GO:0004980

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Name melanocyte-stimulating hormone receptor activity
Categary Function
Go Slim No
Go Link GO:0004980
Unique Molecular Interactions 178
Total Molecular Interactions 373
Total Single Events 2096
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for melanocyte-stimulating hormone receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for melanocyte-stimulating hormone receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
4 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
5 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
6 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
7 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
8 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
9 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
10 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
11 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29
12 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
13 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
14 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09
15 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
16 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05
17 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
18 INT113743 Mc3r Regulation of Gene_expression of Agrp 1 0.05 0.9 0.98
19 INT201614 Mc1r Regulation of Uvbi1 1 0.04 1.42 0.98
20 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
21 INT337899 Positive_regulation of MC3R Positive_regulation of Gene_expression of Bdnf 1 0.31 0 0.87
22 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
23 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
24 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
25 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
26 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
27 INT99335 Binding of Agrp and Mc1r 1 0.30 0 0.77
28 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
29 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
30 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
31 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
32 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
33 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
34 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
35 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68
36 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
37 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68
38 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68
39 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
40 INT110526 OCA2 Regulation of MC1R 1 0.49 0.43 0.65
41 INT99170 Binding of Mc1r and Tyr 1 0.11 0.2 0.64
42 INT104973 SGCG Regulation of Gene_expression of MC1R 1 0.67 0.17 0.63
43 INT148352 Binding of MC1R and XRCC3 1 0.36 0.34 0.62
44 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
45 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
46 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57
47 INT66020 Binding of Mc1r and RBM25 1 0.00 0.42 0.57
48 INT108021 Binding of Pomc and Mc4r 1 0.00 0.97 0.55
49 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
50 INT214164 Binding of Mc4r and Pomc 1 0.39 1.31 0.53
51 INT150243 POMC Positive_regulation of Mc3r 1 0.05 0.88 0.52
52 INT89187 Agrp Negative_regulation of Mc3r 1 0.33 0 0.51
53 INT89186 Agrp Negative_regulation of Mc4r 1 0.40 0 0.51
54 INT130335 Binding of Mc4r and Nr3c2 1 0.06 1.87 0.5
55 INT355687 Art2b Positive_regulation of Gene_expression of Mc3r 1 0.02 1.01 0.48
56 INT93508 Binding of ASIP and Mc1r 1 0.02 0 0.47
57 INT73831 Binding of Mc1r and Pld1 1 0.00 0.16 0.45
58 INT147404 NDP Positive_regulation of MC1R 1 0.22 0.25 0.45
59 INT288370 a Positive_regulation of Mc1r 1 0.39 0 0.44
