GO:0004969

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Name histamine receptor activity
Categary Function
Go Slim No
Go Link GO:0004969
Unique Molecular Interactions 42
Total Molecular Interactions 47
Total Single Events 589
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histamine receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for histamine receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
2 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
3 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
4 INT75370 Positive_regulation of Binding of Hrh1 and RGD735065 1 0.00 0.56 1.41
5 INT75371 Binding of Hrh1 and RGD735065 1 0.00 0.55 1.4
6 INT266811 Binding of HRH1 and HTR2C 1 0.23 2.06 1.4
7 INT185330 Binding of Hrh1 and Tac1 1 0.00 0.1 1.34
8 INT264931 Binding of Gnaz and Hrh1 1 0.01 0.83 1.12
9 INT230594 Binding of Hrh1 and Hrh2 1 0.24 0.99 1.02
10 INT36597 Hrh1 Regulation of Rtcd1 1 0.04 0.36 1.01
11 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94
12 INT70011 Binding of Hrh1 and Insrr 1 0.00 0.4 0.72
13 INT88141 Hrh1 Positive_regulation of 1700061J05Rik 1 0.01 1.08 0.66
14 INT96945 Hrh1 Negative_regulation of Spdya 1 0.00 0.32 0.62
15 INT159840 Binding of HTR1A and HTR6 1 0.39 0.38 0.62
16 INT144598 Hrh2 Positive_regulation of IL2 1 0.01 0.08 0.56
17 INT243276 Hrh4 Positive_regulation of Hrh3 1 0.25 0.78 0.52
18 INT73056 Binding of Hrh1 and Adarb1 1 0.00 0.25 0.49
19 INT72690 Binding of Hrh1 and Slc3a1 1 0.00 0.29 0.45
20 INT63519 Hrh1 Regulation of H2 1 0.02 0.36 0.39
21 INT113992 Binding of HRH1 and LIAS 1 0.00 0.09 0.38
22 INT72264 Binding of Hrh1 and Hrh3 1 0.11 0.16 0.34
23 INT51301 Hrh1 Regulation of Hrh2 1 0.01 0 0.3
24 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
25 INT243273 Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29
26 INT243280 Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29
27 INT243278 Positive_regulation of Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29
28 INT243274 Positive_regulation of Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29
29 INT53544 Binding of CYP2B6 and HRH1 1 0.28 0 0.23
30 INT349668 Binding of HRH1 and PYCARD 1 0.00 0.37 0.21
31 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2
32 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2
33 INT79537 Hrh3 Regulation of Localization of Prl 1 0.13 0.4 0.18
34 INT31714 Hrh1 Positive_regulation of Localization of Ins1 1 0.00 0.36 0.11
35 INT325223 Il13 Regulation of Hrh4 1 0.38 0.58 0.11

