GO:0004945

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Name angiotensin type II receptor activity
Categary Function
Go Slim No
Go Link GO:0004945
Unique Molecular Interactions 232
Total Molecular Interactions 300
Total Single Events 1615
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for angiotensin type II receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for angiotensin type II receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
2 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
3 INT314211 Ngf Positive_regulation of Gene_expression of Agtrap 1 0.04 1.15 1.3
4 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
5 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
6 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
7 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
8 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
9 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84
10 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
11 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
12 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
13 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
14 INT9824 Binding of Agtr2 and Bcl2a1a 1 0.16 0.24 0.64
15 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
16 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
17 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
18 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
19 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
20 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
21 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
22 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
23 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39
24 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39
25 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
26 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
27 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
28 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3
29 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
30 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
31 INT118545 Binding of Agtr2 and Msr1 1 0.00 0.09 0.29
32 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
33 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27
34 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
35 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26
36 INT297258 Binding of Agt and Agtr2 1 0.23 0.7 0.25
37 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23
38 INT230751 Agtr2 Positive_regulation of Gene_expression of Serpine1 1 0.03 1.3 0.23
39 INT155158 Agtr2 Regulation of Rtn4 1 0.00 0.1 0.22
40 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
41 INT281351 Tenc1 Regulation of Agtr2 1 0.06 0.8 0.21
42 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
43 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2
44 INT230749 Crp Regulation of Agtr1a 1 0.07 1.33 0.19
45 INT224086 Binding of Agtr1a and Hspa8 1 0.00 0.1 0.19
46 INT322237 Binding of Agtrap and Hcm 1 0.14 2.3 0.19
47 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
48 INT320883 Agtr2 Positive_regulation of Localization of VEGFA 1 0.08 2.8 0.17
49 INT320884 Agtrap Positive_regulation of Localization of VEGFA 1 0.10 2.81 0.17
50 INT224126 Binding of Hspa8 and Agtr1a 1 0.00 0.09 0.17
51 INT352290 Binding of Agtr1a and P2ry1 1 0.00 0 0.16
52 INT239081 Binding of GH1 and MAS1 1 0.03 1.41 0.15
53 INT138305 Binding of PNN and Agtr2 1 0.01 0.73 0.15
54 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14
55 INT293119 Agtr1a Regulation of Positive_regulation of Crh 1 0.12 0.37 0.14
56 INT293123 Agtr1a Regulation of Negative_regulation of Agt 1 0.14 0.25 0.14
57 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
58 INT256021 Ace Negative_regulation of Gene_expression of Agtrap 1 0.05 0.37 0.13
59 INT281911 Binding of ANG and MAS1 1 0.05 0.39 0.13
60 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