60 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42
61 INT214140 Agrp Positive_regulation of Mc3r 1 0.34 0.23 0.37
62 INT214158 Binding of Agrp and Mc3r 1 0.35 0.18 0.37
63 INT214142 Agrp Positive_regulation of Mc4r 1 0.39 0.23 0.37
64 INT214145 Binding of Agrp and Mc4r 1 0.40 0.18 0.37
65 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
66 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
67 INT214157 Positive_regulation of Mc3r Regulation of Npy 1 0.14 0.49 0.33
68 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32
69 INT112193 MC1R Regulation of Localization of Tnf 1 0.06 0.15 0.31
70 INT75042 Binding of MC2R and MC4R 1 0.00 0.18 0.3
71 INT75041 Binding of MC2R and MC3R 1 0.01 0.18 0.3
72 INT97543 Gtf3a Negative_regulation of Mc1r 1 0.05 0.15 0.3
73 INT97549 KITLG Negative_regulation of Mc1r 1 0.01 0.15 0.3
74 INT97546 Pomc Negative_regulation of Mc1r 1 0.40 0.15 0.3
75 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
76 INT81791 AGRP Negative_regulation of MC1R 2 0.47 0 0.28
77 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28
78 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
79 INT101040 Binding of MC3R and POMC 1 0.30 0.35 0.25
80 INT100280 TXN Positive_regulation of Gene_expression of MC1R 1 0.33 0.22 0.24
81 INT337892 Positive_regulation of Mc4r Positive_regulation of Gene_expression of Nr2f2 1 0.34 0 0.23
82 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23
83 INT155702 MC1R Positive_regulation of CAMP 1 0.48 0 0.2
84 INT83585 Trh Positive_regulation of Mc1r 1 0.50 0.35 0.2
85 INT68852 MC1R Positive_regulation of Localization of POMC 1 0.31 0.47 0.19
86 INT68853 MC1R Regulation of Localization of POMC 1 0.30 0.47 0.19
87 INT210862 Binding of POMC and Mc4r 1 0.34 0.42 0.17
88 INT201609 Uvbi1 Positive_regulation of Gene_expression of Mc1r 1 0.05 0.57 0.17
89 INT328999 POMC Positive_regulation of Mc3r 1 0.16 0 0.16
90 INT329002 POMC Positive_regulation of Mc4r 1 0.13 0 0.16
91 INT201608 Binding of Mc1r and Uvbi1 1 0.03 0.93 0.15
92 INT201622 Binding of Mark3 and Mc1r 1 0.33 0.74 0.15
93 INT201619 Binding of Cdk11b and Mc1r 1 0.28 0.74 0.15
94 INT161095 Agrp Regulation of MC1R 1 0.45 0 0.15
95 INT128499 KLK7 Regulation of Gene_expression of MC1R 1 0.01 0.09 0.15
96 INT111284 AGRP Negative_regulation of MC4R 1 0.46 0 0.14
97 INT81789 Binding of MC1R and GIPC1 1 0.01 0 0.13
98 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
99 INT337900 Ins1 Regulation of MC3R 1 0.12 0.07 0.12
100 INT77873 Uvbi1 Positive_regulation of MC1R 1 0.01 0.34 0.12
101 INT111283 Regulation of Binding of AGRP and MC4R 1 0.48 0 0.12
102 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
103 INT111285 Positive_regulation of Binding of AGRP and MC4R 1 0.50 0 0.12
104 INT77857 TNF Negative_regulation of MC1R 1 0.35 0.34 0.12
105 INT77858 IL1B Positive_regulation of MC1R 1 0.55 0.34 0.12
106 INT81790 Regulation of Binding of AGRP and MC1R 1 0.26 0 0.12
107 INT77861 IL1B Regulation of Gene_expression of MC1R 1 0.49 0.31 0.12
108 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
109 INT83584 Binding of Mc1r and Trh 1 0.36 0.17 0.1
110 INT151136 MC1R Regulation of Mchr1 1 0.00 0.43 0.1
111 INT214161 Pomc Regulation of Mc4r 1 0.21 0.1 0.09
112 INT329000 Binding of POMC and Mc4r 1 0.19 0 0.08
113 INT337898 Positive_regulation of MC3R Regulation of Gene_expression of Nr2f2 1 0.30 0 0.08
114 INT272774 Binding of Mc4r and Fto 1 0.30 0.66 0.08
115 INT83587 Binding of MC4R and Trh 1 0.01 0.19 0.07
116 INT83588 Binding of MC3R and Trh 1 0.28 0.19 0.07
117 INT293973 Binding of POMC and Mc1r 1 0.37 1.8 0.07
118 INT293975 POMC Positive_regulation of Mc1r 1 0.50 0.34 0
119 INT274215 Mc3r Positive_regulation of Gene_expression of Gsr 1 0.14 0.27 0