Single Events

The table below shows the top 100 pain related interactions that have been reported for histamine receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in histamine receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9988 Regulation of Hrh1 22 0.46 12.87 22.13
2 INT667 Negative_regulation of Hrh2 38 0.58 18.11 18.01
3 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65
4 INT49219 Gene_expression of Hrh1 28 0.75 13.77 14.99
5 INT18930 Positive_regulation of Hrh1 20 0.63 7.77 12.96
6 INT9954 Negative_regulation of Hrh1 16 0.52 13.04 11.76
7 INT30008 Binding of Hrh1 17 0.45 6.8 11.41
8 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37
9 INT165 Regulation of HRH1 12 0.45 1.76 7.57
10 INT7743 Binding of Hrh2 19 0.47 7.75 7.11
11 INT26112 Positive_regulation of Hrh2 10 0.69 4.28 5.54
12 INT165010 Gene_expression of Hrh4 8 0.73 6.65 5.35
13 INT40638 Binding of HRH1 14 0.44 5.81 5.09
14 INT7346 Localization of Hrh2 15 0.69 5.78 4.79
15 INT4148 Gene_expression of HRH1 11 0.77 2.71 4.22
16 INT64326 Negative_regulation of Binding of Hrh1 4 0.15 1.41 3.65
17 INT135316 Gene_expression of Hrh3 9 0.74 5.66 3.14
18 INT74596 Gene_expression of Hrh3 11 0.66 0.94 3.12
19 INT12812 Regulation of Hrh3 10 0.51 1.07 2.95
20 INT24880 Positive_regulation of HRH2 7 0.69 1.34 2.74
21 INT755 Regulation of HRH2 7 0.45 2.87 2.68
22 INT101 Negative_regulation of HRH1 8 0.57 3.48 2.55
23 INT38144 Positive_regulation of HRH1 7 0.57 2.57 2.51
24 INT243271 Positive_regulation of Hrh4 4 0.52 3.46 2.31
25 INT18654 Gene_expression of HRH2 9 0.67 5.73 2.19
26 INT65365 Regulation of Binding of Hrh1 2 0.03 0.4 2.19
27 INT38906 Transcription of Hrh2 6 0.62 3.11 2.03
28 INT31096 Binding of HRH2 7 0.37 2 2
29 INT21625 Negative_regulation of Gene_expression of Hrh2 2 0.40 2.4 1.88
30 INT8489 Negative_regulation of Hrh3 5 0.38 1.01 1.83
31 INT69820 Binding of Hrh3 6 0.37 0.89 1.58
32 INT31047 Localization of HRH2 5 0.75 1.84 1.53
33 INT47998 Positive_regulation of Hrh3 4 0.70 1.12 1.51
34 INT55870 Negative_regulation of Gene_expression of Hrh1 2 0.11 0.38 1.39
35 INT325206 Negative_regulation of Hrh4 1 0.55 2.37 1.34
36 INT69821 Negative_regulation of Hrh3 4 0.43 3.59 1.15
37 INT159001 Positive_regulation of Gene_expression of Hrh1 3 0.47 1.71 1.12
38 INT264514 Regulation of Transcription of Hrh2 1 0.02 0.3 1.06
39 INT15186 Negative_regulation of HRH2 8 0.51 2.26 0.99
40 INT65516 Regulation of Positive_regulation of Hrh2 2 0.38 0.24 0.97
41 INT47997 Negative_regulation of Positive_regulation of Hrh3 2 0.38 0.91 0.89
42 INT166226 Negative_regulation of Localization of Hrh2 1 0.03 0.64 0.89
43 INT109542 Negative_regulation of Positive_regulation of Hrh1 1 0.02 0.68 0.79
44 INT152550 Regulation of Hrh3 2 0.45 1.17 0.75
45 INT30315 Regulation of Negative_regulation of Hrh2 2 0.44 0.24 0.7
46 INT20596 Positive_regulation of Localization of Hrh2 1 0.43 0.09 0.69
47 INT44073 Negative_regulation of Binding of HRH2 2 0.43 0.86 0.66
48 INT325207 Negative_regulation of Gene_expression of Hrh4 1 0.40 1.86 0.66
49 INT44072 Positive_regulation of Binding of HRH2 1 0.50 0.59 0.61
50 INT54407 Regulation of Gene_expression of Hrh2 2 0.41 1.63 0.54
51 INT77124 Positive_regulation of Positive_regulation of Hrh1 1 0.29 0.28 0.54
52 INT30388 Positive_regulation of Binding of Hrh2 1 0.09 0.17 0.54
53 INT325204 Regulation of Hrh4 1 0.42 0.97 0.52
54 INT30389 Negative_regulation of Binding of Hrh2 1 0.08 0.16 0.52
55 INT40911 Negative_regulation of Gene_expression of HRH2 3 0.43 1.71 0.48
56 INT66557 Positive_regulation of Localization of Hrh3 1 0.16 0.1 0.48
57 INT66555 Localization of Hrh3 1 0.23 0.1 0.48
58 INT141212 Negative_regulation of HTR6 1 0.41 0.39 0.44
59 INT141678 Localization of Hrh4 1 0.69 0.97 0.44
60 INT154868 Binding of Hrh4 2 0.35 1.01 0.36
61 INT134947 Negative_regulation of Gene_expression of HRH1 1 0.42 0.46 0.36
62 INT325215 Regulation of Gene_expression of Hrh4 1 0.42 0.17 0.32
63 INT38145 Positive_regulation of Positive_regulation of HRH1 1 0.41 0.63 0.32
64 INT179005 Binding of Hrh3 1 0.40 0.52 0.29
65 INT101526 Binding of HTR6 1 0.35 0.6 0.26
66 INT84330 Negative_regulation of Transcription of Hrh2 1 0.38 0.5 0.25
67 INT325208 Regulation of Negative_regulation of Hrh4 1 0.25 0.23 0.25
68 INT29570 Localization of Hrh1 1 0.00 0.2 0.24
69 INT38146 Regulation of Positive_regulation of HRH1 1 0.37 0.5 0.24
70 INT53545 Negative_regulation of Binding of HRH1 1 0.36 0 0.23
71 INT173342 Phosphorylation of HRH1 1 0.04 0.48 0.22
72 INT102 Regulation of Negative_regulation of HRH1 1 0.03 0.43 0.18
73 INT309205 Transcription of Hrh3 1 0.02 0.11 0.17
74 INT179006 Positive_regulation of Negative_regulation of Hrh3 1 0.39 0 0.14
75 INT69819 Positive_regulation of Hrh3 2 0.39 0.62 0.13
76 INT7742 Regulation of Localization of Hrh2 1 0.19 0 0.13
77 INT273295 Negative_regulation of Gene_expression of Hrh3 1 0.41 1.05 0.03
78 INT113997 Regulation of Binding of HRH1 1 0.00 0 0
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