GO:0004974

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Name leukotriene receptor activity
Categary Function
Go Slim No
Go Link GO:0004974
Unique Molecular Interactions 147
Total Molecular Interactions 181
Total Single Events 1316
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for leukotriene receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for leukotriene receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT335435 Ngf Positive_regulation of Ltb4r 1 0.52 1.06 1.16
2 INT218840 Cysltr1 Positive_regulation of Ltp 2 0.02 1.04 1.06
3 INT18828 DNM2 Positive_regulation of Localization of LTB4R 1 0.01 0.07 1.06
4 INT318490 IRF6 Positive_regulation of LTB4R 1 0.01 4.39 1.03
5 INT164287 Ltb4r Positive_regulation of Cysltr2 2 0.41 1.88 1.02
6 INT164281 Ltb4r Positive_regulation of Cysltr1 2 0.32 1.87 1.02
7 INT296283 Kcnip3 Regulation of Positive_regulation of Cysltr1 1 0.01 0.85 0.94
8 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92
9 INT194021 Cysltr1 Negative_regulation of Acc 1 0.02 1.2 0.91
10 INT208731 Binding of pf and Cysltr1 1 0.02 1.74 0.87
11 INT296299 Positive_regulation of Cysltr1 Positive_regulation of Positive_regulation of Rbm39 1 0.00 0.59 0.79
12 INT296297 Positive_regulation of Cysltr1 Positive_regulation of Positive_regulation of Car2 1 0.01 0.59 0.77
13 INT210979 Grm5 Positive_regulation of Cysltr1 1 0.00 0.76 0.75
14 INT210980 Cysltr1 Positive_regulation of Positive_regulation of Dio1 1 0.00 0.81 0.75
15 INT210981 Calb1 Positive_regulation of Cysltr1 1 0.00 0.81 0.69
16 INT210985 Positive_regulation of Calb1 Positive_regulation of Cysltr1 1 0.00 0.81 0.69
17 INT232620 Ptpn4 Regulation of Cysltr1 1 0.02 0.58 0.68
18 INT232617 Grid2ip Regulation of Cysltr1 1 0.03 0.58 0.68
19 INT232613 Gopc Regulation of Cysltr1 1 0.02 0.58 0.68
20 INT232615 Psd Regulation of Cysltr1 1 0.02 0.58 0.68
21 INT146375 Sds Negative_regulation of Positive_regulation of Cysltr1 1 0.02 0.32 0.67
22 INT232622 Magi2 Regulation of Cysltr1 1 0.01 0.58 0.67
23 INT218838 Ppp1r9a Regulation of Cysltr1 1 0.01 1.2 0.63
24 INT248172 Epo Regulation of Cysltr1 1 0.01 0.74 0.63
25 INT218835 Ppp1cc Regulation of Cysltr1 1 0.01 1.19 0.62
26 INT218836 Binding of Ppp1cc and Regulation of Cysltr1 1 0.01 1.2 0.62
27 INT218845 Ppp1cc Positive_regulation of Positive_regulation of Cysltr1 1 0.02 0.92 0.6
28 INT164283 Ltb4r Positive_regulation of Ltc4s 1 0.37 1.1 0.6
29 INT164282 Cysltr1 Positive_regulation of Cysltr2 1 0.17 1.1 0.6
30 INT164284 Ltb4r Positive_regulation of Alox5ap 1 0.34 1.1 0.6
31 INT318488 LTB4R Regulation of FPR2 1 0.01 1.07 0.58
32 INT218844 Cysltr1 Regulation of Car1 1 0.01 1.42 0.55
33 INT318478 Negative_regulation of IRF6 Positive_regulation of LTB4R 1 0.01 2.38 0.53
34 INT268473 Negative_regulation of CNR1 Negative_regulation of Cysltr1 1 0.00 1.02 0.48
35 INT240441 Ltb4r1 Positive_regulation of PPARA 1 0.03 1.01 0.47
36 INT240442 Binding of PPARA and Ltb4r1 1 0.02 0.94 0.46
37 INT193219 Binding of LTC4S and CYSLTR2 2 0.28 2.2 0.44
38 INT318483 Binding of LTB4R and FPR2 1 0.02 0.98 0.42
39 INT335438 Ltb4r2 Positive_regulation of Cysltr2 1 0.04 0.77 0.42
40 INT335437 Ltb4r2 Positive_regulation of Cysltr1 1 0.03 0.77 0.41
41 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41
42 INT335439 Ltb4r Positive_regulation of Ltb4r2 1 0.09 0.76 0.41
