GO:0005168

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Name neurotrophin TRKA receptor binding
Categary Function
Go Slim No
Go Link GO:0005168
Unique Molecular Interactions 146
Total Molecular Interactions 217
Total Single Events 906
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neurotrophin TRKA receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for neurotrophin TRKA receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
2 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
3 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
4 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
5 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
6 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
7 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
8 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
9 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
10 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
11 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01
12 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
13 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
14 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
15 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85
16 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
17 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72
18 INT289333 Binding of Ngfr and Rtn4r 1 0.03 2.35 0.72
19 INT289332 Binding of Ngfr and Lingo1 1 0.04 2.36 0.72
20 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
21 INT82021 Negative_regulation of Binding of Ngfr and Ngf 1 0.29 0.32 0.69
22 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
23 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
24 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
25 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
26 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
27 INT134528 Grin1 Regulation of Ngfr 1 0.03 0 0.57
28 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
29 INT72387 Trim13 Regulation of Phosphorylation of Shc1 1 0.32 0.09 0.54
30 INT76002 Ngf Positive_regulation of Ngfr 1 0.05 0.48 0.53
31 INT245558 Runx3 Regulation of Ngfr 1 0.06 1 0.53
32 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
33 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
34 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
35 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
36 INT341211 Gopc Regulation of Shc1 1 0.02 0.68 0.45
37 INT120295 Ngf Positive_regulation of Positive_regulation of Ngfr 1 0.47 0.22 0.43
38 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
39 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
40 INT73537 Ntf3 Positive_regulation of Ngfr 1 0.21 0.1 0.38
41 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
42 INT73536 Ngf Regulation of Ngfr 1 0.22 0.08 0.37
43 INT112283 Bdnf Regulation of Gene_expression of Ngfr 1 0.14 0.28 0.34
44 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
45 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
46 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
47 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
48 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
49 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
50 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
51 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
52 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
53 INT241451 Mag Positive_regulation of Ngfr 1 0.09 0.1 0.21
54 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21
55 INT291348 IL8 Positive_regulation of Phosphorylation of SHC1 1 0.11 1.16 0.2
56 INT314038 THL Negative_regulation of Pik3r1 1 0.14 0.78 0.18
57 INT280486 Binding of Ngfr and Ntrk2 2 0.18 1.21 0.17
58 INT191355 HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
59 INT191354 Negative_regulation of HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
60 INT241462 Binding of OMG and Ngfr 1 0.11 0.15 0.15
61 INT241457 Binding of Mag and Ngfr 1 0.09 0.15 0.15
