GO:0005085

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Name guanyl-nucleotide exchange factor activity
Categary Function
Go Slim No
Go Link GO:0005085
Unique Molecular Interactions 252
Total Molecular Interactions 314
Total Single Events 1890
Pain Genes Associated 60

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for guanyl-nucleotide exchange factor activity. They are ordered first by their pain relevance and then by number of times they were reported for guanyl-nucleotide exchange factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
2 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
3 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
4 INT133937 Binding of OPRK1 and ARFGEF1 1 0.01 0 1.39
5 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
6 INT264930 Gnaz Positive_regulation of Negative_regulation of Cnr1 1 0.20 0 1.14
7 INT264931 Binding of Gnaz and Hrh1 1 0.01 0.83 1.12
8 INT12684 Binding of Bcar3 and Trim13 1 0.03 0 1.08
9 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
10 INT264926 Binding of Gnaz and Pag1 1 0.08 0.19 0.94
11 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
12 INT210801 Bst2 Positive_regulation of Net1 1 0.35 0.54 0.89
13 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
14 INT125234 Positive_regulation of Binding of BCR and CD40LG 1 0.31 0.76 0.86
15 INT125233 Binding of BCR and CD40LG 1 0.23 0.75 0.85
16 INT54559 KCNMA1 Positive_regulation of Localization of TBXA2R 1 0.01 0.07 0.81
17 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77
18 INT232621 Binding of Gria1 and Psd 1 0.10 0.29 0.77
19 INT81975 Binding of OPRL1 and RASGRP1 1 0.03 0 0.76
20 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
21 INT133941 ARFGEF1 Positive_regulation of OPRK1 1 0.02 0 0.76
22 INT133940 Binding of OPRD1 and ARFGEF1 1 0.02 0 0.73
23 INT133938 Binding of OPRL1 and ARFGEF1 1 0.00 0 0.73
24 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
25 INT197115 Binding of MCF2 and RETNLB 1 0.00 1.06 0.7
26 INT133942 Binding of YY1 and ARFGEF1 1 0.05 0 0.69
27 INT232615 Psd Regulation of Cysltr1 1 0.02 0.58 0.68
28 INT264927 Cnr1 Regulation of Gnaz 1 0.23 0.05 0.66
29 INT206206 Binding of Mcf2l and Obfc1 1 0.02 1.11 0.64
30 INT334594 Binding of GNAI1 and MRGPRD 1 0.01 0.19 0.63
31 INT59635 Binding of Adarb1 and Gnaz 1 0.01 0 0.55
32 INT249717 Binding of NCL and MCF2L 1 0.23 0 0.54
33 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
34 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
35 INT131364 Bcar3 Positive_regulation of Il4 1 0.00 0.37 0.51
36 INT104016 RPGR Positive_regulation of Gene_expression of FOS 1 0.16 0 0.43
37 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43
38 INT80233 Positive_regulation of OPRM1 Positive_regulation of GNAI1 1 0.23 0 0.41
39 INT333512 Binding of GPI and MCF2L 1 0.09 0.75 0.41
40 INT80232 OPRM1 Positive_regulation of GNAI1 1 0.23 0 0.41
41 INT157147 LSS Positive_regulation of PTGIR 1 0.09 0.96 0.36
42 INT268225 TBXA2R Positive_regulation of NAAA 1 0.07 0.98 0.35
43 INT268224 TBXA2R Positive_regulation of Gene_expression of NAAA 1 0.08 0.98 0.35
44 INT157150 Positive_regulation of PTGIR Negative_regulation of Gene_expression of TNF 1 0.12 0.97 0.34
