GO:0005080

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Name protein kinase C binding
Categary Function
Go Slim No
Go Link GO:0005080
Unique Molecular Interactions 783
Total Molecular Interactions 1177
Total Single Events 6767
Pain Genes Associated 59

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase C binding. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase C binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
4 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
5 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
6 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
7 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
8 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
9 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
10 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
11 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
12 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
13 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
14 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
15 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
16 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
17 INT105917 Binding of SLC22A6 and SLC22A8 2 0.31 0.34 1.67
18 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
19 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
20 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
21 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
22 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
23 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
24 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
25 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
26 INT162165 WDTC1 Positive_regulation of PLD2 1 0.50 0 1.25
27 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
28 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
29 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
30 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
31 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
32 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
33 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
34 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
35 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
36 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
37 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07
38 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
39 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
40 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
41 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
42 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
43 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
44 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
45 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
46 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
47 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
48 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
49 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
50 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
51 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
52 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
53 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
54 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
55 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
56 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
57 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
58 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
59 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
60 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
61 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
62 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
63 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
64 INT190868 Binding of Marcks and Ltp 1 0.01 0.87 0.81
65 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
66 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
67 INT107739 Prkcg Negative_regulation of Positive_regulation of Pld2 1 0.46 0 0.79
68 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
69 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
70 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
71 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
72 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
73 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
74 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
75 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
76 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
77 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
78 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
79 INT162164 ARF6 Regulation of Positive_regulation of PLD2 1 0.60 0 0.74
80 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
81 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
82 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
83 INT106992 F2 Positive_regulation of PARD3 3 0.05 1.83 0.72
84 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
85 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
86 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
87 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
88 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
89 INT107741 Binding of OPRM1 and Pld2 1 0.01 0 0.69
90 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
91 INT134287 PLD2 Regulation of Regulation of MRGPRX1 1 0.31 0 0.67
92 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
93 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
94 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
95 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
96 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
97 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
98 INT115812 Binding of Slc22a8 and Mtx1 1 0.08 0.17 0.65
99 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
100 INT113611 Binding of Pick1 and Grip2 1 0.31 0.6 0.63
