GO:0004985

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Name opioid receptor activity
Categary Function
Go Slim No
Go Link GO:0004985
Unique Molecular Interactions 674
Total Molecular Interactions 887
Total Single Events 8617
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for opioid receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for opioid receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
3 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
4 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
5 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
6 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
7 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
8 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
9 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
10 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
11 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
12 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
13 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
14 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
15 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
16 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
17 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
18 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
19 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
20 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
21 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
22 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
23 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
24 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
25 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
26 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
27 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
28 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
29 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
30 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
31 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
32 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
33 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
34 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
35 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
36 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
37 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
38 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
39 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
40 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
41 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96
42 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
43 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
44 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
45 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
46 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92
47 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
48 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
49 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
50 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
51 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
52 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
53 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
54 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
55 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
56 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
57 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
58 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
59 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
60 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
61 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
62 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
63 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
64 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
65 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
66 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
67 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
68 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
69 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
70 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
71 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
72 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
73 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
74 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
75 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
76 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
77 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
78 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
79 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
80 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
81 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
82 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
83 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
84 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
85 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
86 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
87 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
88 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
89 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
90 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
91 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
92 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
93 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
94 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
95 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
96 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
97 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
98 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
99 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
100 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
101 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
102 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
103 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
104 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
105 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
106 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
107 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33
108 INT126831 Binding of Oprk1 and Rbm39 1 0.05 0.88 1.33
109 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
110 INT13755 Binding of Oprd1 and Ap2m1 1 0.20 0 1.32
111 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
112 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
113 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
114 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3
115 INT57263 Binding of Oprd1 and Atxn2l 1 0.02 0 1.29
116 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
117 INT57262 Binding of Gria4 and Oprd1 1 0.06 0 1.29
118 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
119 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
120 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
121 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
122 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
123 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
124 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
125 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
126 INT73710 Mastl Positive_regulation of Localization of Oprl1 1 0.02 0 1.26
127 INT46021 tp Positive_regulation of Oprl1 1 0.22 0 1.26
128 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
129 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
130 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
131 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
132 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
133 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
134 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
135 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
136 INT63864 Oprd1 Regulation of Localization of Prl 2 0.16 0 1.23
137 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
138 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
139 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
140 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22
141 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
142 INT240095 Binding of PDYN and Oprk1 1 0.52 1.3 1.22
143 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
144 INT124157 Oprm1 Negative_regulation of Gnb5 1 0.25 0.4 1.19
145 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
146 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
147 INT66488 Binding of Oprl1 and Cbm4 1 0.01 0 1.17
148 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
149 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
150 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
151 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
152 INT95045 Binding of Commd3 and Oprl1 1 0.34 0 1.16
153 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
154 INT76256 Binding of Slc6a3 and Sigmar1 1 0.20 0 1.16
155 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
156 INT199493 Ngf Regulation of Oprd1 1 0.05 1.05 1.15
157 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
158 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
159 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
160 INT21267 Cck Negative_regulation of Binding of Oprd1 1 0.50 0 1.12
161 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
162 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
163 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
164 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
165 INT60783 Binding of Oprd1 and Cck 1 0.26 0.47 1.09
166 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
167 INT114007 Binding of Crygs and Oprm1 1 0.03 0 1.09
168 INT317561 Binding of Grin1 and Oprm1 1 0.14 0.09 1.08
169 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07
170 INT145407 Oprd1 Regulation of Positive_regulation of Dbi 1 0.17 0 1.07
171 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
172 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
173 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06
174 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
175 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06
176 INT108413 Binding of OPRK1 and Oprd1 1 0.00 0.08 1.04
177 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
178 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
179 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
180 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
181 INT106956 Oprm1 Positive_regulation of Positive_regulation of P9Ehs1 1 0.08 0.54 1.02
182 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
183 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
184 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01
185 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
186 INT98002 Positive_regulation of Oprm1 Positive_regulation of P9Ehs1 1 0.10 0 1
187 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
188 INT317532 Grin1 Regulation of Negative_regulation of Oprm1 1 0.18 0.07 1
189 INT70105 SCD Positive_regulation of Oprm1 1 0.01 0 1
190 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
191 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
192 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 0.20 0.07 1
193 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
194 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
195 INT169500 Negative_regulation of Mirlet7a-1 Regulation of Oprm1 1 0.37 0 0.99
196 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
197 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
198 INT122380 Pnoc Positive_regulation of Oprl1 1 0.36 0.55 0.98
199 INT57555 Binding of Oprm1 and Oprl1 2 0.06 0.05 0.97
200 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97

Single Events

The table below shows the top 100 pain related interactions that have been reported for opioid receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in opioid receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
3 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
4 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
5 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
6 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