43 INT299181 Cysltr1 Regulation of Musk 1 0.08 1.21 0.4
44 INT318484 IRF6 Positive_regulation of Positive_regulation of LTB4R 1 0.01 1.38 0.35
45 INT203166 Negative_regulation of CPOX Positive_regulation of Gene_expression of LTB4R 1 0.00 0.65 0.34
46 INT258574 Cysltr1 Positive_regulation of Positive_regulation of Cnr1 1 0.01 0.07 0.32
47 INT232614 Positive_regulation of Car2 Positive_regulation of Cysltr1 1 0.01 0.62 0.31
48 INT232616 Car2 Positive_regulation of Cysltr1 1 0.02 0.62 0.31
49 INT275555 Binding of Ltb4r1 and COPD 1 0.01 1.02 0.3
50 INT318480 IRF6 Positive_regulation of Gene_expression of LTB4R 1 0.01 1.63 0.29
51 INT301666 Binding of CYP4F2 and Ltb4r1 1 0.02 0.57 0.28
52 INT301668 Ltb4r1 Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27
53 INT318477 Regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1 0.27
54 INT38711 CYSLTR1 Positive_regulation of Gene_expression of PTGS1 1 0.08 0.14 0.25
55 INT267591 CYSLTR1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.87 0.25
56 INT208728 Positive_regulation of Dcn Positive_regulation of Cysltr1 1 0.02 0.3 0.24
57 INT208732 Dcn Positive_regulation of Cysltr1 1 0.02 0.29 0.24
58 INT318485 Positive_regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1.03 0.23
59 INT193215 Binding of CYSLTR1 and CYSLTR2 2 0.09 1.7 0.21
60 INT249892 Cysltr1 Positive_regulation of Gpr17 1 0.09 0.92 0.2
61 INT208730 pf Positive_regulation of Cysltr1 1 0.02 0.38 0.19
62 INT341814 Binding of CYSLTR1 and Aia1 1 0.01 1.33 0.19
63 INT247507 Grk6 Regulation of LTB4R 1 0.02 0.2 0.18
64 INT210978 THL Negative_regulation of Cysltr1 1 0.01 0.27 0.18
65 INT249897 Cysltr1 Positive_regulation of P2ry4 1 0.01 0.7 0.17
66 INT33362 Binding of Ltc4s and Cysltr1 1 0.16 0.21 0.17
67 INT312089 LTB4R Positive_regulation of ALOX5AP 1 0.01 0.32 0.16
68 INT193216 Binding of LTC4S and CYSLTR1 1 0.04 0.71 0.16
69 INT301306 Binding of GPR17 and CYSLTR1 1 0.04 0.42 0.16
70 INT312095 LTB4R Positive_regulation of ALOX5 1 0.01 0.32 0.16
71 INT270995 Binding of CYSLTR2 and OR6B1 1 0.01 2.14 0.15
72 INT340111 Chrna7 Regulation of CYSLTR1 1 0.00 0.25 0.15
73 INT221382 Tlr4 Positive_regulation of Localization of Ltb4r1 1 0.01 1.38 0.14
74 INT152628 Mvk Negative_regulation of Cysltr1 1 0.46 0 0.13
75 INT347462 Binding of CYSLTR1 and ST7L 1 0.00 0.1 0.13
76 INT17437 LTC4S Positive_regulation of CYSLTR1 1 0.03 0.2 0.13
77 INT294725 Binding of LTB4R and LTB4R2 1 0.00 0 0.1
78 INT199436 Binding of Capns1 and Cysltr1 1 0.00 0.79 0.1
79 INT301311 GPR17 Negative_regulation of Binding of CYSLTR1 1 0.04 0.46 0.08
80 INT301309 GPR17 Negative_regulation of CYSLTR1 1 0.04 0.46 0.08
81 INT301308 GPR17 Negative_regulation of Positive_regulation of CYSLTR1 1 0.04 0.46 0.08
82 INT301324 Binding of CYSLTR1 and Lor 1 0.28 0 0.06
83 INT287613 Binding of Fmr1 and Cysltr1 1 0.01 0.18 0.04
84 INT347514 Binding of CYSLTR1 and Ltc4s 1 0.01 0.58 0.03
85 INT301304 CYSLTR2 Positive_regulation of Binding of GPR17 1 0.02 0 0.03
86 INT347516 Binding of CYSLTR2 and Ltc4s 1 0.01 0.4 0.03
87 INT301305 CYSLTR1 Positive_regulation of Binding of GPR17 1 0.04 0 0.03
88 INT273482 Binding of CYSLTR1 and USE1 1 0.00 0.77 0
89 INT126934 Ltb4r Positive_regulation of Positive_regulation of Trpv1 1 0.05 0 0
