GO:0005127

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Name ciliary neurotrophic factor receptor binding
Categary Function
Go Slim No
Go Link GO:0005127
Unique Molecular Interactions 71
Total Molecular Interactions 88
Total Single Events 342
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ciliary neurotrophic factor receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for ciliary neurotrophic factor receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
2 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
3 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
4 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
5 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53
6 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52
7 INT8439 Cntf Regulation of VIP 1 0.20 0.18 0.52
8 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
9 INT56744 CNTF Positive_regulation of Cck 1 0.08 0.09 0.51
10 INT228448 PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
11 INT56736 Cntf Positive_regulation of Chat 1 0.00 0.1 0.49
12 INT228447 Negative_regulation of PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
13 INT56745 CNTF Positive_regulation of Chat 1 0.02 0.1 0.49
14 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45
15 INT291384 Cntf Positive_regulation of Slc1a3 1 0.26 0.34 0.45
16 INT291387 Cntf Positive_regulation of Slc1a2 1 0.12 0.34 0.45
17 INT126018 Binding of Lifr and Tnf 1 0.06 1.61 0.43
18 INT291393 Cntf Regulation of GTS 1 0.05 0 0.42
19 INT328821 Binding of Il6st and Jak1 1 0.05 0 0.38
20 INT91720 Binding of BDNF and CNTF 1 0.09 1.71 0.38
21 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
22 INT328824 Binding of Il6st and TYK2 1 0.02 0 0.38
23 INT352231 VEGFA Negative_regulation of Cntf 1 0.04 0.22 0.34
24 INT352230 VEGFA Negative_regulation of Gene_expression of Cntf 1 0.04 0.22 0.34
25 INT291383 Fig4 Regulation of Gene_expression of Cntf 1 0.10 0 0.28
26 INT63988 Cntf Regulation of Positive_regulation of Sds 1 0.22 0 0.28
27 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
28 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
29 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
30 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
31 INT171903 Binding of TNF and Lifr 1 0.01 0.35 0.22
32 INT294694 REM1 Positive_regulation of LIFR 1 0.01 0.24 0.18
33 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18
34 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17
35 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17
36 INT332285 Binding of KLRD1 and CRLF1 1 0.00 1.71 0.14
37 INT349860 Binding of Cntf and Lifr 1 0.39 0.22 0.1
38 INT299538 Lifr Positive_regulation of Ak5 1 0.07 0.23 0.09
39 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
40 INT250729 Crlf1 Positive_regulation of Localization of TNF 1 0.02 0.92 0.09
41 INT355021 Cntf Positive_regulation of SOAT1 1 0.02 0.7 0.08
42 INT355022 Cntf Positive_regulation of JAK1 1 0.00 0.69 0.08
43 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08
44 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08
45 INT352579 CNTF Negative_regulation of Gene_expression of NPY 1 0.17 0.89 0.07
46 INT112281 Cntf Regulation of Igf1 1 0.22 0.14 0.05
47 INT112280 Ntf3 Regulation of Cntf 1 0.11 0.13 0.05
48 INT198923 Gene_expression of Lrp8 Positive_regulation of Gene_expression of Lifr 1 0.01 0 0.04
49 INT116407 Binding of Bdnf and Cntf 1 0.19 0.05 0
50 INT222569 Cntf Regulation of Localization of Prl 1 0.01 0.06 0
51 INT235594 Binding of LIFR and Rem1 1 0.02 0.36 0
52 INT294316 IL6ST Positive_regulation of Gene_expression of IL11 1 0.22 0 0
53 INT66353 LIF Regulation of Ctf2p 1 0.02 0.47 0
54 INT294693 LPA Regulation of LIFR 1 0.00 0 0
55 INT263865 Binding of Crlf1 and Spna1 1 0.00 0.12 0
56 INT222530 Cntf Regulation of Localization of Gh1 1 0.00 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ciliary neurotrophic factor receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in ciliary neurotrophic factor receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4
2 INT81458 Positive_regulation of Cntf 11 0.47 4.18 3.18
3 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
4 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9
5 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
6 INT178458 Negative_regulation of LIFR 13 0.47 8.75 2.48