120 INT312663 DSE Positive_regulation of Regulation of MC4R 1 0.37 0 0
121 INT201612 Binding of Kit and Mc1r 1 0.34 0.13 0
122 INT274216 Mc3r Regulation of Gene_expression of Gsr 1 0.08 0.27 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for melanocyte-stimulating hormone receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in melanocyte-stimulating hormone receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
2 INT21737 Binding of MC1R 129 0.48 45.45 56.54
3 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
4 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
5 INT64442 Regulation of Mc4r 6 0.62 5.22 19.09
6 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
7 INT64447 Transcription of Mc4r 14 0.61 6.08 15.29
8 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91
9 INT64445 Gene_expression of Mc4r 17 0.78 5.06 12.91
10 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
11 INT71030 Binding of Mc1r 39 0.48 10.27 12.02
12 INT89181 Gene_expression of Mc3r 33 0.77 22.48 11.85
13 INT85017 Positive_regulation of Mc4r 13 0.67 7.56 10.86
14 INT89184 Gene_expression of Mc4r 55 0.77 23.85 10.65
15 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
16 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01
17 INT64449 Negative_regulation of Gene_expression of Mc4r 7 0.58 2 7.86
18 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
19 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5
20 INT64444 Negative_regulation of Mc4r 9 0.58 5.12 6.44
21 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93
22 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
23 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04
24 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92
25 INT105608 Positive_regulation of Mc3r 9 0.68 8.53 4.83
26 INT64446 Negative_regulation of Transcription of Mc4r 4 0.43 1.01 4.8
27 INT64441 Regulation of Transcription of Mc4r 3 0.27 2.93 4.62
28 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54
29 INT64448 Gene_expression of Mc3r 7 0.74 3.27 4.3
30 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12
31 INT210838 Positive_regulation of Mc4r 17 0.53 6.79 3.06
32 INT61136 Localization of MC1R 8 0.75 2.8 2.85
33 INT130028 Positive_regulation of Gene_expression of Mc4r 2 0.45 0.41 2.7
34 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65
35 INT210833 Regulation of Mc4r 4 0.30 1.57 2.38
36 INT155045 Negative_regulation of Gene_expression of Mc1r 7 0.43 1.04 2.33
37 INT133681 Positive_regulation of Gene_expression of Mc3r 5 0.67 5.38 2.19
38 INT214122 Negative_regulation of Mc3r 5 0.43 3.59 2.14
39 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91
40 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85
41 INT101875 Binding of MC4R 6 0.47 0.19 1.73
42 INT162871 Localization of Mc1r 6 0.75 0.61 1.72
43 INT113897 Positive_regulation of Transcription of Mc4r 1 0.45 0 1.7
44 INT178264 Positive_regulation of Gene_expression of Mc4r 10 0.43 3.52 1.57
45 INT93505 Positive_regulation of Positive_regulation of Mc1r 2 0.70 0.33 1.45
46 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41
47 INT214111 Localization of Mc3r 2 0.72 1.81 1.34
48 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26
49 INT214131 Regulation of Mc3r 2 0.52 1.43 1.24
50 INT75053 Gene_expression of MC3R 4 0.53 0.41 1.16
51 INT85626 Positive_regulation of Transcription of Mc1r 2 0.50 1.12 1.1
52 INT331103 Regulation of Transcription of Mc1r 1 0.61 1.1 1.09
53 INT125147 Binding of Mc4r 10 0.41 3.55 1.08
54 INT331098 Negative_regulation of Positive_regulation of Mc4r 1 0.32 1.08 1.07
55 INT75846 Positive_regulation of MC4R 7 0.70 5.73 1.05
56 INT274205 Regulation of Gene_expression of Mc3r 2 0.43 1.96 1.03
57 INT335619 Positive_regulation of MC3R 2 0.67 0.42 1.03