61 INT304188 Agtr2 Negative_regulation of Gene_expression of VEGFA 1 0.06 0.6 0.12
62 INT110176 Nts Regulation of Negative_regulation of Agtr1a 1 0.24 0.09 0.12
63 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
64 INT229359 Agt Positive_regulation of Binding of Agtr1a 1 0.25 0.9 0.12
65 INT119158 Binding of NOS1 and Agtr2 1 0.01 0 0.11
66 INT119157 Agt Positive_regulation of Positive_regulation of Agtr2 1 0.06 0 0.11
67 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
68 INT281912 Binding of AGTR2 and ANG 1 0.13 0.37 0.1
69 INT336990 Binding of AGTR1 and BDKRB2 1 0.03 0 0.1
70 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09
71 INT304887 Agtr2 Positive_regulation of Positive_regulation of Mapk1 1 0.10 0.45 0.09
72 INT304886 Agtr2 Positive_regulation of Ros1 1 0.03 0.45 0.09
73 INT184920 Binding of Agtrap and Slc6a3 1 0.02 0.09 0.09
74 INT322258 Binding of Agtrap and l5H1 1 0.40 0.62 0.09
75 INT279707 Positive_regulation of AGTR1 Regulation of TYRP1 1 0.00 0 0.09
76 INT279706 Positive_regulation of AGTR1 Regulation of TRPC6 1 0.00 0 0.09
77 INT304883 Agtr2 Positive_regulation of Agtrap 1 0.10 0.46 0.09
78 INT233907 Positive_regulation of Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
79 INT304884 Agtrap Positive_regulation of Gene_expression of Ros1 1 0.17 0.48 0.08
80 INT249994 Binding of Agtr1a and Igkv4-55 1 0.01 0.38 0.08
81 INT325489 Agtr2 Positive_regulation of Ephx2 1 0.04 0.51 0.08
82 INT320881 Ang Positive_regulation of Agtrap 1 0.12 1.35 0.08
83 INT233906 Binding of AGTR2 and NLRP3 1 0.01 1.09 0.08
84 INT320880 Chi3l1 Positive_regulation of Agtr2 1 0.01 1.22 0.08
85 INT281900 Positive_regulation of Binding of AGT and AGTR1 1 0.12 0.16 0.07
86 INT200634 Binding of Agtr2 and Ace2 1 0.00 0.91 0.06
87 INT184917 Slc6a3 Positive_regulation of Agtrap 1 0.03 0.08 0.06
88 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06
89 INT184924 Ephb1 Positive_regulation of Agtrap 1 0.01 0.08 0.06
90 INT281909 Binding of AGT and AGTR1 1 0.09 0.16 0.06
91 INT200638 Binding of ACE and Agtr2 1 0.10 0.93 0.06
92 INT289769 Positive_regulation of Agtr2 Negative_regulation of Gene_expression of Col7a1 1 0.00 0.1 0.05
93 INT88773 Positive_regulation of Binding of AGT and Agtrap 1 0.01 0.88 0.05
94 INT336132 Binding of AGTR1 and ANG 1 0.00 0.38 0.05
95 INT320882 Agtr2 Positive_regulation of Gene_expression of VEGFA 1 0.08 0.9 0.04
96 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04
97 INT88774 Binding of AGT and Agtrap 2 0.01 2.13 0.03
98 INT131492 Binding of MAS1 and Mrgpre 1 0.22 0.08 0.03
99 INT302908 Agtr2 Positive_regulation of Gene_expression of Agt 1 0.00 0.22 0.03
100 INT131491 Binding of MAS1 and Mrgprd 1 0.30 0.07 0.03
101 INT88772 Negative_regulation of Binding of AGT and Agtrap 1 0.02 0.89 0.03
102 INT241030 Agtr2 Positive_regulation of Phosphorylation of Mapk1 1 0.06 0.19 0
103 INT322251 Slc6a4 Regulation of Gene_expression of Agtrap 1 0.43 0.63 0
104 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
105 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0
106 INT344401 Agtr2 Positive_regulation of Gene_expression of Spp1 1 0.01 3.21 0
107 INT241021 Agtrap Positive_regulation of Gopc 1 0.19 0.19 0
108 INT320877 Agtr2 Positive_regulation of Pla2g2a 1 0.10 0.67 0
109 INT322243 Agt Regulation of Gene_expression of Agtrap 1 0.50 0.63 0
110 INT149883 Agtr2 Positive_regulation of Gene_expression of Ptgs2 1 0.06 0.31 0
111 INT241023 Mapk1 Positive_regulation of Gene_expression of Agtrap 1 0.40 0.85 0
112 INT241025 Gopc Positive_regulation of Gene_expression of Agtrap 1 0.20 0.83 0
113 INT322239 Ace Regulation of Gene_expression of Agtrap 1 0.44 0.63 0
114 INT320878 Positive_regulation of Agtr2 Positive_regulation of Pla2g2a 1 0.10 0.67 0
115 INT172830 INS Positive_regulation of Agtrap 1 0.01 1.17 0
116 INT322255 Mir155 Regulation of Agtrap 1 0.21 0.33 0
117 INT241026 Agtrap Positive_regulation of Mapk1 1 0.37 0.19 0
118 INT229362 Negative_regulation of Agtr1a Positive_regulation of Positive_regulation of Agtr2 1 0.05 1 0
