GO:0005089

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Name Rho guanyl-nucleotide exchange factor activity
Categary Function
Go Slim No
Go Link GO:0005089
Unique Molecular Interactions 79
Total Molecular Interactions 105
Total Single Events 783
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Rho guanyl-nucleotide exchange factor activity. They are ordered first by their pain relevance and then by number of times they were reported for Rho guanyl-nucleotide exchange factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
2 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
3 INT210801 Bst2 Positive_regulation of Net1 1 0.35 0.54 0.89
4 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
5 INT125234 Positive_regulation of Binding of BCR and CD40LG 1 0.31 0.76 0.86
6 INT125233 Binding of BCR and CD40LG 1 0.23 0.75 0.85
7 INT197115 Binding of MCF2 and RETNLB 1 0.00 1.06 0.7
8 INT206206 Binding of Mcf2l and Obfc1 1 0.02 1.11 0.64
9 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
10 INT249717 Binding of NCL and MCF2L 1 0.23 0 0.54
11 INT333512 Binding of GPI and MCF2L 1 0.09 0.75 0.41
12 INT316884 Positive_regulation of Binding of Cr2 and Bcr 1 0.06 0.86 0.31
13 INT197114 IL1B Regulation of Binding of MCF2 1 0.03 0.48 0.31
14 INT316881 Positive_regulation of Binding of Cd19 and Bcr 1 0.08 0.86 0.31
15 INT316885 Binding of Cr2 and Bcr 1 0.06 0.85 0.3
16 INT316888 Binding of Cd19 and Bcr 1 0.08 0.85 0.3
17 INT235957 Binding of Mog and Bcr 1 0.02 1.13 0.29
18 INT235962 Binding of Bcr and Trav6-3 1 0.00 1.12 0.29
19 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
20 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
21 INT312726 AASS Positive_regulation of FGD1 1 0.02 0.08 0.24
22 INT65013 SOS1 Positive_regulation of Gene_expression of PTGER2 1 0.09 0.16 0.22
23 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21
24 INT257398 Binding of FGD1 and GHRH 1 0.03 0.27 0.2
25 INT127206 Negative_regulation of Cftr Negative_regulation of Positive_regulation of Mcf2l 1 0.16 0.62 0.16
26 INT244045 Binding of Arhgef9 and Gphn 1 0.02 0.2 0.15
27 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
28 INT269548 ARHGEF17 Positive_regulation of RHOA 1 0.01 0 0.12
29 INT279804 ATP6V0A2 Regulation of MCF2 1 0.00 1.76 0.12
30 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
31 INT225743 Binding of SOS1 and RANBP9 1 0.00 0.09 0.1
32 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09
33 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08
34 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08
35 INT263743 Rasgrf1 Positive_regulation of Positive_regulation of Mapk1 1 0.11 0 0.06
36 INT263770 Rasgrf1 Positive_regulation of Positive_regulation of Grin1 1 0.24 0 0.06
37 INT263727 Binding of Grin2b and Rasgrf1 1 0.18 0 0.05
38 INT263730 Binding of Grin2a and Rasgrf1 1 0.23 0 0.05
39 INT231806 ARHGDIA Negative_regulation of ARHGEF1 1 0.02 0.11 0.04
40 INT353314 Edn1 Positive_regulation of Kalrn 1 0.03 0.21 0.04
41 INT231864 Binding of ARHGEF1 and Akt1 1 0.01 0.11 0.04
42 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03