62 INT241453 Binding of Ngfr and Rtn4r 1 0.03 0.15 0.15
63 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15
64 INT129094 Binding of GRP and Pik3r1 1 0.00 0.49 0.12
65 INT129075 Binding of Pik3r1 and Lyn 1 0.00 0.47 0.12
66 INT166153 Pik3r1 Regulation of Gene_expression of Ccr9 1 0.36 0.78 0.12
67 INT317888 Binding of Eef1a1 and Pik3r1 1 0.01 1.04 0.11
68 INT317887 Binding of Mtf1 and Pik3r1 1 0.25 1.04 0.11
69 INT349858 Binding of Ngfr and Ntrk2 1 0.09 0.32 0.11
70 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
71 INT280493 Ngfr Regulation of Protein_catabolism of BDNF 1 0.09 0.14 0.1
72 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
73 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1
74 INT213051 Hdl1 Positive_regulation of Pik3r1 1 0.13 1.93 0.09
75 INT164675 Binding of NGF and Ngfr 1 0.00 0.5 0.08
76 INT164676 Negative_regulation of Binding of NGF and Ngfr 1 0.00 0.5 0.08
77 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
78 INT331796 Akt1 Negative_regulation of Negative_regulation of Pik3r1 1 0.04 0.88 0.08
79 INT340553 Pik3r1 Regulation of Gene_expression of Fbxo32 1 0.04 0.52 0.07
80 INT340317 Binding of Shc1 and Positive_regulation of Frs2 1 0.19 0 0.07
81 INT340320 Binding of Shc1 and Positive_regulation of Pik3r1 1 0.23 0 0.07
82 INT120569 Binding of Egfr and Pik3r1 1 0.40 1.22 0.06
83 INT120570 Positive_regulation of Binding of Egfr and Pik3r1 1 0.55 1.22 0.06
84 INT73194 GRB2 Positive_regulation of Positive_regulation of PLCG2 1 0.19 0.81 0.05
85 INT213016 Regulation of Hdl1 Positive_regulation of Pik3r1 1 0.09 0.97 0.05
86 INT199106 Negative_regulation of Pik3r1 Negative_regulation of Gene_expression of Ros1 1 0.03 0.08 0.04
87 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
88 INT213031 Positive_regulation of Pik3r1 Positive_regulation of Gene_expression of Nos3 1 0.10 0.8 0.04
89 INT241449 Mag Positive_regulation of Protein_catabolism of Ngfr 1 0.09 0 0.03
90 INT234991 Binding of Dsg3 and Positive_regulation of Pik3r1 1 0.05 0.32 0.03
91 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
92 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
93 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
94 INT333878 Shc1 Positive_regulation of EPHB2 1 0.08 0.3 0.03
95 INT201732 Ngfr Positive_regulation of Nfkb1 1 0.01 0.43 0.03
96 INT306646 Mapk1 Regulation of Pik3r1 1 0.03 0.39 0
97 INT200063 Binding of MAGED1 and Ngfr 1 0.44 0.45 0
98 INT191097 Neu1 Positive_regulation of Shc1 1 0.04 1.96 0
99 INT287676 Negative_regulation of Sphk1 Negative_regulation of Pik3r1 1 0.14 0.42 0
100 INT225909 Binding of GRB2 and SOS1 1 0.01 0.11 0
101 INT176551 Binding of Pik3r1 and Spp1 1 0.03 0.65 0
102 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0
103 INT225889 Binding of MET and SHC1 1 0.01 0 0
104 INT142141 Oxt Regulation of Plcg1 1 0.03 0.08 0
105 INT225905 Binding of GRB2 and SHC1 1 0.00 0 0
106 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
107 INT191183 Binding of GRB2 and RECQL5 1 0.37 0.17 0
108 INT239185 Binding of Clk1 and Shc1 1 0.04 2.42 0
109 INT191099 Erbb2 Positive_regulation of Shc1 1 0.08 1.95 0
110 INT338013 Binding of Ngfrap1 and Ngfr 1 0.06 1.3 0
111 INT225906 Binding of GAB1 and GRB2 1 0.01 0.27 0
112 INT200062 Binding of Ngfr and Bbs4 1 0.30 0.3 0
113 INT253565 Akt1 Positive_regulation of Positive_regulation of Pik3r1 1 0.10 0 0
114 INT200053 Binding of Nuc and Ngfr 1 0.10 0.3 0
115 INT275974 Binding of Grb2 and Lat 1 0.33 0 0
116 INT211572 Binding of Kit and Pik3r1 1 0.21 0.06 0
117 INT200057 Binding of Ndn and Ngfr 1 0.43 1.96 0
118 INT275975 Grb2 Positive_regulation of Lcp2 1 0.24 0 0
119 INT303334 Binding of SOS1 and Grb2 1 0.00 0.11 0
120 INT176553 Pik3r1 Positive_regulation of Positive_regulation of Mapk14 1 0.02 0.41 0
121 INT176542 Pik3r1 Positive_regulation of Positive_regulation of Mapk1 1 0.01 0.41 0
122 INT176536 Binding of Pik3r1 and Mtv7 1 0.02 0.46 0
123 INT320346 Binding of Ngfr and Np4 1 0.01 0 0
124 INT171394 Binding of Grb2 and Shc1 1 0.05 0 0
125 INT201742 Binding of Ngfr and Gtf3a 1 0.00 0.77 0