7 INT228442 Localization of Cntf 8 0.63 4.2 2.12
8 INT286801 Positive_regulation of Gene_expression of Cntf 4 0.62 3.01 2.12
9 INT164411 Gene_expression of Crlf1 1 0.71 4.08 2.04
10 INT288630 Gene_expression of Cntf 6 0.75 3.99 1.89
11 INT143983 Gene_expression of Lifr 9 0.47 6.26 1.79
12 INT8422 Binding of Cntf 8 0.37 4.54 1.72
13 INT68582 Localization of CNTF 4 0.73 2.02 1.68
14 INT8421 Regulation of Cntf 6 0.44 1.46 1.67
15 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
16 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
17 INT159009 Regulation of Il6st 2 0.18 2 1.41
18 INT131255 Positive_regulation of Transcription of Lifr 1 0.01 0.99 1.28
19 INT131252 Transcription of Lifr 1 0.02 0.99 1.28
20 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
21 INT283017 Binding of CRLF1 3 0.19 4.32 0.99
22 INT85963 Gene_expression of LIFR 23 0.75 9 0.98
23 INT164400 Positive_regulation of CNTF 3 0.49 1.66 0.96
24 INT162783 Binding of LIFR 1 0.36 1.52 0.86
25 INT352587 Transcription of CNTF 1 0.30 5.18 0.84
26 INT178455 Localization of LIFR 6 0.61 2.24 0.83
27 INT164412 Positive_regulation of Gene_expression of Crlf1 1 0.63 1.66 0.83
28 INT286804 Negative_regulation of Gene_expression of Cntf 2 0.38 0.71 0.79
29 INT120603 Negative_regulation of Cntf 6 0.35 3.57 0.78
30 INT164417 Gene_expression of CRLF1 2 0.34 3.71 0.77
31 INT294699 Negative_regulation of Localization of LIFR 2 0.04 1.52 0.67
32 INT333965 Binding of Il6st 1 0.08 0.9 0.65
33 INT70418 Negative_regulation of CNTF 1 0.58 0.62 0.63
34 INT178456 Positive_regulation of Gene_expression of LIFR 7 0.50 2.74 0.54
35 INT286805 Positive_regulation of Localization of Cntf 1 0.40 1.3 0.52
36 INT228441 Negative_regulation of Localization of Cntf 1 0.19 0.07 0.49
37 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
38 INT164409 Regulation of Crlf1 1 0.41 0.78 0.45
39 INT182014 Positive_regulation of Lifr 1 0.06 0.47 0.38
40 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
41 INT325534 Positive_regulation of CRLF1 1 0.04 0.72 0.36
42 INT81457 Positive_regulation of Regulation of Cntf 1 0.47 0.09 0.34
43 INT164399 Gene_expression of CNTF 5 0.65 1.73 0.33
44 INT171885 Binding of Lifr 2 0.34 2.27 0.3
45 INT126195 Transcription of Il6st 1 0.39 0.2 0.28
46 INT289992 Phosphorylation of Cntf 1 0.30 1 0.22
47 INT289982 Phosphorylation of CNTF 1 0.79 0.99 0.21
48 INT216455 Negative_regulation of Gene_expression of Lifr 1 0.36 1.71 0.2
49 INT344905 Binding of Crlf1 1 0.01 0.4 0.2
50 INT148637 Gene_expression of Lifr 5 0.75 0.92 0.18
51 INT216452 Negative_regulation of Lifr 1 0.36 1.73 0.18
52 INT289348 Positive_regulation of Positive_regulation of Cntf 1 0.20 0.19 0.15
53 INT136520 Positive_regulation of Regulation of IL6ST 1 0.09 0.08 0.13
54 INT314085 Regulation of Gene_expression of CRLF1 1 0.03 1.22 0.1
55 INT299517 Positive_regulation of Gene_expression of Il6st 1 0.06 0.23 0.09
56 INT299520 Positive_regulation of Gene_expression of Lifr 1 0.18 0.23 0.09
57 INT144614 Binding of CNTF 2 0.36 1.44 0.07
58 INT349815 Regulation of Cntf 1 0.26 0.21 0.07
59 INT206151 Positive_regulation of Gene_expression of IL6ST 2 0.24 0.35 0.06
60 INT294329 Regulation of Gene_expression of IL6ST 1 0.22 0 0.05
61 INT253389 Positive_regulation of Positive_regulation of Il6st 1 0.28 0.07 0.05
62 INT294344 Localization of IL6ST 1 0.39 0 0.04
63 INT188226 Regulation of Gene_expression of LIFR 1 0.44 0.73 0.04
64 INT178453 Regulation of LIFR 3 0.50 0.31 0.03
65 INT235585 Negative_regulation of Negative_regulation of LIFR 1 0.16 0.35 0
66 INT178454 Regulation of Positive_regulation of LIFR 1 0.37 0.19 0
67 INT164401 Regulation of Gene_expression of CNTF 1 0.52 0.47 0
68 INT28760 Negative_regulation of Crlf1 1 0.16 0.52 0
69 INT148636 Regulation of Lifr 1 0.20 0.27 0
70 INT299513 Regulation of Gene_expression of Lifr 1 0.23 0.14 0
71 INT164398 Regulation of CNTF 1 0.26 0.77 0
72 INT206153 Phosphorylation of IL6ST 1 0.22 0.05 0
73 INT178452 Negative_regulation of Positive_regulation of LIFR 1 0.35 0.19 0
74 INT120602 Positive_regulation of Negative_regulation of Cntf 1 0.27 0 0
75 INT206156 Positive_regulation of Phosphorylation of IL6ST 1 0.14 0.05 0
76 INT350524 Localization of Crlf1 1 0.24 0.68 0
77 INT144616 Positive_regulation of Binding of CNTF 1 0.49 0.53 0
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