7 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
8 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
9 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
10 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
11 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
12 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
13 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
14 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
15 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
16 INT114 Binding of Oprl1 139 0.48 23 103.35
17 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
18 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
19 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
20 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
21 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
22 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
23 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
24 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
25 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
26 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
27 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
28 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
29 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
30 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
31 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
32 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
33 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
34 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
35 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
36 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
37 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
38 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
39 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
40 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
41 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
42 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
43 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61
44 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
45 INT6179 Binding of Oprk1 37 0.48 9.24 24.83
46 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
47 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
48 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
49 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
50 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18
51 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
52 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
53 INT48006 Negative_regulation of Oprk1 27 0.58 10.14 19.11
54 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44
55 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
56 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
57 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63
58 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
59 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49
60 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
61 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
62 INT29352 Negative_regulation of Oprd1 16 0.58 6.51 14.6
63 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34
64 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
65 INT20715 Binding of Sigmar1 45 0.48 4.03 13.17
66 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
67 INT99587 Positive_regulation of Gene_expression of Oprk1 15 0.57 5.26 12.39
68 INT13338 Regulation of Sigmar1 22 0.57 2.91 11.35
69 INT76138 Transcription of Oprk1 21 0.72 5.79 11.25
70 INT90903 Positive_regulation of Positive_regulation of Oprk1 13 0.47 3.49 11.18
71 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
72 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
73 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
74 INT1321 Localization of Oprl1 18 0.76 1.74 9.56
75 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4
76 INT21223 Positive_regulation of Gene_expression of Oprl1 10 0.70 2.21 9.24
77 INT20835 Negative_regulation of Negative_regulation of Oprm1 10 0.43 0.56 8.96
78 INT69528 Regulation of Gene_expression of Oprk1 10 0.45 4.27 8.84
79 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72
80 INT98835 Positive_regulation of Transcription of Oprm1 15 0.65 2.47 8.67
81 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38
82 INT31394 Negative_regulation of Localization of Oprd1 3 0.39 2.38 7.89
83 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85
84 INT60148 Regulation of Sigmar1 20 0.43 7.23 7.76
85 INT12734 Regulation of Binding of Oprl1 10 0.62 2.23 7.71
86 INT62372 Positive_regulation of Localization of Oprm1 8 0.50 0.46 7.71
87 INT105185 Negative_regulation of Gene_expression of Oprk1 9 0.42 3.53 7.53
88 INT20845 Positive_regulation of Negative_regulation of Oprd1 7 0.70 1.81 7.33
89 INT6239 Regulation of Regulation of Oprd1 7 0.45 0.34 7.26
90 INT5311 Regulation of Negative_regulation of Oprd1 11 0.43 0.99 7.23
91 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92
92 INT62524 Negative_regulation of Phosphorylation of Oprm1 7 0.59 0.08 6.92
93 INT75228 Positive_regulation of Negative_regulation of Oprm1 8 0.49 0.95 6.9
94 INT12838 Gene_expression of SIGMAR1 30 0.78 3.52 6.81
95 INT94855 Regulation of Gene_expression of Oprl1 9 0.62 1.82 6.66
96 INT54062 Transcription of Oprd1 11 0.68 1.05 6.65
97 INT1597 Negative_regulation of Binding of Oprl1 11 0.59 1.38 6.62
98 INT5932 Regulation of Regulation of Oprm1 7 0.61 0.44 6.47
99 INT21294 Gene_expression of OGFR 32 0.78 5.75 6.41
100 INT290523 Phosphorylation of Oprk1 3 0.81 3.1 6.34
101 INT49883 Gene_expression of NPBWR1 9 0.77 3.66 6.32
102 INT53135 Positive_regulation of Localization of Oprm1 2 0.50 0 6.12
103 INT91575 Positive_regulation of Phosphorylation of Oprd1 8 0.02 0.23 6.07
104 INT26555 Regulation of Positive_regulation of Oprd1 6 0.59 2.47 5.76
105 INT67214 Transcription of Oprl1 9 0.69 1.8 5.66
106 INT25242 Positive_regulation of Sigmar1 17 0.66 3.93 5.65
107 INT112927 Negative_regulation of Localization of Oprm1 4 0.39 0.31 5.59
108 INT55917 Binding of Sigmar1 26 0.45 12.65 5.58
109 INT104226 Localization of Oprk1 12 0.75 3.22 5.41
