GO:0004938

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Name alpha2-adrenergic receptor activity
Categary Function
Go Slim No
Go Link GO:0004938
Unique Molecular Interactions 131
Total Molecular Interactions 174
Total Single Events 1647
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for alpha2-adrenergic receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for alpha2-adrenergic receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
2 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
3 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
4 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
5 INT70270 Binding of ADRA2B and Pnoc 2 0.02 0.15 1.08
6 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
7 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
8 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
9 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
10 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
11 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
12 INT56459 ADRA2C Positive_regulation of Localization of AHSP 1 0.23 0 0.78
13 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
14 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
15 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
16 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
17 INT81832 Binding of ADRA2C and CRYGS 1 0.06 0 0.66
18 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
19 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
20 INT31418 Positive_regulation of Adra2c Positive_regulation of Gcg 1 0.22 0 0.65
21 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
22 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
23 INT78580 Binding of Adra2b and Oprd1 1 0.01 0.07 0.57
24 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
25 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
26 INT135799 Binding of Adra1d and Adra2b 1 0.02 0 0.48
27 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
28 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
29 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
30 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
31 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
32 INT132580 Binding of ADRA2C and Htr1a 1 0.41 0.27 0.45
33 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
34 INT29254 Positive_regulation of ADRA2C Positive_regulation of Localization of GH1 1 0.13 0.06 0.44
35 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
36 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
37 INT145576 Binding of Adra2c and Hcn4 1 0.21 0.19 0.4
38 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
39 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
40 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
41 INT145574 Regulation of Binding of Adra2c and Hcn4 1 0.26 0.19 0.4
42 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
43 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
44 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
45 INT31713 Adra2c Regulation of Localization of Ins1 1 0.22 0.31 0.35
46 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
47 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
48 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
49 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
50 INT26942 Adra2c Positive_regulation of Localization of Ins1 1 0.13 0 0.28
51 INT7850 Adra2c Regulation of Localization of Gcg 1 0.08 0 0.27
52 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
53 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
54 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
55 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
56 INT81833 Negative_regulation of Binding of ADRA2C and CRYGS 1 0.06 0 0.19
57 INT148397 Adra2c Regulation of Gnb3 1 0.12 0.08 0.19
58 INT71547 ADRA2C Positive_regulation of Localization of GCG 1 0.01 0.14 0.17
59 INT71548 ADRA2C Negative_regulation of Localization of INS 1 0.04 0.13 0.16
60 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15
61 INT81831 Positive_regulation of Binding of ADRA2C and CRYGS 1 0.07 0 0.14
62 INT103425 Binding of Adra2a and Cyth2 1 0.00 0 0.14
63 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
64 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
65 INT72302 Regulation of ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
66 INT72304 ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
67 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
68 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
69 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
70 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
71 INT264780 Binding of ADRA2B and Regulation of MRGPRX1 1 0.00 0 0.05
72 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for alpha2-adrenergic receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in alpha2-adrenergic receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
3 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
4 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
5 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
6 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
7 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
8 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
9 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
10 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
11 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
12 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
13 INT5678 Gene_expression of ADRA2C 17 0.74 2.62 6.24
14 INT18443 Positive_regulation of ADRA2C 12 0.69 2.61 5.48
15 INT26940 Positive_regulation of Adra2c 9 0.49 2.21 5.27
16 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
17 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
