GO:0005097

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Name Rab GTPase activator activity
Categary Function
Go Slim No
Go Link GO:0005097
Unique Molecular Interactions 42
Total Molecular Interactions 52
Total Single Events 414
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Rab GTPase activator activity. They are ordered first by their pain relevance and then by number of times they were reported for Rab GTPase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT201241 Positive_regulation of GDI2 Positive_regulation of Regulation of AGFG1 1 0.01 0 0.82
2 INT150863 Grtp1 Negative_regulation of Gpt 1 0.09 0.58 0.71
3 INT155610 FPR1 Positive_regulation of Phosphorylation of SGSM3 1 0.04 0.68 0.71
4 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 0.43 0.1 0.62
5 INT2686 Binding of Thra and SGSM3 1 0.36 0.1 0.61
6 INT69826 Binding of SST and TBC1D4 1 0.08 1.49 0.56
7 INT202969 Positive_regulation of SGSM3 Positive_regulation of MCRS1 1 0.02 1.22 0.47
8 INT202964 SGSM3 Positive_regulation of MCRS1 1 0.03 1.21 0.47
9 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
10 INT109282 Gdi2 Negative_regulation of Gtpbp4 1 0.01 0.13 0.32
11 INT122873 SEMA6A Positive_regulation of SGSM3 1 0.54 0 0.26
12 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15
13 INT253123 Il6 Positive_regulation of Phosphorylation of Tbc1d4 1 0.38 0.63 0.15
14 INT71301 Gdi2 Negative_regulation of Tk1 1 0.00 0.21 0.12
15 INT253141 Ins1 Positive_regulation of Phosphorylation of Tbc1d4 1 0.09 0.29 0.09
16 INT253148 Ins1 Regulation of Phosphorylation of Tbc1d4 1 0.09 0.42 0.09
17 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
18 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
19 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
20 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
21 INT246784 Negative_regulation of Tsc2 Positive_regulation of Negative_regulation of Ogg1 1 0.20 0.43 0
22 INT246811 Ros1 Positive_regulation of Tsc2 1 0.02 0 0
23 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
24 INT246794 Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.03 0.66 0
25 INT260578 Binding of IGHG3 and SGSM3 1 0.00 1.07 0
26 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
27 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
28 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
29 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0
30 INT246809 Negative_regulation of Tsc2 Positive_regulation of Positive_regulation of Ogg1 1 0.20 0.45 0
31 INT246801 Negative_regulation of Akt1 Negative_regulation of Phosphorylation of Tsc2 1 0.17 0 0
32 INT246792 Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.78 0
33 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0
34 INT246798 Akt1 Regulation of Tsc2 1 0.16 0.34 0
35 INT260577 Binding of ALPP and SGSM3 1 0.00 1.06 0
36 INT22675 Binding of USP6 and PNMA1 1 0.02 0 0
37 INT246797 Tgfb1i1 Positive_regulation of Phosphorylation of Tsc2 1 0.01 0.66 0
38 INT246806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.32 0
39 INT122536 FGF2 Positive_regulation of Positive_regulation of SGSM3 1 0.73 0 0
40 INT246803 Binding of Akt1 and Tsc2 1 0.14 0.85 0
41 INT246790 Gene_expression of Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.02 0 0
42 INT246800 Binding of Tsc2 and Ogg1 1 0.16 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Rab GTPase activator activity. They are ordered first by their pain relevance and then by number of times they were reported in Rab GTPase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31