45 INT75643 NCOR2 Positive_regulation of Positive_regulation of EIF2B3 1 0.00 0 0.33
46 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 0.02 0.39 0.33
47 INT75641 AR Positive_regulation of Positive_regulation of EIF2B3 1 0.02 0 0.33
48 INT35666 MPZ Regulation of Gene_expression of TBXA2R 1 0.02 0.57 0.32
49 INT241740 Sdhb Regulation of Rapgef5 1 0.02 0.34 0.32
50 INT198779 Binding of Dlg4 and Psd 10 0.25 0.09 0.31
51 INT316884 Positive_regulation of Binding of Cr2 and Bcr 1 0.06 0.86 0.31
52 INT197114 IL1B Regulation of Binding of MCF2 1 0.03 0.48 0.31
53 INT316881 Positive_regulation of Binding of Cd19 and Bcr 1 0.08 0.86 0.31
54 INT316885 Binding of Cr2 and Bcr 1 0.06 0.85 0.3
55 INT316888 Binding of Cd19 and Bcr 1 0.08 0.85 0.3
56 INT235957 Binding of Mog and Bcr 1 0.02 1.13 0.29
57 INT235962 Binding of Bcr and Trav6-3 1 0.00 1.12 0.29
58 INT118852 Positive_regulation of GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
59 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
60 INT118846 GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
61 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
62 INT118856 Positive_regulation of GNA14 Positive_regulation of STAT3 1 0.01 0.14 0.26
63 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
64 INT118851 GNA14 Positive_regulation of RAF1 1 0.00 0.14 0.26
65 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
66 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
67 INT80138 PLA2G2A Positive_regulation of Localization of TBXA2R 1 0.30 0.15 0.24
68 INT312726 AASS Positive_regulation of FGD1 1 0.02 0.08 0.24
69 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
70 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
71 INT312517 Rapgef1 Negative_regulation of Rbp4 1 0.01 0.9 0.22
72 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21
73 INT257989 PTGER2 Positive_regulation of RASGRP1 1 0.01 0.61 0.21
74 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21
75 INT257398 Binding of FGD1 and GHRH 1 0.03 0.27 0.2
76 INT244299 FFAR1 Positive_regulation of PTH1R 1 0.00 0.4 0.2
77 INT50153 Positive_regulation of Bcar3 Positive_regulation of Gene_expression of Dcn 1 0.01 0.06 0.19
78 INT207339 TBXA2R Negative_regulation of Negative_regulation of CYP27A1 1 0.01 0 0.17
79 INT207348 TBXA2R Negative_regulation of CPOX 1 0.03 0 0.17
80 INT207354 TBXA2R Regulation of Gene_expression of CYP27A1 1 0.01 0 0.17
81 INT44903 Binding of EIF2S1 and Sergef 1 0.02 0.32 0.17
82 INT76196 Binding of HTR1A and EIF2B3 1 0.06 0 0.17
83 INT207350 TBXA2R Regulation of Gene_expression of ABCA1 1 0.10 0 0.17
84 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
85 INT207357 TBXA2R Positive_regulation of CYP27A1 1 0.01 0 0.16
86 INT207349 TBXA2R Regulation of CYP27A1 1 0.01 0 0.16
87 INT15523 INS Negative_regulation of FFAR1 1 0.02 0.35 0.16
88 INT15524 GCG Negative_regulation of FFAR1 1 0.07 0.35 0.16
89 INT216711 P2RY1 Negative_regulation of P2RY12 1 0.28 0.09 0.16
90 INT127206 Negative_regulation of Cftr Negative_regulation of Positive_regulation of Mcf2l 1 0.16 0.62 0.16
91 INT15525 MIA3 Negative_regulation of FFAR1 1 0.01 0.35 0.16