43 INT232900 Binding of ABR and Krt8 1 0.03 0.49 0.03
44 INT287062 Gopc Positive_regulation of Positive_regulation of Vav1 1 0.18 0.15 0
45 INT225909 Binding of GRB2 and SOS1 1 0.01 0.11 0
46 INT284092 HNF1A Positive_regulation of FGD2 1 0.15 1.16 0
47 INT269546 TBXA2R Regulation of ARHGEF15 1 0.00 0 0
48 INT72209 BCR Positive_regulation of Mapk13 1 0.00 0 0
49 INT302909 Nav2 Positive_regulation of Arhgef16 1 0.02 0.52 0
50 INT218509 Binding of BCR and Cfb 1 0.00 0.18 0
51 INT232899 Krt18 Negative_regulation of Binding of ABR 1 0.05 0.68 0
52 INT203587 MCF2 Negative_regulation of Gene_expression of CPOX 1 0.00 0.6 0
53 INT199110 Vav1 Positive_regulation of Binding of Sergef 1 0.04 0.23 0
54 INT218514 BCR Negative_regulation of Binding of Cfb 1 0.00 0.18 0
55 INT294412 Binding of Vav2 and Vav3 1 0.41 0.65 0
56 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0
57 INT228118 Binding of Fyn and Vav1 1 0.11 0.21 0
58 INT303334 Binding of SOS1 and Grb2 1 0.00 0.11 0
59 INT232895 Krt18 Positive_regulation of Gene_expression of ABR 1 0.46 0.09 0
60 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0
61 INT287061 Chrm2 Positive_regulation of Phosphorylation of Vav1 1 0.14 0.15 0
62 INT288827 Binding of Rasgrf2 and Vav1 1 0.40 0.37 0
63 INT194926 Binding of CD40LG and Positive_regulation of BCR 1 0.04 0.39 0
64 INT228115 Gene_expression of Chrm2 Positive_regulation of Phosphorylation of Vav1 1 0.16 0.26 0
65 INT232896 Krt8 Negative_regulation of Binding of ABR 1 0.04 0.68 0
66 INT287075 Positive_regulation of Vav1 Positive_regulation of Gene_expression of Prdm1 1 0.14 0.15 0
67 INT232384 Binding of BCR and C6orf25 1 0.00 0.91 0
68 INT347225 Hck Regulation of Positive_regulation of Bcr 1 0.15 0.07 0
69 INT229629 Binding of BCR and PAEP 1 0.04 0.37 0
70 INT313687 Binding of BCR and IFIH1 1 0.09 0.23 0
71 INT232894 Binding of ABR and Rab27a 1 0.08 0.3 0
72 INT279803 ATP6V0A2 Negative_regulation of MCF2 1 0.00 1.95 0
73 INT183855 Binding of RHOC and ARHGEF3 1 0.02 1.8 0
74 INT288828 Binding of ras and Rasgrf2 1 0.10 0.41 0
75 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0
76 INT273197 Binding of BCR and COPD 1 0.03 0.4 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Rho guanyl-nucleotide exchange factor activity. They are ordered first by their pain relevance and then by number of times they were reported in Rho guanyl-nucleotide exchange factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT127203 Positive_regulation of Mcf2l 14 0.43 9.84 7.03
2 INT20944 Gene_expression of Mcf2l 13 0.58 5.96 4.76
3 INT34184 Localization of FGD1 7 0.65 2.68 4.21
4 INT58875 Positive_regulation of FGD1 20 0.60 3.88 4.19
5 INT127202 Negative_regulation of Mcf2l 8 0.50 6.7 4.15
6 INT151684 Gene_expression of MCF2L 7 0.54 6.25 3.76
7 INT127200 Localization of Mcf2l 7 0.64 4.8 3.25
8 INT61714 Binding of FGD1 12 0.35 7.72 2.91
9 INT158083 Gene_expression of FGD1 24 0.67 6.82 2.83
10 INT249718 Binding of MCF2L 6 0.16 3.52 2.36
11 INT149441 Positive_regulation of MCF2L 5 0.61 3.96 1.82
12 INT59790 Binding of BCR 16 0.36 15.34 1.75
