GO:0005112

From wiki-pain
Jump to: navigation, search
Name Notch binding
Categary Function
Go Slim No
Go Link GO:0005112
Unique Molecular Interactions 103
Total Molecular Interactions 142
Total Single Events 777
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Notch binding. They are ordered first by their pain relevance and then by number of times they were reported for Notch binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 0.02 2.15 3.12
2 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9
3 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
4 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
5 INT149632 Binding of HK1 and NCOR2 1 0.01 0.13 1.58
6 INT27932 Binding of CCK and NCOR2 1 0.01 0.91 1.47
7 INT54737 PPBP Regulation of NCOR2 1 0.01 0.15 1.01
8 INT52761 Dll1 Regulation of Sptan1 1 0.07 0 0.89
9 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
10 INT239533 Binding of MTNR1A and NCOR2 1 0.01 0.53 0.87
11 INT292987 SGCG Positive_regulation of NCOR2 1 0.00 0.29 0.87
12 INT97913 NCOR2 Regulation of ABAT 1 0.00 0 0.85
13 INT151882 Binding of YY1 and DLL1 1 0.00 0 0.79
14 INT151883 Negative_regulation of Binding of YY1 and DLL1 1 0.00 0 0.79
15 INT56895 Binding of GNRH1 and NCOR2 1 0.02 0 0.76
16 INT98770 Binding of Dll1 and Gt(pU21)50Imeg 1 0.05 0 0.74
17 INT75399 Regulation of Binding of Dll1 and Oprd1 1 0.08 0 0.74
18 INT98771 Binding of Dll1 and Oprm1 1 0.29 0 0.74
19 INT75398 Binding of Dll1 and Oprd1 1 0.11 0 0.74
20 INT148381 UFM1 Positive_regulation of JAG1 1 0.00 1.13 0.63
21 INT148379 UFM1 Positive_regulation of DLL1 1 0.00 1.13 0.63
22 INT86644 Binding of OPRD1 and DLL1 1 0.28 0.17 0.58
23 INT81267 Negative_regulation of Binding of MLN and NCOR2 1 0.02 0.28 0.56
24 INT172248 Binding of KNG1 and NCOR2 1 0.02 0.19 0.52
25 INT81265 Binding of MLN and NCOR2 1 0.02 0.23 0.51
26 INT70183 Binding of PRCP and NCOR2 1 0.04 0.08 0.46
27 INT172238 Binding of NPBWR2 and NCOR2 1 0.01 0.27 0.44
28 INT172247 Binding of NCOR2 and QRFPR 1 0.01 0.12 0.43
29 INT76154 Binding of NCOR2 and Negative_regulation of Localization of PLOD1 1 0.02 0 0.42
30 INT76153 Binding of NCOR2 and Negative_regulation of Localization of LHB 1 0.00 0 0.42
31 INT99122 Binding of Cacna2d3 and DLL1 1 0.02 0 0.41
32 INT282820 Binding of TACR1 and NCOR2 1 0.00 0.88 0.39
33 INT75643 NCOR2 Positive_regulation of Positive_regulation of EIF2B3 1 0.00 0 0.33
34 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32
35 INT56250 Binding of NBN and NCOR2 1 0.00 0 0.3
36 INT130108 DLL3 Negative_regulation of Positive_regulation of MAPK1 1 0.13 0 0.28
37 INT172240 Binding of GPR37 and NCOR2 1 0.01 0 0.27
38 INT279278 NCOR2 Regulation of CDCP1 1 0.00 5.41 0.25
39 INT88191 Binding of NCOR2 and ZAK 1 0.00 0.17 0.21
40 INT239536 Binding of CXCR2 and NCOR2 1 0.00 0 0.2
41 INT172245 Binding of ADM and NCOR2 1 0.01 0 0.15
42 INT136606 Binding of RAN and DLL1 1 0.33 0.45 0.15
43 INT254488 Dtx1 Regulation of Sorbs1 1 0.01 0 0.12
44 INT254490 Dtx1 Regulation of Gopc 1 0.04 0 0.12
45 INT29223 Binding of NCOR2 and CALCRL 1 0.00 0 0.1
46 INT254492 Dtx1 Regulation of Cldn11 1 0.03 0 0.09
