GO:0004930

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Name G-protein coupled receptor activity
Categary Function
Go Slim No
Go Link GO:0004930
Unique Molecular Interactions 5018
Total Molecular Interactions 7092
Total Single Events 55851
Pain Genes Associated 496

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for G-protein coupled receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
3 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
4 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
5 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
6 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
7 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
8 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
9 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
10 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
11 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
12 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
13 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
14 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58
15 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
16 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
17 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
18 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
19 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
20 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
21 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
22 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
23 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
24 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
25 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
26 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
27 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
28 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
29 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
30 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
31 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
32 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
33 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
34 INT64883 Ptger2 Positive_regulation of Ina 1 0.03 1.26 3.64
35 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
36 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
37 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
38 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
39 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
40 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
41 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
42 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
43 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
44 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
45 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
46 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
47 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
48 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
49 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
50 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
51 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
52 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
53 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
54 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
55 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
56 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
57 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
58 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
59 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
60 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
61 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
62 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
63 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
64 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
65 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
66 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
67 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
68 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
69 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
70 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
71 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
72 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
73 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
74 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
75 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
76 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
77 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
78 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
79 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
80 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48
81 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
82 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
83 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
84 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
85 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
86 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
87 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
88 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
89 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
90 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
91 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
92 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
93 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
94 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
95 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
96 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
97 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
98 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
99 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
100 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
101 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
102 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
103 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
104 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
105 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
106 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
107 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
108 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
109 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
110 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96
111 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
112 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94
113 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
114 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
115 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
116 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92
117 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
118 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
119 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
120 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
121 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
122 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
123 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
124 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
125 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
126 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83
127 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
128 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
129 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
130 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
131 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
132 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
133 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
134 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
135 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
136 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
137 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
138 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
139 INT276863 Gpr65 Regulation of Trpv1 1 0.25 1.78 1.75
140 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
141 INT31534 Binding of Sst and Oprl1 2 0.16 0.53 1.74
142 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
143 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
144 INT253895 Binding of Htr1b and Htr1d 1 0.40 0.52 1.74
145 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
146 INT14910 Binding of GPR182 and SIT1 1 0.02 1.87 1.73
147 INT182565 Ptger2 Regulation of Trpv1 1 0.25 1.34 1.73
148 INT79365 Pnoc Negative_regulation of Oprl1 2 0.41 0.16 1.72
149 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 0.39 0.39 1.72
150 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
151 INT264922 Binding of Cnr1 and Mors1 1 0.14 0.1 1.71
152 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
153 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
154 INT157459 Binding of CX3CR1 and CX3CL1 1 0.32 2.12 1.7
155 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
156 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
157 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
158 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
159 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
160 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
161 INT69666 Binding of OPRL1 and Pnoc 2 0.45 0.06 1.66
162 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
163 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
164 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
165 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
166 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
167 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
168 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
169 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
170 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
171 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
172 INT138777 Binding of Galr2 and Galr1 1 0.08 1.18 1.64
173 INT182563 Ptger2 Positive_regulation of Ptger1 1 0.22 1.4 1.64
174 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
175 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
176 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
177 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
178 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
179 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
180 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
181 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
182 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
183 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
184 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
185 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
186 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
187 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
188 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
189 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
190 INT127253 Binding of Npb and Npbwr1 2 0.29 0.61 1.55
191 INT6768 Oprl1 Regulation of Localization of Prl 2 0.12 0 1.55
192 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
193 INT111892 Ptger2 Regulation of Ptger1 1 0.08 2.09 1.55
194 INT264950 Binding of FPR1 and BOC 1 0.11 0.67 1.55
195 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
196 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
197 INT66713 Binding of BDKRB1 and KNG1 2 0.22 0.39 1.53
198 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