92 INT244045 Binding of Arhgef9 and Gphn 1 0.02 0.2 0.15
93 INT306268 CRKL Positive_regulation of RASGRP1 1 0.02 0.54 0.14
94 INT271003 Binding of TBXA2R and Aia1 1 0.01 1.81 0.14
95 INT263747 Neto1 Positive_regulation of Psd 1 0.24 0 0.14
96 INT80139 PLA2G2A Positive_regulation of Gene_expression of TBXA2R 1 0.30 0.15 0.14
97 INT287262 Binding of Cyth3 and Shbdp1 1 0.00 0.15 0.14
98 INT293697 Dock2 Positive_regulation of Akt1 1 0.14 0.08 0.13
99 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13
100 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
101 INT109410 RASGRP1 Regulation of Gene_expression of PPARG 1 0.03 0.76 0.13
102 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13
103 INT227954 Chrm4 Regulation of Chrm5 1 0.24 0.33 0.13
104 INT270996 TBXA2R Regulation of LTC4S 1 0.24 0.83 0.13
105 INT269548 ARHGEF17 Positive_regulation of RHOA 1 0.01 0 0.12
106 INT279804 ATP6V0A2 Regulation of MCF2 1 0.00 1.76 0.12
107 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
108 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
109 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1
110 INT258517 Negative_regulation of CPOX Negative_regulation of Binding of PTGIR 1 0.04 0.33 0.1
111 INT132511 RASGRP1 Positive_regulation of OPCML 1 0.29 0.44 0.1
112 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
113 INT132510 RASGRP1 Negative_regulation of OPCML 1 0.25 0.44 0.1
114 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1
115 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09
116 INT96045 Capn1 Regulation of Rasgrp1 1 0.01 0.44 0.09
117 INT311811 Binding of REN and RASGRP1 1 0.16 0.68 0.08
118 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08
119 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08
120 INT250662 FNTA Positive_regulation of Positive_regulation of RASGRP1 1 0.00 0.79 0.07
121 INT231847 Binding of Akt1 and Sergef 1 0.00 0.23 0.07
122 INT132512 RASGRP1 Regulation of OPCML 1 0.16 0.32 0.06
123 INT263743 Rasgrf1 Positive_regulation of Positive_regulation of Mapk1 1 0.11 0 0.06
124 INT263770 Rasgrf1 Positive_regulation of Positive_regulation of Grin1 1 0.24 0 0.06
125 INT229601 Binding of DIS3 and RLS 1 0.14 2.19 0.06
126 INT227562 GNAI1 Negative_regulation of GLUL 1 0.01 0 0.06
127 INT269568 PTGIR Regulation of TMPO 1 0.01 0.06 0.05
128 INT269556 PTGIR Negative_regulation of TMPO 1 0.01 0 0.05
129 INT263727 Binding of Grin2b and Rasgrf1 1 0.18 0 0.05
130 INT263730 Binding of Grin2a and Rasgrf1 1 0.23 0 0.05
131 INT342466 Binding of FFAR1 and MAFD1 1 0.03 0.87 0.05
132 INT231806 ARHGDIA Negative_regulation of ARHGEF1 1 0.02 0.11 0.04
133 INT353314 Edn1 Positive_regulation of Kalrn 1 0.03 0.21 0.04
134 INT269551 TBXA2R Positive_regulation of CSH1 1 0.00 0.09 0.04
135 INT198777 Binding of Psd and Psds1 1 0.05 0 0.04
136 INT231864 Binding of ARHGEF1 and Akt1 1 0.01 0.11 0.04
137 INT149751 Rapgef3 Regulation of Phosphorylation of Akt1 1 0.50 0.39 0.04
138 INT231865 ARHGDIA Negative_regulation of Sergef 1 0.01 0.05 0.04
139 INT269570 TBXA2R Positive_regulation of PAFAH2 1 0.00 0.09 0.04
140 INT269545 PTGDS Regulation of PTGIR 1 0.01 0 0.04
141 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
