GO:0004968

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Name gonadotropin-releasing hormone receptor activity
Categary Function
Go Slim No
Go Link GO:0004968
Unique Molecular Interactions 108
Total Molecular Interactions 158
Total Single Events 1752
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for gonadotropin-releasing hormone receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for gonadotropin-releasing hormone receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
2 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
3 INT30042 Binding of YY1 and Gnrhr 1 0.18 0 1.47
4 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45
5 INT3575 Sst Regulation of Localization of Gnrhr 2 0.24 0 1.24
6 INT29713 Crh Negative_regulation of Localization of Gnrhr 1 0.39 0 1.12
7 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07
8 INT120315 Gnrhr Negative_regulation of Positive_regulation of Ngf 1 0.11 0.85 1.07
9 INT120318 Gnrhr Negative_regulation of Ngf 1 0.11 0.85 1.07
10 INT775 Nts Positive_regulation of Gnrhr 2 0.18 0 1.02
11 INT36682 Gh1 Regulation of Gene_expression of Gnrhr 2 0.08 0 0.96
12 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95
13 INT28656 Calca Negative_regulation of Localization of Gnrhr 1 0.19 0 0.91
14 INT76062 Gnrhr Positive_regulation of Localization of LH 1 0.10 0 0.9
15 INT15730 Ghrh Positive_regulation of Gnrhr 2 0.14 0.08 0.84
16 INT18663 PDYN Negative_regulation of Binding of Gnrhr 1 0.01 0 0.83
17 INT33995 Ghrh Regulation of Gnrhr 2 0.18 0.43 0.77
18 INT40707 Sst Positive_regulation of Localization of Gnrhr 1 0.26 0 0.76
19 INT3570 Trh Regulation of Localization of Gnrhr 2 0.26 0.3 0.75
20 INT31306 Ghrh Regulation of Localization of Gnrhr 2 0.14 1 0.73
21 INT1312 Pomc Positive_regulation of Gnrhr 2 0.11 0.22 0.7
22 INT35920 Penk Positive_regulation of Gnrhr 1 0.29 0 0.67
23 INT74468 Adcyap1 Positive_regulation of Localization of Gnrhr 1 0.27 0 0.67
24 INT42779 Scn4a Positive_regulation of Localization of Gnrhr 1 0.10 0 0.66
25 INT781 Prss12 Positive_regulation of Gene_expression of Gnrhr 1 0.10 0 0.65
26 INT779 Nts Positive_regulation of Gene_expression of Gnrhr 1 0.28 0 0.65
27 INT40450 Cck Regulation of Gnrhr 1 0.23 0 0.65
28 INT773 Prss12 Positive_regulation of Gnrhr 1 0.04 0 0.64
29 INT54155 Positive_regulation of Glra2 Positive_regulation of Localization of Gnrhr 1 0.02 0 0.63
30 INT82065 Negative_regulation of Gnrhr Negative_regulation of Localization of LH 1 0.45 0 0.61
31 INT26997 SST Positive_regulation of Negative_regulation of Gnrhr 1 0.00 0.08 0.59
32 INT30462 Gnrhr Positive_regulation of Localization of Gh1 2 0.21 0.08 0.58
33 INT30267 Binding of Crh and Gnrhr 1 0.33 0.65 0.57
34 INT45736 Prl Positive_regulation of Gene_expression of Gnrhr 1 0.00 0.1 0.56
35 INT32484 Gnrhr Regulation of GHRH 1 0.01 0 0.55
36 INT311524 Gnrhr Positive_regulation of Transcription of Grin2a 1 0.02 0.54 0.55
37 INT55206 Prl Negative_regulation of Gnrhr 1 0.37 0 0.54
38 INT311521 Gnrhr Positive_regulation of Gene_expression of Gria1 1 0.00 0.54 0.54
39 INT149886 Npw Negative_regulation of Localization of Gnrhr 1 0.36 0 0.54
40 INT311522 Gnrhr Positive_regulation of Transcription of Gria1 1 0.00 0.54 0.54
41 INT149885 Npw Negative_regulation of Gnrhr 1 0.36 0 0.54
42 INT55203 Prl Negative_regulation of Localization of Gnrhr 1 0.37 0 0.51
43 INT49150 GAL Regulation of Localization of Gnrhr 1 0.00 0.09 0.51
44 INT1311 Lct Positive_regulation of Localization of Gnrhr 1 0.03 0 0.45
45 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
46 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
47 INT83749 Gnrhr Positive_regulation of Gene_expression of Fos 2 0.21 0.14 0.39