101 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
102 INT160880 Pld2 Positive_regulation of Oprm1 1 0.07 0.08 0.63
103 INT160882 Pld2 Positive_regulation of Gene_expression of Oprm1 1 0.06 0.08 0.63
104 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
105 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
106 INT166387 Binding of Gnb2l1 and Mdk 1 0.30 0.24 0.61
107 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
108 INT166385 Binding of Araf and Gnb2l1 1 0.23 0.24 0.6
109 INT296463 Binding of Gria1 and Pick1 1 0.16 0.32 0.59
110 INT308803 Binding of Pld1 and Pld2 1 0.13 1.11 0.59
111 INT296486 Binding of Pick1 and GRIP1 1 0.03 0.32 0.59
112 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
113 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
114 INT296475 Binding of Pick1 and Myo18a 2 0.01 1.63 0.57
115 INT145617 Ngf Positive_regulation of Gene_expression of Fez1 1 0.43 0.57 0.57
116 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
117 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
118 INT333991 Binding of FLNA and SELL 1 0.00 1.69 0.55
119 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
120 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
121 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
122 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
123 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54
124 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
125 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
126 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
127 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53
128 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
129 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
130 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
131 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
132 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5
133 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
134 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
135 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5
136 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
137 INT304578 Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf 1 0.06 0.9 0.49
138 INT160881 Positive_regulation of Oprm1 Positive_regulation of Positive_regulation of Pld2 1 0.05 0.08 0.48
139 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
140 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
141 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
142 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
143 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
144 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46
145 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
146 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
147 INT349853 Binding of Hspb1 and Jun 1 0.14 2.3 0.45
148 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
149 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
150 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
151 INT265137 Olah Positive_regulation of Localization of Marcks 1 0.03 0 0.42
152 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
153 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
154 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
155 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
156 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
157 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
158 INT354719 Binding of ASIC1 and Pick1 1 0.40 2.34 0.4
159 INT106114 Binding of ASIC2 and Pick1 1 0.14 0.1 0.4
160 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
161 INT106116 Binding of ASIC1 and Pick1 1 0.04 0.1 0.4
162 INT338044 F2 Positive_regulation of Pard3 1 0.08 0.38 0.4
163 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
164 INT106115 Pick1 Positive_regulation of Phosphorylation of ASIC2 1 0.13 0.07 0.39
165 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
166 INT106117 Pick1 Positive_regulation of ASIC2 1 0.14 0.09 0.39
167 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
168 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
169 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
170 INT296476 Binding of Pick1 and Rbm39 1 0.00 0.57 0.37
171 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
172 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
173 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
174 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
175 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
176 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
177 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
178 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
179 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
180 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
181 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
182 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
183 INT333893 Negative_regulation of HDAC9 Negative_regulation of Gene_expression of TNF 1 0.09 1.03 0.34
184 INT134080 OPA1 Negative_regulation of Phosphorylation of Gnb2l1 1 0.03 0.22 0.34
185 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
186 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
187 INT354697 Positive_regulation of Binding of Gria2 and Pick1 1 0.08 0.73 0.33
188 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
189 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
190 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
191 INT337412 AKT3 Negative_regulation of Localization of AKT2 1 0.09 0.5 0.32
192 INT113950 FLNA Regulation of Oprd1 1 0.00 0.16 0.32
193 INT337418 AKT2 Negative_regulation of Localization of AKT3 1 0.09 0.5 0.32
194 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
195 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
196 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
197 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
198 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
199 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