142 INT172234 Binding of GPR87 and P2RY12 1 0.24 0 0.03
143 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03
144 INT232900 Binding of ABR and Krt8 1 0.03 0.49 0.03
145 INT269554 MAPKAP1 Regulation of PTGIR 1 0.00 0.07 0.03
146 INT302171 PTGER4 Positive_regulation of RASGRP1 1 0.01 1.03 0.03
147 INT198780 Regulation of Binding of Dlg4 and Psd 1 0.14 0 0.03
148 INT291103 FFAR1 Regulation of Gene_expression of PDK4 1 0.03 0 0
149 INT287062 Gopc Positive_regulation of Positive_regulation of Vav1 1 0.18 0.15 0
150 INT96044 Rasgrp1 Positive_regulation of Gene_expression of Nos2 1 0.14 0.05 0
151 INT27743 IRF6 Positive_regulation of TBXA2R 1 0.01 1.03 0
152 INT291095 FFAR1 Regulation of PDHA1 1 0.03 0.27 0
153 INT284092 HNF1A Positive_regulation of FGD2 1 0.15 1.16 0
154 INT269546 TBXA2R Regulation of ARHGEF15 1 0.00 0 0
155 INT291105 FFAR1 Negative_regulation of PDP1 1 0.05 0.29 0
156 INT72209 BCR Positive_regulation of Mapk13 1 0.00 0 0
157 INT194716 Positive_regulation of Binding of VAV1 and ZAP70 1 0.04 0 0
158 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
159 INT291100 PDP1 Regulation of FFAR1 1 0.03 0 0
160 INT302909 Nav2 Positive_regulation of Arhgef16 1 0.02 0.52 0
161 INT269578 GOPC Positive_regulation of Phosphorylation of PTGIR 1 0.01 0 0
162 INT288830 Binding of ras and Sergef 1 0.03 0.41 0
163 INT217779 POLR2B Regulation of Gene_expression of RASGRP1 1 0.01 0.2 0
164 INT269547 PTGIR Regulation of Phosphorylation of RHOA 1 0.02 0 0
165 INT339096 Ezh2 Regulation of Rcc1 1 0.02 1.1 0
166 INT334320 EGFR Positive_regulation of RASGRP1 1 0.05 0.76 0
167 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
168 INT218509 Binding of BCR and Cfb 1 0.00 0.18 0
169 INT224023 Binding of GOPC and P2RY12 1 0.02 0.69 0
170 INT34762 Binding of PTGIR and REN 1 0.30 0.24 0
171 INT96046 Rasgrp1 Negative_regulation of Mpo 1 0.23 0.06 0
172 INT235181 IRF6 Positive_regulation of RASGRP1 1 0.00 0.2 0
173 INT232899 Krt18 Negative_regulation of Binding of ABR 1 0.05 0.68 0
174 INT203587 MCF2 Negative_regulation of Gene_expression of CPOX 1 0.00 0.6 0
175 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0
176 INT338194 Regulation of VAV3 Regulation of AR 1 0.31 0.49 0
177 INT199110 Vav1 Positive_regulation of Binding of Sergef 1 0.04 0.23 0
178 INT218514 BCR Negative_regulation of Binding of Cfb 1 0.00 0.18 0
179 INT194711 LAT Positive_regulation of Binding of VAV1 1 0.03 0 0
180 INT217778 MAP3K3 Regulation of Gene_expression of RASGRP1 1 0.09 0.19 0
181 INT269581 PTGIR Regulation of RHOA 1 0.02 0 0
182 INT294412 Binding of Vav2 and Vav3 1 0.41 0.65 0
183 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0
184 INT228118 Binding of Fyn and Vav1 1 0.11 0.21 0
185 INT232895 Krt18 Positive_regulation of Gene_expression of ABR 1 0.46 0.09 0
186 INT268595 Gene_expression of Mirlet7a-1 Negative_regulation of RASGRP1 1 0.00 0.59 0
187 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0
188 INT224027 Binding of P2RX1 and P2RY12 1 0.10 0.71 0
189 INT96043 Rasgrp1 Negative_regulation of Sdcbp 1 0.02 0.06 0
190 INT354967 Binding of Psd and Dlgap1 1 0.15 0.09 0
191 INT217773 MIR208A Regulation of Gene_expression of RASGRP1 1 0.06 0.2 0
192 INT175400 RASGRP1 Positive_regulation of MAP3K5 1 0.00 1.2 0
193 INT287061 Chrm2 Positive_regulation of Phosphorylation of Vav1 1 0.14 0.15 0
194 INT286422 Binding of Cdc42ep5 and Dock4 1 0.01 0.84 0
195 INT288827 Binding of Rasgrf2 and Vav1 1 0.40 0.37 0
196 INT194692 Binding of VAV1 and LAT 1 0.02 0 0
197 INT292566 Binding of TNFRSF1A and MADD 1 0.05 0.09 0
198 INT269553 TMPO Regulation of PTGIR 1 0.01 0 0
199 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0
200 INT263744 Binding of Psd and Neto1 1 0.19 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for guanyl-nucleotide exchange factor activity. They are ordered first by their pain relevance and then by number of times they were reported in guanyl-nucleotide exchange factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22276 Gene_expression of TBXA2R 65 0.77 23.22 14.21
2 INT18830 Localization of TBXA2R 25 0.81 7.14 9.28
3 INT264910 Positive_regulation of Gnaz 1 0.30 0 7.82
4 INT22275 Negative_regulation of TBXA2R 25 0.54 8.67 7.34
5 INT127203 Positive_regulation of Mcf2l 14 0.43 9.84 7.03
6 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69
7 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07
8 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47
9 INT34770 Negative_regulation of PTGIR 16 0.41 8.52 5.21
10 INT75645 Binding of EIF2B3 10 0.07 0.21 4.9
11 INT20944 Gene_expression of Mcf2l 13 0.58 5.96 4.76
12 INT17391 Gene_expression of GNAI1 11 0.75 5.26 4.7
13 INT17393 Positive_regulation of GNAI1 17 0.49 2.42 4.66
14 INT34184 Localization of FGD1 7 0.65 2.68 4.21
15 INT58875 Positive_regulation of FGD1 20 0.60 3.88 4.19
16 INT127202 Negative_regulation of Mcf2l 8 0.50 6.7 4.15
17 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
18 INT133953 Gene_expression of ARFGEF1 1 0.07 0 3.87
19 INT151684 Gene_expression of MCF2L 7 0.54 6.25 3.76
20 INT16608 Positive_regulation of FFAR1 40 0.37 18.48 3.59
21 INT22274 Negative_regulation of Gene_expression of TBXA2R 12 0.58 3.32 3.28
22 INT127200 Localization of Mcf2l 7 0.64 4.8 3.25
23 INT22277 Positive_regulation of Gene_expression of TBXA2R 13 0.69 5.95 2.92
24 INT61714 Binding of FGD1 12 0.35 7.72 2.91
25 INT198753 Binding of Psd 18 0.20 1.66 2.84
26 INT158083 Gene_expression of FGD1 24 0.67 6.82 2.83
27 INT264915 Positive_regulation of Localization of Gnaz 1 0.19 0 2.68
28 INT44150 Regulation of TBXA2R 10 0.19 3.94 2.62
29 INT49218 Negative_regulation of Localization of TBXA2R 5 0.59 0.32 2.58
30 INT29835 Regulation of Gene_expression of TBXA2R 7 0.50 3.92 2.57
31 INT169798 Positive_regulation of Rapgef3 1 0.45 1.7 2.56
32 INT249718 Binding of MCF2L 6 0.16 3.52 2.36
33 INT21611 Negative_regulation of RASGRP1 20 0.35 11.76 2.15
34 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
35 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
36 INT17390 Regulation of GNAI1 5 0.04 3.58 2.03
37 INT35485 Regulation of PTGIR 7 0.19 4.5 2
38 INT9427 Binding of TBXA2R 8 0.31 2.71 1.91
39 INT25871 Negative_regulation of Gnaz 3 0.23 0 1.89
40 INT149441 Positive_regulation of MCF2L 5 0.61 3.96 1.82
41 INT17387 Gene_expression of Gnaz 3 0.50 0.4 1.81
42 INT216715 Gene_expression of P2RY12 24 0.72 3.42 1.77
43 INT59790 Binding of BCR 16 0.36 15.34 1.75
