GO:0005068

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Name transmembrane receptor protein tyrosine kinase adaptor activity
Categary Function
Go Slim No
Go Link GO:0005068
Unique Molecular Interactions 72
Total Molecular Interactions 101
Total Single Events 721
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein tyrosine kinase adaptor activity. They are ordered first by their pain relevance and then by number of times they were reported for transmembrane receptor protein tyrosine kinase adaptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
2 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
3 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
4 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
5 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
6 INT118919 Binding of FRTS and Sh2b2 1 0.24 0 0.39
7 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
8 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
9 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
10 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
11 INT213798 Sh2b2 Regulation of tf 1 0.12 0.53 0.27
12 INT213799 Sh2b2 Regulation of Tfeb 1 0.26 0.54 0.27
13 INT213812 Sh2b2 Positive_regulation of Tfeb 1 0.44 0.45 0.2
14 INT291348 IL8 Positive_regulation of Phosphorylation of SHC1 1 0.11 1.16 0.2
15 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19
16 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
17 INT246843 Positive_regulation of Binding of Irs1 and Ppp1r13b 1 0.18 0.28 0.16
18 INT207112 Sh2b2 Positive_regulation of Phosphorylation of Akt2 1 0.68 0.24 0.12
19 INT207115 Sh2b2 Positive_regulation of Akt2 1 0.49 0.24 0.12
20 INT246844 Binding of Irs1 and Myl7 1 0.05 0.43 0.11
21 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
22 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
23 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
24 INT301619 Positive_regulation of Irs1 Positive_regulation of Gene_expression of Srebf1 1 0.10 0.67 0.08
25 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
26 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
27 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08
28 INT301649 Irs1 Negative_regulation of Transcription of G6pc 1 0.05 0.65 0.08
29 INT246839 Binding of Irs1 and Gopc 1 0.16 0.15 0.08
30 INT340317 Binding of Shc1 and Positive_regulation of Frs2 1 0.19 0 0.07
31 INT246842 Binding of Ins1 and Irs1 1 0.16 0.63 0.06
32 INT330852 Fasl Positive_regulation of TRAT1 1 0.05 0.4 0.06
33 INT127723 CSF1 Positive_regulation of TRAT1 1 0.01 0.26 0.06
34 INT240873 Ins1 Positive_regulation of Phosphorylation of Irs1 1 0.05 0 0.05
35 INT267158 Binding of IRS1 and SHMT2 1 0.02 0.46 0.05
36 INT197917 Binding of ESR1 and Sh2b2 1 0.01 0 0.04
37 INT240893 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Irs1 1 0.08 0.36 0.04
38 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04
39 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04
40 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
41 INT207555 GH1 Negative_regulation of Phosphorylation of IRS1 1 0.10 0.28 0.03
42 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03
43 INT246834 Phosphorylation of Irs1 Negative_regulation of Ins1 1 0.14 0.44 0.03
44 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
45 INT179949 Binding of Ins1 and Irs1 1 0.31 0.32 0.03
46 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03
47 INT235693 Binding of Clcn1 and Gab2 1 0.19 2.96 0
48 INT284311 RPS6KB1 Positive_regulation of Phosphorylation of IRS1 1 0.18 0.24 0
49 INT235689 Alb Regulation of Gene_expression of Gab2 1 0.10 0 0
50 INT342358 Binding of Irs1 and Erap1 1 0.37 0 0