13 INT106534 Gene_expression of Dock9 3 0.65 1.62 1.63
14 INT101859 Gene_expression of MCF2 34 0.49 19.45 1.51
15 INT235954 Gene_expression of Bcr 1 0.13 6.77 1.47
16 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45
17 INT42391 Positive_regulation of BCR 7 0.49 4.93 1.44
18 INT106198 Negative_regulation of Kalrn 9 0.58 6.08 1.39
19 INT32118 Regulation of Mcf2l 6 0.39 3.05 1.34
20 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22
21 INT36517 Negative_regulation of MCF2 14 0.42 6.43 1.02
22 INT316159 Regulation of FGD1 1 0.01 0.59 0.99
23 INT17554 Regulation of ABR 6 0.54 2.21 0.98
24 INT127199 Negative_regulation of Positive_regulation of Mcf2l 1 0.14 2.77 0.98
25 INT20757 Binding of MCF2 4 0.07 0.71 0.95
26 INT42390 Regulation of Positive_regulation of BCR 1 0.00 0 0.87
27 INT34188 Positive_regulation of Localization of FGD1 1 0.01 0 0.87
28 INT34185 Negative_regulation of Localization of FGD1 1 0.00 0 0.87
29 INT114176 Positive_regulation of SOS1 3 0.20 1.5 0.86
30 INT110208 Binding of ABR 2 0.35 10.49 0.81
31 INT115757 Negative_regulation of ABR 3 0.57 0.53 0.8
32 INT257400 Positive_regulation of Gene_expression of FGD1 3 0.50 0.79 0.78
33 INT22096 Negative_regulation of SOS1 4 0.25 1.63 0.71
34 INT158084 Negative_regulation of FGD1 4 0.21 1.82 0.69
35 INT191194 Localization of MCF2 7 0.11 2.29 0.65
36 INT65016 Gene_expression of SOS1 4 0.61 0.47 0.65
37 INT106533 Positive_regulation of Gene_expression of Dock9 1 0.49 0.33 0.65
38 INT2644 Gene_expression of Kalrn 3 0.54 0.33 0.62
39 INT155770 Protein_catabolism of Mcf2l 1 0.56 0.05 0.58
40 INT197117 Negative_regulation of Localization of MCF2 1 0.03 0.81 0.56
41 INT130242 Positive_regulation of Kalrn 5 0.67 1.17 0.51
42 INT273550 Positive_regulation of Bcr 14 0.68 6.71 0.49
43 INT65019 Regulation of SOS1 2 0.56 0.42 0.49
44 INT199553 Gene_expression of Bcr 25 0.76 13.83 0.48
45 INT106197 Regulation of Kalrn 2 0.31 1.11 0.48
46 INT320452 Negative_regulation of MCF2L 1 0.13 0.5 0.46
47 INT232886 Regulation of Gene_expression of ABR 3 0.06 1.42 0.45
48 INT30080 Binding of Arhgef16 1 0.11 0.54 0.45
49 INT34037 Regulation of Arhgef16 1 0.15 0.6 0.45
50 INT273555 Negative_regulation of Bcr 17 0.57 9.65 0.44
51 INT21353 Binding of Mcf2l 3 0.38 1.03 0.43
52 INT127085 Regulation of Gene_expression of Dock9 1 0.17 0.95 0.41
53 INT127201 Regulation of Negative_regulation of Mcf2l 1 0.09 0.96 0.39
54 INT75496 Positive_regulation of MCF2 7 0.08 3.86 0.38
55 INT333516 Regulation of MCF2L 1 0.09 0.82 0.37
56 INT193674 Binding of Bcr 10 0.47 4.3 0.36
57 INT235948 Regulation of Gene_expression of Bcr 1 0.08 1.58 0.36
58 INT340381 Transcription of FGD1 1 0.07 0.35 0.35
59 INT199557 Positive_regulation of Gene_expression of Bcr 6 0.68 4.21 0.3
60 INT129166 Positive_regulation of Bcr 2 0.28 1.18 0.29
61 INT169371 Positive_regulation of Positive_regulation of Mcf2l 1 0.43 0.78 0.28
62 INT65017 Negative_regulation of Gene_expression of SOS1 1 0.39 0.16 0.23
63 INT65022 Positive_regulation of Gene_expression of SOS1 1 0.45 0.16 0.22
64 INT192748 Localization of BCR 4 0.68 2.4 0.18
