GO:0004937

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Name alpha1-adrenergic receptor activity
Categary Function
Go Slim No
Go Link GO:0004937
Unique Molecular Interactions 156
Total Molecular Interactions 216
Total Single Events 2092
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for alpha1-adrenergic receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for alpha1-adrenergic receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
2 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
3 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
4 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
5 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15
6 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
7 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
8 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
9 INT86960 ADRA1D Negative_regulation of Prl 1 0.00 0 0.97
10 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
11 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
12 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
13 INT106457 SPOP Positive_regulation of Negative_regulation of ADRA1D 1 0.02 0.56 0.84
14 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
15 INT16491 Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
16 INT16498 Binding of ADRA1D and LPA 1 0.10 0.78 0.78
17 INT16493 Positive_regulation of Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
18 INT16497 Positive_regulation of Binding of ADRA1D and LPA 1 0.10 0.78 0.78
19 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
20 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
21 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
22 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
23 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
24 INT18231 Binding of ADRA1D and HP 2 0.14 0.17 0.64
25 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
26 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
27 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
28 INT55873 Binding of ADRA1D and GNRH1 1 0.08 0 0.54
29 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
30 INT55872 Binding of ADRA1D and CRH 1 0.26 0 0.54
31 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
32 INT135799 Binding of Adra1d and Adra2b 1 0.02 0 0.48
33 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
34 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
35 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
36 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
37 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
38 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
39 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
40 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
41 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
42 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
43 INT64384 Agt Negative_regulation of Son 1 0.26 0 0.39
44 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
45 INT53257 CALCRL Negative_regulation of Binding of Agt 1 0.00 0 0.36
46 INT10944 Binding of ADRA1D and TRPV1 1 0.01 0 0.35
47 INT44112 Agt Regulation of Penk 1 0.08 0 0.35
48 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34
49 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
50 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
51 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34
52 INT162157 Binding of SGCG and Agt 1 0.33 0.35 0.33
53 INT44654 Phc1 Negative_regulation of Adra1a 1 0.00 0.4 0.33
54 INT147436 Agt Positive_regulation of Gene_expression of Ros1 1 0.02 0.5 0.33
55 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
56 INT44127 Agt Negative_regulation of DSPP 1 0.02 0 0.32
57 INT56115 Agt Regulation of Lhb 1 0.16 0 0.32
58 INT59326 Binding of Adra1a and Positive_regulation of Binding of Npy 1 0.44 0 0.31
59 INT39317 Binding of ADRA1D and PTAFR 1 0.54 0.54 0.3