51 INT225889 Binding of MET and SHC1 1 0.01 0 0
52 INT225905 Binding of GRB2 and SHC1 1 0.00 0 0
53 INT280615 Fig4 Regulation of Gene_expression of Irs1 1 0.05 0 0
54 INT321722 Negative_regulation of Binding of Irs1 and Ppp1r13b 1 0.20 0.07 0
55 INT321715 Regulation of Binding of Irs1 and Ppp1r13b 1 0.15 0.05 0
56 INT304350 INS Positive_regulation of Protein_catabolism of IRS1 1 0.09 0.78 0
57 INT240880 Mapk8 Positive_regulation of Protein_catabolism of Irs1 1 0.21 0.14 0
58 INT304347 INS Positive_regulation of Phosphorylation of IRS1 1 0.09 0.77 0
59 INT342360 Binding of H2-K1 and Irs1 1 0.10 0 0
60 INT240900 Negative_regulation of Ros1 Positive_regulation of Gene_expression of Irs1 1 0.08 0.13 0
61 INT235695 Gab2 Positive_regulation of Clcn1 1 0.20 0.52 0
62 INT323495 Ghrl Positive_regulation of Irs1 1 0.20 0.5 0
63 INT342361 Binding of Irs1 and Rdh9 1 0.38 0 0
64 INT284313 Binding of IRS1 and SART3 1 0.07 0.32 0
65 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
66 INT284312 Negative_regulation of Binding of IRS1 and SART3 1 0.08 0.32 0
67 INT240901 Negative_regulation of Ros1 Negative_regulation of Phosphorylation of Irs1 1 0.07 0.15 0
68 INT321713 Ins1 Positive_regulation of Irs1 1 0.04 0.05 0
69 INT342357 Binding of Irs1 and Irf6 1 0.37 0 0
70 INT235696 Regulation of Binding of Clcn1 and Gab2 1 0.18 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein tyrosine kinase adaptor activity. They are ordered first by their pain relevance and then by number of times they were reported in transmembrane receptor protein tyrosine kinase adaptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT43524 Positive_regulation of Sh2b2 16 0.58 2.95 5.78
2 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
3 INT92509 Regulation of Sh2b2 7 0.35 3.41 3.8
4 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
5 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
6 INT48292 Negative_regulation of Sh2b2 9 0.26 2.14 3.26
7 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
8 INT182893 Gene_expression of Sh2b2 8 0.65 1.74 2.65
9 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
10 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
11 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87
12 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
13 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
14 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
15 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
16 INT257750 Positive_regulation of Gene_expression of SHC1 1 0.60 3.1 1.04
17 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
18 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
19 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
20 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
21 INT284739 Positive_regulation of Gene_expression of Sh2b2 2 0.26 0.83 0.71
22 INT280678 Transcription of Irs1 1 0.45 0.87 0.68
23 INT182036 Gene_expression of Sh2b2 2 0.13 1.74 0.67
24 INT242655 Binding of Irs1 1 0.29 1.45 0.66
25 INT235687 Positive_regulation of Gab2 1 0.59 1.52 0.63
26 INT3501 Localization of Sh2b2 6 0.73 0.88 0.62
27 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
28 INT115255 Negative_regulation of Phosphorylation of Irs1 6 0.45 3.71 0.56
29 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55
30 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
31 INT158517 Regulation of Irs1 2 0.39 1.02 0.5
32 INT246828 Binding of Irs1 9 0.37 2.68 0.42
33 INT235635 Negative_regulation of Phosphorylation of IRS1 7 0.37 3.78 0.42
34 INT145861 Regulation of Gene_expression of Irs1 2 0.41 0.83 0.41
35 INT257756 Regulation of Gene_expression of SHC1 1 0.39 1.13 0.41
