GO:0005150

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Name interleukin-1, Type I receptor binding
Categary Function
Go Slim No
Go Link GO:0005150
Unique Molecular Interactions 139
Total Molecular Interactions 196
Total Single Events 1441
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-1, Type I receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-1, Type I receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
2 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
3 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
4 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
5 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
6 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
7 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
8 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
9 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
10 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97
11 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
12 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
13 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91
14 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
15 INT21944 Il1a Negative_regulation of Gnrh1 1 0.34 0 0.89
16 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
17 INT224583 CSF2 Positive_regulation of IL1RN 1 0.02 1.3 0.88
18 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
19 INT187226 Vip Positive_regulation of Gene_expression of Il1rn 1 0.04 0.96 0.82
20 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
21 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
22 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
23 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
24 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68
25 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
26 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66
27 INT92872 SON Positive_regulation of IL1RN 1 0.06 0.64 0.65
28 INT279398 Binding of IL1RN and Il1rn 1 0.00 0.51 0.63
29 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
30 INT255997 Binding of Il1rn and H7 1 0.01 1.21 0.63
31 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
32 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
33 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
34 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
35 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
36 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
37 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
38 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6
39 INT85487 IL1RN Negative_regulation of IL1R1 1 0.02 0 0.57
40 INT143938 Il1rn Negative_regulation of Il1b 1 0.04 0.52 0.57
41 INT143940 Il1rn Negative_regulation of Il1f5 1 0.00 0.51 0.57
42 INT8401 Il1a Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
43 INT8395 Il1a Regulation of Gene_expression of Vip 1 0.01 0.38 0.56
44 INT85265 Binding of Il1rn and Insrr 1 0.01 0 0.54
45 INT171896 Binding of Ifnar1 and Il1rn 1 0.00 0.81 0.54
46 INT316735 Il1 Positive_regulation of Gene_expression of Il1rn 1 0.00 0.53 0.53
47 INT8396 Il1a Regulation of Nts 1 0.00 0.38 0.53
48 INT8399 Il1a Regulation of Vip 1 0.00 0.38 0.53
49 INT130726 Negative_regulation of Binding of IL1B and Il1rn 1 0.01 0.6 0.48
50 INT130723 Binding of IL1A and Il1rn 1 0.01 0.59 0.47
51 INT130724 Negative_regulation of Binding of IL1A and Il1rn 1 0.01 0.59 0.47
52 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
53 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
54 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
55 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
56 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
57 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
58 INT159438 seb Positive_regulation of Gene_expression of Il1a 1 0.02 0 0.41
59 INT159439 sea Positive_regulation of Gene_expression of Il1a 1 0.07 0 0.41
60 INT171898 Il1rn Regulation of Gene_expression of Il1 1 0.02 0.92 0.4
61 INT279392 SFTPA1 Positive_regulation of IL1RN 1 0.00 0.19 0.4
62 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
63 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
64 INT237415 Il1rn Regulation of Il10 1 0.03 0.96 0.39
65 INT237417 Il1rn Regulation of Il4 1 0.02 0.96 0.39
66 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37
67 INT264481 Il1a Positive_regulation of Mapk14 1 0.02 0 0.37
68 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
69 INT21945 Negative_regulation of Il1a Negative_regulation of LH 1 0.18 0 0.36
70 INT230499 Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1 1 0.01 0.85 0.36
71 INT224584 Binding of IL1RN and SIGMAR1 1 0.00 0.73 0.36
72 INT334951 IL6 Positive_regulation of Regulation of IL1RN 1 0.23 1.11 0.35
73 INT21946 Il1a Negative_regulation of LH 1 0.18 0 0.35
74 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35
75 INT334949 IL6 Regulation of Regulation of IL1RN 1 0.13 1.11 0.35
76 INT334950 IL6 Regulation of IL1RN 1 0.13 1.11 0.35
77 INT92871 Positive_regulation of SON Positive_regulation of IL1RN 1 0.06 0.33 0.34
78 INT78063 Il1a Positive_regulation of Il1b 1 0.02 0.07 0.32
79 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
80 INT203085 Positive_regulation of Binding of Il1a and Myd88 1 0.07 0.65 0.32
81 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
82 INT21947 Il1a Positive_regulation of Localization of Pomc 1 0.48 0 0.32
83 INT203087 Binding of Il1a and Myd88 1 0.05 0.65 0.31
84 INT304277 CCNE1 Positive_regulation of IL1RN 1 0.00 1.93 0.31
85 INT229600 Tlr4 Positive_regulation of Il1a 1 0.00 0.41 0.3
86 INT50310 Binding of Il1a and Ptger2 1 0.20 0.06 0.28
87 INT188518 Il1a Negative_regulation of Gene_expression of Ptger2 1 0.00 0.17 0.28
88 INT188517 Il1a Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.28
89 INT188524 Il1a Positive_regulation of Ptges 1 0.00 0.31 0.28
90 INT256001 Ang Negative_regulation of Il1rn 1 0.11 0.25 0.27
91 INT220381 Il1a Positive_regulation of Gene_expression of Igfbp1 1 0.01 0.28 0.27
92 INT255996 H7 Negative_regulation of Il1rn 1 0.01 0.25 0.27
93 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26
94 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
95 INT264477 Il1a Positive_regulation of Jun 1 0.02 0.17 0.2
96 INT264470 Il1a Positive_regulation of Il6 1 0.06 0.18 0.2
97 INT222543 Il1a Regulation of Chat 1 0.01 0.64 0.19
98 INT222525 Il1a Regulation of Localization of Gh1 1 0.00 0.64 0.19
99 INT220243 IL1RN Negative_regulation of Gene_expression of DPEP1 1 0.20 0.22 0.19
100 INT222494 Negative_regulation of Il1a Negative_regulation of Positive_regulation of Il6 1 0.00 0.79 0.19
101 INT203088 Il1a Positive_regulation of Gene_expression of Mmp3 1 0.03 0.26 0.18
102 INT66035 FOLR2 Negative_regulation of Il1a 1 0.00 0.56 0.18
103 INT173938 Il1rn Negative_regulation of Il1 1 0.00 0.18 0.17
104 INT221352 Tnf Negative_regulation of Il1a 1 0.05 0.3 0.15
105 INT220240 IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.12
106 INT300570 Binding of IL1RN and SUGT1P2 1 0.01 0.43 0.12
107 INT340421 Il1a Positive_regulation of Csk 1 0.00 0.98 0.12
108 INT71310 Il1a Positive_regulation of NOS1 1 0.07 0.09 0.11
109 INT71311 Il1a Positive_regulation of Positive_regulation of NOS1 1 0.07 0.09 0.11
110 INT128696 Il1a Positive_regulation of Phosphorylation of Ephb1 1 0.26 0.82 0.1
111 INT222511 Il1a Positive_regulation of Gene_expression of Fst 1 0.01 0.32 0.08
112 INT220248 IL1RN Regulation of Gene_expression of LONP1 1 0.04 0 0.08
113 INT222662 Il1a Positive_regulation of Gene_expression of INCENP 1 0.00 0.32 0.08
114 INT220241 IL1RN Regulation of Gene_expression of DPEP1 1 0.24 0 0.08
115 INT220238 IL1RN Regulation of Protein_catabolism of DPEP1 1 0.14 0 0.08
116 INT188519 Il1a Positive_regulation of Ptgis 1 0.03 0.08 0.08
117 INT188525 Il1a Regulation of Ptges 1 0.00 0.07 0.04
118 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03
119 INT203094 Il1a Positive_regulation of Gene_expression of B4GALNT1 1 0.00 0.05 0.03
120 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03
121 INT220236 Positive_regulation of IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.03
122 INT340423 Il1rn Regulation of Binding of Ccl2 1 0.21 0.99 0
123 INT164244 Binding of IL1RN and Mmp3 1 0.01 0 0
124 INT164240 Negative_regulation of Il1rn Negative_regulation of Mmp3 1 0.00 0 0
125 INT164245 Negative_regulation of Binding of IL1RN and Mmp3 1 0.01 0 0
126 INT66034 FOLR2 Negative_regulation of Gene_expression of Il1a 1 0.00 0.18 0
127 INT186415 IL1RN Regulation of Gene_expression of IL1B 1 0.25 0.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-1, Type I receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-1, Type I receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
2 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62
3 INT5966 Localization of Il1a 50 0.78 22.91 26.54
4 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
5 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
6 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08
7 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66
8 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82
9 INT72565 Localization of IL1RN 45 0.80 23.59 13.17
10 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
11 INT87844 Binding of IL1RN 40 0.41 24.37 11.92
12 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
13 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31
14 INT6474 Positive_regulation of Gene_expression of IL1RN 34 0.69 21.87 10.99
15 INT5308 Regulation of Il1a 17 0.44 10.8 7.31
16 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71
17 INT69980 Negative_regulation of Il1rn 11 0.33 7.75 6.7
18 INT126395 Positive_regulation of Gene_expression of Il1rn 11 0.41 7.66 6.25
19 INT73902 Regulation of Gene_expression of IL1RN 6 0.61 4.59 6.14
20 INT107441 Positive_regulation of Gene_expression of Il1rn 7 0.46 3.24 5.95
21 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44
22 INT58338 Negative_regulation of Localization of Il1a 8 0.25 3.13 5.18
23 INT73905 Transcription of IL1RN 10 0.71 9.16 5.04
24 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83
25 INT92199 Negative_regulation of Gene_expression of IL1RN 14 0.58 10.11 4.71
26 INT81485 Negative_regulation of IL1RN 19 0.57 8.3 4.69
27 INT50309 Binding of Il1a 22 0.40 5.4 4.49
28 INT76683 Positive_regulation of Il1rn 9 0.51 9.3 4.41
29 INT83646 Binding of Il1rn 12 0.37 4.41 3.51
30 INT40232 Transcription of Il1rn 8 0.53 9.6 3.37
31 INT171888 Binding of Il1rn 13 0.38 5.53 3.13
32 INT54619 Negative_regulation of Positive_regulation of Il1a 6 0.42 5.68 3.12
33 INT76679 Positive_regulation of Transcription of Il1rn 1 0.37 9.13 2.55
34 INT62064 Negative_regulation of Gene_expression of Il1rn 6 0.32 4.81 2.53
35 INT69981 Positive_regulation of Negative_regulation of Il1rn 2 0.09 3.28 2.48
36 INT5968 Positive_regulation of Localization of Il1a 4 0.65 1.36 2.42
37 INT131928 Localization of Il1rn 3 0.74 2.22 2.24
38 INT150884 Transcription of Il1a 6 0.47 3.12 2.19
39 INT173931 Regulation of Gene_expression of Il1rn 3 0.60 2.68 1.84
40 INT73904 Positive_regulation of Localization of IL1RN 2 0.69 1.5 1.38
41 INT129253 Positive_regulation of Positive_regulation of Il1a 5 0.49 2.97 1.31
42 INT92873 Positive_regulation of Positive_regulation of IL1RN 3 0.47 1.82 1.28
43 INT162757 Regulation of Localization of Il1a 3 0.37 1.22 1.25
44 INT101022 Regulation of Il1rn 5 0.44 2.15 1.21
45 INT190077 Regulation of Transcription of Il1a 2 0.02 0.87 0.99
46 INT292529 Phosphorylation of Il1rn 1 0.09 1 0.97
47 INT145851 Negative_regulation of Positive_regulation of Il1rn 1 0.08 0.7 0.95
48 INT173929 Regulation of Il1rn 5 0.26 3.02 0.93
49 INT145852 Negative_regulation of Negative_regulation of Il1rn 1 0.08 0.69 0.93
50 INT344365 Phosphorylation of Il1a 1 0.61 1.01 0.92
51 INT165401 Phosphorylation of IL1RN 2 0.09 1.51 0.91
52 INT255990 Localization of Il1rn 6 0.73 1.74 0.9
53 INT171889 Negative_regulation of Gene_expression of Il1rn 3 0.08 2.31 0.9
54 INT73903 Positive_regulation of Transcription of IL1RN 2 0.69 1.15 0.87
55 INT116032 Transcription of Il1rn 4 0.70 2.19 0.84
56 INT187381 Regulation of Localization of IL1RN 1 0.00 1.05 0.74
57 INT88190 Negative_regulation of Binding of Il1rn 1 0.36 0.46 0.68
58 INT292526 Negative_regulation of Negative_regulation of Il1a 1 0.05 0.87 0.66
59 INT114182 Negative_regulation of Positive_regulation of Il1rn 1 0.15 0 0.49
60 INT250838 Protein_catabolism of Il1a 1 0.13 1.16 0.49
61 INT255986 Negative_regulation of Negative_regulation of Il1rn 1 0.34 0.26 0.45
62 INT250843 Negative_regulation of Protein_catabolism of Il1a 1 0.06 0.9 0.43
63 INT323910 Negative_regulation of Positive_regulation of IL1RN 1 0.05 0.57 0.42
64 INT292528 Regulation of Positive_regulation of Il1a 1 0.06 0.52 0.39
65 INT344829 Positive_regulation of Positive_regulation of Il1rn 1 0.02 0.53 0.33
66 INT116035 Negative_regulation of Transcription of Il1rn 1 0.57 0.1 0.29
67 INT255991 Negative_regulation of Binding of Il1rn 1 0.34 0.26 0.27
68 INT323609 Positive_regulation of Binding of Il1rn 1 0.21 0.63 0.26
69 INT255985 Protein_catabolism of Il1rn 1 0.52 0.37 0.25
70 INT60460 Positive_regulation of Negative_regulation of Il1a 1 0.36 0 0.18
71 INT285224 Positive_regulation of Transcription of Il1rn 1 0.45 0.72 0.15
72 INT250827 Positive_regulation of Protein_catabolism of Il1a 1 0.07 0.21 0.09
73 INT340415 Regulation of Gene_expression of Il1rn 1 0.27 1.02 0.07
74 INT188502 Positive_regulation of Binding of Il1a 2 0.07 0 0.04
75 INT220260 Protein_catabolism of IL1RN 1 0.59 0.14 0
76 INT285222 Negative_regulation of Regulation of Il1rn 1 0.42 1.02 0
77 INT203070 Regulation of Negative_regulation of Il1a 1 0.14 0 0
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