2 INT75521 Positive_regulation of Positive_regulation of SGSM3 13 0.67 7.99 13.54
3 INT10654 Negative_regulation of SGSM3 31 0.57 12.24 11.7
4 INT87644 Phosphorylation of SGSM3 12 0.80 2.08 7.04
5 INT75250 Negative_regulation of Positive_regulation of SGSM3 5 0.57 2.47 5.24
6 INT75530 Regulation of SGSM3 11 0.60 7.22 4.48
7 INT38859 Gene_expression of SGSM3 14 0.75 12.98 4.09
8 INT85233 Localization of SGSM3 11 0.78 10.91 3.41
9 INT116078 Positive_regulation of Phosphorylation of SGSM3 4 0.67 0.09 3.24
10 INT38858 Positive_regulation of Gene_expression of SGSM3 5 0.49 4.15 3.05
11 INT102763 Gene_expression of TBC1D4 3 0.03 0.81 2.76
12 INT98662 Negative_regulation of Phosphorylation of SGSM3 2 0.57 0.52 1.58
13 INT2683 Binding of SGSM3 6 0.36 7.98 1.2
14 INT98175 Regulation of Regulation of SGSM3 1 0.44 0.87 0.81
15 INT85234 Regulation of Negative_regulation of SGSM3 1 0.26 1.13 0.79
16 INT253116 Phosphorylation of Tbc1d4 1 0.47 2.08 0.77
17 INT201253 Positive_regulation of GDI2 1 0.27 0 0.76
18 INT108772 Negative_regulation of Gdi2 1 0.08 0.42 0.67
19 INT98660 Positive_regulation of Localization of SGSM3 2 0.45 1.67 0.62
20 INT69829 Binding of TBC1D4 1 0.07 1.49 0.56
21 INT201255 Binding of GDI2 2 0.17 0.2 0.55
22 INT122644 Phosphorylation of Gdi2 1 0.16 0.07 0.39
23 INT33881 Negative_regulation of Gdi2 1 0.01 0 0.37
24 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
25 INT253115 Negative_regulation of Phosphorylation of Tbc1d4 1 0.34 0.44 0.24
26 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
27 INT98661 Negative_regulation of Localization of SGSM3 1 0.41 0.52 0.2
28 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12
29 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12
30 INT246772 Regulation of Phosphorylation of Tsc2 1 0.26 1.37 0.09
31 INT238567 Gene_expression of Syngap1 1 0.47 0.15 0.08
32 INT225725 Phosphorylation of RAB3GAP1 1 0.04 0.33 0.06
33 INT225724 Positive_regulation of RAB3GAP1 1 0.03 0.34 0.06
34 INT246770 Positive_regulation of Negative_regulation of Tsc2 1 0.20 1.91 0.05
35 INT253112 Regulation of Phosphorylation of Tbc1d4 1 0.26 0.07 0.04
36 INT119227 Gene_expression of Tsc2 8 0.68 10.67 0.03
37 INT260582 Transcription of SGSM3 1 0.05 1.55 0.03
38 INT253113 Gene_expression of Tbc1d4 1 0.13 0.07 0.03
39 INT176155 Gene_expression of USP6 7 0.65 1.84 0
40 INT246774 Positive_regulation of Tsc2 6 0.41 2.4 0
41 INT228895 Binding of Tsc2 5 0.30 2.41 0
42 INT246755 Regulation of Tsc2 4 0.50 1.01 0
43 INT196297 Localization of USP6 2 0.73 0.33 0
44 INT258049 Phosphorylation of TBC1D4 2 0.01 1.02 0
45 INT300048 Binding of USP6 2 0.47 0.51 0
46 INT246761 Positive_regulation of Gene_expression of Tsc2 2 0.41 1.17 0
47 INT246777 Regulation of Gene_expression of Tsc2 1 0.19 0 0
48 INT128359 Positive_regulation of Negative_regulation of SGSM3 1 0.45 0 0
49 INT246754 Negative_regulation of Binding of Tsc2 1 0.18 0.12 0
50 INT119082 Negative_regulation of Gene_expression of SGSM3 1 0.41 0 0
51 INT246747 Negative_regulation of Negative_regulation of Tsc2 1 0.18 0.56 0
52 INT246780 Protein_catabolism of Tsc2 1 0.28 0.15 0
53 INT246752 Negative_regulation of Gene_expression of Tsc2 1 0.25 0.52 0
54 INT246759 Positive_regulation of Phosphorylation of Tsc2 1 0.29 9.31 0
55 INT246751 Positive_regulation of Binding of Tsc2 1 0.21 0.15 0
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