110 INT5978 Positive_regulation of SIGMAR1 13 0.42 0.72 5.35
111 INT140142 Positive_regulation of Sigmar1 17 0.63 3.78 5.26
112 INT91401 Binding of OGFR 12 0.41 4.1 4.47
113 INT23738 Regulation of Transcription of Oprd1 6 0.26 0.48 4.3
114 INT105998 Protein_catabolism of Oprm1 5 0.95 0.88 4.08
115 INT29671 Regulation of Localization of Oprd1 4 0.24 1.04 3.92
116 INT64668 Regulation of SIGMAR1 13 0.60 0.54 3.91
117 INT65460 Positive_regulation of Gene_expression of Oprd1 8 0.69 1.87 3.87
118 INT71322 Positive_regulation of Binding of Oprd1 4 0.33 0.97 3.87
119 INT72290 Localization of Sigmar1 21 0.74 4.35 3.54
120 INT1508 Positive_regulation of Binding of Oprl1 6 0.62 1.38 3.54
121 INT14558 Regulation of Positive_regulation of Oprl1 6 0.43 2.49 3.5
122 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48
123 INT5929 Positive_regulation of Regulation of Oprm1 4 0.50 0.56 3.48
124 INT60646 Regulation of Gene_expression of Oprd1 4 0.60 1.76 3.46
125 INT114571 Gene_expression of Sigmar1 39 0.77 36.78 3.4
126 INT8731 Regulation of Localization of Oprm1 3 0.43 0.25 3.4
127 INT68812 Regulation of Regulation of Oprm1 5 0.40 0.16 3.28
128 INT59301 Negative_regulation of Positive_regulation of Oprk1 4 0.58 1.33 3.24
129 INT54060 Regulation of Transcription of Oprd1 3 0.57 0.59 3.18
130 INT82035 Negative_regulation of Phosphorylation of Oprd1 3 0.13 0 3.16
131 INT59455 Localization of Oprd1 3 0.20 0.22 3.01
132 INT120601 Positive_regulation of Gene_expression of OGFR 9 0.70 2.73 3
133 INT54632 Negative_regulation of Gene_expression of Oprd1 5 0.58 2.22 2.9
134 INT12117 Regulation of Negative_regulation of Oprl1 6 0.44 1.49 2.82
135 INT28729 Negative_regulation of Negative_regulation of Oprd1 3 0.43 0.33 2.79
136 INT70377 Regulation of Transcription of Oprm1 3 0.47 0.93 2.78
137 INT34501 Positive_regulation of Positive_regulation of Oprd1 4 0.43 0.31 2.77
138 INT16715 Positive_regulation of Transcription of Oprd1 3 0.66 0.6 2.74
139 INT45375 Protein_catabolism of Oprl1 2 0.85 0.56 2.71
140 INT33996 Positive_regulation of Negative_regulation of Oprl1 4 0.53 1.34 2.68
141 INT29064 Gene_expression of Sigmar1 9 0.77 2.48 2.65
142 INT91402 Negative_regulation of OGFR 12 0.59 2.77 2.6
143 INT53605 Regulation of Binding of Oprd1 2 0.42 0 2.26
144 INT297507 Positive_regulation of Phosphorylation of Oprk1 1 0.50 0.63 2.26
145 INT123851 Positive_regulation of Gene_expression of NPBWR1 1 0.69 1.52 2.25
146 INT71952 Regulation of Negative_regulation of Oprm1 3 0.43 0.09 2.18
147 INT50782 Positive_regulation of Phosphorylation of Oprd1 1 0.16 0 2.07
148 INT62522 Regulation of Phosphorylation of Oprm1 3 0.13 0 1.96
149 INT105704 Positive_regulation of Regulation of Oprl1 2 0.46 1.23 1.95
150 INT7829 Negative_regulation of Positive_regulation of Oprd1 2 0.30 0.41 1.95
151 INT80918 Regulation of Transcription of Oprk1 1 0.62 1.2 1.89
152 INT40479 Negative_regulation of SIGMAR1 6 0.52 1.26 1.88
153 INT107332 Negative_regulation of Regulation of Sigmar1 1 0.19 0 1.86
154 INT76994 Negative_regulation of Gene_expression of Oprl1 3 0.59 0.75 1.73
155 INT49882 Positive_regulation of NPBWR1 5 0.67 0.89 1.56
156 INT130552 Negative_regulation of Localization of Oprm1 2 0.31 0.37 1.53
157 INT61890 Localization of SIGMAR1 6 0.40 0.3 1.52
158 INT1318 Positive_regulation of Positive_regulation of Oprl1 3 0.64 0.33 1.52
159 INT50777 Phosphorylation of Oprd1 2 0.32 0 1.51
160 INT25241 Negative_regulation of Sigmar1 10 0.56 2.97 1.5
161 INT91404 Negative_regulation of Binding of OGFR 3 0.38 1.54 1.46
162 INT105997 Positive_regulation of Protein_catabolism of Oprm1 2 0.66 0.41 1.45
163 INT65248 Positive_regulation of OGFR 6 0.49 2.05 1.43
164 INT21106 Regulation of Phosphorylation of Oprm1 3 0.61 0 1.43
165 INT90703 Positive_regulation of Transcription of Oprk1 2 0.45 0.73 1.42
166 INT54752 Negative_regulation of Negative_regulation of Oprl1 2 0.41 0.25 1.39
167 INT49881 Gene_expression of NPBWR2 5 0.76 0.22 1.35
168 INT75931 Positive_regulation of Binding of Oprk1 2 0.50 0.83 1.33
169 INT85667 Negative_regulation of Negative_regulation of Oprm1 3 0.37 0.54 1.31
170 INT50776 Regulation of Phosphorylation of Oprd1 1 0.01 0 1.3
171 INT95830 Phosphorylation of Oprl1 1 0.02 0 1.27
172 INT26153 Localization of Sigmar1 4 0.80 0.1 1.26
173 INT32562 Negative_regulation of Localization of Oprl1 2 0.49 0.43 1.23
174 INT14138 Regulation of Localization of Oprm1 1 0.28 0 1.23
175 INT169618 Localization of OGFR 2 0.72 0.38 1.22
176 INT129374 Negative_regulation of Regulation of Oprm1 3 0.43 0.58 1.18
177 INT95374 Negative_regulation of Transcription of Oprd1 1 0.10 0 1.17
178 INT51897 Binding of OPCML 8 0.43 5.59 1.11
179 INT80966 Negative_regulation of Transcription of Oprd1 1 0.59 0 1.07
180 INT106690 Positive_regulation of Gene_expression of SIGMAR1 5 0.61 0.12 1.03
181 INT21108 Negative_regulation of Phosphorylation of Oprm1 2 0.43 0 0.98
182 INT70604 Positive_regulation of Positive_regulation of Sigmar1 2 0.50 0 0.98
183 INT172294 Binding of NPBWR1 1 0.41 0.27 0.96
184 INT76139 Negative_regulation of Transcription of Oprk1 2 0.57 0.22 0.95
185 INT120164 Gene_expression of OPCML 47 0.77 36.89 0.94
186 INT26326 Regulation of Binding of Sigmar1 4 0.27 0.66 0.9
187 INT107333 Regulation of Regulation of Sigmar1 1 0.27 0 0.9
188 INT90072 Regulation of Regulation of Oprd1 1 0.41 0 0.9
189 INT167761 Phosphorylation of Sigmar1 1 0.46 0.22 0.88
190 INT167762 Positive_regulation of Phosphorylation of Sigmar1 1 0.34 0.22 0.88
191 INT52886 Regulation of Regulation of Oprl1 1 0.41 0.61 0.85
192 INT123412 Negative_regulation of Transcription of Oprm1 2 0.56 0.06 0.79
193 INT90904 Regulation of Positive_regulation of Oprk1 2 0.40 0 0.76
194 INT55921 Negative_regulation of Transcription of Oprm1 1 0.43 0 0.76
195 INT49880 Positive_regulation of NPBWR2 3 0.49 0.14 0.74
196 INT151217 Phosphorylation of SIGMAR1 2 0.04 0.41 0.72
197 INT110346 Regulation of Binding of Oprk1 1 0.31 0 0.72
198 INT167760 Positive_regulation of Positive_regulation of Sigmar1 2 0.32 0.42 0.68
199 INT129375 Negative_regulation of Regulation of Oprm1 1 0.28 0.49 0.68
200 INT93245 Protein_catabolism of Oprd1 1 0.34 0 0.65
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