60 INT116853 Chdh Regulation of Positive_regulation of Agt 1 0.11 0.19 0.28
61 INT45541 Agt Positive_regulation of Lnpep 1 0.03 0 0.27
62 INT45545 Agt Positive_regulation of Oxt 1 0.23 0 0.27
63 INT126550 Agt Positive_regulation of Gene_expression of Nsfl1c 1 0.39 1.07 0.26
64 INT9528 Agt Positive_regulation of Localization of Pomc 2 0.50 0.14 0.25
65 INT126547 Agt Positive_regulation of Nfkb1 1 0.46 0.99 0.25
66 INT126548 Negative_regulation of Agt Positive_regulation of Nfkb1 1 0.29 0.99 0.25
67 INT297258 Binding of Agt and Agtr2 1 0.23 0.7 0.25
68 INT123221 Binding of ADRA1D and TNFAIP6 1 0.03 0.76 0.25
69 INT126553 Agt Positive_regulation of Nfkb1 1 0.06 0.99 0.25
70 INT126551 Agt Positive_regulation of Gene_expression of Ptgs1 1 0.25 0.92 0.24
71 INT126552 Agt Positive_regulation of Gene_expression of Ptgs2 1 0.32 0.92 0.24
72 INT119717 Binding of ADRA1D and F12 1 0.35 0.23 0.23
73 INT126549 Agt Positive_regulation of Ptgs2 1 0.32 0.9 0.23
74 INT126791 RASL12 Positive_regulation of ADRA1D 1 0.24 2.62 0.22
75 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
76 INT222566 Agt Positive_regulation of Localization of Prl 1 0.08 0.23 0.21
77 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
78 INT275159 Agt Positive_regulation of Phosphorylation of Stat3 1 0.04 1.44 0.2
79 INT249993 Binding of Agt and Igkv4-55 1 0.02 0.49 0.2
80 INT6697 Binding of GLUL and Positive_regulation of Positive_regulation of ADRA1D 1 0.23 0.16 0.19
81 INT28432 ADRA1D Positive_regulation of MPG 1 0.54 0.2 0.19
82 INT75148 Binding of ADRA1B and ZNF594 1 0.00 0.16 0.18
83 INT184540 Agt Regulation of Gene_expression of Ccl2 1 0.08 1.66 0.18
84 INT41978 Binding of Agt and Htr1a 1 0.41 0.54 0.18
85 INT45029 Binding of ADRA1D and CELA3B 1 0.32 0.17 0.17
86 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
87 INT22820 ADRA1D Regulation of ELANE 1 0.21 0 0.15
88 INT72817 Agt Negative_regulation of Avp 1 0.07 0.34 0.14
89 INT293115 Agt Regulation of Positive_regulation of Crh 1 0.16 0.37 0.14
90 INT293117 Agt Regulation of Gene_expression of Aqp2 1 0.23 0.36 0.14
91 INT293123 Agtr1a Regulation of Negative_regulation of Agt 1 0.14 0.25 0.14
92 INT33749 Crh Positive_regulation of Localization of Agt 1 0.31 0 0.13
93 INT59807 ADRA1D Positive_regulation of PLCB1 1 0.33 0 0.13
94 INT59810 ADRA1D Positive_regulation of AGT 1 0.01 0 0.13
95 INT351974 Agt Positive_regulation of Gene_expression of Stk11 1 0.51 11.1 0.12
96 INT107226 Agt Positive_regulation of AFF1 1 0.01 0 0.12
97 INT44974 Agt Positive_regulation of Gene_expression of Ptger2 1 0.02 0.42 0.12
98 INT33750 Apoa2 Regulation of Agt 1 0.07 0 0.12
99 INT229359 Agt Positive_regulation of Binding of Agtr1a 1 0.25 0.9 0.12
100 INT119157 Agt Positive_regulation of Positive_regulation of Agtr2 1 0.06 0 0.11
101 INT222503 Agt Positive_regulation of Localization of Gh1 1 0.02 0.23 0.11
102 INT37489 Binding of ADRA1D and Alb 1 0.34 0.84 0.11
103 INT300306 Agt Positive_regulation of Mapk14 1 0.14 1.51 0.11
104 INT46502 Agt Positive_regulation of Odc1 1 0.18 0 0.1
105 INT96563 Binding of ADRA1D and UCN2 1 0.19 1.34 0.1
106 INT10906 Agt Regulation of Localization of Nppb 1 0.10 0.19 0.1
107 INT171164 Agt Regulation of Positive_regulation of Rorb 1 0.02 0.64 0.1
108 INT257870 Agt Positive_regulation of Akt1 2 0.18 1.5 0.09
109 INT87038 Binding of ADRA1D and Col5a3 1 0.03 0.48 0.09
110 INT354753 Ren Regulation of Agt 1 0.14 0.98 0.08
111 INT300304 Positive_regulation of Mapk14 Positive_regulation of Agt 1 0.14 1.5 0.08
112 INT171165 Agt Positive_regulation of Positive_regulation of Nfkb1 1 0.23 1.09 0.08
113 INT354754 Regulation of Ren Regulation of Agt 1 0.14 0.98 0.08
114 INT249987 Agt Negative_regulation of Lnpep 1 0.11 0.53 0.07
115 INT351981 Mtpn Positive_regulation of Gene_expression of Agt 1 0.04 0.41 0.05
116 INT32744 Agt Positive_regulation of Localization of Pomc 1 0.06 0.14 0.04