36 INT145863 Negative_regulation of Gene_expression of Irs1 3 0.45 1.51 0.4
37 INT197880 Binding of Sh2b2 2 0.19 0 0.38
38 INT243808 Positive_regulation of Transcription of Sh2b2 1 0.29 0.86 0.33
39 INT158521 Positive_regulation of Negative_regulation of Irs1 1 0.02 0.57 0.33
40 INT243807 Transcription of Sh2b2 1 0.39 0.85 0.33
41 INT235680 Gene_expression of Gab2 1 0.66 4.93 0.29
42 INT313251 Negative_regulation of Positive_regulation of Sh2b2 1 0.12 0 0.29
43 INT240830 Positive_regulation of Protein_catabolism of Irs1 2 0.69 0.82 0.26
44 INT284738 Positive_regulation of Localization of Sh2b2 1 0.09 0.6 0.26
45 INT246817 Positive_regulation of Binding of Irs1 1 0.50 0.37 0.23
46 INT240818 Protein_catabolism of Irs1 3 0.98 1 0.22
47 INT89406 Negative_regulation of Positive_regulation of IRS1 1 0.22 0.93 0.22
48 INT246824 Negative_regulation of Irs1 6 0.43 2.13 0.17
49 INT284323 Regulation of IRS1 2 0.45 1.6 0.16
50 INT240841 Regulation of Gene_expression of Irs1 3 0.45 0.75 0.15
51 INT120962 Negative_regulation of Negative_regulation of Irs1 1 0.25 0.38 0.15
52 INT330850 Positive_regulation of TRAT1 1 0.05 0.54 0.15
53 INT301563 Positive_regulation of Positive_regulation of Irs1 1 0.16 1.32 0.15
54 INT351894 Negative_regulation of SHC1 1 0.12 0.69 0.14
55 INT230807 Regulation of Phosphorylation of Irs1 3 0.45 1.59 0.13
56 INT235682 Binding of Gab2 1 0.41 2.37 0.13
57 INT235672 Negative_regulation of Gab2 1 0.50 0.44 0.11
58 INT246818 Negative_regulation of Gene_expression of Irs1 3 0.42 1.25 0.1
59 INT191353 Localization of SHC1 2 0.73 0.75 0.1
60 INT304385 Protein_catabolism of IRS1 2 0.42 1.8 0.1
61 INT291370 Phosphorylation of SHC1 1 0.14 0.57 0.1
62 INT240850 Regulation of Irs1 2 0.47 0.64 0.09
63 INT246825 Regulation of Positive_regulation of Irs1 1 0.45 0.47 0.09
64 INT246819 Negative_regulation of Binding of Irs1 3 0.42 0.62 0.07
65 INT235675 Protein_catabolism of Gab2 1 0.84 1.71 0.06
66 INT235676 Localization of Gab2 1 0.63 1.12 0.05
67 INT301556 Negative_regulation of Positive_regulation of Irs1 1 0.10 1.63 0.04
68 INT332299 Negative_regulation of Gene_expression of IRS1 1 0.31 0.65 0.04
69 INT235632 Binding of IRS1 2 0.28 1.01 0.03
70 INT200785 Phosphorylation of Gab2 2 0.69 0 0.03
71 INT284335 Regulation of Gene_expression of IRS1 1 0.18 0.06 0.03
72 INT191352 Regulation of SHC1 2 0.14 1.46 0
73 INT246829 Localization of Irs1 2 0.74 0.9 0
74 INT268145 Negative_regulation of Sh2b2 1 0.41 0.07 0
75 INT268165 Binding of Sh2b2 1 0.36 0.13 0
76 INT246826 Positive_regulation of Localization of Irs1 1 0.50 0.76 0
77 INT323089 Positive_regulation of Transcription of Irs1 1 0.44 0.26 0
78 INT304382 Positive_regulation of Protein_catabolism of IRS1 1 0.16 0.77 0
79 INT284324 Positive_regulation of Gene_expression of IRS1 1 0.31 0.24 0
80 INT200804 Positive_regulation of Phosphorylation of Gab2 1 0.38 0 0
81 INT176532 Binding of SHC1 1 0.36 1.3 0
82 INT323107 Transcription of Irs1 1 0.50 0.26 0
83 INT235674 Regulation of Gab2 1 0.38 0.32 0
84 INT117327 Negative_regulation of Negative_regulation of Sh2b2 1 0.25 0.13 0
85 INT280661 Negative_regulation of Transcription of Irs1 1 0.37 0 0
86 INT235679 Negative_regulation of Positive_regulation of Gab2 1 0.36 0.44 0
87 INT117326 Positive_regulation of Negative_regulation of Sh2b2 1 0.27 0.16 0
88 INT304383 Negative_regulation of Protein_catabolism of IRS1 1 0.15 0.77 0
89 INT98752 Negative_regulation of TRAT1 1 0.08 0.12 0
90 INT179948 Negative_regulation of Positive_regulation of Irs1 1 0.45 0.36 0
91 INT235630 Localization of IRS1 1 0.70 0.38 0
92 INT179947 Positive_regulation of Irs1 1 0.53 0.83 0
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