47 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
48 INT268673 Binding of NCOR2 and BCOR 1 0.01 2.54 0.07
49 INT351422 Mfng Negative_regulation of Jag1 1 0.06 1.29 0.07
50 INT268675 Binding of NCOR2 and SIN3A 1 0.27 2.54 0.07
51 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
52 INT279276 PDGFA Positive_regulation of NCOR2 1 0.00 1.02 0.06
53 INT328293 Binding of JAG2 and GHS 1 0.03 0.09 0.05
54 INT328365 Binding of JAG2 and Ghrl 1 0.03 0.07 0.05
55 INT303393 Binding of Jag1 and Tceb2 1 0.03 0.29 0.04
56 INT332483 Binding of JAG1 and SGPP2 1 0.21 0.23 0.04
57 INT303389 Binding of Jag1 and Cul5 1 0.20 0.29 0.04
58 INT302974 Nqo1 Positive_regulation of Jag2 1 0.00 0.45 0.04
59 INT316060 Binding of Erbb4 and Ncor2 1 0.12 0.41 0.03
60 INT172252 Binding of GPR4 and NCOR2 1 0.01 0 0.03
61 INT279288 PDGFB Positive_regulation of NCOR2 1 0.00 0.52 0.03
62 INT172242 Binding of NCOR2 and P2RY13 1 0.01 0 0.03
63 INT172233 Binding of GPR68 and NCOR2 1 0.01 0 0.03
64 INT292081 Binding of EDN1 and NCOR2 1 0.00 0.98 0.03
65 INT173055 Binding of VEGFA and NCOR2 1 0.02 0.34 0.03
66 INT316056 Binding of Ncor2 and Tab2 1 0.12 0.41 0.03
67 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
68 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
69 INT233905 PPARA Positive_regulation of Localization of NCOR2 1 0.01 0.19 0
70 INT303397 Binding of Jag1 and Gopc 1 0.13 0 0
71 INT303398 Jag1 Positive_regulation of Protein_catabolism of Myh3 1 0.52 0 0
72 INT303405 Binding of NPAT and Jag1 1 0.39 0 0
73 INT227218 Binding of JAG1 and CD8A 1 0.05 0.5 0
74 INT273886 Binding of Dll1 and Trip12 1 0.34 0.1 0
75 INT303404 Binding of TCAP and Jag1 1 0.39 0 0
76 INT189549 Binding of RUNX1T1 and NCOR2 1 0.02 0.58 0
77 INT320824 VEGFA Positive_regulation of DLL4 1 0.40 0.41 0
78 INT130900 Jag2 Regulation of Localization of Ifng 1 0.01 0.05 0
79 INT130901 Jag2 Negative_regulation of Positive_regulation of Kitl 1 0.00 0.05 0
80 INT303399 Binding of Jag1 and Myh3 1 0.50 0.85 0
81 INT320825 VEGFA Positive_regulation of Gene_expression of DLL4 1 0.40 0.41 0
82 INT130903 Jag2 Negative_regulation of Positive_regulation of Il6 1 0.01 0.06 0
83 INT303391 Binding of Jag1 and Tceb1 1 0.44 0 0
84 INT354427 Binding of NCOR2 and ANGPTL4 1 0.34 0.07 0
85 INT235167 Binding of Hdac3 and Ncor2 1 0.01 0.28 0
86 INT303386 Binding of Jag1 and Laptm5 1 0.02 0 0
87 INT235164 Binding of Atxn1 and Ncor2 1 0.15 0.42 0
88 INT130899 Jag2 Negative_regulation of Ifng 1 0.03 0.05 0
89 INT303390 Binding of Jag1 and Myo1f 1 0.07 0 0
90 INT354428 Positive_regulation of Binding of NCOR2 and ANGPTL4 1 0.44 0.07 0
91 INT303400 Jag1 Positive_regulation of Protein_catabolism of Gopc 1 0.25 0 0
92 INT130902 Jag2 Regulation of Localization of Il2 1 0.01 0.05 0
93 INT303395 Positive_regulation of Binding of Jag1 and Myo1f 1 0.07 0 0
94 INT273887 Binding of Jag1 and Notch2 1 0.02 1.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Notch binding. They are ordered first by their pain relevance and then by number of times they were reported in Notch binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6855 Binding of NCOR2 71 0.41 15.64 28.96
