INT258581 Gene_expression of Il1rap 3 0.14 2.59 2.43
15 INT36029 Negative_regulation of Il1r1 9 0.41 4.64 2.3
16 INT52601 Positive_regulation of Il1rl1 12 0.66 1.34 2.22
17 INT98983 Gene_expression of IL18R1 6 0.13 2.35 2.22
18 INT76681 Transcription of Il1rap 3 0.25 4.46 2.18
19 INT25286 Localization of IL1RL1 7 0.56 3.17 2.07
20 INT98989 Positive_regulation of IL18R1 6 0.47 2.69 1.91
21 INT67895 Negative_regulation of IL1R1 7 0.57 5.76 1.9
22 INT124559 Gene_expression of Il1r1 4 0.54 2.14 1.89
23 INT250922 Binding of IL18R1 1 0.09 3 1.86
24 INT85492 Localization of IL1R1 6 0.72 2.44 1.85
25 INT220585 Gene_expression of Il1r2 17 0.72 17.42 1.51
26 INT52873 Localization of Il1r1 4 0.56 1.28 1.48
27 INT28681 Gene_expression of Il1rl1 4 0.55 3.04 1.46
28 INT126396 Negative_regulation of Transcription of Il1rap 1 0.15 1.35 1.32
29 INT74287 Regulation of IL1RAP 1 0.05 0.8 1.29
30 INT124560 Negative_regulation of Il1r1 2 0.07 0.77 1.14
31 INT28493 Positive_regulation of IL1RL1 10 0.47 3.44 1.11
32 INT6630 Binding of IL1RAP 4 0.17 1.07 1.08
33 INT98489 Binding of Il1r1 3 0.36 1.46 1.06
34 INT114586 Positive_regulation of Positive_regulation of Il1rap 1 0.17 0.07 0.88
35 INT7552 Negative_regulation of IL1RL1 12 0.42 1.68 0.87
36 INT63442 Localization of Il1rl1 2 0.12 0.05 0.87
37 INT76682 Positive_regulation of Transcription of Il1rap 1 0.17 3.15 0.87
38 INT36028 Positive_regulation of Gene_expression of Il1r1 4 0.40 1.82 0.81
39 INT151626 Negative_regulation of Gene_expression of Il1r1 1 0.20 1.33 0.8
40 INT98986 Localization of IL18R1 2 0.53 1.11 0.79
41 INT112947 Regulation of Il1r1 2 0.24 0.36 0.78
42 INT112386 Positive_regulation of Gene_expression of IL1RL1 4 0.47 2.72 0.77
43 INT112945 Transcription of Il1r1 1 0.39 0.32 0.76
44 INT28682 Negative_regulation of Gene_expression of Il1rl1 2 0.42 0.31 0.75
45 INT228470 Phosphorylation of Il1rap 1 0.11 1.34 0.7
46 INT146971 Gene_expression of IL1R2 3 0.67 2.69 0.69
47 INT264435 Positive_regulation of Gene_expression of IL1R2 2 0.10 2.46 0.69
48 INT195104 Positive_regulation of Il1r1 4 0.40 2.18 0.68
49 INT164916 Binding of IL1RL1 9 0.33 1.84 0.66
50 INT64438 Regulation of IL1R1 2 0.26 1.62 0.64
51 INT264962 Positive_regulation of Positive_regulation of IL1RAP 1 0.04 0.24 0.62
52 INT174248 Negative_regulation of Positive_regulation of Il1rap 1 0.00 0.95 0.61
53 INT174249 Positive_regulation of Il1rap 1 0.01 0.95 0.61
54 INT104910 Binding of Il1rap 1 0.25 0.6 0.58
55 INT125530 Negative_regulation of Gene_expression of IL1RAP 1 0.12 1.13 0.57
56 INT125531 Negative_regulation of IL1RAP 1 0.12 1.13 0.57
57 INT82749 Negative_regulation of Gene_expression of IL1RL1 4 0.40 2 0.52
58 INT146970 Negative_regulation of IL1R2 1 0.43 1.22 0.52
59 INT146968 Negative_regulation of Negative_regulation of IL1R2 1 0.43 1.03 0.52
60 INT98988 Positive_regulation of Positive_regulation of IL18R1 1 0.03 0.56 0.47
61 INT114588 Phosphorylation of Il1rap 1 0.22 0 0.46