90 INT273483 Binding of RNASEL and CYSLTR1 1 0.00 0.78 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for leukotriene receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in leukotriene receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52
2 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72
3 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36
4 INT16635 Gene_expression of Ltb4r 27 0.64 17.05 13.21
5 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49
6 INT18833 Positive_regulation of LTB4R 19 0.69 27.61 10.17
7 INT5822 Gene_expression of Ltb4r1 51 0.76 37.43 7.2
8 INT28424 Regulation of Cysltr1 17 0.41 7.33 6.34
9 INT16210 Localization of LTB4R 14 0.54 6.58 6.19
10 INT127062 Positive_regulation of Gene_expression of LTB4R 18 0.34 15.9 5.64
11 INT16211 Negative_regulation of LTB4R 11 0.29 13 5.62
12 INT51679 Negative_regulation of Gene_expression of LTB4R 12 0.29 7.21 4.74
13 INT170988 Positive_regulation of CYSLTR1 15 0.34 6.23 4.44
14 INT146373 Negative_regulation of Positive_regulation of Cysltr1 11 0.05 5.39 4.44
15 INT76339 Positive_regulation of Ltb4r1 23 0.45 22.78 3.58
16 INT33474 Negative_regulation of Ltb4r 9 0.13 4.02 3.28
17 INT16637 Negative_regulation of Gene_expression of Ltb4r 9 0.35 3.19 3.26
18 INT16212 Negative_regulation of Localization of LTB4R 6 0.39 1.9 3.26
19 INT51686 Regulation of Gene_expression of LTB4R 10 0.26 5.02 2.99
20 INT164272 Gene_expression of Cysltr1 5 0.59 4.34 2.9
21 INT13634 Gene_expression of CYSLTR1 19 0.75 11.24 2.88
22 INT21350 Negative_regulation of Ltb4r1 11 0.33 6.77 2.88
23 INT104035 Gene_expression of LTB4R2 12 0.66 7.41 2.76
24 INT51298 Binding of Ltb4r 11 0.27 3.99 2.7
25 INT54358 Localization of Ltb4r1 13 0.34 14.31 2.6
26 INT193251 Binding of CYSLTR1 13 0.32 8.32 2.57
27 INT128365 Positive_regulation of Gene_expression of Ltb4r1 10 0.60 8.04 2.53
28 INT33630 Regulation of Ltb4r 5 0.09 2.95 2.47
29 INT61039 Localization of Ltb4r 7 0.59 9.51 2.44
30 INT164271 Transcription of Ltb4r 2 0.56 4.16 2.4
31 INT189122 Positive_regulation of Positive_regulation of Cysltr1 8 0.17 5.11 2.26
32 INT51684 Regulation of LTB4R 6 0.36 3.04 2.15
33 INT40104 Binding of Cysltr1 11 0.38 4.56 1.95
34 INT232602 Regulation of Positive_regulation of Cysltr1 4 0.03 2.13 1.79
35 INT335412 Transcription of Cysltr1 1 0.52 2.19 1.75
36 INT335422 Transcription of Ltb4r2 1 0.10 2.13 1.7
37 INT49508 Regulation of Ltb4r1 3 0.18 4.28 1.66
38 INT51678 Negative_regulation of Protein_catabolism of LTB4R 1 0.29 0.27 1.6
39 INT54826 Binding of LTB4R 7 0.29 1.51 1.59
40 INT51682 Protein_catabolism of LTB4R 1 0.59 0.27 1.58
41 INT165368 Positive_regulation of Gene_expression of Cysltr1 8 0.46 2.47 1.35
42 INT128361 Negative_regulation of Positive_regulation of Ltb4r1 3 0.37 2.74 1.31
43 INT38788 Negative_regulation of CYSLTR1 8 0.42 4.5 1.16
44 INT18834 Positive_regulation of Localization of LTB4R 2 0.29 0.24 1.14
45 INT335421 Gene_expression of Ltb4r2 1 0.10 1.21 1.12
46 INT163794 Localization of CYSLTR1 4 0.45 2.4 1.08
47 INT235705 Regulation of Gene_expression of Cysltr1 1 0.36 0.5 1.07
48 INT164278 Localization of Cysltr1 2 0.57 2.3 1.01
49 INT16636 Positive_regulation of Ltb4r 8 0.26 4.48 0.92
50 INT95917 Gene_expression of CYSLTR2 10 0.64 6.1 0.82
51 INT81030 Localization of Cysltr1 2 0.20 1.38 0.8
52 INT136494 Negative_regulation of Localization of Ltb4r 2 0.08 1.77 0.77