44 INT25192 Positive_regulation of Gene_expression of GNAI1 5 0.49 1.08 1.7
45 INT44647 Positive_regulation of TBXA2R 14 0.57 6.95 1.64
46 INT106534 Gene_expression of Dock9 3 0.65 1.62 1.63
47 INT119346 Positive_regulation of PTGIR 9 0.58 6.2 1.61
48 INT110041 Gene_expression of CHRM4 5 0.52 0.72 1.57
49 INT101859 Gene_expression of MCF2 34 0.49 19.45 1.51
50 INT198743 Gene_expression of Psd 11 0.37 1.34 1.5
51 INT121347 Binding of GNAS 8 0.13 3.99 1.47
52 INT235954 Gene_expression of Bcr 1 0.13 6.77 1.47
53 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45
54 INT42391 Positive_regulation of BCR 7 0.49 4.93 1.44
55 INT169799 Binding of Rapgef3 1 0.30 1.04 1.43
56 INT75647 Positive_regulation of Binding of EIF2B3 3 0.07 0.11 1.42
57 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
58 INT106198 Negative_regulation of Kalrn 9 0.58 6.08 1.39
59 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37
60 INT96039 Regulation of Rasgrp1 1 0.37 0.44 1.36
61 INT32118 Regulation of Mcf2l 6 0.39 3.05 1.34
62 INT78658 Localization of PTGIR 6 0.18 2.46 1.33
63 INT264906 Localization of Gnaz 1 0.28 0 1.33
64 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
65 INT264899 Positive_regulation of Positive_regulation of Gnaz 1 0.19 0 1.32
66 INT8063 Regulation of RASGRP1 15 0.36 9.15 1.3
67 INT281406 Gene_expression of RAPGEFL1 1 0.13 7.09 1.29
68 INT119350 Binding of PTGIR 6 0.40 1.25 1.26
69 INT25806 Binding of GNAI1 5 0.47 0.15 1.24
70 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22
71 INT67471 Negative_regulation of Gene_expression of PTGIR 6 0.12 2.42 1.21
72 INT110042 Binding of CHRM4 1 0.25 0.55 1.15
73 INT185696 Negative_regulation of P2RY12 8 0.57 4.87 1.12
74 INT15527 Gene_expression of FFAR1 19 0.61 11.15 1.08
75 INT36517 Negative_regulation of MCF2 14 0.42 6.43 1.02
76 INT170818 Localization of RASGRP1 4 0.44 1.93 1.02
77 INT95028 Gene_expression of Chrm4 8 0.39 2.66 0.99
78 INT316159 Regulation of FGD1 1 0.01 0.59 0.99
79 INT17554 Regulation of ABR 6 0.54 2.21 0.98
80 INT139150 Regulation of Psd 4 0.35 0.28 0.98
81 INT79081 Negative_regulation of Gene_expression of Gnaz 1 0.03 0 0.98
82 INT127199 Negative_regulation of Positive_regulation of Mcf2l 1 0.14 2.77 0.98
83 INT268232 Phosphorylation of PTGIR 4 0.11 1.91 0.95
84 INT20757 Binding of MCF2 4 0.07 0.71 0.95
85 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93
86 INT6708 Phosphorylation of GNAI1 2 0.25 0.36 0.93
87 INT15531 Regulation of FFAR1 9 0.48 4.25 0.89
88 INT96967 Positive_regulation of Positive_regulation of GNAI1 2 0.49 0.16 0.87
89 INT42390 Regulation of Positive_regulation of BCR 1 0.00 0 0.87
90 INT34188 Positive_regulation of Localization of FGD1 1 0.01 0 0.87
91 INT34185 Negative_regulation of Localization of FGD1 1 0.00 0 0.87
92 INT16609 Localization of FFAR1 8 0.40 2.65 0.81
93 INT110208 Binding of ABR 2 0.35 10.49 0.81
94 INT264911 Regulation of Gnaz 1 0.10 0 0.81
95 INT241722 Gene_expression of Rapgef5 1 0.24 1.34 0.81
96 INT115757 Negative_regulation of ABR 3 0.57 0.53 0.8
97 INT50145 Positive_regulation of Bcar3 4 0.02 0.47 0.79
98 INT257400 Positive_regulation of Gene_expression of FGD1 3 0.50 0.79 0.78