62 INT67894 Transcription of IL1R1 4 0.67 2.17 0.45
63 INT220608 Localization of Il1r2 5 0.24 2.46 0.44
64 INT80742 Regulation of Il1rl1 1 0.08 0.09 0.37
65 INT164919 Transcription of IL1RL1 2 0.64 2.74 0.35
66 INT220586 Positive_regulation of Il1r2 5 0.43 2.76 0.34
67 INT201841 Negative_regulation of Negative_regulation of IL1R1 1 0.01 0.78 0.34
68 INT229092 Positive_regulation of Localization of IL1R1 1 0.14 0.41 0.34
69 INT307682 Localization of IL1R2 1 0.57 0.57 0.34
70 INT226389 Localization of Il1rl1 2 0.53 0.93 0.31
71 INT124558 Regulation of Gene_expression of Il1r1 1 0.07 0.29 0.28
72 INT319433 Positive_regulation of Localization of IL1RL1 1 0.35 1.39 0.26
73 INT201860 Negative_regulation of Transcription of IL1R1 1 0.01 0.85 0.26
74 INT220569 Protein_catabolism of Il1r2 3 0.20 0.64 0.25
75 INT226397 Positive_regulation of Il1rl1 2 0.31 1.04 0.25
76 INT230491 Regulation of Il1r1 1 0.01 0.76 0.25
77 INT251084 Positive_regulation of Gene_expression of Il1r2 1 0.43 1.04 0.24
78 INT209897 Positive_regulation of Gene_expression of IL1RAP 1 0.04 0.67 0.21
79 INT11234 Positive_regulation of IL1R2 1 0.41 1 0.19
80 INT159606 Transcription of IL18R1 1 0.13 0.23 0.17
81 INT159602 Positive_regulation of Transcription of IL18R1 1 0.09 0.23 0.17
82 INT325238 Negative_regulation of Il1rl1 1 0.27 0.55 0.17
83 INT229093 Negative_regulation of Localization of IL1R1 1 0.12 0.39 0.15
84 INT325252 Positive_regulation of Gene_expression of Il1rl1 1 0.36 0.43 0.15
85 INT319410 Positive_regulation of Transcription of IL1RL1 1 0.48 1.49 0.14
86 INT116052 Phosphorylation of Il1rl1 1 0.05 0.1 0.13
87 INT220567 Positive_regulation of Positive_regulation of Il1r2 2 0.15 0.36 0.11
88 INT181002 Localization of IL1RAP 1 0.10 0.35 0.11
89 INT339482 Binding of Il1rap 1 0.01 0 0.1
90 INT220577 Positive_regulation of Localization of Il1r2 1 0.15 0.27 0.1
91 INT25287 Negative_regulation of Localization of IL1RL1 1 0.04 0 0.09
92 INT72901 Negative_regulation of Il1rl1 2 0.27 0.59 0.06
93 INT262678 Binding of Il1r2 1 0.11 0.15 0.04
94 INT211317 Positive_regulation of Positive_regulation of IL1RL1 1 0.25 0.09 0.04
95 INT220575 Negative_regulation of Localization of Il1r2 1 0.13 0.07 0.03
96 INT325243 Regulation of Gene_expression of Il1rl1 1 0.44 0 0
97 INT262684 Negative_regulation of Gene_expression of Il1r2 1 0.12 0.06 0
98 INT146969 Negative_regulation of Gene_expression of IL1R2 1 0.43 0.24 0
99 INT164913 Regulation of Gene_expression of IL1RAP 1 0.09 0.09 0
100 INT286002 Negative_regulation of Binding of IL1RL1 1 0.02 0 0
101 INT193363 Regulation of Binding of IL1RL1 1 0.02 0 0
102 INT325235 Transcription of Il1rl1 1 0.49 0.15 0
103 INT325245 Positive_regulation of Localization of Il1rl1 1 0.31 0 0
104 INT159599 Positive_regulation of Gene_expression of IL18R1 1 0.09 0.06 0
105 INT164914 Regulation of Gene_expression of IL1RL1 1 0.40 0.09 0
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