2 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23
3 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54
4 INT40478 Negative_regulation of NCOR2 23 0.48 12.77 14.56
5 INT50056 Positive_regulation of Dll1 13 0.67 3.16 13.7
6 INT56883 Positive_regulation of Dll1 8 0.49 3.49 12.25
7 INT56884 Gene_expression of Dll1 9 0.48 1.15 8.98
8 INT56019 Gene_expression of Dll1 11 0.78 3.38 8.71
9 INT29229 Regulation of NCOR2 20 0.42 5.75 8.08
10 INT55859 Binding of Dll1 6 0.35 0 7.64
11 INT58607 Negative_regulation of Dll1 9 0.43 1.89 7.06
12 INT70287 Positive_regulation of Gene_expression of Dll1 6 0.70 3.58 6.55
13 INT71406 Regulation of Dll1 3 0.35 0.79 4.44
14 INT10542 Gene_expression of DLL1 16 0.71 3.7 4.21
15 INT40036 Binding of DLL1 10 0.36 2.88 3.95
16 INT72179 Negative_regulation of Dll1 5 0.33 4.09 3.84
17 INT62678 Negative_regulation of JAG1 8 0.41 6.95 3.5
18 INT49190 Regulation of Dll1 3 0.44 0.26 3.24
19 INT55148 Binding of Dll1 5 0.48 0.66 2.97
20 INT66891 Negative_regulation of Positive_regulation of Dll1 1 0.41 0 2.72
21 INT43483 Gene_expression of DLL4 7 0.60 0.89 2.59
22 INT67329 Positive_regulation of Positive_regulation of Dll1 2 0.32 0 2.56
23 INT29228 Negative_regulation of Binding of NCOR2 4 0.02 0.62 2.47
24 INT132315 Positive_regulation of DLL1 6 0.67 3.4 2.45
25 INT87028 Positive_regulation of Positive_regulation of NCOR2 4 0.01 0.92 2.09
26 INT130112 Gene_expression of DLL3 1 0.25 0 2
27 INT303352 Gene_expression of Jag1 19 0.73 7.68 1.89
28 INT159099 Negative_regulation of Positive_regulation of Dll1 1 0.25 0.74 1.76
29 INT159100 Regulation of Positive_regulation of Dll1 1 0.26 0.7 1.73
30 INT54738 Negative_regulation of Negative_regulation of NCOR2 2 0.37 1.01 1.7
31 INT159098 Negative_regulation of Gene_expression of Dll1 1 0.18 0.62 1.65
32 INT52757 Localization of Dll1 1 0.20 0 1.6
33 INT117033 Gene_expression of JAG1 13 0.65 11.46 1.52
34 INT105296 Regulation of DLL1 3 0.11 0.77 1.43
35 INT190880 Binding of Ncor2 11 0.27 2.24 1.34
36 INT303362 Regulation of Jag1 2 0.22 2.91 1.22
37 INT133371 Negative_regulation of Binding of Dll1 1 0.41 0.5 1.22
38 INT232639 Positive_regulation of Jag2 4 0.14 10.63 1.03
39 INT99121 Transcription of DLL1 1 0.14 0 1.02
40 INT98171 Binding of DLL4 2 0.23 0.1 1.01
41 INT81269 Negative_regulation of Positive_regulation of NCOR2 1 0.02 0.54 0.8
42 INT29230 Regulation of Binding of NCOR2 2 0.08 0 0.79
43 INT303347 Positive_regulation of Gene_expression of Jag1 6 0.65 4.06 0.77
44 INT99120 Positive_regulation of Transcription of DLL1 1 0.10 0 0.77
45 INT98172 Regulation of Binding of DLL4 1 0.14 0.1 0.71
46 INT139089 Negative_regulation of Gene_expression of Dll1 2 0.43 0 0.69
47 INT74781 Regulation of JAG1 6 0.39 2.75 0.63
48 INT148382 Positive_regulation of JAG1 5 0.23 3.88 0.63
49 INT151401 Localization of JAG1 4 0.65 1.88 0.58
50 INT173078 Phosphorylation of NCOR2 2 0.04 0.44 0.57
51 INT69761 Gene_expression of Jag2 5 0.67 6.17 0.53
52 INT232640 Binding of Jag2 1 0.12 4.1 0.49
53 INT151400 Binding of JAG1 14 0.37 7.96 0.39
