GO:0005159

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Name insulin-like growth factor receptor binding
Categary Function
Go Slim No
Go Link GO:0005159
Unique Molecular Interactions 938
Total Molecular Interactions 1288
Total Single Events 16135
Pain Genes Associated 30

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin-like growth factor receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for insulin-like growth factor receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
5 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
6 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
8 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
9 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
10 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
11 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
12 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
13 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
14 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
15 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
16 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
17 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
18 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
19 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
20 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
21 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
22 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
23 INT30135 S100A9 Positive_regulation of REN 1 0.32 0.32 1
24 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
25 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
26 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
27 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
28 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
29 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
30 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
31 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
32 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
33 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
34 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
35 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
36 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
37 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
38 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
39 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
40 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
41 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
42 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
43 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
44 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
45 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
46 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
47 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
48 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
49 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
50 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
51 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
52 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
53 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
54 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
55 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
56 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
57 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
58 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
59 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
60 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
61 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
62 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
63 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
64 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
65 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
66 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
67 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
68 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
69 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
70 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
71 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
72 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
73 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
74 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
75 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
76 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
77 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
78 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
79 INT72387 Trim13 Regulation of Phosphorylation of Shc1 1 0.32 0.09 0.54
80 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
81 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
82 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
83 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
84 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
85 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
86 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
87 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
88 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
89 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
90 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
91 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
92 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
93 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
94 INT264137 IFNA1 Positive_regulation of Socs1 1 0.01 0.38 0.46
95 INT39142 ras Positive_regulation of REN 1 0.01 1.34 0.45
96 INT341211 Gopc Regulation of Shc1 1 0.02 0.68 0.45
97 INT39143 ras Positive_regulation of Gene_expression of REN 1 0.01 1.35 0.45
98 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
99 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
100 INT246024 IL23A Positive_regulation of SOCS2 1 0.01 0.99 0.43
101 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
102 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
103 INT264135 Socs1 Positive_regulation of Protein_catabolism of TOLLIP 1 0.00 0.33 0.41
104 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
105 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
106 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
107 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
108 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
109 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
110 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
111 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
112 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
113 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
114 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
115 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
116 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
117 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
118 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
119 INT175016 Binding of REN and S100A6 2 0.11 1.13 0.37
120 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
121 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
122 INT39094 Negative_regulation of Nts Positive_regulation of Localization of Ren 1 0.16 0 0.37
123 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
124 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
125 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
126 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
127 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
128 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
129 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
130 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
131 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
132 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
133 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
134 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
135 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
136 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
137 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
138 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
139 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
140 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
141 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
142 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
143 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
144 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
145 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
146 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
147 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
148 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
149 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
150 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
151 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
152 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
153 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
154 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
155 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
156 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
157 INT315394 IFNA1 Positive_regulation of Gene_expression of Socs1 1 0.01 0.41 0.31
158 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
159 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
160 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
161 INT315398 IFNA1 Positive_regulation of Socs1 1 0.01 0.41 0.3
162 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
163 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
164 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
165 INT175017 Negative_regulation of Binding of REN and S100A6 1 0.13 0.45 0.29
166 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
167 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
168 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
169 INT175018 Positive_regulation of Binding of REN and S100A6 1 0.15 0.45 0.29
170 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
171 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
172 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
173 INT71550 GTPBP4 Regulation of Localization of INS 1 0.00 0.16 0.28
174 INT291201 Regulation of INS Positive_regulation of GOPC 1 0.00 0.35 0.28
175 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
176 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
177 INT291200 INS Positive_regulation of GOPC 1 0.01 0.3 0.28
178 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
179 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
180 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
181 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27
182 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27
183 INT224406 INS Regulation of Localization of PYY 1 0.11 0.27 0.27
184 INT224405 INS Regulation of Localization of CCK 1 0.12 0.27 0.27
185 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
186 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
187 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
188 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
189 INT291261 INS Positive_regulation of Phosphorylation of Mdk 1 0.01 0.28 0.25
190 INT309888 INS Positive_regulation of Gene_expression of FAAH 1 0.04 1.19 0.25
191 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
192 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
193 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24
194 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24
195 INT14642 PENK Positive_regulation of REN 1 0.72 0.19 0.23
196 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
197 INT87750 IGFBP3 Negative_regulation of INS 1 0.11 0.86 0.23
198 INT63196 INS Positive_regulation of IL2 1 0.10 0.3 0.23
199 INT14643 PENK Positive_regulation of Positive_regulation of REN 1 0.48 0.19 0.23
200 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin-like growth factor receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in insulin-like growth factor receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
4 INT46 Localization of Ren 233 0.81 46.15 62.44
5 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
6 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
7 INT251 Regulation of INS 398 0.62 232.47 55.04
8 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
9 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
10 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
11 INT654 Localization of REN 250 0.81 75.12 47.86
12 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
13 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
14 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
15 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
16 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
17 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
18 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
19 INT1116 Regulation of Ren 103 0.62 27.66 33.26
20 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
21 INT8691 Localization of Insr 85 0.80 9.27 30.32
22 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
23 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
24 INT5300 Regulation of Insr 54 0.60 11.33 29.26
25 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
26 INT2140 Regulation of REN 104 0.62 28.24 24.49
27 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
28 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
29 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
30 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
31 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
32 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
33 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
34 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
35 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
36 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56
37 INT14572 Binding of INS 205 0.48 175.43 13.38
38 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
39 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
40 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
41 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
42 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
43 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
44 INT661 Gene_expression of REN 100 0.78 48.21 11.36
45 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
46 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
47 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81
48 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
49 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
50 INT34777 Localization of IGF1 82 0.80 42.68 8.62
51 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
52 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
53 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
54 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
55 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
56 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
57 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
58 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
59 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
60 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
61 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
62 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
63 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
64 INT53871 Gene_expression of Socs1 32 0.71 22.83 6.21
65 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
66 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
67 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
68 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
69 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
70 INT151032 Localization of Igf1 49 0.76 26.32 5.71
71 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
72 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
73 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
74 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
75 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
76 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
77 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
78 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
79 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
80 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
81 INT3097 Binding of Ren 12 0.48 3.15 4.4
82 INT98357 Binding of Gnas 11 0.41 1.87 4.35
83 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
84 INT49360 Localization of Igf1 22 0.76 6.96 4.26
85 INT51084 Binding of Insr 13 0.30 4.25 4.23
86 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
87 INT83035 Binding of INSR 16 0.47 9.29 4.11
88 INT72385 Phosphorylation of Shc1 11 0.52 1.62 4.1
89 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
90 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
91 INT25709 Negative_regulation of Igf2 11 0.56 9.38 3.76
92 INT10116 Localization of INSR 11 0.57 5.43 3.48
93 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
94 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
95 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
96 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27
97 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
98 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
99 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
100 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
101 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
102 INT16130 Binding of IGF1 67 0.48 27.43 2.95
103 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
104 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
105 INT72384 Positive_regulation of Phosphorylation of Shc1 1 0.32 0.48 2.9
106 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
107 INT9335 Gene_expression of Igf2 18 0.72 12.76 2.78
108 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
109 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
110 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
111 INT136681 Gene_expression of Shc1 13 0.77 9.67 2.52
112 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
113 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
114 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
115 INT66544 Binding of Igf1 23 0.46 8.33 2.44
116 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41
117 INT39394 Regulation of Ren1 13 0.45 4.83 2.4
118 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38
119 INT9327 Localization of Igf2 8 0.80 5.07 2.36
120 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
121 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31
122 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
123 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26
124 INT57132 Positive_regulation of Igf2 9 0.50 5.15 2.22
125 INT184054 Negative_regulation of Gene_expression of Socs1 7 0.53 9.18 2.22
126 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
127 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
128 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
129 INT3533 Binding of REN 24 0.37 10.84 2.16
130 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
131 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11
132 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
133 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
134 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
135 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
136 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
137 INT122534 Binding of Shc1 6 0.48 3.59 1.94
138 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
139 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9
140 INT184042 Negative_regulation of Socs1 9 0.46 8.1 1.88
141 INT114059 Localization of Insr 10 0.46 3.49 1.87
142 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87
143 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
144 INT184068 Positive_regulation of Socs1 7 0.51 4.03 1.73
145 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
146 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
147 INT232645 Transcription of INSR 2 0.09 1.19 1.71
148 INT1500 Negative_regulation of Gene_expression of Ren 10 0.43 4.44 1.68
149 INT3084 Negative_regulation of Negative_regulation of REN 6 0.42 2.2 1.68
150 INT254250 Regulation of Socs1 5 0.06 3.04 1.66
151 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
152 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
153 INT136680 Negative_regulation of Gene_expression of Shc1 4 0.43 3.36 1.57
154 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
155 INT19342 Regulation of Insr 12 0.24 6.11 1.54
156 INT184052 Localization of Socs1 3 0.59 4.07 1.54
157 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
158 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
159 INT44164 Localization of Ren1 18 0.49 10.53 1.49
160 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
161 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43
162 INT136678 Positive_regulation of Gene_expression of Shc1 4 0.50 2.93 1.42
163 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
164 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
165 INT90491 Binding of Igf1 25 0.44 9.75 1.36
166 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
167 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
168 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
169 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
170 INT47 Negative_regulation of Negative_regulation of Ren 2 0.59 0.34 1.25
171 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
172 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
173 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
174 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21
175 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
176 INT9324 Negative_regulation of Gene_expression of Igf2 6 0.50 5.12 1.2
177 INT25710 Regulation of Igf2 6 0.62 3.1 1.17
178 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
179 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
180 INT183046 Transcription of INS 25 0.70 11.14 1.13
181 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
182 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
183 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
184 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
185 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07
186 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
187 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05
188 INT257750 Positive_regulation of Gene_expression of SHC1 1 0.60 3.1 1.04
189 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
190 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
191 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
192 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
193 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
194 INT2482 Regulation of Positive_regulation of REN 4 0.59 2.62 0.91
195 INT34779 Regulation of IGF2 7 0.38 4.34 0.9
196 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
197 INT23756 Regulation of Negative_regulation of REN 5 0.44 0.77 0.87
198 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
199 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
200 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
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