GO:0005123

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Name death receptor binding
Categary Function
Go Slim No
Go Link GO:0005123
Unique Molecular Interactions 49
Total Molecular Interactions 57
Total Single Events 260
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for death receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for death receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT161048 Nrm Positive_regulation of Prdm4 1 0.56 1.47 0.86
2 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
3 INT88024 Ifng Positive_regulation of Gene_expression of Faslg 2 0.50 1.19 0.53
4 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
5 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
6 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
7 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
8 INT355018 Binding of FAS and Faslg 1 0.12 1.34 0.37
9 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
10 INT145284 Msr1 Negative_regulation of FEM1B 1 0.01 0 0.29
11 INT31507 FEM1B Positive_regulation of Localization of POMC 1 0.51 0 0.29
12 INT31508 FEM1B Positive_regulation of Gene_expression of CRH 1 0.54 0 0.28
13 INT31505 CRH Positive_regulation of Gene_expression of FEM1B 1 0.54 0 0.28
14 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
15 INT348789 Positive_regulation of Binding of MYD88 and Tlr4 1 0.46 0.93 0.2
16 INT88022 Tnf Positive_regulation of Gene_expression of Faslg 1 0.26 0.76 0.2
17 INT234720 Cxcl1 Positive_regulation of Gene_expression of Faslg 1 0.08 0.2 0.16
18 INT234719 Cxcl1 Regulation of Gene_expression of Faslg 1 0.08 0.2 0.15
19 INT346501 MYD88 Positive_regulation of Nfkb1 1 0.01 0.5 0.13
20 INT254227 Binding of Ripk1 and Ticam1 3 0.07 0.18 0.11
21 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1
22 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
23 INT343858 Binding of AKT1 and MYD88 1 0.02 0.26 0.1
24 INT277090 VEGFA Positive_regulation of Negative_regulation of Faslg 1 0.02 1.67 0.09
25 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
26 INT251566 Binding of Ripk1 and Gtf3a 1 0.00 0.67 0.08
27 INT350802 Binding of MYD88 and TLR3 1 0.01 0 0.04
28 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
29 INT290313 Binding of MYD88 and TLR7 1 0.03 0.1 0.03
30 INT185851 BID Positive_regulation of BAK1 1 0.43 0.73 0
31 INT323703 FADD Positive_regulation of FAS 1 0.26 0.75 0
32 INT185854 BID Positive_regulation of BAD 1 0.39 0.74 0
33 INT338013 Binding of Ngfrap1 and Ngfr 1 0.06 1.3 0
34 INT336035 Positive_regulation of CASP8 Positive_regulation of BID 1 0.03 0.5 0
35 INT292566 Binding of TNFRSF1A and MADD 1 0.05 0.09 0
36 INT237918 BID Positive_regulation of Gene_expression of BAX 1 0.04 1.31 0
37 INT201763 BID Positive_regulation of Positive_regulation of Bax 1 0.01 0.43 0
38 INT185850 BID Positive_regulation of BAX 1 0.41 0.73 0
39 INT292559 Binding of TNFRSF1A and FADD 1 0.05 0.09 0
40 INT198005 Binding of BID and MCL1 1 0.24 2.04 0
41 INT198023 Binding of BAK1 and BID 1 0.12 0.82 0
42 INT292564 Binding of TNFRSF1A and RIPK1 1 0.06 0.09 0
43 INT237917 BID Positive_regulation of Positive_regulation of BAX 1 0.04 1.31 0
44 INT336034 CASP8 Positive_regulation of BID 1 0.03 0.5 0
45 INT193341 auditory Positive_regulation of CASP8AP2 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for death receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in death receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86851 Gene_expression of Faslg 45 0.75 24.42 9.21
2 INT88019 Positive_regulation of Gene_expression of Faslg 16 0.67 11.31 5.05
3 INT104928 Positive_regulation of BID 10 0.67 6.9 3.41
4 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15
5 INT158827 Positive_regulation of FADD 7 0.43 2.6 2.54
6 INT93395 Transcription of Faslg 6 0.51 5.64 2.26