65 INT347214 Positive_regulation of Negative_regulation of Bcr 1 0.38 1.43 0.17
66 INT119070 Phosphorylation of SOS1 2 0.79 0.94 0.15
67 INT191179 Regulation of MCF2 12 0.06 8.54 0.14
68 INT129165 Positive_regulation of Binding of Bcr 1 0.00 0.59 0.14
69 INT129167 Binding of Bcr 1 0.00 0.59 0.14
70 INT149302 Regulation of ARHGEF3 1 0.14 1.02 0.14
71 INT149301 Binding of ARHGEF3 1 0.20 1.02 0.14
72 INT232877 Negative_regulation of Binding of ABR 1 0.06 1.88 0.14
73 INT232880 Phosphorylation of ABR 1 0.79 0.76 0.13
74 INT232875 Negative_regulation of Phosphorylation of ABR 1 0.41 0.76 0.13
75 INT269636 Phosphorylation of ARHGEF17 1 0.02 0 0.12
76 INT320145 Negative_regulation of Phosphorylation of Bcr 2 0.35 0.23 0.11
77 INT320147 Phosphorylation of Bcr 2 0.67 0.64 0.11
78 INT171092 Positive_regulation of Gene_expression of MCF2 6 0.05 1.57 0.1
79 INT25530 Positive_regulation of ABR 3 0.33 0.34 0.1
80 INT249113 Localization of Bcr 1 0.57 0.08 0.1
81 INT149303 Positive_regulation of ARHGEF3 1 0.37 0.77 0.1
82 INT241421 Negative_regulation of Rgnef 1 0.11 0.12 0.1
83 INT316168 Negative_regulation of Negative_regulation of FGD1 1 0.01 0 0.1
84 INT149306 Negative_regulation of ARHGEF3 1 0.23 0.8 0.1
85 INT328094 Positive_regulation of Gene_expression of ABR 1 0.33 0 0.09
86 INT257399 Phosphorylation of FGD1 1 0.54 0.2 0.09
87 INT346319 Negative_regulation of Gene_expression of Mcf2l 1 0.19 0 0.09
88 INT130240 Transcription of Kalrn 1 0.62 0 0.09
89 INT294408 Positive_regulation of Vav2 1 0.50 0.7 0.08
90 INT347217 Negative_regulation of Gene_expression of Bcr 1 0.35 0.17 0.08
91 INT130238 Regulation of Positive_regulation of Kalrn 1 0.24 0 0.08
92 INT199072 Negative_regulation of Vav1 2 0.58 9.64 0.07
93 INT232885 Positive_regulation of Binding of ABR 1 0.07 0.5 0.07
94 INT270629 Gene_expression of Vav3 3 0.78 9.71 0.06
95 INT294400 Transcription of Vav2 1 0.53 0 0.06
96 INT294404 Transcription of Vav3 1 0.53 0 0.06
97 INT294398 Gene_expression of Vav2 1 0.78 10.67 0.06
98 INT184012 Protein_catabolism of Vav1 1 0.96 0.34 0.05
99 INT184064 Regulation of Protein_catabolism of Vav1 1 0.26 0.34 0.05
100 INT269655 Positive_regulation of ARHGEF17 1 0.02 0 0.04
101 INT288817 Negative_regulation of Rasgrf2 1 0.58 6.19 0.04
102 INT320146 Regulation of Gene_expression of Bcr 1 0.37 0.07 0.04
103 INT249116 Regulation of Bcr 1 0.24 0.33 0.04
104 INT191178 Negative_regulation of Regulation of MCF2 1 0.02 0.37 0.04
105 INT199080 Localization of Vav1 2 0.66 1.74 0.03
106 INT78141 Localization of Kalrn 2 0.44 0.63 0.03
107 INT153880 Negative_regulation of Negative_regulation of Kalrn 1 0.41 0.44 0.03
108 INT199101 Positive_regulation of Localization of Vav1 1 0.18 0.34 0.03
109 INT228104 Gene_expression of Vav1 13 0.77 12.18 0
110 INT287041 Binding of Vav1 6 0.37 3.4 0
111 INT136181 Negative_regulation of BCR 5 0.42 2.94 0
112 INT151794 Gene_expression of ARHGEF1 4 0.49 0 0
113 INT199095 Phosphorylation of Vav1 3 0.42 0.6 0
114 INT287052 Positive_regulation of Vav1 2 0.50 3.51 0
115 INT201927 Regulation of BCR 2 0.26 1.94 0
116 INT294394 Negative_regulation of Gene_expression of Vav2 1 0.43 0.77 0
