GO:0005010

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Name insulin-like growth factor-activated receptor activity
Categary Function
Go Slim No
Go Link GO:0005010
Unique Molecular Interactions 68
Total Molecular Interactions 94
Total Single Events 768
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin-like growth factor-activated receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for insulin-like growth factor-activated receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
2 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
3 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
4 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
5 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
6 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
7 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
8 INT139454 Binding of IGF2R and Icam1 1 0.00 0.4 0.21
9 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19
10 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
11 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
12 INT246843 Positive_regulation of Binding of Irs1 and Ppp1r13b 1 0.18 0.28 0.16
13 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
14 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
15 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
16 INT246844 Binding of Irs1 and Myl7 1 0.05 0.43 0.11
17 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
18 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
19 INT301619 Positive_regulation of Irs1 Positive_regulation of Gene_expression of Srebf1 1 0.10 0.67 0.08
20 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
21 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
22 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08
23 INT301649 Irs1 Negative_regulation of Transcription of G6pc 1 0.05 0.65 0.08
24 INT246839 Binding of Irs1 and Gopc 1 0.16 0.15 0.08
25 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06
26 INT246842 Binding of Ins1 and Irs1 1 0.16 0.63 0.06
27 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
28 INT240873 Ins1 Positive_regulation of Phosphorylation of Irs1 1 0.05 0 0.05
29 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
30 INT267158 Binding of IRS1 and SHMT2 1 0.02 0.46 0.05
31 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05
32 INT240893 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Irs1 1 0.08 0.36 0.04
33 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04
34 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04
35 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
36 INT207555 GH1 Negative_regulation of Phosphorylation of IRS1 1 0.10 0.28 0.03
37 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03
38 INT246834 Phosphorylation of Irs1 Negative_regulation of Ins1 1 0.14 0.44 0.03
39 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
40 INT179949 Binding of Ins1 and Irs1 1 0.31 0.32 0.03
41 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03
42 INT284311 RPS6KB1 Positive_regulation of Phosphorylation of IRS1 1 0.18 0.24 0
43 INT210362 Binding of GPM6A and IGF2R 1 0.00 0.57 0
44 INT342358 Binding of Irs1 and Erap1 1 0.37 0 0
45 INT280615 Fig4 Regulation of Gene_expression of Irs1 1 0.05 0 0
46 INT321722 Negative_regulation of Binding of Irs1 and Ppp1r13b 1 0.20 0.07 0
47 INT321715 Regulation of Binding of Irs1 and Ppp1r13b 1 0.15 0.05 0
48 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
49 INT315065 IGF1R Regulation of Gene_expression of PAR4 1 0.37 0.53 0
50 INT304350 INS Positive_regulation of Protein_catabolism of IRS1 1 0.09 0.78 0
51 INT240880 Mapk8 Positive_regulation of Protein_catabolism of Irs1 1 0.21 0.14 0
52 INT315049 IGF1R Regulation of MT1X 1 0.29 0.52 0
53 INT304347 INS Positive_regulation of Phosphorylation of IRS1 1 0.09 0.77 0
54 INT319320 Binding of EGI and IGF1R 1 0.02 0.85 0
55 INT342360 Binding of H2-K1 and Irs1 1 0.10 0 0
56 INT240900 Negative_regulation of Ros1 Positive_regulation of Gene_expression of Irs1 1 0.08 0.13 0
57 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0
58 INT323495 Ghrl Positive_regulation of Irs1 1 0.20 0.5 0
59 INT342361 Binding of Irs1 and Rdh9 1 0.38 0 0
60 INT284313 Binding of IRS1 and SART3 1 0.07 0.32 0
61 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
62 INT284312 Negative_regulation of Binding of IRS1 and SART3 1 0.08 0.32 0
63 INT240901 Negative_regulation of Ros1 Negative_regulation of Phosphorylation of Irs1 1 0.07 0.15 0
64 INT321713 Ins1 Positive_regulation of Irs1 1 0.04 0.05 0
65 INT307584 Binding of EGFR and IGF1R 1 0.03 0.52 0
66 INT342357 Binding of Irs1 and Irf6 1 0.37 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin-like growth factor-activated receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in insulin-like growth factor-activated receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
2 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
3 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
4 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
5 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
6 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
7 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
8 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
9 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
10 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
11 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
12 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
13 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