7 INT88016 Negative_regulation of Gene_expression of Faslg 5 0.54 2.18 1.93
8 INT102147 Negative_regulation of Faslg 5 0.19 4.56 1.92
9 INT93394 Positive_regulation of Transcription of Faslg 1 0.24 3.57 1.57
10 INT134148 Gene_expression of FADD 4 0.66 3.35 1.54
11 INT137819 Binding of Faslg 3 0.09 1.78 1.51
12 INT162463 Localization of BID 6 0.73 7.47 1.5
13 INT121859 Negative_regulation of Protein_catabolism of BID 3 0.42 2.1 1.46
14 INT88015 Positive_regulation of Faslg 5 0.65 5.73 1.44
15 INT134147 Positive_regulation of Gene_expression of FADD 2 0.59 1.59 1.31
16 INT23525 Regulation of FEM1B 5 0.44 1.26 1.22
17 INT104926 Positive_regulation of Protein_catabolism of BID 2 0.49 2.12 1.22
18 INT121861 Regulation of BID 4 0.31 2.73 1.15
19 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93
20 INT237858 Positive_regulation of MYD88 5 0.49 2.93 0.9
21 INT158825 Phosphorylation of FADD 1 0.81 1.63 0.89
22 INT166126 Gene_expression of MYD88 5 0.54 2.67 0.84
23 INT86852 Regulation of Faslg 3 0.42 1.67 0.79
24 INT264973 Binding of MYD88 4 0.35 1.2 0.74
25 INT155089 Negative_regulation of FADD 2 0.42 1.31 0.71
26 INT33317 Negative_regulation of RIPK1 1 0.31 0.05 0.67
27 INT31512 Gene_expression of FEM1B 3 0.65 0.43 0.6
28 INT269801 Gene_expression of MADD 1 0.14 4.17 0.6
29 INT264963 Positive_regulation of Binding of MYD88 1 0.17 0.18 0.52
30 INT148985 Positive_regulation of Positive_regulation of BID 1 0.53 0.84 0.48
31 INT158823 Positive_regulation of Binding of FADD 1 0.43 0.23 0.47
32 INT161266 Positive_regulation of Ripk1 1 0.49 0.09 0.47
33 INT158826 Binding of FADD 1 0.41 0.23 0.47
34 INT88021 Regulation of Gene_expression of Faslg 4 0.60 2.6 0.38
35 INT246422 Transcription of MYD88 2 0.52 0.77 0.38
36 INT121860 Negative_regulation of BID 2 0.29 1.92 0.38
37 INT121862 Negative_regulation of Negative_regulation of BID 1 0.29 0.54 0.38
38 INT158821 Positive_regulation of Phosphorylation of FADD 1 0.49 0.58 0.33
39 INT193357 Gene_expression of CASP8AP2 3 0.65 1 0.28
40 INT158822 Regulation of Phosphorylation of FADD 1 0.39 0.55 0.25
41 INT88018 Positive_regulation of Positive_regulation of Faslg 1 0.47 0.75 0.23
42 INT302807 Gene_expression of Ripk1 1 0.04 0.93 0.23
43 INT94547 Localization of Faslg 1 0.76 0.71 0.21
44 INT242901 Regulation of Gene_expression of MYD88 2 0.18 0.19 0.19
45 INT242897 Positive_regulation of Gene_expression of MYD88 2 0.20 0.27 0.19
46 INT185911 Phosphorylation of BID 3 0.71 1.75 0.17
47 INT240602 Gene_expression of RIPK1 2 0.58 0.69 0.16
48 INT90058 Negative_regulation of Gene_expression of FEM1B 1 0.41 0.43 0.13
49 INT242898 Regulation of MYD88 2 0.33 0.88 0.11
50 INT323740 Regulation of FADD 1 0.13 1.08 0.11
51 INT89676 Gene_expression of BID 8 0.31 8.98 0.1
52 INT251555 Binding of Ripk1 1 0.17 1.16 0.04
53 INT336054 Binding of BID 3 0.19 1.32 0
54 INT237967 Positive_regulation of Localization of BID 2 0.21 2.83 0
55 INT292588 Positive_regulation of Positive_regulation of FADD 1 0.11 0.2 0
56 INT193356 Phosphorylation of CASP8AP2 1 0.06 0.08 0
57 INT337979 Gene_expression of Ngfrap1 1 0.68 2.63 0
58 INT292589 Positive_regulation of Localization of RIPK1 1 0.15 0 0
59 INT337995 Positive_regulation of Gene_expression of Ngfrap1 1 0.61 1.35 0
60 INT292578 Positive_regulation of RIPK1 1 0.07 0 0
61 INT336052 Negative_regulation of Binding of BID 1 0.22 0.56 0
62 INT193359 Positive_regulation of CASP8AP2 1 0.04 0.09 0
63 INT299546 Negative_regulation of Gene_expression of RIPK1 1 0.02 0.06 0
64 INT336055 Regulation of Protein_catabolism of BID 1 0.14 0.5 0
65 INT252760 Binding of RIPK1 1 0.19 0.77 0
66 INT292592 Regulation of Localization of RIPK1 1 0.13 0 0
67 INT193365 Positive_regulation of Phosphorylation of CASP8AP2 1 0.04 0.09 0
68 INT292593 Localization of RIPK1 1 0.22 0 0
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