99 INT185692 Phosphorylation of TBXA2R 2 0.46 0.67 0.78
100 INT9428 Negative_regulation of Binding of TBXA2R 2 0.33 0.17 0.76
101 INT119349 Regulation of Binding of PTGIR 2 0.43 0.76 0.76
102 INT54560 Positive_regulation of Localization of TBXA2R 1 0.13 0 0.76
103 INT157156 Negative_regulation of Positive_regulation of PTGIR 1 0.12 1.78 0.71
104 INT158084 Negative_regulation of FGD1 4 0.21 1.82 0.69
105 INT75646 Positive_regulation of EIF2B3 2 0.06 0.11 0.68
106 INT198751 Negative_regulation of Psd 2 0.27 0.47 0.66
107 INT96968 Regulation of Positive_regulation of GNAI1 1 0.07 0.17 0.66
108 INT191194 Localization of MCF2 7 0.11 2.29 0.65
109 INT106533 Positive_regulation of Gene_expression of Dock9 1 0.49 0.33 0.65
110 INT35282 Positive_regulation of Chrm4 4 0.45 0.81 0.64
111 INT268229 Positive_regulation of Phosphorylation of TBXA2R 1 0.28 0.6 0.64
112 INT268233 Positive_regulation of Phosphorylation of PTGIR 1 0.07 0.6 0.64
113 INT2644 Gene_expression of Kalrn 3 0.54 0.33 0.62
114 INT268231 Regulation of Gene_expression of PTGIR 2 0.05 0.77 0.62
115 INT133947 Positive_regulation of Localization of ARFGEF1 1 0.05 0 0.62
116 INT133948 Localization of ARFGEF1 1 0.09 0 0.62
117 INT88078 Negative_regulation of Chrm4 3 0.25 2.74 0.61
118 INT123401 Positive_regulation of Localization of PTGIR 1 0.06 0.98 0.6
119 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
120 INT269801 Gene_expression of MADD 1 0.14 4.17 0.6
121 INT8066 Binding of RASGRP1 10 0.36 4.65 0.58
122 INT155770 Protein_catabolism of Mcf2l 1 0.56 0.05 0.58
123 INT197117 Negative_regulation of Localization of MCF2 1 0.03 0.81 0.56
124 INT130242 Positive_regulation of Kalrn 5 0.67 1.17 0.51
125 INT216713 Positive_regulation of Gene_expression of P2RY12 1 0.65 0.55 0.51
126 INT273550 Positive_regulation of Bcr 14 0.68 6.71 0.49
127 INT69417 Positive_regulation of Positive_regulation of RASGRP1 4 0.29 3.92 0.49
128 INT199553 Gene_expression of Bcr 25 0.76 13.83 0.48
129 INT106197 Regulation of Kalrn 2 0.31 1.11 0.48
130 INT320452 Negative_regulation of MCF2L 1 0.13 0.5 0.46
131 INT232886 Regulation of Gene_expression of ABR 3 0.06 1.42 0.45
132 INT30080 Binding of Arhgef16 1 0.11 0.54 0.45
133 INT34037 Regulation of Arhgef16 1 0.15 0.6 0.45
134 INT273555 Negative_regulation of Bcr 17 0.57 9.65 0.44
135 INT43586 Positive_regulation of Cyth3 1 0.01 0.1 0.44
136 INT21353 Binding of Mcf2l 3 0.38 1.03 0.43
137 INT158313 Positive_regulation of Psd 3 0.39 1.96 0.43
138 INT268226 Positive_regulation of Gene_expression of PTGIR 2 0.06 0.51 0.43
139 INT127085 Regulation of Gene_expression of Dock9 1 0.17 0.95 0.41
140 INT127201 Regulation of Negative_regulation of Mcf2l 1 0.09 0.96 0.39
141 INT75496 Positive_regulation of MCF2 7 0.08 3.86 0.38
142 INT258519 Negative_regulation of Negative_regulation of TBXA2R 1 0.02 0.35 0.38
143 INT183266 Negative_regulation of CHRM4 2 0.30 0 0.37
144 INT333516 Regulation of MCF2L 1 0.09 0.82 0.37
145 INT193674 Binding of Bcr 10 0.47 4.3 0.36
146 INT194779 Binding of VAV1 2 0.14 1.62 0.36
147 INT212763 Regulation of CHRM4 1 0.02 0.42 0.36
148 INT95029 Transcription of Chrm4 1 0.25 0 0.36
149 INT235948 Regulation of Gene_expression of Bcr 1 0.08 1.58 0.36