58 INT106860 Regulation of Transcription of MC1R 1 0.45 0 1
59 INT113735 Negative_regulation of Gene_expression of Mc3r 2 0.39 0.9 0.98
60 INT113738 Regulation of Gene_expression of Mc3r 1 0.03 0.9 0.98
61 INT113736 Negative_regulation of Positive_regulation of Mc4r 1 0.08 1.11 0.93
62 INT107474 Positive_regulation of Negative_regulation of Mc1r 1 0.61 0.41 0.89
63 INT109108 Transcription of Mc3r 2 0.61 0.78 0.82
64 INT111289 Regulation of MC4R 4 0.43 1 0.78
65 INT125413 Regulation of Regulation of MC1R 1 0.45 0.09 0.78
66 INT85018 Positive_regulation of Positive_regulation of Mc4r 3 0.24 0.11 0.76
67 INT153419 Regulation of Binding of MC1R 1 0.40 1.38 0.7
68 INT109580 Positive_regulation of Mc3r 2 0.48 1.09 0.69
69 INT136139 Transcription of Mc4r 4 0.70 1.83 0.62
70 INT231014 Negative_regulation of MC4R 4 0.43 5.52 0.58
71 INT210835 Phosphorylation of Mc4r 1 0.51 0.06 0.52
72 INT210837 Localization of Mc4r 5 0.73 0.87 0.51
73 INT69701 Positive_regulation of Transcription of MC1R 5 0.46 2 0.51
74 INT113978 Positive_regulation of Localization of MC1R 1 0.24 1.2 0.51
75 INT355682 Negative_regulation of Positive_regulation of Mc3r 1 0.41 1.04 0.47
76 INT214095 Binding of Mc3r 1 0.32 0.67 0.41
77 INT211706 Negative_regulation of Localization of Mc1r 1 0.42 0 0.37
78 INT126808 Localization of Mc4r 2 0.36 1.13 0.35
79 INT214121 Regulation of Positive_regulation of Mc3r 1 0.33 0.49 0.33
80 INT355683 Regulation of Localization of Mc3r 1 0.43 0.3 0.31
81 INT312681 Negative_regulation of Gene_expression of MC4R 1 0.35 0.15 0.31
82 INT214102 Positive_regulation of Transcription of Mc4r 1 0.49 0.4 0.3
83 INT117115 Regulation of Positive_regulation of MC1R 1 0.33 0.38 0.29
84 INT142717 Positive_regulation of Negative_regulation of MC1R 1 0.47 0.36 0.28
85 INT337877 Positive_regulation of Positive_regulation of Mc4r 1 0.33 0 0.23
86 INT214129 Negative_regulation of Gene_expression of Mc3r 1 0.36 0.21 0.23
87 INT337883 Positive_regulation of Positive_regulation of MC3R 1 0.49 0.37 0.22
88 INT288358 Positive_regulation of Binding of Mc1r 1 0.41 0 0.19
89 INT257502 Binding of MC3R 3 0.36 0.98 0.18
90 INT316205 Negative_regulation of Binding of MC3R 1 0.41 0.89 0.18
91 INT75847 Regulation of Positive_regulation of MC4R 1 0.35 0.83 0.18
92 INT109583 Binding of Mc3r 1 0.34 0.22 0.18
93 INT109579 Binding of Mc4r 1 0.36 0.22 0.18
94 INT316201 Regulation of Transcription of Mc4r 1 0.43 0.64 0.16
95 INT111286 Positive_regulation of Binding of MC4R 1 0.47 0 0.13
96 INT210839 Regulation of Positive_regulation of Mc4r 1 0.37 0.2 0.11
97 INT214109 Regulation of Binding of Mc4r 1 0.39 0.78 0.08
98 INT214118 Positive_regulation of Binding of Mc4r 1 0.43 1.01 0.08
99 INT136134 Negative_regulation of Gene_expression of Mc4r 2 0.35 0.64 0.07
100 INT85629 Regulation of Regulation of Mc1r 1 0.34 0.39 0.07
101 INT111288 Regulation of Binding of MC4R 1 0.22 0 0.06
102 INT261202 Regulation of MC3R 2 0.05 0.09 0.05
103 INT214124 Negative_regulation of Binding of Mc4r 1 0.42 0.19 0.05
104 INT214107 Negative_regulation of Binding of Mc3r 1 0.36 0.19 0.05
105 INT335615 Regulation of Regulation of MC3R 1 0.05 0.09 0.05
106 INT335618 Positive_regulation of Gene_expression of MC4R 1 0.13 0.08 0.05
107 INT136138 Regulation of Gene_expression of Mc4r 1 0.25 0.64 0.04
108 INT316200 Regulation of Negative_regulation of Mc4r 1 0.43 1.05 0.03
109 INT141377 Transcription of MC4R 2 0.65 0.25 0
110 INT125148 Positive_regulation of Negative_regulation of Mc4r 1 0.50 0 0
111 INT335614 Positive_regulation of Regulation of MC1R 1 0.23 0 0
112 INT312671 Regulation of Transcription of MC4R 1 0.43 0.1 0
113 INT312675 Positive_regulation of Positive_regulation of MC4R 1 0.44 0 0
114 INT141376 Transcription of MC3R 1 0.40 0.16 0
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