GO:0005152

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Name interleukin-1 receptor antagonist activity
Categary Function
Go Slim No
Go Link GO:0005152
Unique Molecular Interactions 136
Total Molecular Interactions 201
Total Single Events 1602
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-1 receptor antagonist activity. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-1 receptor antagonist activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
2 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
3 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
4 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
5 INT27425 Mtr Positive_regulation of Gene_expression of Il1f5 1 0.06 0 1.3
6 INT143941 Il1f5 Negative_regulation of Gene_expression of Fos 1 0.00 1.03 1.11
7 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
8 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
9 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
10 INT224583 CSF2 Positive_regulation of IL1RN 1 0.02 1.3 0.88
11 INT199389 Prok2 Positive_regulation of Localization of Il1f5 1 0.05 1.17 0.88
12 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
13 INT187226 Vip Positive_regulation of Gene_expression of Il1rn 1 0.04 0.96 0.82
14 INT54668 Mtr Regulation of Gene_expression of Il1f5 1 0.00 0.2 0.76
15 INT21535 Binding of Il2 and Il1f5 1 0.13 0 0.73
16 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68
17 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66
18 INT92872 SON Positive_regulation of IL1RN 1 0.06 0.64 0.65
19 INT82383 Penk Positive_regulation of Gene_expression of Il1f5 1 0.04 0 0.65
20 INT279398 Binding of IL1RN and Il1rn 1 0.00 0.51 0.63
21 INT27426 Mtr Positive_regulation of Localization of Il1f5 1 0.06 0 0.63
22 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
23 INT255997 Binding of Il1rn and H7 1 0.01 1.21 0.63
24 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
25 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
26 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
27 INT327166 RETNLB Regulation of IL36RN 1 0.00 2.25 0.59
28 INT120207 Binding of UTS2R and Il1f5 1 0.09 1.28 0.59
29 INT85487 IL1RN Negative_regulation of IL1R1 1 0.02 0 0.57
30 INT143938 Il1rn Negative_regulation of Il1b 1 0.04 0.52 0.57
31 INT143940 Il1rn Negative_regulation of Il1f5 1 0.00 0.51 0.57
32 INT85265 Binding of Il1rn and Insrr 1 0.01 0 0.54
33 INT171896 Binding of Ifnar1 and Il1rn 1 0.00 0.81 0.54
34 INT316735 Il1 Positive_regulation of Gene_expression of Il1rn 1 0.00 0.53 0.53
35 INT58633 Negative_regulation of Il1f5 Negative_regulation of Mpo 1 0.15 0.98 0.48
36 INT130726 Negative_regulation of Binding of IL1B and Il1rn 1 0.01 0.6 0.48
37 INT217760 Il1f5 Positive_regulation of Gene_expression of Cpox 1 0.00 0.27 0.47
38 INT130723 Binding of IL1A and Il1rn 1 0.01 0.59 0.47
39 INT217759 Il1f5 Positive_regulation of Cpox 1 0.00 0.27 0.47
40 INT130724 Negative_regulation of Binding of IL1A and Il1rn 1 0.01 0.59 0.47
41 INT25618 Pomc Regulation of Gene_expression of Il1f5 1 0.17 0 0.42
42 INT171898 Il1rn Regulation of Gene_expression of Il1 1 0.02 0.92 0.4
43 INT279392 SFTPA1 Positive_regulation of IL1RN 1 0.00 0.19 0.4
44 INT237415 Il1rn Regulation of Il10 1 0.03 0.96 0.39
45 INT237417 Il1rn Regulation of Il4 1 0.02 0.96 0.39
46 INT230499 Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1 1 0.01 0.85 0.36
47 INT224584 Binding of IL1RN and SIGMAR1 1 0.00 0.73 0.36
48 INT87023 ZAK Positive_regulation of Gene_expression of IL36RN 1 0.03 0.62 0.36
49 INT334951 IL6 Positive_regulation of Regulation of IL1RN 1 0.23 1.11 0.35
50 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35
51 INT334949 IL6 Regulation of Regulation of IL1RN 1 0.13 1.11 0.35
52 INT334950 IL6 Regulation of IL1RN 1 0.13 1.11 0.35
53 INT32445 Pomc Positive_regulation of Il1f5 1 0.21 0 0.34
54 INT92871 Positive_regulation of SON Positive_regulation of IL1RN 1 0.06 0.33 0.34
55 INT304277 CCNE1 Positive_regulation of IL1RN 1 0.00 1.93 0.31
56 INT25614 Pomc Regulation of Localization of Il1f5 1 0.07 0 0.31
57 INT62550 Il1f5 Regulation of Gene_expression of Icam1 1 0.05 0.44 0.28
58 INT256001 Ang Negative_regulation of Il1rn 1 0.11 0.25 0.27
59 INT255996 H7 Negative_regulation of Il1rn 1 0.01 0.25 0.27
60 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26
61 INT107954 Il1f5 Positive_regulation of Hdc 1 0.09 0.3 0.26
62 INT111313 IL36RN Positive_regulation of Gene_expression of MGST1 1 0.07 0.66 0.22
63 INT39567 Txnrd1 Regulation of Localization of Il1f5 1 0.04 0.18 0.21
64 INT220243 IL1RN Negative_regulation of Gene_expression of DPEP1 1 0.20 0.22 0.19
65 INT291041 IL6 Regulation of IL36RN 1 0.00 1.09 0.17
66 INT173938 Il1rn Negative_regulation of Il1 1 0.00 0.18 0.17
67 INT49201 Binding of Pomc and Il1f5 1 0.08 0.2 0.16
68 INT299012 Binding of Il18bp and Il1f5 1 0.00 0 0.14
69 INT171902 TNF Positive_regulation of Il1f5 1 0.05 0.52 0.14
70 INT220240 IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.12
71 INT300570 Binding of IL1RN and SUGT1P2 1 0.01 0.43 0.12
72 INT186243 IL36RN Positive_regulation of B4GALNT1 1 0.00 0.43 0.12
73 INT306925 IL36RN Positive_regulation of HAMP 1 0.01 1.39 0.1
74 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 0.06 1.07 0.1
75 INT298994 Binding of Il18 and Il1f5 1 0.01 0 0.1
76 INT33808 IL36RN Regulation of Regulation of LIPE 1 0.13 0.09 0.09
77 INT37238 Nono Positive_regulation of IL36RN 1 0.00 0.32 0.09
78 INT220248 IL1RN Regulation of Gene_expression of LONP1 1 0.04 0 0.08
79 INT220241 IL1RN Regulation of Gene_expression of DPEP1 1 0.24 0 0.08
80 INT220238 IL1RN Regulation of Protein_catabolism of DPEP1 1 0.14 0 0.08
81 INT299009 Il1f5 Negative_regulation of Il18 1 0.01 0 0.07
82 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03
83 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03
84 INT220236 Positive_regulation of IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.03
85 INT340423 Il1rn Regulation of Binding of Ccl2 1 0.21 0.99 0
86 INT164244 Binding of IL1RN and Mmp3 1 0.01 0 0
87 INT164240 Negative_regulation of Il1rn Negative_regulation of Mmp3 1 0.00 0 0
88 INT164245 Negative_regulation of Binding of IL1RN and Mmp3 1 0.01 0 0
89 INT32601 Tlr4 Positive_regulation of Gene_expression of Il1f5 1 0.04 0 0
90 INT186415 IL1RN Regulation of Gene_expression of IL1B 1 0.25 0.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-1 receptor antagonist activity. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-1 receptor antagonist activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62
2 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08
3 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66
4 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82
5 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83
6 INT72565 Localization of IL1RN 45 0.80 23.59 13.17
7 INT87844 Binding of IL1RN 40 0.41 24.37 11.92
8 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31
9 INT6474 Positive_regulation of Gene_expression of IL1RN 34 0.69 21.87 10.99
10 INT25613 Gene_expression of Il1f5 32 0.77 13.29 10.44
11 INT5864 Localization of IL36RN 19 0.44 14.5 6.87
12 INT25609 Localization of Il1f5 17 0.80 10.66 6.71
13 INT69980 Negative_regulation of Il1rn 11 0.33 7.75 6.7
14 INT126395 Positive_regulation of Gene_expression of Il1rn 11 0.41 7.66 6.25
15 INT73902 Regulation of Gene_expression of IL1RN 6 0.61 4.59 6.14
16 INT107441 Positive_regulation of Gene_expression of Il1rn 7 0.46 3.24 5.95
17 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44
18 INT73905 Transcription of IL1RN 10 0.71 9.16 5.04
19 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83
20 INT92199 Negative_regulation of Gene_expression of IL1RN 14 0.58 10.11 4.71
21 INT81485 Negative_regulation of IL1RN 19 0.57 8.3 4.69
22 INT36041 Negative_regulation of Gene_expression of IL36RN 11 0.11 9.47 4.46
23 INT76683 Positive_regulation of Il1rn 9 0.51 9.3 4.41
24 INT83646 Binding of Il1rn 12 0.37 4.41 3.51
25 INT40232 Transcription of Il1rn 8 0.53 9.6 3.37
26 INT16976 Negative_regulation of IL36RN 6 0.49 5.08 3.31
27 INT8246 Positive_regulation of IL36RN 13 0.43 9.15 3.16
28 INT171888 Binding of Il1rn 13 0.38 5.53 3.13
29 INT25601 Binding of IL36RN 5 0.35 1.93 2.9
30 INT21533 Positive_regulation of Il1f5 7 0.25 4.78 2.77
31 INT27422 Positive_regulation of Gene_expression of Il1f5 5 0.69 0 2.57
32 INT76679 Positive_regulation of Transcription of Il1rn 1 0.37 9.13 2.55
33 INT62064 Negative_regulation of Gene_expression of Il1rn 6 0.32 4.81 2.53
34 INT69981 Positive_regulation of Negative_regulation of Il1rn 2 0.09 3.28 2.48
35 INT131928 Localization of Il1rn 3 0.74 2.22 2.24
36 INT21013 Regulation of Gene_expression of IL36RN 4 0.11 1.71 2.11
37 INT173931 Regulation of Gene_expression of Il1rn 3 0.60 2.68 1.84
38 INT53233 Binding of Il1f5 3 0.13 2.14 1.83
39 INT38930 Regulation of IL36RN 4 0.21 2.14 1.8
40 INT53835 Negative_regulation of Localization of IL36RN 3 0.17 1.27 1.63
41 INT16917 Positive_regulation of Gene_expression of IL36RN 8 0.12 6.17 1.56
42 INT25600 Regulation of Binding of IL36RN 2 0.05 1.31 1.55
43 INT21012 Regulation of Localization of IL36RN 2 0.10 0.46 1.48
44 INT27424 Positive_regulation of Localization of Il1f5 3 0.69 0.68 1.43
45 INT73904 Positive_regulation of Localization of IL1RN 2 0.69 1.5 1.38
46 INT92873 Positive_regulation of Positive_regulation of IL1RN 3 0.47 1.82 1.28
47 INT101022 Regulation of Il1rn 5 0.44 2.15 1.21
48 INT53235 Regulation of Il1f5 3 0.19 2.45 1.01
49 INT292529 Phosphorylation of Il1rn 1 0.09 1 0.97
50 INT58632 Negative_regulation of Il1f5 3 0.13 3.5 0.96
51 INT145851 Negative_regulation of Positive_regulation of Il1rn 1 0.08 0.7 0.95
52 INT173929 Regulation of Il1rn 5 0.26 3.02 0.93
53 INT145852 Negative_regulation of Negative_regulation of Il1rn 1 0.08 0.69 0.93
54 INT165401 Phosphorylation of IL1RN 2 0.09 1.51 0.91
55 INT255990 Localization of Il1rn 6 0.73 1.74 0.9
56 INT171889 Negative_regulation of Gene_expression of Il1rn 3 0.08 2.31 0.9
57 INT27423 Regulation of Gene_expression of Il1f5 5 0.61 0.2 0.89
58 INT58631 Negative_regulation of Localization of Il1f5 2 0.13 1.8 0.89
59 INT73903 Positive_regulation of Transcription of IL1RN 2 0.69 1.15 0.87
60 INT116032 Transcription of Il1rn 4 0.70 2.19 0.84
61 INT28644 Negative_regulation of Gene_expression of Il1f5 3 0.55 1.01 0.76
62 INT187381 Regulation of Localization of IL1RN 1 0.00 1.05 0.74
63 INT88190 Negative_regulation of Binding of Il1rn 1 0.36 0.46 0.68
64 INT114182 Negative_regulation of Positive_regulation of Il1rn 1 0.15 0 0.49
65 INT255986 Negative_regulation of Negative_regulation of Il1rn 1 0.34 0.26 0.45
66 INT15718 Negative_regulation of Positive_regulation of IL36RN 1 0.01 0.6 0.45
67 INT15716 Positive_regulation of Localization of IL36RN 1 0.01 0.6 0.45
68 INT323910 Negative_regulation of Positive_regulation of IL1RN 1 0.05 0.57 0.42
69 INT344829 Positive_regulation of Positive_regulation of Il1rn 1 0.02 0.53 0.33
70 INT116035 Negative_regulation of Transcription of Il1rn 1 0.57 0.1 0.29
71 INT179500 Transcription of Il1f5 1 0.01 0.33 0.28
72 INT71277 Regulation of Localization of Il1f5 1 0.26 0.17 0.27
73 INT255991 Negative_regulation of Binding of Il1rn 1 0.34 0.26 0.27
74 INT323609 Positive_regulation of Binding of Il1rn 1 0.21 0.63 0.26
75 INT255985 Protein_catabolism of Il1rn 1 0.52 0.37 0.25
76 INT53232 Positive_regulation of Binding of Il1f5 2 0.14 1.74 0.19
77 INT35101 Positive_regulation of Protein_catabolism of IL36RN 1 0.50 0.07 0.15
78 INT285224 Positive_regulation of Transcription of Il1rn 1 0.45 0.72 0.15
79 INT35100 Protein_catabolism of IL36RN 1 0.99 0.07 0.15
80 INT340415 Regulation of Gene_expression of Il1rn 1 0.27 1.02 0.07
81 INT220260 Protein_catabolism of IL1RN 1 0.59 0.14 0
82 INT285222 Negative_regulation of Regulation of Il1rn 1 0.42 1.02 0
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