117 INT60222 Agt Regulation of Gene_expression of Jun 1 0.14 0 0.04
118 INT257875 Agt Positive_regulation of Pik3cg 1 0.06 0.37 0.04
119 INT249988 Agt Regulation of Ca2 1 0.18 0.9 0.04
120 INT60223 Agt Regulation of Gene_expression of Fos 1 0.50 0 0.04
121 INT257874 Agt Positive_regulation of Mtor 1 0.04 0.37 0.04
122 INT257868 Agt Positive_regulation of Rps6kb1 1 0.10 0.37 0.04
123 INT249991 Agt Regulation of Fig4 1 0.12 0.57 0.04
124 INT60221 Agt Regulation of Gene_expression of Egr1 1 0.42 0 0.04
125 INT249990 Agt Positive_regulation of Positive_regulation of Ca2 1 0.20 0.65 0.04
126 INT293121 Avp Regulation of Gene_expression of Agt 1 0.06 0.78 0.04
127 INT249989 Agt Positive_regulation of Ca2 1 0.20 1.6 0.04
128 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03
129 INT351973 Agt Positive_regulation of Gene_expression of Fig4 1 0.07 1.33 0.03
130 INT351972 Binding of Agt and Stk11 1 0.27 0.74 0
131 INT229713 Binding of Agt and Ren 1 0.14 0 0
132 INT117647 Agt Regulation of Nos1 1 0.19 0.13 0
133 INT351980 Agt Positive_regulation of Phosphorylation of Prkag1 1 0.03 0.74 0
134 INT229714 Positive_regulation of Binding of Agt and Ren 1 0.18 0 0
135 INT351975 Agt Positive_regulation of Stk11 1 0.34 0.39 0
136 INT98356 ADRA1D Positive_regulation of Positive_regulation of ESR1 1 0.02 0.05 0
137 INT354755 Binding of Agt and Fabp6 1 0.00 0.52 0
138 INT183462 Agt Positive_regulation of Ros1 1 0.02 0.11 0
139 INT65004 Negative_regulation of Ace Positive_regulation of Agt 1 0.40 0 0
140 INT10905 Edn1 Regulation of Agt 1 0.11 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for alpha1-adrenergic receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in alpha1-adrenergic receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
2 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
3 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
4 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11
5 INT1158 Regulation of Agt 106 0.61 29.4 30.29
6 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78
7 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87
8 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31
9 INT2066 Localization of Agt 56 0.80 9.95 16.25
10 INT7523 Regulation of ADRA1D 42 0.45 11.63 14.52
11 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
12 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
13 INT4199 Binding of Agt 76 0.48 21.06 12.66
14 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
15 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
16 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
17 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
18 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
19 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
20 INT256 Localization of ADRA1D 11 0.78 2.91 6.85
21 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
22 INT335 Binding of Adra1a 16 0.36 6.16 6
23 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
24 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
25 INT27694 Positive_regulation of Positive_regulation of ADRA1D 10 0.70 1.52 3.57
26 INT19539 Positive_regulation of Gene_expression of ADRA1D 10 0.67 9.4 2.9
27 INT26705 Transcription of ADRA1D 6 0.67 3.99 2.74
28 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
29 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
30 INT6521 Negative_regulation of Gene_expression of ADRA1D 4 0.57 3.19 2.14
31 INT15211 Localization of Adra1a 3 0.16 0 2.08
32 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
33 INT45 Negative_regulation of Positive_regulation of Adra1a 4 0.43 0.84 1.97
34 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
35 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
36 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
37 INT99387 Positive_regulation of Negative_regulation of ADRA1D 1 0.07 0.54 1.74