150 INT340381 Transcription of FGD1 1 0.07 0.35 0.35
151 INT209226 Localization of Psd 2 0.31 0.09 0.34
152 INT281404 Localization of RAPGEFL1 1 0.12 4.49 0.34
153 INT216723 Regulation of P2RY12 5 0.42 1.82 0.33
154 INT172280 Binding of P2RY12 3 0.35 0.77 0.33
155 INT216733 Localization of P2RY12 2 0.70 0.32 0.33
156 INT136943 Positive_regulation of Rapgef3 2 0.67 1.25 0.33
157 INT216728 Negative_regulation of Gene_expression of P2RY12 1 0.40 0.11 0.33
158 INT268228 Regulation of Binding of TBXA2R 1 0.25 0.13 0.33
159 INT278102 Binding of GNA15 1 0.01 0.16 0.32
160 INT15532 Negative_regulation of FFAR1 6 0.33 2.32 0.3
161 INT199557 Positive_regulation of Gene_expression of Bcr 6 0.68 4.21 0.3
162 INT86395 Negative_regulation of Binding of EIF2B3 1 0.05 0.06 0.3
163 INT9815 Binding of FFAR1 6 0.29 3.54 0.29
164 INT129166 Positive_regulation of Bcr 2 0.28 1.18 0.29
165 INT169371 Positive_regulation of Positive_regulation of Mcf2l 1 0.43 0.78 0.28
166 INT16607 Regulation of Positive_regulation of FFAR1 1 0.14 0.32 0.28
167 INT118873 Binding of GNA14 1 0.01 0.13 0.27
168 INT185688 Regulation of Localization of TBXA2R 3 0.15 1.09 0.26
169 INT227951 Regulation of Chrm4 1 0.18 1.45 0.26
170 INT118875 Gene_expression of GNA14 1 0.02 0.09 0.26
171 INT216719 Regulation of Gene_expression of P2RY12 1 0.57 0.22 0.26
172 INT124366 Gene_expression of GNA15 1 0.11 0 0.25
173 INT227591 Localization of GNAI1 1 0.05 0.11 0.24
174 INT108902 Localization of GNAS 5 0.13 1.31 0.23
175 INT93646 Positive_regulation of P2RY12 3 0.65 1.08 0.23
176 INT118869 Phosphorylation of GNA14 1 0.02 0.15 0.23
177 INT109415 Negative_regulation of Positive_regulation of RASGRP1 5 0.34 2.16 0.22
178 INT8064 Negative_regulation of Binding of RASGRP1 2 0.28 0.83 0.22
179 INT216720 Negative_regulation of Binding of P2RY12 1 0.40 0 0.2
180 INT192748 Localization of BCR 4 0.68 2.4 0.18
181 INT132523 Positive_regulation of Gene_expression of RASGRP1 2 0.29 1.29 0.18
182 INT96038 Positive_regulation of Rasgrp1 2 0.30 0.55 0.17
183 INT347214 Positive_regulation of Negative_regulation of Bcr 1 0.38 1.43 0.17
184 INT15530 Positive_regulation of Gene_expression of FFAR1 4 0.39 1.84 0.16
185 INT223459 Gene_expression of Dock4 2 0.71 1.5 0.16
186 INT223465 Regulation of Dock4 1 0.08 0.13 0.16
187 INT223463 Regulation of Gene_expression of Dock4 1 0.31 0.13 0.16
188 INT16606 Negative_regulation of Localization of FFAR1 2 0.29 0.5 0.15
189 INT185694 Regulation of Phosphorylation of TBXA2R 1 0.15 0.07 0.15
190 INT192952 Negative_regulation of DIS3 1 0.21 0.42 0.15
191 INT191179 Regulation of MCF2 12 0.06 8.54 0.14
192 INT170468 Regulation of Gene_expression of RASGRP1 2 0.17 1.68 0.14
193 INT129165 Positive_regulation of Binding of Bcr 1 0.00 0.59 0.14
194 INT129167 Binding of Bcr 1 0.00 0.59 0.14
195 INT149302 Regulation of ARHGEF3 1 0.14 1.02 0.14
196 INT149301 Binding of ARHGEF3 1 0.20 1.02 0.14
197 INT232877 Negative_regulation of Binding of ABR 1 0.06 1.88 0.14
198 INT118872 Positive_regulation of GNA14 1 0.02 0.1 0.14
199 INT196243 Localization of CHRM4 1 0.56 0 0.13
200 INT232880 Phosphorylation of ABR 1 0.79 0.76 0.13
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