GO:0005072

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Name transforming growth factor beta receptor, cytoplasmic mediator activity
Categary Function
Go Slim No
Go Link GO:0005072
Unique Molecular Interactions 70
Total Molecular Interactions 92
Total Single Events 635
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transforming growth factor beta receptor, cytoplasmic mediator activity. They are ordered first by their pain relevance and then by number of times they were reported for transforming growth factor beta receptor, cytoplasmic mediator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
2 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
3 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
4 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
5 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
6 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
7 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
8 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
9 INT31444 ENG Positive_regulation of Prl 1 0.01 0 1.14
10 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
11 INT32187 Binding of ENG and Negative_regulation of Localization of LH 1 0.01 0 0.91
12 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
13 INT32719 ENG Regulation of LH 2 0.00 0 0.64
14 INT31443 ENG Positive_regulation of Localization of Pomc 1 0.00 0 0.63
15 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
16 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
17 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
18 INT32151 ENG Positive_regulation of Gene_expression of IFNA1 1 0.37 0 0.53
19 INT32291 ENG Negative_regulation of LH 2 0.00 0 0.52
20 INT30618 Slc3a1 Regulation of ENG 1 0.00 0 0.5
21 INT30619 Pomc Regulation of ENG 1 0.00 0 0.5
22 INT102214 ENG Negative_regulation of HP 1 0.01 0 0.49
23 INT60872 Binding of ENG and Abat 1 0.00 0 0.49
24 INT60871 ENG Regulation of Localization of LH 1 0.00 0 0.49
25 INT43695 ENG Regulation of Regulation of Prl 1 0.00 0 0.47
26 INT60870 ENG Negative_regulation of Localization of LH 1 0.00 0 0.47
27 INT102213 Binding of ENG and HP 1 0.01 0 0.47
28 INT202516 Positive_regulation of Binding of ENG and Penk 1 0.03 0.58 0.42
29 INT202515 Binding of ENG and Penk 1 0.02 0.57 0.41
30 INT32720 Negative_regulation of ENG Regulation of LH 1 0.00 0 0.41
31 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
32 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
33 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
34 INT55404 Binding of ENG and Th 1 0.02 0 0.3
35 INT29137 ENG Regulation of POMC 1 0.00 0 0.28
36 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28
37 INT32156 Binding of ENG and Oprd1 1 0.00 0 0.26
38 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
39 INT43713 ENG Regulation of Prl 1 0.00 0 0.23
40 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
41 INT32294 ENG Positive_regulation of Trh 1 0.01 0 0.13
42 INT60399 ENG Regulation of Localization of Prl 1 0.04 0.57 0.1
43 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
44 INT158011 KLRF1 Positive_regulation of ENG 1 0.03 0.39 0.09
45 INT158012 Binding of ENG and FLT1 1 0.21 0.39 0.09
46 INT32290 ENG Regulation of Positive_regulation of Trh 1 0.01 0 0.09
47 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
48 INT25491 TFPI Regulation of Localization of ENG 1 0.27 0.31 0.06
49 INT25490 Binding of ENG and TFPI 1 0.27 0.4 0.06
50 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
51 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
52 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
53 INT302141 CDKN1C Regulation of CDKN1B 1 0.09 0.26 0.05
54 INT32293 ENG Regulation of Positive_regulation of Gnrh1 1 0.00 0 0.04
55 INT32297 ENG Regulation of Positive_regulation of LH 1 0.00 0 0.04
56 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04
57 INT340614 Binding of ENG and MMP9 1 0.16 0.14 0
58 INT325154 CDKN1B Negative_regulation of CCNE2 1 0.07 0.1 0
59 INT314373 Binding of Cd34 and Eng 1 0.08 0.9 0
60 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
61 INT32148 POMC Regulation of ENG 1 0.24 0 0
62 INT15847 Avp Positive_regulation of Localization of ENG 1 0.07 0 0
63 INT340613 Binding of COL4A4 and ENG 1 0.07 0.14 0
64 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
65 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
66 INT354115 MIR222 Regulation of Gene_expression of CDKN1B 1 0.07 0.98 0
67 INT228287 Binding of ENG and Cd14 1 0.20 0.25 0
68 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
69 INT201756 CDKN1B Positive_regulation of Localization of Ccnd1 1 0.04 0 0
70 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transforming growth factor beta receptor, cytoplasmic mediator activity. They are ordered first by their pain relevance and then by number of times they were reported in transforming growth factor beta receptor, cytoplasmic mediator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
2 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
3 INT10799 Localization of ENG 63 0.78 18.67 27.28
4 INT7674 Regulation of ENG 42 0.30 11.41 14.44
5 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61
6 INT23375 Binding of ENG 17 0.47 6.02 6.46
7 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
8 INT15844 Positive_regulation of Localization of ENG 7 0.67 4.2 3.47
9 INT32222 Negative_regulation of Gene_expression of ENG 9 0.37 2.23 2.89
10 INT22071 Positive_regulation of Gene_expression of ENG 13 0.50 5.44 2.62
11 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
12 INT13997 Regulation of Gene_expression of ENG 11 0.36 3.31 2.31
13 INT12133 Regulation of Localization of ENG 3 0.03 0.57 2.24
14 INT32135 Positive_regulation of Positive_regulation of ENG 2 0.02 0.98 1.99
15 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
16 INT15845 Negative_regulation of Localization of ENG 3 0.05 0.76 1.71
17 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
18 INT32717 Negative_regulation of Regulation of ENG 3 0.00 0.43 1.25
19 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24
20 INT51863 Negative_regulation of Negative_regulation of ENG 2 0.04 0.51 1.13
21 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
22 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
23 INT11763 Positive_regulation of Regulation of ENG 1 0.01 0.97 0.64
24 INT90939 Positive_regulation of Eng 9 0.64 4.62 0.57
25 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
26 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
27 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
28 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
29 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
30 INT131558 Protein_catabolism of ENG 1 0.01 0 0.18
31 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
32 INT90940 Binding of Eng 5 0.35 1.92 0.13
33 INT233868 Localization of CDKN1B 2 0.73 0.37 0.09
34 INT26064 Regulation of Positive_regulation of ENG 1 0.01 0.1 0.09
35 INT90941 Negative_regulation of Eng 1 0.31 0.25 0.09
36 INT233871 Negative_regulation of Protein_catabolism of CDKN1B 1 0.57 0.27 0.08
37 INT265338 Regulation of Eng 2 0.42 0.94 0.05
38 INT245858 Positive_regulation of Gene_expression of Eng 1 0.12 0 0.03
39 INT289876 Localization of Eng 3 0.44 0.59 0
40 INT190471 Transcription of ENG 3 0.21 1.76 0
41 INT265314 Regulation of Gene_expression of Eng 2 0.42 0.68 0
42 INT265324 Negative_regulation of Gene_expression of Eng 2 0.40 0.9 0
43 INT325178 Regulation of Positive_regulation of CDKN1B 1 0.44 0.05 0
44 INT325180 Negative_regulation of Gene_expression of CDKN1B 1 0.57 0.25 0
45 INT197394 Protein_catabolism of Eng 1 0.07 0.13 0
46 INT310171 Phosphorylation of Eng 1 0.24 0.5 0
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