38 INT3152 Transcription of Agt 7 0.72 5.09 1.68
39 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57
40 INT31052 Gene_expression of Adra1d 5 0.65 1.46 1.53
41 INT14803 Positive_regulation of Positive_regulation of Adra1a 4 0.35 0.49 1.36
42 INT26703 Positive_regulation of Transcription of ADRA1D 3 0.49 1.99 1.34
43 INT11306 Regulation of Gene_expression of Agt 7 0.45 3.29 1.31
44 INT19319 Negative_regulation of Binding of Agt 9 0.42 3.42 1.24
45 INT6520 Regulation of Gene_expression of ADRA1D 5 0.44 1.15 1.18
46 INT28594 Positive_regulation of Transcription of Agt 2 0.47 1.3 1.15
47 INT26881 Regulation of Binding of ADRA1D 3 0.44 1.05 0.94
48 INT125157 Negative_regulation of Gene_expression of Adra1a 1 0.18 0.54 0.8
49 INT38735 Protein_catabolism of Agt 7 0.99 2.79 0.7
50 INT160461 Phosphorylation of Agt 1 0.31 0.4 0.7
51 INT160463 Positive_regulation of Phosphorylation of Agt 1 0.19 0.41 0.7
52 INT139092 Negative_regulation of Gene_expression of Adra1d 1 0.07 0 0.69
53 INT139088 Positive_regulation of Gene_expression of Adra1d 1 0.05 0 0.69
54 INT6734 Localization of Adra1a 3 0.31 0.25 0.67
55 INT18657 Negative_regulation of Binding of Adra1a 2 0.43 0.17 0.56
56 INT56708 Positive_regulation of Positive_regulation of Adra1a 1 0.25 0 0.55
57 INT40021 Regulation of Binding of Agt 4 0.59 1.53 0.53
58 INT13738 Negative_regulation of Positive_regulation of Adra1a 3 0.29 0.08 0.52
59 INT32618 Regulation of Positive_regulation of Agt 2 0.43 0.42 0.52
60 INT21090 Regulation of Negative_regulation of Adra1a 1 0.18 0.35 0.52
61 INT61010 Negative_regulation of Regulation of ADRA1D 1 0.41 0 0.48
62 INT26917 Regulation of Adra1d 2 0.21 1.56 0.47
63 INT35592 Regulation of Regulation of ADRA1D 1 0.44 0 0.47
64 INT99588 Positive_regulation of Binding of Agt 2 0.69 0.23 0.45
65 INT14039 Regulation of Regulation of Agt 1 0.30 0 0.44
66 INT66593 Regulation of Gene_expression of Adra1a 2 0.05 0 0.39
67 INT102164 Positive_regulation of Binding of Adra1a 1 0.35 0.19 0.37
68 INT34162 Regulation of Regulation of Adra1a 1 0.02 0 0.36
69 INT19414 Positive_regulation of Localization of ADRA1D 2 0.49 0.89 0.35
70 INT4636 Positive_regulation of Regulation of Agt 4 0.50 1.3 0.3
71 INT113578 Negative_regulation of Adra1d 2 0.42 0.24 0.3
72 INT43398 Regulation of Localization of Agt 1 0.28 0 0.3
73 INT44623 Positive_regulation of Regulation of Adra1a 1 0.04 0.64 0.29
74 INT44766 Negative_regulation of Binding of ADRA1D 2 0.42 0.71 0.27
75 INT42351 Regulation of Positive_regulation of Adra1a 1 0.01 0 0.26
76 INT118118 Positive_regulation of Binding of Adra1a 1 0.18 0.3 0.26
77 INT39107 Positive_regulation of Binding of ADRA1D 1 0.49 0.52 0.25
78 INT1440 Binding of Adra1d 1 0.16 0 0.24
79 INT122590 Transcription of Adra1a 1 0.03 0.73 0.24
80 INT113577 Transcription of Adra1d 1 0.52 0.27 0.23
81 INT39288 Regulation of Binding of Adra1a 1 0.20 0.35 0.2
82 INT74928 Gene_expression of ADRA1B 1 0.04 0 0.18
83 INT102528 Regulation of Positive_regulation of ADRA1D 1 0.44 0.09 0.18
84 INT1770 Positive_regulation of Negative_regulation of Agt 2 0.49 1.09 0.17
85 INT31927 Positive_regulation of Localization of Adra1a 1 0.10 0.17 0.16
86 INT26455 Negative_regulation of Positive_regulation of ADRA1D 1 0.41 0.1 0.13
87 INT119156 Positive_regulation of Protein_catabolism of Agt 1 0.49 0 0.13
88 INT263872 Localization of Adra1d 1 0.01 2.5 0.11
89 INT74929 Positive_regulation of Gene_expression of ADRA1B 1 0.02 0 0.09
90 INT88135 Negative_regulation of Transcription of Agt 1 0.34 0.16 0.08
91 INT24707 Protein_catabolism of ADRA1D 1 0.86 0.6 0.08
92 INT125793 Protein_catabolism of Adra1a 1 0.39 0.24 0.05
93 INT354748 Negative_regulation of Protein_catabolism of Agt 1 0.43 0.58 0.04
94 INT263879 Positive_regulation of Adra1d 1 0.00 0.47 0.04
95 INT27724 Regulation of Negative_regulation of Agt 2 0.35 0.32 0
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