18 INT5675 Gene_expression of Adra2c 7 0.75 1.25 4.58
19 INT30160 Positive_regulation of ADRA2B 14 0.29 1.92 4.37
20 INT13134 Binding of ADRA2C 11 0.46 0.73 3.86
21 INT8711 Binding of Adra2b 6 0.42 0.08 3.78
22 INT30181 Gene_expression of Adra2b 10 0.62 1.89 3.48
23 INT277 Negative_regulation of Adra2c 8 0.43 1.89 3.42
24 INT18459 Regulation of Adra2c 6 0.45 0.42 3.4
25 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
26 INT38760 Positive_regulation of Adra2c 3 0.39 1.82 3.04
27 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
28 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
29 INT15265 Gene_expression of Adra2c 5 0.54 1.8 2.83
30 INT30870 Negative_regulation of Adra2b 8 0.44 4.5 2.8
31 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
32 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
33 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
34 INT7848 Regulation of Adra2c 3 0.33 1.74 2.37
35 INT53540 Gene_expression of ADRA2B 10 0.46 1.78 2.33
36 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
37 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
38 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
39 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
40 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
41 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
42 INT40907 Localization of Adra2c 3 0.71 0 1.46
43 INT40906 Negative_regulation of Localization of Adra2c 1 0.43 0 1.46
44 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
45 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
46 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
47 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
48 INT55318 Localization of ADRA2C 3 0.73 1.39 1.3
49 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
50 INT30161 Negative_regulation of Positive_regulation of ADRA2B 2 0.05 0.25 1.24
51 INT231592 Binding of ADRA2B 5 0.18 0.13 1.23
52 INT82729 Transcription of Adra2b 1 0.02 1.05 1.23
53 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
54 INT6519 Positive_regulation of Gene_expression of ADRA2C 3 0.44 0.71 1.1
55 INT76497 Transcription of Adra2c 2 0.21 0.08 1.07
56 INT41043 Regulation of Adra2b 3 0.39 0.47 1.03
57 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
58 INT26012 Binding of Adra2c 2 0.48 0 1.01
59 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
60 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
61 INT33665 Positive_regulation of Gene_expression of Adra2c 1 0.50 0.43 0.89
62 INT65230 Negative_regulation of Adra2c 3 0.42 0.44 0.88
63 INT124538 Positive_regulation of Gene_expression of Adra2c 1 0.27 0.75 0.87
64 INT40928 Regulation of Binding of ADRA2C 1 0.43 0 0.82
65 INT14130 Regulation of ADRA2C 4 0.45 1.57 0.79
66 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
67 INT110117 Negative_regulation of Positive_regulation of Adra2c 1 0.12 0.33 0.77
68 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
69 INT28057 Binding of Adra2c 4 0.36 0.25 0.75
70 INT55317 Transcription of ADRA2C 6 0.63 0.36 0.74
71 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
72 INT95816 Regulation of Positive_regulation of Adra2c 2 0.28 0.66 0.68
73 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
74 INT29256 Positive_regulation of Positive_regulation of ADRA2C 2 0.46 0.06 0.59
75 INT82128 Negative_regulation of Transcription of Adra2a 1 0.18 1.32 0.55
76 INT59394 Regulation of Regulation of Adra2a 1 0.17 0 0.55
77 INT31363 Positive_regulation of Regulation of Adra2a 1 0.04 0 0.55
78 INT30428 Positive_regulation of Binding of ADRA2A 1 0.34 0.59 0.53
79 INT18442 Negative_regulation of ADRA2C 2 0.49 0.61 0.51
80 INT77904 Negative_regulation of Gene_expression of Adra2a 2 0.43 0.87 0.5
81 INT41146 Negative_regulation of Localization of Adra2a 1 0.37 0.1 0.49
82 INT68529 Negative_regulation of ADRA2B 3 0.14 0.79 0.47
83 INT29102 Transcription of ADRA2A 2 0.27 0.83 0.46
84 INT61414 Positive_regulation of Gene_expression of ADRA2B 2 0.18 0.13 0.44
85 INT278 Positive_regulation of Negative_regulation of Adra2c 1 0.47 0.27 0.42
86 INT33171 Positive_regulation of Negative_regulation of Adra2a 1 0.39 0 0.4
87 INT6492 Regulation of ADRA2B 2 0.06 0.31 0.38
88 INT29100 Negative_regulation of Binding of ADRA2A 1 0.19 0.84 0.37
89 INT97767 Positive_regulation of Adra2b 3 0.45 1.75 0.34
90 INT29101 Positive_regulation of Transcription of ADRA2A 1 0.19 0.76 0.32
91 INT26941 Localization of Adra2c 2 0.23 0 0.3
92 INT26939 Positive_regulation of Positive_regulation of Adra2c 1 0.16 0 0.3
93 INT26858 Regulation of Positive_regulation of ADRA2C 3 0.32 0.63 0.29
94 INT261826 Phosphorylation of ADRA2B 1 0.03 0.38 0.29
95 INT13453 Regulation of Negative_regulation of Adra2a 2 0.27 0.49 0.28
96 INT134176 Gene_expression of ADRA2A 4 0.58 1.45 0.25
97 INT25928 Positive_regulation of Negative_regulation of ADRA2A 1 0.05 0 0.23
98 INT255069 Positive_regulation of Binding of ADRA2B 1 0.18 0.13 0.23
99 INT25814 Negative_regulation of Binding of ADRA2C 1 0.31 0.08 0.23
100 INT18444 Positive_regulation of Negative_regulation of ADRA2C 1 0.42 0.61 0.19
101 INT306554 Regulation of Localization of ADRA2C 1 0.26 0.98 0.17
102 INT356473 Transcription of ADRA2B 1 0.20 0.08 0.14
103 INT134177 Positive_regulation of Gene_expression of ADRA2A 1 0.10 0.26 0.12
104 INT134178 Positive_regulation of Regulation of ADRA2A 1 0.10 0.24 0.12
105 INT72309 Positive_regulation of Positive_regulation of ADRA2B 1 0.01 0.17 0.09
106 INT38754 Regulation of Negative_regulation of Adra2b 1 0.34 0.44 0.08
107 INT210662 Transcription of Adra2a 1 0.01 0.09 0
108 INT87516 Negative_regulation of Gene_expression of ADRA2C 1 0.41 0.1 0
109 INT157839 Positive_regulation of Gene_expression of Adra2b 1 0.03 0 0
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