GO:0004915

From wiki-pain
Jump to: navigation, search
Name interleukin-6 receptor activity
Categary Function
Go Slim No
Go Link GO:0004915
Unique Molecular Interactions 47
Total Molecular Interactions 95
Total Single Events 385
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-6 receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-6 receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
2 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
3 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
4 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
5 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
6 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
7 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
8 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45
9 INT328821 Binding of Il6st and Jak1 1 0.05 0 0.38
10 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
11 INT328824 Binding of Il6st and TYK2 1 0.02 0 0.38
12 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24
13 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23
14 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
15 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18
16 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17
17 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17
18 INT289245 Binding of Il6ra and Positive_regulation of Gene_expression of Ptger2 1 0.00 0.82 0.15
19 INT333764 Il6 Regulation of Gene_expression of Il6ra 1 0.02 0.52 0.12
20 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08
21 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08
22 INT289258 Binding of ABCA1 and Il6ra 1 0.00 0.33 0.07
23 INT289244 Binding of Il11ra1 and Il6ra 1 0.01 0.33 0.07
24 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05
25 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03
26 INT294316 IL6ST Positive_regulation of Gene_expression of IL11 1 0.22 0 0
27 INT269138 Binding of Il6ra and Rps7 1 0.01 0.85 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-6 receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-6 receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
2 INT174816 Binding of IL6R 14 0.09 11.26 3.63
3 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
4 INT126716 Positive_regulation of Il6r 8 0.42 4.31 3.1
5 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
6 INT333961 Binding of Il6r 1 0.07 3.67 2.29
7 INT114317 Gene_expression of Il6r 9 0.54 3.4 1.89
8 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83
9 INT160814 Gene_expression of Il6ra 15 0.07 9.61 1.73
10 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
11 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
12 INT159009 Regulation of Il6st 2 0.18 2 1.41
13 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
14 INT114318 Positive_regulation of Gene_expression of Il6r 2 0.28 1.84 1.09
15 INT261600 Positive_regulation of Gene_expression of Il6ra 7 0.05 6.22 0.84
16 INT333963 Localization of Il6r 1 0.10 0.75 0.83
17 INT289232 Localization of Il6ra 1 0.06 2.12 0.75
18 INT102311 Regulation of IL6R 4 0.12 2.37 0.74
19 INT333965 Binding of Il6st 1 0.08 0.9 0.65
20 INT169725 Binding of Il6ra 4 0.07 3.99 0.59
21 INT289237 Positive_regulation of Il6ra 1 0.05 3.84 0.59
22 INT169726 Negative_regulation of Il6ra 3 0.05 3.14 0.53
23 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49
24 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
25 INT260859 Negative_regulation of Binding of IL6R 1 0.06 1.08 0.38
26 INT130943 Regulation of Il6r 3 0.40 0.36 0.37
27 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
28 INT90405 Positive_regulation of Gene_expression of IL6R 3 0.03 1.85 0.31
29 INT173941 Negative_regulation of Gene_expression of IL6R 2 0.04 0.48 0.29
30 INT126195 Transcription of Il6st 1 0.39 0.2 0.28
31 INT130944 Regulation of Gene_expression of Il6r 1 0.00 0.21 0.25
32 INT280656 Protein_catabolism of Il6r 1 0.69 0 0.22
33 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21
34 INT289225 Positive_regulation of Positive_regulation of Il6ra 1 0.04 0.77 0.14
35 INT136520 Positive_regulation of Regulation of IL6ST 1 0.09 0.08 0.13
36 INT333743 Regulation of Gene_expression of Il6ra 1 0.05 0.45 0.12
37 INT280688 Regulation of Regulation of Il6r 1 0.40 0 0.12
38 INT299517 Positive_regulation of Gene_expression of Il6st 1 0.06 0.23 0.09
39 INT298670 Regulation of Gene_expression of IL6R 1 0.01 0.43 0.07
40 INT206151 Positive_regulation of Gene_expression of IL6ST 2 0.24 0.35 0.06
41 INT294329 Regulation of Gene_expression of IL6ST 1 0.22 0 0.05
42 INT253389 Positive_regulation of Positive_regulation of Il6st 1 0.28 0.07 0.05
43 INT280648 Negative_regulation of Transcription of Il6r 1 0.38 0 0.05
44 INT280667 Transcription of Il6r 1 0.62 0 0.05
45 INT294344 Localization of IL6ST 1 0.39 0 0.04
46 INT206153 Phosphorylation of IL6ST 1 0.22 0.05 0
47 INT206156 Positive_regulation of Phosphorylation of IL6ST 1 0.14 0.05 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox