GO:0005138

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Name interleukin-6 receptor binding
Categary Function
Go Slim No
Go Link GO:0005138
Unique Molecular Interactions 2229
Total Molecular Interactions 3367
Total Single Events 29499
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-6 receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-6 receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
2 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
3 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
4 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
5 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
6 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
7 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
8 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
9 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
10 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
11 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
12 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
13 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
14 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
15 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
16 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
17 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
18 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
19 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
20 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
21 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
22 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
23 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
24 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
25 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
26 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
27 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
28 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
29 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
30 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
31 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
32 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
33 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
34 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
35 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
36 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
37 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
38 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
39 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
40 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
41 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
42 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
43 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
44 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
45 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
46 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
47 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
48 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
49 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
50 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
51 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
52 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
53 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
54 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
55 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
56 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
57 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
58 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
59 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
60 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
61 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
62 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
63 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
64 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
65 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
66 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
67 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
68 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
69 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
70 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
71 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
72 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
73 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
74 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
75 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
76 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
77 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
78 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
79 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
80 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
81 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
82 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
83 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
84 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
85 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
86 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
87 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
88 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
89 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
90 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
91 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
92 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
93 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87
94 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
95 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86
96 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
97 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
98 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
99 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85
100 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
101 INT54992 Il6 Negative_regulation of Prl 1 0.00 0.86 0.84