119 INT333044 Positive_regulation of Binding of AGTR1 and Trpv4 1 0.48 0 0
120 INT241027 Positive_regulation of Agtr2 Positive_regulation of Protein_catabolism of Sypl 1 0.00 0.85 0
121 INT333045 Binding of AGTR1 and Gopc 1 0.05 0 0
122 INT241029 Agtrap Positive_regulation of Hmbs 1 0.07 0.83 0
123 INT337011 Binding of CALCRL and Agtrap 1 0.00 0 0
124 INT241028 Agtrap Positive_regulation of Gene_expression of Gopc 1 0.20 0.83 0
125 INT333043 Binding of AGTR1 and Trpv4 1 0.50 0 0
126 INT213584 Binding of AGTR2 and ACE 1 0.17 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for angiotensin type II receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in angiotensin type II receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
2 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
3 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
4 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
5 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
6 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
7 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
8 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
9 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69
10 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
11 INT239217 Gene_expression of Agtrap 47 0.78 48.8 4.44
12 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
13 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
14 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07
15 INT9822 Binding of Agtr2 9 0.36 3 3.93
16 INT17819 Regulation of Agtr2 10 0.51 9.33 3.9
17 INT39986 Regulation of Agtr2 13 0.45 10.39 3.55
18 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
19 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94
20 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
21 INT70789 Negative_regulation of Agtrap 26 0.48 16.39 2.18
22 INT49731 Transcription of Agtr2 4 0.44 0.95 2.06
23 INT53036 Binding of Agtr2 9 0.33 3.74 1.99
24 INT149761 Negative_regulation of MAS1 5 0.29 1.91 1.95
25 INT182505 Positive_regulation of Gene_expression of AGTR1 12 0.65 13.18 1.77
26 INT149762 Regulation of MAS1 8 0.31 5.34 1.61
27 INT112668 Positive_regulation of Gene_expression of Agtr2 7 0.50 3.8 1.58
28 INT68100 Positive_regulation of Positive_regulation of Agtr2 2 0.08 0.83 1.51
29 INT182514 Binding of AGTR1 18 0.47 13.35 1.48
30 INT182511 Regulation of AGTR1 7 0.44 8.25 1.4
31 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37
32 INT44147 Positive_regulation of Gene_expression of Agtr2 11 0.50 9.02 1.28
33 INT61100 Localization of Agtr2 7 0.51 2.53 1.13
34 INT148072 Gene_expression of Agtr1a 5 0.75 9.41 1.13
35 INT181973 Positive_regulation of MAS1 8 0.49 7.64 1.07
36 INT137515 Binding of Agtrap 7 0.48 3.2 1.06
37 INT131488 Binding of MAS1 9 0.36 8.49 1.01
38 INT123731 Positive_regulation of Agtrap 12 0.50 7.91 1
39 INT182512 Positive_regulation of Positive_regulation of AGTR1 5 0.47 4.88 0.97
40 INT182513 Regulation of AGTR2 4 0.14 4.31 0.91
41 INT240986 Regulation of Agtrap 4 0.45 2.21 0.88
42 INT229710 Localization of Agtr1a 3 0.60 0.57 0.84
43 INT239222 Positive_regulation of Gene_expression of Agtrap 10 0.57 7.54 0.83
44 INT102894 Localization of AGTR1 5 0.73 1.75 0.74
45 INT137080 Positive_regulation of Positive_regulation of Agtr2 3 0.26 2.34 0.74
46 INT137081 Positive_regulation of Regulation of Agtr2 1 0.24 0.54 0.72
47 INT103886 Negative_regulation of Negative_regulation of Agtr2 5 0.31 2.16 0.71
48 INT85023 Negative_regulation of Gene_expression of Agtr2 4 0.57 2.97 0.71
49 INT141062 Negative_regulation of Gene_expression of Agtr2 2 0.18 1.61 0.7
50 INT148341 Gene_expression of MAS1 9 0.65 4.19 0.68
51 INT111196 Negative_regulation of Negative_regulation of Agtr1a 2 0.42 0.49 0.65
52 INT112666 Positive_regulation of Transcription of Agtr2 1 0.32 0.74 0.65
53 INT151956 Regulation of Positive_regulation of Agtrap 2 0.45 0.72 0.61
54 INT267971 Regulation of Localization of AGTR1 1 0.16 1.46 0.57
55 INT159150 Negative_regulation of Positive_regulation of Agtr1a 1 0.38 0.72 0.56
56 INT233916 Positive_regulation of AGTR2 5 0.37 3.67 0.51
57 INT151957 Positive_regulation of Positive_regulation of Agtrap 1 0.41 0 0.49
58 INT182508 Positive_regulation of Gene_expression of AGTR2 1 0.26 3.13 0.46
59 INT107385 Regulation of Negative_regulation of AGTR1 2 0.15 1.26 0.42
60 INT182507 Negative_regulation of Gene_expression of AGTR1 1 0.40 1.13 0.4
61 INT330125 Transcription of AGTR1 1 0.52 1.29 0.39
62 INT182510 Negative_regulation of Gene_expression of AGTR2 1 0.23 0.78 0.37
63 INT224111 Phosphorylation of Agtr1a 1 0.01 0 0.35
64 INT102889 Positive_regulation of Localization of AGTR1 3 0.38 0.43 0.34
65 INT126578 Regulation of Gene_expression of Agtr2 2 0.49 1.08 0.34
66 INT356392 Negative_regulation of Positive_regulation of Agtr2 1 0.07 1.01 0.32
67 INT182515 Binding of AGTR2 3 0.32 2.4 0.29
68 INT182509 Regulation of Gene_expression of AGTR2 1 0.24 1.72 0.29
69 INT136741 Protein_catabolism of Agtr2 1 0.07 0 0.26
70 INT263255 Negative_regulation of Negative_regulation of AGTR1 2 0.30 2.88 0.25
71 INT63417 Regulation of Negative_regulation of Agtr1a 1 0.26 0.1 0.25
72 INT247022 Transcription of Agtr1a 2 0.46 1.47 0.21
73 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2
74 INT31926 Negative_regulation of Negative_regulation of Agtr2 1 0.00 0.19 0.2
75 INT230740 Regulation of Agtr1a 2 0.15 3.5 0.19
76 INT17822 Regulation of Gene_expression of Agtr2 1 0.05 0.1 0.18
77 INT307798 Negative_regulation of Gene_expression of Agtrap 3 0.31 4.73 0.17
78 INT268208 Transcription of Agtr2 1 0.05 3.15 0.17
79 INT326469 Positive_regulation of Negative_regulation of AGTR2 1 0.09 2.96 0.16
80 INT236359 Negative_regulation of Positive_regulation of Agtr2 2 0.07 1.61 0.15
81 INT209796 Positive_regulation of Agtr1a 1 0.15 0.56 0.15
82 INT181974 Positive_regulation of Positive_regulation of MAS1 1 0.01 1.28 0.14
83 INT241008 Phosphorylation of Agtr2 1 0.09 0.13 0.14
84 INT288916 Negative_regulation of Positive_regulation of AGTR1 2 0.44 1.2 0.13
85 INT320866 Negative_regulation of Positive_regulation of Agtrap 2 0.21 2.15 0.13
86 INT241009 Phosphorylation of Agtrap 1 0.52 0.13 0.13
87 INT355657 Negative_regulation of Transcription of Agtr1a 1 0.38 1.17 0.13
88 INT355655 Regulation of Transcription of Agtr1a 1 0.29 1.15 0.13
89 INT99725 Negative_regulation of Agtr1a 5 0.57 1.03 0.12
90 INT229356 Negative_regulation of Binding of Agtr1a 1 0.36 0.89 0.12
91 INT356371 Localization of Agtr2 1 0.04 0.74 0.11
92 INT143360 Regulation of Negative_regulation of Agtr2 1 0.27 0.56 0.1
93 INT242222 Positive_regulation of Negative_regulation of AGTR1 1 0.35 1.77 0.1
94 INT247024 Positive_regulation of Transcription of Agtr1a 1 0.19 0.33 0.09
95 INT209797 Regulation of Positive_regulation of Agtr1a 1 0.10 0.29 0.08
96 INT333041 Regulation of Positive_regulation of AGTR1 1 0.44 0 0.07
97 INT239219 Localization of Agtrap 2 0.50 5.81 0.06
98 INT288913 Regulation of Positive_regulation of AGTR2 1 0.28 0.43 0.06
99 INT267699 Positive_regulation of Binding of MAS1 1 0.03 0.45 0.06
100 INT182487 Positive_regulation of Gene_expression of Agtr1a 2 0.19 1.32 0.04
101 INT179198 Regulation of Gene_expression of AGTR1 2 0.25 2.04 0.04
102 INT240997 Regulation of Negative_regulation of Agtrap 1 0.37 0.48 0.04
103 INT307801 Transcription of Agtrap 3 0.69 4.05 0
104 INT322229 Positive_regulation of Transcription of Agtrap 1 0.50 0.4 0
105 INT240985 Positive_regulation of Binding of Agtr2 1 0.07 0.83 0
106 INT288912 Protein_catabolism of AGTR1 1 0.66 0.29 0
107 INT103887 Positive_regulation of Negative_regulation of Agtr2 1 0.08 0.1 0
108 INT313043 Localization of MAS1 1 0.21 0.13 0
109 INT333040 Regulation of Binding of AGTR1 1 0.44 0 0
110 INT240996 Protein_catabolism of Agtr2 1 0.12 0.18 0
111 INT240990 Positive_regulation of Protein_catabolism of Agtr2 1 0.07 0.18 0
112 INT241016 Negative_regulation of Protein_catabolism of Agtr2 1 0.06 0.18 0
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