48 INT34865 Ghrh Positive_regulation of Gene_expression of Gnrhr 1 0.07 0 0.37
49 INT74466 Mzb1 Positive_regulation of Localization of Gnrhr 1 0.28 0 0.37
50 INT42042 Binding of Gnrhr and MCG 1 0.01 0.26 0.35
51 INT12710 Gnrhr Regulation of Prl 1 0.00 0.63 0.35
52 INT54930 Gnrhr Regulation of Gene_expression of Ghrh 1 0.10 0.16 0.34
53 INT27099 Vip Positive_regulation of Localization of Gnrhr 1 0.01 0.36 0.33
54 INT8975 Gal Positive_regulation of Localization of Gnrhr 1 0.00 0.06 0.33
55 INT74469 GNRH1 Positive_regulation of Localization of Gnrhr 1 0.04 0 0.31
56 INT30266 Binding of Penk and Gnrhr 1 0.10 0.32 0.29
57 INT60448 NPY Positive_regulation of Gnrhr 1 0.01 0 0.29
58 INT60449 GAL Positive_regulation of Gnrhr 1 0.00 0 0.29
59 INT59757 Man2a2 Positive_regulation of Localization of Gnrhr 1 0.07 0 0.29
60 INT30264 Binding of Pomc and Gnrhr 1 0.22 0.32 0.29
61 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
62 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
63 INT38352 LH Regulation of Localization of Gnrhr 1 0.21 0 0.27
64 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
65 INT38353 Gnrh1 Regulation of Localization of Gnrhr 1 0.20 0 0.27
66 INT60914 Iapp Regulation of Gnrhr 1 0.17 0 0.27
67 INT157080 Ghrl Positive_regulation of Localization of Gnrhr 2 0.23 0.7 0.26
68 INT77736 Pnoc Positive_regulation of Localization of Gnrhr 1 0.24 0 0.23
69 INT40448 Cck Regulation of Localization of Gnrhr 1 0.23 0 0.23
70 INT143909 SST Regulation of Gnrhr 1 0.00 0 0.22
71 INT19905 Trh Regulation of Gnrhr 1 0.00 0.25 0.22
72 INT3615 Gnrhr Regulation of Localization of Gh1 1 0.26 0 0.19
73 INT3619 Trh Positive_regulation of Localization of Gnrhr 2 0.48 0.2 0.18
74 INT325421 PHF20 Positive_regulation of Localization of Gnrhr 1 0.00 0.39 0.17
75 INT30419 Gnrhr Regulation of Sst 1 0.02 0.27 0.15
76 INT25149 Gnrhr Regulation of Localization of Ins1 1 0.21 0.1 0.15
77 INT30421 Gnrhr Regulation of Crh 1 0.11 0.27 0.15
78 INT49683 Negative_regulation of Sst Positive_regulation of Localization of Gnrhr 1 0.01 0 0.15
79 INT31848 SST Regulation of Localization of Gnrhr 1 0.01 0 0.14
80 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
81 INT34760 Gh1 Positive_regulation of Localization of Gnrhr 1 0.09 0 0.13
82 INT122221 Gnrhr Regulation of Gene_expression of LH 1 0.03 0 0.12
83 INT339254 GNRHR Regulation of GNRH1 1 0.24 0.23 0.12
84 INT117857 Mln Positive_regulation of Localization of Gnrhr 1 0.14 0 0.12
85 INT64590 Gnrhr Positive_regulation of Positive_regulation of Ins1 1 0.14 0.33 0.12
86 INT122230 Gnrhr Regulation of Gene_expression of Pomc 1 0.00 0 0.12
87 INT122229 Gnrhr Regulation of Gene_expression of Gnrh1 1 0.05 0 0.12
88 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
89 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
90 INT157079 Ghrl Positive_regulation of Gnrhr 1 0.23 0 0.09
91 INT144865 Positive_regulation of Gnrhr Positive_regulation of Localization of Gh1 1 0.27 0 0.09
92 INT34930 Gh1 Regulation of Localization of Gnrhr 1 0.04 0 0.08
93 INT84505 Ghsr Positive_regulation of Localization of Gnrhr 1 0.20 0 0.07
94 INT66590 Gnrhr Regulation of Ldlr 1 0.02 0.4 0.06
95 INT299457 Foxl2 Positive_regulation of Gnrhr 1 0.42 0.56 0.05
96 INT299461 Foxl2 Regulation of Gnrhr 1 0.24 0.12 0
97 INT299454 Gene_expression of Foxl2 Positive_regulation of Positive_regulation of Gnrhr 1 0.42 0 0
98 INT100609 Gnrhr Regulation of Cyp2c22 1 0.02 0.19 0
99 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 0.01 0.53 0
100 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0
101 INT334922 GNRHR Positive_regulation of Gene_expression of PLOD1 1 0.08 0.53 0
102 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0