102 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
103 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
104 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83
105 INT342999 IL6 Positive_regulation of Gene_expression of HIST2H2AA3 1 0.00 0.4 0.83
106 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
107 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
108 INT135278 Gt(pU21)50Imeg Negative_regulation of Positive_regulation of Il6 1 0.02 0.26 0.8
109 INT160411 Tat Positive_regulation of Il6 1 0.17 0.89 0.8
110 INT135277 Gt(pU21)50Imeg Negative_regulation of Il6 1 0.02 0.23 0.78
111 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
112 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
113 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
114 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
115 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
116 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
117 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
118 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73
119 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
120 INT124352 Il6 Positive_regulation of Positive_regulation of Gorasp2 1 0.10 1.19 0.73
121 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
122 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72
123 INT237325 Il6 Positive_regulation of Gene_expression of Ik 2 0.00 2.09 0.72
124 INT209057 Il6 Positive_regulation of Csf2 1 0.03 0.38 0.72
125 INT163946 Binding of ERAP1 and Il23r 1 0.23 0.56 0.72
126 INT209039 Il6 Positive_regulation of Il17a 1 0.05 0.38 0.72
127 INT209056 Il6 Positive_regulation of Elf1 1 0.10 0.38 0.72
128 INT209059 Il6 Positive_regulation of Cxcl1 1 0.06 0.38 0.72
129 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72
130 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72
131 INT209060 Il6 Positive_regulation of Ccr1 1 0.01 0.38 0.72
132 INT51005 PDYN Positive_regulation of IL6 1 0.08 0.84 0.72
133 INT260551 Igh-Dex Negative_regulation of Il6 1 0.09 0.37 0.72
134 INT160711 Binding of KIR3DL1 and ERAP1 1 0.15 0.71 0.71
135 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
136 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
137 INT91700 Il6 Negative_regulation of Oprd1 1 0.23 0 0.7
138 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7
139 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
140 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
141 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
142 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69
143 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
144 INT76655 POMC Positive_regulation of Transcription of Il6 1 0.01 0 0.68
145 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
146 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
147 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67
148 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
149 INT164782 Il6 Regulation of Gene_expression of Cx3cr1 1 0.27 0.79 0.67
150 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66
151 INT82384 Penk Positive_regulation of Gene_expression of Il6 1 0.15 0 0.66
152 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65
153 INT121812 IL6 Regulation of OPRM1 1 0.22 0.27 0.65
154 INT209054 Il17a Positive_regulation of Gene_expression of Il6 1 0.10 0.45 0.65
155 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65
156 INT209055 S100a8 Positive_regulation of Gene_expression of Il6 1 0.01 0.45 0.64
157 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
158 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63
159 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63
160 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
161 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
162 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
163 INT264335 Binding of IL-17 and Positive_regulation of Localization of Il6 1 0.13 1.62 0.62
164 INT71527 Negative_regulation of OPRD1 Negative_regulation of Positive_regulation of Il6 1 0.00 0.15 0.62
165 INT114319 TNF Positive_regulation of Gene_expression of Il6r 1 0.05 0.91 0.61
166 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61
167 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
168 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
169 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
170 INT71525 Oprd1 Regulation of Il6 1 0.16 0.19 0.6
171 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6
172 INT91699 Il6 Regulation of Gene_expression of Oprl1 1 0.06 0 0.6
173 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
174 INT140890 Il10 Regulation of Il6 1 0.35 0.73 0.58
175 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
176 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58
177 INT121813 IL6 Positive_regulation of OPRM1 1 0.28 0.28 0.58
178 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
179 INT151461 Olr1745 Negative_regulation of Gene_expression of Il6 1 0.03 0.81 0.57
180 INT142312 Lalba Negative_regulation of Localization of Il6 1 0.23 0.73 0.57
181 INT231712 GAGE2C Regulation of Transcription of IL6 1 0.01 1.01 0.57
182 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
183 INT307016 IGKV1-17 Positive_regulation of Gene_expression of IL6 1 0.00 1.01 0.56
184 INT265463 CSPG4 Negative_regulation of Gene_expression of IL6 1 0.06 1.6 0.56
185 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56
186 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
187 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54
188 INT231711 GPR174 Regulation of Transcription of IL6 1 0.01 0.96 0.54
189 INT137016 Il6 Positive_regulation of Gene_expression of Acta2 1 0.01 0.75 0.54
190 INT182021 Binding of TNF and Il6 2 0.04 0.74 0.53
191 INT261608 Il6 Negative_regulation of Gene_expression of TNF 1 0.03 1.27 0.53
192 INT100597 Regulation of RPL21P132 Positive_regulation of IL6 1 0.01 0.45 0.53
193 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53
194 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53
195 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
196 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52
197 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52
198 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
199 INT8439 Cntf Regulation of VIP 1 0.20 0.18 0.52
200 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-6 receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-6 receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
3 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
4 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
5 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
6 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
7 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
8 INT12082 Localization of IL6 365 0.81 241.78 105.78
9 INT19511 Localization of Il6 212 0.81 118.17 67.67
10 INT11937 Localization of Il6 228 0.81 139.83 64.39
11 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
12 INT10706 Regulation of Il6 150 0.62 93.23 62.34
13 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
14 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
15 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
16 INT9210 Regulation of IL6 166 0.62 125.61 49.95
17 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
18 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
19 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
20 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
21 INT9655 Regulation of Il6 98 0.62 70.92 31.95
22 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
23 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
24 INT86437 Binding of IL6 154 0.48 121.22 29.3
25 INT51474 Binding of Il6 55 0.48 44.99 20.52
26 INT49985 Transcription of Il6 62 0.72 40.13 20.29
27 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
28 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
29 INT61626 Transcription of IL6 73 0.72 42.04 17.86
30 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
31 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
32 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
33 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
34 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
35 INT54763 Binding of Il6 82 0.48 63.27 12.89
36 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
37 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
38 INT50933 Transcription of Il6 38 0.72 24.31 11.58
39 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
40 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
41 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
42 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4
43 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
44 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
45 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
46 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34
47 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19
48 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08
49 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
50 INT52133 Regulation of Localization of Il6 7 0.61 5.35 4.37
51 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
52 INT174816 Binding of IL6R 14 0.09 11.26 3.63
53 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53
54 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49
55 INT81403 Positive_regulation of Regulation of Il6 4 0.44 1.81 3.37
56 INT64715 Phosphorylation of Il6 7 0.81 4.24 3.36
57 INT81458 Positive_regulation of Cntf 11 0.47 4.18 3.18
58 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
59 INT126716 Positive_regulation of Il6r 8 0.42 4.31 3.1
60 INT94947 Positive_regulation of Transcription of Il6 9 0.67 6.91 3.04
61 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95
62 INT159709 Binding of ERAP1 12 0.47 3.42 2.91
63 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
64 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
65 INT64714 Positive_regulation of Phosphorylation of Il6 4 0.50 3.22 2.67
66 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61
67 INT10558 Regulation of Regulation of IL6 6 0.45 4.94 2.33
68 INT333961 Binding of Il6r 1 0.07 3.67 2.29
69 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14
70 INT228442 Localization of Cntf 8 0.63 4.2 2.12
71 INT286801 Positive_regulation of Gene_expression of Cntf 4 0.62 3.01 2.12
72 INT52197 Negative_regulation of Transcription of Il6 8 0.43 3.8 2.05
73 INT161121 Binding of Erap1 2 0.48 1.99 1.99
74 INT114317 Gene_expression of Il6r 9 0.54 3.4 1.89
75 INT288630 Gene_expression of Cntf 6 0.75 3.99 1.89
76 INT64959 Positive_regulation of Negative_regulation of IL6 5 0.42 5.16 1.86
77 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
78 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83
79 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
80 INT155455 Negative_regulation of Phosphorylation of Il6 1 0.31 2.5 1.76
81 INT8422 Binding of Cntf 8 0.37 4.54 1.72
82 INT68582 Localization of CNTF 4 0.73 2.02 1.68
83 INT8421 Regulation of Cntf 6 0.44 1.46 1.67
84 INT135275 Regulation of Negative_regulation of Il6 4 0.45 0.89 1.67
85 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
86 INT216932 Positive_regulation of Negative_regulation of Il6 3 0.38 4.88 1.55
87 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
88 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
89 INT98448 Regulation of Binding of Il6 3 0.39 2.6 1.46
90 INT77368 Regulation of Regulation of Il6 3 0.35 1.86 1.45
91 INT98449 Positive_regulation of Binding of Il6 3 0.44 2.96 1.44
92 INT87062 Positive_regulation of Binding of IL6 10 0.49 11.8 1.42
93 INT159009 Regulation of Il6st 2 0.18 2 1.41
94 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
95 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
96 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
97 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
98 INT190075 Regulation of Transcription of Il6 2 0.45 2.17 1.18
99 INT10559 Negative_regulation of Regulation of IL6 4 0.37 1.76 1.1
100 INT114318 Positive_regulation of Gene_expression of Il6r 2 0.28 1.84 1.09
101 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
102 INT134260 Negative_regulation of Transcription of Il6 2 0.25 1.39 0.99
103 INT152021 Regulation of Negative_regulation of IL6 3 0.32 1.38 0.98
104 INT164400 Positive_regulation of CNTF 3 0.49 1.66 0.96
105 INT64958 Negative_regulation of Transcription of IL6 6 0.50 3.58 0.92
106 INT115192 Phosphorylation of IL6 7 0.70 1.55 0.84
107 INT352587 Transcription of CNTF 1 0.30 5.18 0.84
108 INT333963 Localization of Il6r 1 0.10 0.75 0.83
109 INT192851 Phosphorylation of Il6 7 0.68 3.12 0.82
110 INT286804 Negative_regulation of Gene_expression of Cntf 2 0.38 0.71 0.79
111 INT120603 Negative_regulation of Cntf 6 0.35 3.57 0.78
112 INT45645 Negative_regulation of Erap1 2 0.11 0.07 0.77
113 INT300843 Regulation of Transcription of Il6 3 0.37 3.4 0.76
114 INT145747 Regulation of ERAP1 1 0.25 0.19 0.76
115 INT102311 Regulation of IL6R 4 0.12 2.37 0.74
116 INT52196 Negative_regulation of Regulation of Il6 3 0.42 3.42 0.74
117 INT158354 Negative_regulation of Binding of Il6 2 0.20 2.21 0.71
118 INT333965 Binding of Il6st 1 0.08 0.9 0.65
119 INT70418 Negative_regulation of CNTF 1 0.58 0.62 0.63
120 INT261602 Positive_regulation of Binding of Il6 2 0.50 1.75 0.62
121 INT138730 Negative_regulation of Negative_regulation of Il6 3 0.09 1.04 0.61
122 INT264490 Regulation of Negative_regulation of Il6 2 0.23 1.18 0.6
123 INT154643 Negative_regulation of ERAP1 1 0.11 0.69 0.58
124 INT188433 Negative_regulation of Binding of IL6 6 0.42 2.03 0.56
125 INT61025 Negative_regulation of Negative_regulation of Il6 3 0.43 1.15 0.56
126 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
127 INT286805 Positive_regulation of Localization of Cntf 1 0.40 1.3 0.52
128 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
129 INT220268 Regulation of Regulation of Il6 2 0.12 0.89 0.49
130 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49
131 INT228441 Negative_regulation of Localization of Cntf 1 0.19 0.07 0.49
132 INT115189 Regulation of Phosphorylation of IL6 1 0.04 0 0.48
133 INT240020 Regulation of Binding of IL6 4 0.36 4.38 0.46
134 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
135 INT98447 Positive_regulation of Negative_regulation of Il6 1 0.44 0.75 0.45
136 INT285471 Negative_regulation of Binding of Il6 2 0.21 1.33 0.41
137 INT251556 Localization of Adam17 2 0.38 2 0.39
138 INT260859 Negative_regulation of Binding of IL6R 1 0.06 1.08 0.38
139 INT130943 Regulation of Il6r 3 0.40 0.36 0.37
140 INT82552 Negative_regulation of Regulation of Il6 2 0.38 1.43 0.36
141 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
142 INT81457 Positive_regulation of Regulation of Cntf 1 0.47 0.09 0.34
143 INT164399 Gene_expression of CNTF 5 0.65 1.73 0.33
144 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
145 INT90405 Positive_regulation of Gene_expression of IL6R 3 0.03 1.85 0.31
146 INT143536 Protein_catabolism of Il6 2 0.69 1.89 0.31
147 INT187284 Positive_regulation of Gene_expression of Adam17 3 0.20 1.32 0.29
148 INT173941 Negative_regulation of Gene_expression of IL6R 2 0.04 0.48 0.29
149 INT126195 Transcription of Il6st 1 0.39 0.2 0.28
150 INT194162 Protein_catabolism of Il6 2 0.12 0.79 0.27
151 INT211287 Regulation of Binding of Il6 1 0.06 0.1 0.27
152 INT62619 Positive_regulation of Negative_regulation of Erap1 1 0.05 0 0.27
153 INT201071 Positive_regulation of Regulation of Il6 2 0.39 0.45 0.25
154 INT130944 Regulation of Gene_expression of Il6r 1 0.00 0.21 0.25
155 INT298665 Positive_regulation of Protein_catabolism of IL6 1 0.09 2.03 0.25
156 INT180101 Phosphorylation of Adam17 3 0.37 0.25 0.24
157 INT78865 Localization of Adam17 1 0.43 0.34 0.23
158 INT289992 Phosphorylation of Cntf 1 0.30 1 0.22
159 INT280656 Protein_catabolism of Il6r 1 0.69 0 0.22
160 INT320154 Phosphorylation of IL6R 1 0.04 1.13 0.21
161 INT289982 Phosphorylation of CNTF 1 0.79 0.99 0.21
162 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
163 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
164 INT289348 Positive_regulation of Positive_regulation of Cntf 1 0.20 0.19 0.15
165 INT188222 Positive_regulation of Regulation of IL6 2 0.29 0.51 0.13
166 INT169349 Regulation of Adam17 1 0.37 0.97 0.13
167 INT342327 Positive_regulation of Erap1 1 0.43 1.1 0.13
168 INT298669 Negative_regulation of Protein_catabolism of IL6 1 0.08 1.02 0.13
169 INT136520 Positive_regulation of Regulation of IL6ST 1 0.09 0.08 0.13
170 INT280688 Regulation of Regulation of Il6r 1 0.40 0 0.12
171 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
172 INT299517 Positive_regulation of Gene_expression of Il6st 1 0.06 0.23 0.09
173 INT187285 Protein_catabolism of Adam17 1 0.12 0.94 0.09
174 INT4418 Positive_regulation of ERAP1 4 0.45 1.21 0.08
175 INT356064 Regulation of Negative_regulation of Adam17 1 0.23 0.24 0.08
176 INT356054 Regulation of Phosphorylation of Adam17 1 0.20 0.25 0.08
177 INT180096 Positive_regulation of Phosphorylation of Adam17 1 0.07 0 0.08
178 INT144614 Binding of CNTF 2 0.36 1.44 0.07
179 INT298670 Regulation of Gene_expression of IL6R 1 0.01 0.43 0.07
180 INT349815 Regulation of Cntf 1 0.26 0.21 0.07
181 INT206151 Positive_regulation of Gene_expression of IL6ST 2 0.24 0.35 0.06
182 INT253097 Negative_regulation of Phosphorylation of Il6 1 0.35 0.23 0.06
183 INT294329 Regulation of Gene_expression of IL6ST 1 0.22 0 0.05
184 INT253389 Positive_regulation of Positive_regulation of Il6st 1 0.28 0.07 0.05
185 INT280648 Negative_regulation of Transcription of Il6r 1 0.38 0 0.05
186 INT280667 Transcription of Il6r 1 0.62 0 0.05
187 INT180094 Binding of Adam17 1 0.06 0 0.05
188 INT294344 Localization of IL6ST 1 0.39 0 0.04
189 INT159707 Gene_expression of ERAP1 4 0.66 0.69 0
190 INT342328 Regulation of Erap1 1 0.25 0 0
191 INT163945 Positive_regulation of Gene_expression of ERAP1 1 0.26 0.09 0
192 INT164401 Regulation of Gene_expression of CNTF 1 0.52 0.47 0
193 INT164398 Regulation of CNTF 1 0.26 0.77 0
194 INT206153 Phosphorylation of IL6ST 1 0.22 0.05 0
195 INT120602 Positive_regulation of Negative_regulation of Cntf 1 0.27 0 0
196 INT206156 Positive_regulation of Phosphorylation of IL6ST 1 0.14 0.05 0
197 INT144616 Positive_regulation of Binding of CNTF 1 0.49 0.53 0
198 INT285394 Binding of Adam17 1 0.31 0.93 0
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