14 INT210399 Gene_expression of IGF2R 22 0.65 17.1 1.23
15 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
16 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
17 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
18 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
19 INT139449 Negative_regulation of IGF2R 5 0.15 2.58 0.87
20 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
21 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
22 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
23 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
24 INT280678 Transcription of Irs1 1 0.45 0.87 0.68
25 INT242655 Binding of Irs1 1 0.29 1.45 0.66
26 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
27 INT115255 Negative_regulation of Phosphorylation of Irs1 6 0.45 3.71 0.56
28 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55
29 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
30 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
31 INT158517 Regulation of Irs1 2 0.39 1.02 0.5
32 INT246828 Binding of Irs1 9 0.37 2.68 0.42
33 INT235635 Negative_regulation of Phosphorylation of IRS1 7 0.37 3.78 0.42
34 INT145861 Regulation of Gene_expression of Irs1 2 0.41 0.83 0.41
35 INT145863 Negative_regulation of Gene_expression of Irs1 3 0.45 1.51 0.4
36 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
37 INT139450 Binding of IGF2R 3 0.19 1.75 0.36
38 INT158521 Positive_regulation of Negative_regulation of Irs1 1 0.02 0.57 0.33
39 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
40 INT240830 Positive_regulation of Protein_catabolism of Irs1 2 0.69 0.82 0.26
41 INT246817 Positive_regulation of Binding of Irs1 1 0.50 0.37 0.23
42 INT240818 Protein_catabolism of Irs1 3 0.98 1 0.22
43 INT89406 Negative_regulation of Positive_regulation of IRS1 1 0.22 0.93 0.22
44 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21
45 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
46 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2
47 INT168938 Negative_regulation of Phosphorylation of Igf1r 1 0.40 1.1 0.19
48 INT246824 Negative_regulation of Irs1 6 0.43 2.13 0.17
49 INT277469 Regulation of Gene_expression of IGF2R 1 0.22 0 0.17
50 INT284323 Regulation of IRS1 2 0.45 1.6 0.16
51 INT240841 Regulation of Gene_expression of Irs1 3 0.45 0.75 0.15
52 INT168939 Negative_regulation of Igf1r 1 0.40 1.01 0.15
53 INT120962 Negative_regulation of Negative_regulation of Irs1 1 0.25 0.38 0.15
54 INT301563 Positive_regulation of Positive_regulation of Irs1 1 0.16 1.32 0.15
55 INT230807 Regulation of Phosphorylation of Irs1 3 0.45 1.59 0.13
56 INT9320 Regulation of Transcription of Igf1r 1 0.04 0.36 0.13
57 INT9333 Regulation of Igf1r 1 0.07 0.36 0.13
58 INT92590 Positive_regulation of Gene_expression of IGF1R 3 0.57 2.31 0.12
59 INT92589 Positive_regulation of IGF1R 4 0.38 0.98 0.11
60 INT210393 Positive_regulation of Gene_expression of IGF2R 2 0.26 1.29 0.11
61 INT246818 Negative_regulation of Gene_expression of Irs1 3 0.42 1.25 0.1
62 INT304385 Protein_catabolism of IRS1 2 0.42 1.8 0.1
63 INT312954 Regulation of Binding of IGF1R 1 0.13 0 0.1
64 INT250519 Negative_regulation of Igf1r 5 0.42 2.7 0.09
65 INT240850 Regulation of Irs1 2 0.47 0.64 0.09
66 INT246825 Regulation of Positive_regulation of Irs1 1 0.45 0.47 0.09
67 INT92587 Positive_regulation of Positive_regulation of IGF1R 1 0.38 0.38 0.08
68 INT349623 Negative_regulation of Binding of Igf1r 1 0.39 0.51 0.08
69 INT250508 Negative_regulation of Gene_expression of Igf1r 1 0.42 2.01 0.08
70 INT349620 Binding of Igf1r 1 0.34 0.51 0.08
71 INT246819 Negative_regulation of Binding of Irs1 3 0.42 0.62 0.07
72 INT234462 Phosphorylation of IGF1R 2 0.42 0.99 0.06
73 INT339196 Positive_regulation of IGF2R 1 0.39 0.66 0.06
74 INT315099 Localization of IGF1R 2 0.55 0.36 0.04
75 INT301556 Negative_regulation of Positive_regulation of Irs1 1 0.10 1.63 0.04
76 INT319330 Transcription of IGF2R 1 0.33 1.34 0.04
77 INT332299 Negative_regulation of Gene_expression of IRS1 1 0.31 0.65 0.04
78 INT235632 Binding of IRS1 2 0.28 1.01 0.03
79 INT234471 Negative_regulation of Phosphorylation of IGF1R 1 0.04 0.76 0.03
80 INT325289 Regulation of IGF2R 1 0.06 1.12 0.03
81 INT284335 Regulation of Gene_expression of IRS1 1 0.18 0.06 0.03
82 INT334692 Localization of Igf1r 1 0.09 0.89 0.03
83 INT222308 Regulation of IGF1R 3 0.12 2.18 0
84 INT339214 Negative_regulation of Gene_expression of IGF1R 2 0.22 0.4 0
85 INT282728 Regulation of Igf1r 2 0.18 0.92 0
86 INT246829 Localization of Irs1 2 0.74 0.9 0
87 INT321694 Positive_regulation of Phosphorylation of Igf1r 1 0.27 0.2 0
88 INT338259 Positive_regulation of Binding of IGF1R 1 0.27 1.38 0
89 INT246826 Positive_regulation of Localization of Irs1 1 0.50 0.76 0
90 INT319333 Transcription of IGF1R 1 0.31 0.85 0
91 INT321704 Positive_regulation of Positive_regulation of Igf1r 1 0.18 0.17 0
92 INT323089 Positive_regulation of Transcription of Irs1 1 0.44 0.26 0
93 INT304382 Positive_regulation of Protein_catabolism of IRS1 1 0.16 0.77 0
94 INT284324 Positive_regulation of Gene_expression of IRS1 1 0.31 0.24 0
95 INT323107 Transcription of Irs1 1 0.50 0.26 0
96 INT280661 Negative_regulation of Transcription of Irs1 1 0.37 0 0
97 INT304383 Negative_regulation of Protein_catabolism of IRS1 1 0.15 0.77 0
98 INT179948 Negative_regulation of Positive_regulation of Irs1 1 0.45 0.36 0
99 INT235630 Localization of IRS1 1 0.70 0.38 0
100 INT179947 Positive_regulation of Irs1 1 0.53 0.83 0
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