200 INT40148 Penk Negative_regulation of Prkcdbp 1 0.63 0 0.31

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase C binding. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase C binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT221172 Binding of Flna 32 0.42 1.37 51.59
4 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
5 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
6 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
7 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
8 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
9 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
10 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
11 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
12 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
13 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
14 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9
15 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
16 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
17 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
18 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
19 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
20 INT221167 Gene_expression of Flna 11 0.60 0.69 11.81
21 INT18412 Binding of PLEK 49 0.47 17.82 10.72
22 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
23 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55
24 INT3366 Localization of PLEK 44 0.78 15.83 9.55
25 INT159116 Gene_expression of Gnb2l1 12 0.77 2.79 9.49
26 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
27 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
28 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
29 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
30 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
31 INT221173 Negative_regulation of Binding of Flna 4 0.33 0.13 8.25
32 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
33 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
34 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
35 INT73181 Gene_expression of Hspb1 24 0.78 15.84 7.31
36 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
37 INT166383 Positive_regulation of Gene_expression of Gnb2l1 1 0.69 2.19 7.02
38 INT71496 Positive_regulation of Hspb1 15 0.69 14.7 6.86
39 INT107737 Positive_regulation of Pld2 11 0.67 0.33 6.45
40 INT134290 Positive_regulation of PLD2 10 0.68 3.06 6.44
41 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36
42 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
43 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
44 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
45 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
46 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
47 INT159115 Negative_regulation of Gene_expression of Gnb2l1 3 0.42 1.33 5.59
48 INT100222 Binding of Src 9 0.26 5.41 5.37
49 INT95099 Gene_expression of SLC22A8 14 0.67 1.59 5.14
50 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11
51 INT139162 Localization of Marcks 1 0.34 0 5.1
52 INT95101 Binding of SLC22A8 6 0.48 0.75 5.07
53 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
54 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
55 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
56 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81
57 INT87156 Phosphorylation of Marcks 8 0.40 2.48 4.8
58 INT134657 Localization of Akt1 37 0.68 11.58 4.62
59 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
60 INT159122 Positive_regulation of Gnb2l1 8 0.69 2.2 4.61
61 INT115805 Gene_expression of PLD2 7 0.76 12.49 4.51
62 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
63 INT39948 Binding of FLNA 45 0.42 58.05 4.27
64 INT95102 Localization of SLC22A8 3 0.75 0.69 4.24
65 INT75136 Binding of Akt1 27 0.27 8.81 4.15
66 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
67 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
68 INT221168 Localization of Flna 1 0.58 0.05 4.05
69 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
70 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97
71 INT190858 Phosphorylation of Marcks 1 0.33 6.29 3.86
72 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
73 INT136692 Localization of Akt1 12 0.78 2.14 3.65
74 INT122327 Regulation of Src 6 0.59 0.59 3.6
75 INT107555 Gene_expression of Marcks 8 0.58 1.22 3.56
76 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
77 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
78 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
79 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
80 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23
81 INT154198 Binding of Pick1 9 0.48 6.91 3.16
82 INT96304 Gene_expression of Slc22a8 9 0.66 0.63 3.12
83 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
84 INT115806 Positive_regulation of Gene_expression of PLD2 5 0.57 7.12 3.11
85 INT130441 Phosphorylation of MARCKS 8 0.37 3.24 3.09
86 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
87 INT92355 Negative_regulation of Marcks 4 0.48 0 3.07
88 INT200670 Gene_expression of AKT2 25 0.75 16.25 3
89 INT221171 Positive_regulation of Localization of Flna 1 0.39 0.05 2.9
90 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
91 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
92 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
93 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
94 INT166378 Positive_regulation of Gene_expression of Pick1 6 0.61 1.94 2.77
95 INT24068 Localization of Hspb1 6 0.78 6.11 2.75
96 INT166381 Negative_regulation of Gnb2l1 1 0.43 0.73 2.68
97 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
98 INT214355 Binding of Akt1 13 0.36 3.72 2.59
99 INT28817 Binding of TRPV4 6 0.39 3.92 2.59
100 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
101 INT99550 Regulation of FLNA 51 0.54 27.88 2.58
102 INT46646 Localization of FLNA 19 0.73 18.83 2.53
103 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
104 INT259224 Negative_regulation of Flna 1 0.23 0.15 2.51