103 INT261357 Negative_regulation of Gh1 Regulation of Gnrhr 1 0.00 1.26 0
104 INT334917 GNRHR Positive_regulation of Gene_expression of FSHR 1 0.05 0.53 0
105 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0
106 INT188292 Ghrl Regulation of Gnrhr 1 0.01 0.19 0
107 INT299437 Regulation of Foxl2 Regulation of Gnrhr 1 0.21 0.05 0
108 INT299441 Foxl2 Regulation of Gene_expression of Gnrhr 1 0.24 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for gonadotropin-releasing hormone receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in gonadotropin-releasing hormone receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT767 Localization of Gnrhr 565 0.80 106.68 214.57
2 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56
3 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64
4 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23
5 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66
6 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54
7 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93
8 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41
9 INT18660 Binding of Gnrhr 45 0.41 10.6 16.85
10 INT327 Negative_regulation of Positive_regulation of Gnrhr 17 0.53 4.22 10.21
11 INT14368 Regulation of Gene_expression of Gnrhr 13 0.61 3.23 8.45
12 INT18345 Positive_regulation of Positive_regulation of Gnrhr 16 0.42 4.99 4.91
13 INT33071 Negative_regulation of Gene_expression of Gnrhr 13 0.53 5.99 4.41
14 INT16588 Positive_regulation of Gene_expression of Gnrhr 14 0.62 4.76 3.35
15 INT15062 Transcription of Gnrhr 9 0.65 1.88 3.2
16 INT1360 Negative_regulation of Regulation of Gnrhr 5 0.43 0.77 2.86
17 INT15607 Localization of GNRHR 14 0.62 7.56 2.3
18 INT21037 Regulation of Regulation of Gnrhr 2 0.45 0.21 2.3
19 INT43165 Regulation of Positive_regulation of Gnrhr 3 0.27 0.1 1.86
20 INT51952 Negative_regulation of Binding of Gnrhr 4 0.46 0.29 1.81
21 INT35209 Positive_regulation of Negative_regulation of Gnrhr 5 0.48 1.38 1.53
22 INT15605 Regulation of Localization of GNRHR 4 0.40 0 1.36
23 INT167716 Negative_regulation of Gene_expression of Gnrhr 2 0.35 6.64 0.93
24 INT32963 Negative_regulation of Localization of GNRHR 3 0.29 2.48 0.84
25 INT36811 Regulation of Binding of Gnrhr 1 0.35 0 0.78
26 INT167717 Gene_expression of Gnrhr 5 0.55 2.49 0.69
27 INT139927 Localization of Gnrhr 4 0.74 0.1 0.59
28 INT21377 Regulation of GNRHR 3 0.58 0.14 0.59
29 INT51953 Positive_regulation of Binding of Gnrhr 2 0.36 0.73 0.59
30 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53
31 INT32962 Positive_regulation of Localization of GNRHR 3 0.41 0.59 0.49
32 INT177438 Negative_regulation of GNRHR 3 0.18 3.39 0.4
33 INT295911 Positive_regulation of Transcription of Gnrhr 1 0.02 0.98 0.39
34 INT13064 Positive_regulation of GNRHR 2 0.36 0.93 0.35
35 INT21376 Regulation of Regulation of GNRHR 1 0.26 0 0.34
36 INT151710 Negative_regulation of Transcription of Gnrhr 1 0.42 0.09 0.23
37 INT151709 Transcription of Gnrhr 1 0.71 0.09 0.22
38 INT139926 Regulation of Localization of Gnrhr 1 0.18 0 0.21
39 INT113159 Negative_regulation of Gnrhr 1 0.33 0 0.19
40 INT95417 Regulation of Gnrhr 3 0.48 0 0.16
41 INT10523 Negative_regulation of Negative_regulation of Gnrhr 2 0.36 0.86 0.16
42 INT55048 Transcription of GNRHR 2 0.69 0.63 0.13
43 INT95418 Regulation of Regulation of Gnrhr 1 0.35 0 0.08
44 INT169094 Positive_regulation of Localization of Gnrhr 1 0.38 0 0.07
45 INT161017 Regulation of Transcription of Gnrhr 1 0.41 0 0
46 INT55046 Binding of GNRHR 1 0.37 0.53 0
47 INT161015 Negative_regulation of Transcription of Gnrhr 1 0.39 0 0
48 INT299412 Positive_regulation of Gnrhr 1 0.38 0 0
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