117 INT294407 Positive_regulation of Negative_regulation of Vav3 1 0.50 0.73 0
118 INT287053 Phosphorylation of Vav2 1 0.43 0 0
119 INT288812 Regulation of Gene_expression of Vav1 1 0.45 3.41 0
120 INT320148 Negative_regulation of Negative_regulation of Bcr 1 0.35 0.2 0
121 INT273551 Positive_regulation of Binding of Bcr 1 0.49 1.03 0
122 INT288808 Positive_regulation of Transcription of Rasgrf2 1 0.46 0.88 0
123 INT199088 Positive_regulation of Phosphorylation of Vav1 1 0.18 0.25 0
124 INT294396 Regulation of Vav2 1 0.45 1.43 0
125 INT288801 Regulation of Rasgrf2 1 0.27 1.12 0
126 INT273557 Transcription of Bcr 1 0.70 0.3 0
127 INT129750 Regulation of Localization of Kalrn 1 0.25 0 0
128 INT339687 Positive_regulation of ARHGEF1 1 0.03 0.44 0
129 INT201926 Phosphorylation of BCR 1 0.36 0.5 0
130 INT218478 Transcription of BCR 1 0.01 0.32 0
131 INT232881 Regulation of Binding of ABR 1 0.07 1.43 0
132 INT129754 Positive_regulation of Localization of Kalrn 1 0.28 0 0
133 INT339689 Positive_regulation of Positive_regulation of ARHGEF1 1 0.03 0.44 0
134 INT294409 Regulation of Vav3 1 0.45 1.42 0
135 INT232878 Protein_catabolism of ABR 1 0.96 0.09 0
136 INT294397 Regulation of Binding of Vav3 1 0.45 0.87 0
137 INT273544 Negative_regulation of Transcription of Bcr 1 0.42 0.3 0
138 INT288819 Negative_regulation of Transcription of Vav1 1 0.42 1.23 0
139 INT288804 Transcription of Vav1 1 0.68 3.37 0
140 INT288816 Regulation of Gene_expression of Rasgrf2 1 0.61 5.36 0
141 INT288800 Negative_regulation of Gene_expression of Rasgrf2 1 0.58 0.88 0
142 INT288799 Binding of Rasgrf2 1 0.37 0.84 0
143 INT288803 Positive_regulation of Gene_expression of Vav1 1 0.50 1.05 0
144 INT288820 Transcription of Rasgrf2 1 0.68 3.93 0
145 INT129749 Phosphorylation of Kalrn 1 0.35 0 0
146 INT294403 Localization of Vav3 1 0.80 0.96 0
147 INT288805 Positive_regulation of Rasgrf2 1 0.69 0.88 0
148 INT343180 Positive_regulation of Negative_regulation of MCF2 1 0.01 0.1 0
149 INT273549 Negative_regulation of Binding of Bcr 1 0.42 0.24 0
150 INT232884 Localization of ABR 1 0.10 1.05 0
151 INT294004 Transcription of MCF2 1 0.00 0.82 0
152 INT288818 Gene_expression of Rasgrf2 1 0.77 12.76 0
153 INT294401 Localization of Vav2 1 0.80 0.97 0
154 INT288813 Positive_regulation of Gene_expression of Rasgrf2 1 0.69 1.23 0
155 INT232882 Transcription of ABR 1 0.09 0.61 0
156 INT259507 Regulation of Bcr 1 0.26 0.38 0
157 INT294406 Positive_regulation of Negative_regulation of Vav2 1 0.50 0.73 0
158 INT294395 Binding of Vav2 1 0.48 0.82 0
159 INT294402 Binding of Vav3 1 0.48 2.43 0
160 INT232876 Positive_regulation of Localization of ABR 1 0.07 0.24 0
161 INT288814 Regulation of Vav1 1 0.12 1.12 0
162 INT294399 Negative_regulation of Vav3 1 0.59 1.59 0
163 INT232874 Negative_regulation of Localization of ABR 1 0.06 0.24 0
164 INT288806 Negative_regulation of Transcription of Rasgrf2 1 0.42 1.01 0
165 INT288802 Regulation of Negative_regulation of Rasgrf2 1 0.27 0.8 0
166 INT294405 Negative_regulation of Vav2 1 0.59 1.58 0
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