199 INT192081 Igkv11-125 Positive_regulation of Cnr1 1 0.10 0.23 1.51
200 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in G-protein coupled receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
3 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
4 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
5 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
6 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
7 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
8 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
9 INT1212 Binding of Oprl1 312 0.48 28.6 225.15
10 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
11 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
12 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
13 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
14 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
15 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
16 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
17 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93
18 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
19 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99
20 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
21 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74
22 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
23 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
24 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
25 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
26 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
27 INT114 Binding of Oprl1 139 0.48 23 103.35
28 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
29 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4
30 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
31 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
32 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
33 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
34 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
35 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
36 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13
37 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68
38 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
39 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17
40 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
41 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1
42 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42
43 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
44 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
45 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
46 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
47 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59
48 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16
49 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
50 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
51 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
52 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
53 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
54 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
55 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
56 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
57 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14
58 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
59 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
60 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
61 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
62 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
63 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
64 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
65 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
66 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
67 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
68 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84
69 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21
70 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
71 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
72 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
73 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
74 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
75 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
76 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
77 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
78 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
79 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
80 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
81 INT13501 Binding of Drd2 65 0.48 23.76 35.6
82 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
83 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
84 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
85 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52
86 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
87 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
88 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
89 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52
90 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
91 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
92 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
93 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
94 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
95 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
96 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
97 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11
98 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62
99 INT6177 Binding of Htr1a 65 0.47 17.65 30.59
100 INT29477 Transcription of Oprl1 52 0.72 5.05 30.52
101 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49
102 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
103 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
104 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
105 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
106 INT6765 Localization of Oprl1 49 0.81 5.11 28.87
107 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58
108 INT182223 Gene_expression of CXCR5 57 0.76 51.49 28.4
109 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
110 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
111 INT233457 Gene_expression of Gpr65 56 0.68 26.57 27.94
112 INT5097 Localization of Sstr1 30 0.64 0.38 27.92
113 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
114 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
115 INT111359 Localization of Cnr1 55 0.81 11.25 27.41
116 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
117 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
118 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19
119 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13
120 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27
121 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
122 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
123 INT28834 Positive_regulation of Bdkrb1 38 0.69 30.48 26.89
124 INT22764 Localization of Ptger2 81 0.64 24.38 26.77
125 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
126 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61
127 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57
128 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
129 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26
130 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
131 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47
132 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89
133 INT6179 Binding of Oprk1 37 0.48 9.24 24.83
134 INT12484 Binding of Drd2 45 0.48 15.17 24.72
135 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
136 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
137 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
138 INT18400 Localization of Glp1r 97 0.80 11.96 24.32
139 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14
140 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8
141 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56
142 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
143 INT12475 Gene_expression of OPRL1 35 0.77 3.63 23.11
144 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
145 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03
146 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
147 INT6270 Binding of HTR1D 55 0.47 9.54 22.86
148 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
149 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78
150 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
151 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
152 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
153 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
154 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14
155 INT9988 Regulation of Hrh1 22 0.46 12.87 22.13
156 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92
157 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38
158 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27
159 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
160 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87
161 INT49774 Binding of DRD2 48 0.48 17.42 20.73
162 INT166115 Positive_regulation of Gene_expression of Lpar1 42 0.61 31 20.71
163 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
164 INT1334 Negative_regulation of Binding of Oprl1 29 0.59 3.03 20.62
165 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31
166 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18
167 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12
168 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
169 INT7487 Gene_expression of Htr1a 36 0.75 11.08 20.05
170 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04
171 INT41494 Negative_regulation of Gene_expression of Tacr1 25 0.58 11.73 19.91
172 INT9782 Binding of HTR1B 43 0.47 12.08 19.83
173 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81
174 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
175 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45
176 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
177 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
178 INT11243 Localization of NPY 33 0.78 11.18 19.24
179 INT5160 Localization of PTAFR 61 0.80 42.6 19.16
180 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12
181 INT48006 Negative_regulation of Oprk1 27 0.58 10.14 19.11
182 INT64442 Regulation of Mc4r 6 0.62 5.22 19.09
183 INT32910 Positive_regulation of Gene_expression of Oprl1 22 0.70 7.07 19.03
184 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19
185 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91
186 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
187 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7
188 INT40811 Binding of OPRL1 26 0.48 2.76 18.68
189 INT66004 Binding of Cnr2 35 0.48 12.82 18.63
190 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
191 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44
192 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
193 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16
194 INT182217 Gene_expression of CCR9 8 0.75 44.81 18.15
195 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11
196 INT667 Negative_regulation of Hrh2 38 0.58 18.11 18.01
197 INT67975 Gene_expression of Bdkrb2 38 0.68 21.69 17.94
198 INT116978 Gene_expression of CCR6 53 0.78 56 17.73
199 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
200 INT8332 Positive_regulation of OPRD1 30 0.61 3.88 17.65
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