53 INT299178 Binding of Cysltr1 1 0.14 1.8 0.77
54 INT221379 Positive_regulation of Localization of Ltb4r1 3 0.04 4.08 0.64
55 INT340106 Negative_regulation of Positive_regulation of CYSLTR1 1 0.08 0.62 0.62
56 INT51681 Regulation of Localization of LTB4R 1 0.16 0.17 0.6
57 INT199424 Negative_regulation of Gene_expression of Cysltr1 2 0.35 0.71 0.59
58 INT28422 Negative_regulation of Regulation of Cysltr1 1 0.01 0 0.56
59 INT128363 Negative_regulation of Gene_expression of Ltb4r1 5 0.50 2.53 0.52
60 INT129013 Positive_regulation of Positive_regulation of Ltb4r1 2 0.03 1.48 0.49
61 INT290630 Positive_regulation of Cysltr1 1 0.07 1.22 0.49
62 INT290632 Regulation of Positive_regulation of Cysltr1 1 0.06 1.23 0.49
63 INT37895 Positive_regulation of Gene_expression of CYSLTR1 4 0.48 2.97 0.44
64 INT299180 Negative_regulation of Localization of Cysltr1 1 0.16 1.22 0.42
65 INT299182 Negative_regulation of Localization of CYSLTR1 1 0.11 1.22 0.42
66 INT318503 Positive_regulation of Positive_regulation of LTB4R 1 0.03 1.91 0.41
67 INT33631 Regulation of Negative_regulation of Ltb4r 1 0.06 0.5 0.39
68 INT193254 Binding of CYSLTR2 4 0.15 0.93 0.38
69 INT145801 Negative_regulation of Binding of Cysltr1 2 0.39 1.89 0.35
70 INT21349 Binding of Ltb4r1 4 0.07 2.9 0.34
71 INT59827 Regulation of Gene_expression of Ltb4r 2 0.10 0.33 0.31
72 INT299179 Positive_regulation of Gene_expression of Cysltr1 1 0.18 0.51 0.29
73 INT188093 Regulation of Gene_expression of Ltb4r1 4 0.60 3.73 0.28
74 INT193257 Positive_regulation of CYSLTR2 4 0.18 1.81 0.27
75 INT259881 Negative_regulation of Binding of LTB4R 1 0.35 0.16 0.27
76 INT270999 Positive_regulation of Gene_expression of CYSLTR2 1 0.44 2.81 0.27
77 INT141617 Regulation of Cysltr1 2 0.10 1.33 0.26
78 INT38790 Regulation of CYSLTR1 3 0.18 0.25 0.2
79 INT259882 Phosphorylation of LTB4R 1 0.56 0.56 0.2
80 INT61040 Positive_regulation of Localization of Ltb4r 2 0.03 2.24 0.19
81 INT318504 Negative_regulation of Negative_regulation of LTB4R 1 0.02 0.82 0.19
82 INT81029 Negative_regulation of Localization of Cysltr1 1 0.12 1.12 0.17
83 INT231923 Protein_catabolism of Ltb4r1 1 0.02 0 0.16
84 INT318502 Positive_regulation of Binding of LTB4R 1 0.03 0.2 0.14
85 INT95918 Regulation of Gene_expression of CYSLTR2 2 0.24 0.39 0.13
86 INT193264 Regulation of Gene_expression of CYSLTR1 2 0.30 0.96 0.12
87 INT193263 Transcription of CYSLTR2 1 0.19 1.11 0.12
88 INT193259 Transcription of LTB4R2 1 0.24 1.11 0.12
89 INT193252 Transcription of LTB4R 1 0.33 1.11 0.12
90 INT193262 Transcription of CYSLTR1 1 0.36 1.11 0.12
91 INT294729 Binding of LTB4R2 1 0.15 0 0.1
92 INT309919 Protein_catabolism of Cysltr1 1 0.02 0.82 0.1
93 INT16634 Positive_regulation of Gene_expression of Ltb4r 1 0.26 0.16 0.08
94 INT95919 Regulation of CYSLTR2 2 0.24 0.08 0.04
95 INT330568 Regulation of Localization of Ltb4r 1 0.04 0.67 0.04
96 INT221381 Transcription of Ltb4r1 1 0.04 0.33 0.04
97 INT36247 Protein_catabolism of CYSLTR1 1 0.77 0 0
98 INT172864 Negative_regulation of Localization of Ltb4r1 1 0.05 1.04 0
99 INT172863 Negative_regulation of Binding of Ltb4r1 1 0.04 0.76 0
100 INT259883 Regulation of LTB4R2 1 0.14 1.04 0
101 INT36248 Negative_regulation of Protein_catabolism of CYSLTR1 1 0.37 0 0
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