54 INT173095 Positive_regulation of Gene_expression of NCOR2 3 0.39 2.83 0.39
55 INT130109 Negative_regulation of Gene_expression of DLL3 1 0.14 0 0.38
56 INT130110 Regulation of Gene_expression of DLL3 1 0.20 0 0.33
57 INT232637 Localization of Jag2 2 0.21 2.07 0.32
58 INT172303 Localization of NCOR2 6 0.06 1.3 0.3
59 INT10543 Negative_regulation of DLL1 3 0.14 0.67 0.3
60 INT69762 Negative_regulation of Jag2 1 0.42 0.07 0.3
61 INT238367 Positive_regulation of Binding of Ncor2 1 0.11 0.32 0.27
62 INT273867 Binding of Jag1 18 0.45 3.14 0.25
63 INT130115 Positive_regulation of DLL3 1 0.07 0 0.25
64 INT303374 Negative_regulation of Jag1 2 0.48 0.9 0.23
65 INT254481 Regulation of Dtx1 1 0.04 0 0.16
66 INT136609 Positive_regulation of Binding of DLL1 1 0.49 0.45 0.15
67 INT236573 Positive_regulation of Ncor2 1 0.49 1.06 0.15
68 INT238365 Negative_regulation of Binding of Ncor2 1 0.09 0.26 0.14
69 INT136922 Positive_regulation of Gene_expression of DLL1 2 0.46 1.28 0.13
70 INT136919 Negative_regulation of Gene_expression of DLL1 1 0.54 0.3 0.13
71 INT262100 Gene_expression of Ncor2 3 0.42 0.31 0.12
72 INT29227 Positive_regulation of Binding of NCOR2 2 0.03 0.33 0.12
73 INT136924 Positive_regulation of JAG2 1 0.04 0.34 0.1
74 INT302950 Negative_regulation of Gene_expression of Jag2 1 0.08 1.42 0.09
75 INT302960 Positive_regulation of Protein_catabolism of Jag2 1 0.08 0.87 0.07
76 INT302941 Protein_catabolism of Jag2 1 0.11 0.86 0.07
77 INT243508 Negative_regulation of Dtx1 1 0.01 0.55 0.06
78 INT302958 Negative_regulation of Positive_regulation of Jag2 1 0.08 0.51 0.06
79 INT328343 Gene_expression of JAG2 1 0.09 0.08 0.05
80 INT328345 Localization of JAG2 1 0.10 0.08 0.05
81 INT219231 Positive_regulation of Gene_expression of JAG1 1 0.40 1.18 0.05
82 INT328339 Binding of JAG2 1 0.06 0.09 0.05
83 INT302959 Positive_regulation of Positive_regulation of Jag2 1 0.10 0.24 0.04
84 INT302966 Positive_regulation of Gene_expression of Jag2 1 0.08 0.4 0.04
85 INT316040 Localization of Ncor2 2 0.28 0.57 0.03
86 INT268694 Regulation of Gene_expression of NCOR2 2 0.42 1.27 0.03
87 INT233914 Positive_regulation of Localization of NCOR2 1 0.04 0.2 0.03
88 INT303349 Positive_regulation of Jag1 5 0.57 1.23 0
89 INT286388 Transcription of Jag1 2 0.65 0.64 0
90 INT320826 Positive_regulation of DLL4 1 0.39 0.41 0
91 INT320829 Negative_regulation of DLL4 1 0.45 2.26 0
92 INT307205 Regulation of Binding of Ncor2 1 0.28 0.1 0
93 INT354435 Negative_regulation of Gene_expression of NCOR2 1 0.54 0.16 0
94 INT303366 Negative_regulation of Gene_expression of Jag1 1 0.55 0.48 0
95 INT320828 Regulation of DLL4 1 0.21 0.46 0
96 INT303370 Protein_catabolism of Jag1 1 0.62 0.05 0
97 INT257560 Regulation of Negative_regulation of JAG1 1 0.13 0.48 0
98 INT303356 Localization of Jag1 1 0.70 0.09 0
99 INT303348 Positive_regulation of Transcription of Jag1 1 0.44 0.64 0
100 INT303353 Negative_regulation of Binding of Jag1 1 0.40 0 0
101 INT303367 Negative_regulation of Positive_regulation of Jag1 1 0.35 0.28 0
102 INT340580 Regulation of Localization of Jag2 1 0.01 0.32 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox