GO:0005153

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Name interleukin-8 receptor binding
Categary Function
Go Slim No
Go Link GO:0005153
Unique Molecular Interactions 233
Total Molecular Interactions 349
Total Single Events 3100
Pain Genes Associated 1

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-8 receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-8 receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
2 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
3 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
4 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
5 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
6 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
7 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86
8 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
9 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
10 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
11 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
12 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
13 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01
14 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
15 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
16 INT311102 IL8 Positive_regulation of CXCR7 1 0.00 1.74 0.98
17 INT311143 IL8 Positive_regulation of Cxcr1 1 0.04 1.74 0.98
18 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
19 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
20 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95
21 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
22 INT182206 Binding of CXCR5 and IL8 1 0.30 1.25 0.94
23 INT182196 Binding of IL8 and CXCL13 1 0.27 1.24 0.93
24 INT250976 Binding of FMOD and IL8 1 0.08 1.26 0.91
25 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
26 INT62956 CXCR2 Positive_regulation of IL8 1 0.30 0 0.88
27 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85
28 INT87494 CALCA Positive_regulation of IL8 1 0.48 0.15 0.81
29 INT87492 CALCA Regulation of IL8 1 0.28 0.15 0.81
30 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8
31 INT87493 Binding of CALCA and Positive_regulation of Gene_expression of IL8 1 0.52 0.18 0.76
32 INT248244 Binding of IL8 and SDC2 1 0.02 1.57 0.72
33 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71
34 INT120037 IL8 Positive_regulation of Prap1 1 0.00 0.99 0.7
35 INT120019 IL8 Positive_regulation of CCL3 1 0.02 0.99 0.7
36 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
37 INT194618 Il17a Positive_regulation of Gene_expression of IL8 2 0.01 1.94 0.67
38 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
39 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 0.11 2.87 0.66
40 INT292893 TNF Regulation of IL8 2 0.27 1.3 0.63
41 INT66602 TFF2 Positive_regulation of Gene_expression of IL8 1 0.01 0 0.63
42 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
43 INT342989 IL8 Regulation of SFTPA1 1 0.02 0.38 0.6
44 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59
45 INT169299 CNR1 Positive_regulation of Localization of IL8 1 0.20 0.11 0.59
46 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59
47 INT283434 Lcn2 Positive_regulation of Localization of IL8 1 0.07 1.33 0.51
48 INT286352 IL6 Positive_regulation of Gene_expression of IL8 2 0.24 1.32 0.48
49 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48
50 INT135591 CSF2 Regulation of IL8 1 0.09 1.27 0.48
51 INT144110 PRSS1 Positive_regulation of Gene_expression of IL8 1 0.21 1.38 0.48
52 INT132445 TF Positive_regulation of IL8 1 0.11 2.23 0.46
53 INT106243 Oprm1 Regulation of Gene_expression of IL8 1 0.00 0 0.45
54 INT186711 IK Positive_regulation of Localization of IL8 1 0.00 0.39 0.44
55 INT355571 MIF Positive_regulation of IL8 1 0.04 1.05 0.44
56 INT304281 IL8 Positive_regulation of TBK1 1 0.01 2.35 0.44
57 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43
58 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42
59 INT331799 IL8 Negative_regulation of Mapk14 1 0.01 1.6 0.42
60 INT303857 DDR1 Positive_regulation of IL8 1 0.05 1.5 0.42
61 INT316063 Ps Positive_regulation of IL8 1 0.09 1.33 0.41
62 INT316065 Eif1 Positive_regulation of IL8 1 0.01 1.34 0.41
63 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41
64 INT221027 ELANE Positive_regulation of IL8 2 0.14 1.3 0.4
65 INT103131 Positive_regulation of NFKB1 Regulation of Gene_expression of IL8 1 0.27 0.68 0.4
66 INT265465 CSPG4 Negative_regulation of Gene_expression of IL8 1 0.07 0.98 0.39
67 INT103130 DCSTAMP Positive_regulation of Gene_expression of IL8 1 0.09 0.65 0.39
68 INT292892 IL4 Regulation of IL8 1 0.01 0.25 0.39
69 INT292886 IL2 Regulation of IL8 1 0.03 0.25 0.39
70 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38
71 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38
72 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37
73 INT171296 TNFSF12 Positive_regulation of IL8 1 0.01 0.87 0.37
74 INT286351 IL8 Positive_regulation of Gene_expression of IRF6 1 0.03 0.71 0.36
75 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 0.07 1.11 0.36
76 INT286347 IL8 Positive_regulation of Gene_expression of IL6 1 0.11 0.7 0.36
77 INT103386 Negative_regulation of SLC9A1 Negative_regulation of Gene_expression of IL8 1 0.02 0.97 0.36
78 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
79 INT54570 Positive_regulation of NFKB1 Positive_regulation of Gene_expression of IL8 1 0.24 0.77 0.35
80 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34
81 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
82 INT311265 RENBP Regulation of IL8 1 0.03 1.59 0.33
83 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
84 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 0.11 0.51 0.32
85 INT259639 MAPK14 Regulation of Gene_expression of IL8 1 0.02 1.2 0.32
86 INT322964 Binding of IL8 and Cxcl12 1 0.30 0.2 0.32
87 INT170994 KNG1 Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.32
88 INT260893 CRH Positive_regulation of Gene_expression of IL8 1 0.28 0.05 0.31
89 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
90 INT304278 CCNE1 Positive_regulation of IL8 1 0.02 1.93 0.31
91 INT174657 IL8 Positive_regulation of Gene_expression of LTBR 1 0.01 1.53 0.3
92 INT130946 IL8 Positive_regulation of Il6 1 0.00 0.29 0.3
93 INT281734 MT1JP Positive_regulation of Localization of IL8 1 0.02 0.64 0.3
94 INT342985 IL8 Positive_regulation of PPBP 1 0.02 0.66 0.3
95 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
96 INT126006 Binding of ALB and IL8 1 0.41 0.28 0.28
97 INT207436 IL8 Negative_regulation of Gene_expression of PLA2G7 1 0.10 0.9 0.28
98 INT67193 IL8 Regulation of Localization of SST 1 0.00 0.66 0.28
99 INT258858 CTSB Positive_regulation of Gene_expression of IL8 1 0.00 0.64 0.28
100 INT67199 Tgfa Regulation of Localization of IL8 1 0.00 0.66 0.28
101 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28
102 INT301668 Ltb4r1 Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27
103 INT322966 Binding of IL8 and Darc 1 0.02 0.45 0.27
104 INT301671 Ltc4s Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27
105 INT137166 IL8 Positive_regulation of CXCR2 1 0.24 0.28 0.27
106 INT67198 IL8 Regulation of Tgfa 1 0.00 0.65 0.27
107 INT101508 PPARA Regulation of IL8 1 0.31 0.53 0.27
108 INT101509 PPARA Regulation of Gene_expression of IL8 1 0.31 0.53 0.27
109 INT282648 IL8 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
110 INT155530 IRF6 Regulation of Gene_expression of IL8 1 0.06 0.79 0.26
111 INT252794 Binding of IL8 and TNF 1 0.02 0.75 0.25
112 INT252795 IL8 Positive_regulation of Positive_regulation of FOS 1 0.01 0.75 0.25
113 INT278941 MST1 Regulation of Gene_expression of IL8 1 0.01 0.4 0.25
114 INT252816 IL8 Regulation of Positive_regulation of FOS 1 0.01 0.75 0.25
115 INT266801 Dlst Positive_regulation of IL8 1 0.00 0.95 0.25
116 INT171271 TNFSF12 Positive_regulation of Transcription of IL8 1 0.01 0.44 0.25
117 INT179200 Binding of ICAM1 and IL8 1 0.03 1.02 0.25
118 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24
119 INT311268 RENBP Regulation of Gene_expression of IL8 1 0.02 1.05 0.24
120 INT133246 IL1B Regulation of Localization of IL8 1 0.56 0.16 0.23
121 INT303992 Il1 Positive_regulation of Gene_expression of IL8 1 0.00 0.55 0.23
122 INT217349 Mip Positive_regulation of IL8 1 0.05 1.28 0.22
123 INT221385 Tlr4 Positive_regulation of IL8 1 0.05 1.79 0.2
124 INT344399 IL8 Regulation of Gene_expression of Crp 1 0.03 0.59 0.2
125 INT291348 IL8 Positive_regulation of Phosphorylation of SHC1 1 0.11 1.16 0.2
126 INT286348 IL8 Positive_regulation of IL10 1 0.08 0.18 0.19
127 INT326737 IL8 Positive_regulation of Gene_expression of ARG1 1 0.38 2.41 0.19
128 INT244243 Regulation of Binding of IL8 and Ccl3 1 0.04 0.05 0.18
129 INT126007 Negative_regulation of Binding of ALB and IL8 1 0.37 0.18 0.18
130 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18
131 INT244240 Binding of IL8 and Ccr5 1 0.03 0.05 0.18
132 INT244241 Binding of IL8 and Ccl3 1 0.05 0.05 0.18
133 INT322965 Binding of IL8 and Cxcr2 1 0.28 0.51 0.18
134 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
135 INT248237 Binding of IL8 and SDC3 1 0.02 0.52 0.18
136 INT244242 Negative_regulation of Binding of IL8 and Ccl3 1 0.06 0.05 0.18
137 INT326739 IL8 Regulation of Gene_expression of ARG2 1 0.35 0.46 0.17
138 INT244230 Binding of IL8 and CCL18 1 0.02 0.23 0.17
139 INT353040 IL4 Positive_regulation of IL8 1 0.02 0.99 0.16
140 INT226524 BTPs Negative_regulation of IL8 1 0.01 0.28 0.16
141 INT226519 BTPs Negative_regulation of Gene_expression of IL8 1 0.02 0.28 0.16
142 INT278947 PTGER2 Regulation of Gene_expression of IL8 1 0.04 0.32 0.16
143 INT353039 IL4 Positive_regulation of Localization of IL8 1 0.02 0.99 0.16
144 INT298475 LPA Positive_regulation of Gene_expression of IL8 1 0.07 0.38 0.15
145 INT111486 Binding of IFNG and IL8 1 0.13 0.28 0.15
146 INT183707 Ducm1 Positive_regulation of Gene_expression of IL8 1 0.02 0.62 0.15
147 INT273171 PDE4A Regulation of IL8 1 0.05 0.53 0.15
148 INT307755 TNF Regulation of Gene_expression of IL8 1 0.02 0.5 0.14
149 INT326733 Negative_regulation of IL8 Negative_regulation of Gene_expression of ARG2 1 0.24 0.33 0.14
150 INT326735 Negative_regulation of IL8 Negative_regulation of Gene_expression of ARG1 1 0.32 0.33 0.14
151 INT329371 IL8 Negative_regulation of Jun 1 0.00 0.95 0.13
152 INT253328 Binding of IL8 and Scrib 1 0.04 0.79 0.12
153 INT171269 TNFSF12 Positive_regulation of Gene_expression of IL8 1 0.01 0.09 0.12
154 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12
155 INT72312 IL8 Positive_regulation of reticulocyte alpha 4 beta 1 1 0.00 0.3 0.12
156 INT171277 Binding of TNFSF12 and Positive_regulation of Transcription of IL8 1 0.01 0.21 0.12
157 INT319735 Positive_regulation of Binding of IL6 and IL8 1 0.01 1.35 0.11
158 INT176020 IL8 Negative_regulation of Phosphorylation of HMGCR 1 0.00 0.1 0.11
159 INT179159 IL8 Regulation of Gene_expression of IL6 1 0.02 0.12 0.11
160 INT229393 Negative_regulation of PRSS1 Negative_regulation of Gene_expression of IL8 1 0.00 0.86 0.11
161 INT179165 IL8 Regulation of Gene_expression of IL13 1 0.02 0.12 0.11
162 INT292087 SRC Regulation of IL8 1 0.02 1.43 0.11
163 INT355579 VEGFA Positive_regulation of Gene_expression of IL8 1 0.04 1.22 0.1
164 INT294451 KLK4 Negative_regulation of IL8 1 0.01 0 0.1
165 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1
166 INT203629 IL8 Negative_regulation of Timp1 1 0.05 0 0.1
167 INT293411 IL8 Regulation of IL11 1 0.03 1.17 0.1
168 INT99242 IFNG Regulation of IL8 1 0.23 0.57 0.1
169 INT203589 IL8 Negative_regulation of VEGFA 1 0.03 0 0.1
170 INT203583 IL8 Negative_regulation of TIMP2 1 0.03 0 0.1
171 INT355578 VEGFA Positive_regulation of Positive_regulation of IL8 1 0.03 1.42 0.1
172 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1
173 INT263340 Ptger2 Positive_regulation of IL8 1 0.01 0.15 0.1
174 INT203593 IL8 Negative_regulation of VEGFC 1 0.00 0 0.1
175 INT126005 Binding of IL8 and OXA1L 1 0.30 0.1 0.1
176 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1
177 INT203627 Cxcl1 Negative_regulation of IL8 1 0.00 0 0.1
178 INT293409 IL8 Regulation of VEGFA 1 0.04 1.18 0.1
179 INT203584 IL6 Negative_regulation of IL8 1 0.03 0 0.1
180 INT77649 Positive_regulation of JUN Positive_regulation of Transcription of IL8 1 0.01 0.79 0.09
181 INT338432 Il23a Positive_regulation of Gene_expression of IL8 1 0.01 1.63 0.09
182 INT4262 IL8 Positive_regulation of Localization of Adh1 1 0.12 0 0.09
183 INT318999 Binding of IL8 and ACCS 1 0.03 3.52 0.09
184 INT338433 Il17f Positive_regulation of Gene_expression of IL8 1 0.01 1.62 0.09
185 INT293415 HRAS Positive_regulation of Localization of IL8 1 0.01 0.73 0.09
186 INT226912 Slc11a1 Positive_regulation of Localization of IL8 1 0.05 0.58 0.08
187 INT337181 Binding of IL8 and PTGER2 1 0.01 0.5 0.08
188 INT210601 IL8 Positive_regulation of TNFSF11 1 0.06 1.46 0.08
189 INT276816 IL8 Positive_regulation of Gene_expression of Hgs 1 0.03 0.13 0.08
190 INT180983 IRF6 Regulation of Localization of IL8 1 0.06 0.38 0.08
191 INT210599 IL8 Regulation of TNFSF11 1 0.05 1.44 0.08
192 INT189152 MTNR1B Negative_regulation of Localization of IL8 1 0.00 0.15 0.07
193 INT171261 IL8 Positive_regulation of MMP1 1 0.04 0.05 0.07
194 INT171267 TNFSF12 Negative_regulation of IL8 1 0.00 0.06 0.07
195 INT226913 Slc11a1 Positive_regulation of Gene_expression of IL8 1 0.05 0.63 0.07
196 INT171275 IL8 Positive_regulation of PTGER2 1 0.01 0.05 0.07
197 INT283433 Nt5e Positive_regulation of Localization of IL8 1 0.01 0.21 0.07
198 INT191002 F2 Positive_regulation of Gene_expression of IL8 1 0.02 0.46 0.06
199 INT267593 IL8 Positive_regulation of Localization of MUC1 1 0.00 1.06 0.06
200 INT318997 Binding of CSF2 and IL8 1 0.05 1.76 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-8 receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-8 receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10832 Gene_expression of IL8 1050 0.78 698.72 270
2 INT12339 Localization of IL8 437 0.81 251.87 117.39
3 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62
4 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34
5 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2
6 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21
7 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71
8 INT10835 Regulation of IL8 79 0.49 53.04 24.14
9 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8
10 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46
11 INT10834 Binding of IL8 65 0.48 41.66 16.53
12 INT52107 Transcription of IL8 63 0.72 41.66 16.06
13 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05
14 INT74422 Regulation of Localization of IL8 21 0.62 10.19 5.99
15 INT75833 Negative_regulation of Positive_regulation of IL8 15 0.53 6.69 5.59
16 INT75831 Positive_regulation of Transcription of IL8 21 0.63 13.56 4.98
17 INT68255 Regulation of Positive_regulation of IL8 12 0.41 5.71 3.91
18 INT115622 Positive_regulation of Binding of IL8 7 0.44 5.79 2.69
19 INT77651 Negative_regulation of Transcription of IL8 8 0.43 4.48 2.16
20 INT91664 Positive_regulation of Negative_regulation of IL8 5 0.40 3.28 1.62
21 INT103389 Negative_regulation of Negative_regulation of IL8 3 0.39 2.2 0.86
22 INT274171 Negative_regulation of Binding of IL8 3 0.38 1.2 0.79
23 INT179168 Regulation of Transcription of IL8 4 0.43 1.88 0.63
24 INT115623 Regulation of Binding of IL8 2 0.40 0.08 0.61
25 INT170057 Regulation of Negative_regulation of IL8 1 0.33 0.99 0.58
26 INT102778 Phosphorylation of IL8 1 0.43 0.94 0.38
27 INT116783 Protein_catabolism of IL8 3 0.86 1.11 0.16
28 INT170138 Positive_regulation of Regulation of IL8 2 0.22 0.89 0.04
29 INT326767 Regulation of Regulation of IL8 1 0.13 1.03 0.03
30 INT180279 Positive_regulation of Phosphorylation of IL8 1 0.09 0.05 0
31 INT315111 Positive_regulation of Protein_catabolism of IL8 1 0.37 0.63 0
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