105 INT115199 Localization of Trpv4 12 0.79 3.65 2.5
106 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
107 INT190863 Negative_regulation of Phosphorylation of Marcks 1 0.23 4.71 2.47
108 INT159809 Localization of Trpv4 6 0.78 3.67 2.46
109 INT159117 Regulation of Gene_expression of Gnb2l1 3 0.56 0.5 2.36
110 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35
111 INT156299 Phosphorylation of Trpv4 8 0.80 2.46 2.31
112 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
113 INT86426 Gene_expression of Hspb1 16 0.78 10.86 2.26
114 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
115 INT221177 Negative_regulation of Gene_expression of Flna 2 0.33 0 2.22
116 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18
117 INT13243 Gene_expression of Sqstm1 4 0.30 2.07 2.06
118 INT107554 Transcription of Marcks 1 0.59 0 2.06
119 INT221179 Regulation of Flna 1 0.24 0.13 2.04
120 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
121 INT166380 Positive_regulation of Pick1 5 0.44 1.26 1.95
122 INT48850 Gene_expression of PKN1 16 0.52 1.93 1.92
123 INT265157 Positive_regulation of Localization of Marcks 1 0.23 0 1.91
124 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
125 INT109071 Positive_regulation of Phosphorylation of Marcks 2 0.20 0.48 1.88
126 INT118511 Gene_expression of Pard3 5 0.57 0.76 1.86
127 INT153044 Negative_regulation of Gene_expression of Marcks 2 0.37 0 1.84
128 INT191154 Binding of HDAC9 20 0.36 14.12 1.83
129 INT159120 Protein_catabolism of Gnb2l1 1 0.26 0.37 1.79
130 INT137670 Positive_regulation of Gene_expression of Trpv4 12 0.68 3.42 1.77
131 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
132 INT149153 Positive_regulation of Gene_expression of Trpv4 12 0.70 3.37 1.72
133 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
134 INT221166 Positive_regulation of Flna 2 0.39 0.09 1.7
135 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
136 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
137 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
138 INT5682 Regulation of Prkcdbp 3 0.44 0.53 1.62
139 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
140 INT153045 Negative_regulation of Negative_regulation of Marcks 1 0.37 0 1.54
141 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
142 INT149152 Negative_regulation of Trpv4 5 0.58 1.8 1.52
143 INT98455 Regulation of Src 4 0.20 1.76 1.48
144 INT107735 Positive_regulation of Positive_regulation of Pld2 3 0.48 0 1.47
145 INT259219 Negative_regulation of Negative_regulation of Flna 1 0.23 0 1.47
146 INT332792 Positive_regulation of Gene_expression of HDAC9 5 0.45 4.61 1.44
147 INT115807 Negative_regulation of PLD2 3 0.57 0.69 1.43
148 INT195724 Gene_expression of SDC4 8 0.28 3.99 1.32
149 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
150 INT24069 Negative_regulation of Localization of Hspb1 3 0.14 3.93 1.3
151 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
152 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
153 INT190865 Positive_regulation of Phosphorylation of Marcks 1 0.20 1.79 1.28
154 INT107732 Gene_expression of Pld2 1 0.75 0 1.25
155 INT258053 Positive_regulation of Negative_regulation of HDAC9 8 0.27 7.37 1.23
156 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23
157 INT25836 Positive_regulation of Prkcdbp 1 0.08 0 1.2
158 INT160054 Localization of AKT2 4 0.73 1.93 1.18
159 INT115810 Negative_regulation of Slc22a8 3 0.41 0.27 1.18
160 INT76303 Negative_regulation of Positive_regulation of Hspb1 1 0.42 0.49 1.17
161 INT113607 Positive_regulation of Pick1 1 0.48 0.82 1.13
162 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
163 INT249522 Positive_regulation of Binding of Src 1 0.22 0.68 1.12
164 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
165 INT124167 Regulation of Positive_regulation of Src 2 0.13 0.47 1.1
166 INT181497 Regulation of Regulation of TRPV4 1 0.23 0.69 1.08
167 INT261816 Positive_regulation of Localization of Trpv4 2 0.47 1.16 1.07
168 INT71498 Binding of Hspb1 7 0.42 7.38 1.05
169 INT71499 Localization of Hspb1 4 0.72 1.38 1.05
170 INT123213 Negative_regulation of SLC22A8 2 0.35 1.43 1.05
171 INT123962 Phosphorylation of Hspb1 8 0.82 2.08 1.04
172 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
173 INT130444 Positive_regulation of MARCKS 2 0.12 0.61 1.02
174 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
175 INT116659 Regulation of Pick1 3 0.41 0.86 1.01
176 INT125892 Regulation of Hspb1 2 0.48 4.28 0.98
177 INT166377 Gene_expression of Pick1 3 0.68 2.9 0.97
178 INT108805 Binding of Slc22a8 3 0.18 0.44 0.97
179 INT317504 Protein_catabolism of Src 1 0.49 0.13 0.97
180 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95
181 INT24067 Negative_regulation of Hspb1 1 0.11 0.67 0.95
182 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
183 INT130439 Negative_regulation of Phosphorylation of MARCKS 2 0.19 1.03 0.94
184 INT100221 Negative_regulation of Phosphorylation of Src 2 0.24 0.74 0.93
185 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
186 INT162169 Negative_regulation of Positive_regulation of PLD2 1 0.56 0 0.92
187 INT142423 Negative_regulation of Positive_regulation of FLNA 2 0.05 0.99 0.89
188 INT160056 Positive_regulation of AKT2 3 0.48 1.43 0.88
189 INT271605 Regulation of Gene_expression of AKT2 1 0.44 0.81 0.87
190 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
191 INT265178 Positive_regulation of Gene_expression of Marcks 1 0.23 0 0.85
192 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
193 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
194 INT168284 Localization of Slc22a8 1 0.78 0.1 0.82
195 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
196 INT156175 Positive_regulation of Positive_regulation of Trpv4 5 0.50 0.86 0.8
197 INT107552 Regulation of Marcks 2 0.37 0.48 0.8
198 INT143912 Localization of Src 4 0.48 2.51 0.78
199 INT48851 Positive_regulation of Gene_expression of PKN1 2 0.27 0.67 0.78
200 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
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