126 INT211574 Regulation of Binding of Kit and Pik3r1 1 0.16 0.06 0
127 INT275979 Binding of Grb2 and Lcp2 1 0.23 0 0
128 INT142143 F2r Regulation of Plcg1 1 0.02 0.07 0
129 INT306618 Myoz1 Regulation of Pik3r1 1 0.00 0.39 0
130 INT323500 Ghrl Positive_regulation of Grb2 1 0.13 0.5 0
131 INT200061 Binding of Ngfr and Fez1 1 0.31 0.3 0
132 INT176550 Pik3r1 Positive_regulation of Gene_expression of Spp1 1 0.05 0.47 0
133 INT290372 Binding of Ngfr and Scarb1 1 0.01 0.48 0
134 INT253567 Binding of Pik3r1 and Sp3 1 0.11 0.06 0
135 INT201741 Binding of Rhoa and Ngfr 1 0.01 1 0
136 INT142142 F2r Positive_regulation of Phosphorylation of Plcg1 1 0.03 0.08 0
137 INT211571 Pik3r1 Positive_regulation of Gene_expression of Kit 1 0.30 0.3 0
138 INT200055 Binding of Ngfr and Mageh1 1 0.33 0.45 0
139 INT191185 Binding of GRB2 and H3F3B 1 0.34 0.08 0
140 INT225901 Binding of GRB2 and MET 1 0.00 0.33 0
141 INT278380 Syk Positive_regulation of Pik3r1 1 0.13 0 0
142 INT275981 Grb2 Positive_regulation of Lat 1 0.35 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neurotrophin TRKA receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in neurotrophin TRKA receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
2 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
3 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
4 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
5 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
6 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
7 INT96259 Positive_regulation of Plcg1 11 0.49 3.01 11.15
8 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
9 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
10 INT110004 Gene_expression of Plcg1 7 0.41 2.61 7.87
11 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
12 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73
13 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
14 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
15 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
16 INT64711 Regulation of Ngfr 10 0.45 3.12 4.33
17 INT72385 Phosphorylation of Shc1 11 0.52 1.62 4.1
18 INT121170 Positive_regulation of Gene_expression of Ngfr 10 0.64 9.32 3.94
19 INT121171 Negative_regulation of Gene_expression of Ngfr 6 0.58 3.46 3.89
20 INT55907 Binding of Ngfr 13 0.47 5.79 3.75
21 INT61540 Negative_regulation of Gene_expression of Ngfr 11 0.59 6.36 3.43
22 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
23 INT72384 Positive_regulation of Phosphorylation of Shc1 1 0.32 0.48 2.9
24 INT61541 Positive_regulation of Gene_expression of Ngfr 7 0.53 2.87 2.75
25 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
26 INT136681 Gene_expression of Shc1 13 0.77 9.67 2.52
27 INT75225 Transcription of Ngfr 4 0.60 1.95 2.44
28 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
29 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
30 INT110003 Phosphorylation of Plcg1 2 0.37 0.91 1.96
31 INT122534 Binding of Shc1 6 0.48 3.59 1.94
32 INT64712 Localization of Ngfr 4 0.78 1.19 1.91
33 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87
34 INT140247 Negative_regulation of Negative_regulation of Ngfr 3 0.33 3.15 1.59
35 INT136680 Negative_regulation of Gene_expression of Shc1 4 0.43 3.36 1.57
36 INT163594 Regulation of Ngfr 5 0.43 2.55 1.53
37 INT136678 Positive_regulation of Gene_expression of Shc1 4 0.50 2.93 1.42
38 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
39 INT64713 Regulation of Gene_expression of Ngfr 4 0.50 2.04 1.36
40 INT138939 Positive_regulation of Transcription of Ngfr 3 0.43 0.89 1.31
41 INT164372 Positive_regulation of Positive_regulation of Ngfr 6 0.62 4.1 1.22
42 INT110001 Binding of Plcg1 2 0.36 0.44 1.21
43 INT110392 Transcription of Ngfr 3 0.52 2.48 1.19
44 INT257750 Positive_regulation of Gene_expression of SHC1 1 0.60 3.1 1.04
45 INT163595 Positive_regulation of Regulation of Ngfr 1 0.46 0.57 1.04
46 INT110000 Positive_regulation of Phosphorylation of Plcg1 1 0.23 0.49 1.02
47 INT77639 Phosphorylation of Plcg1 5 0.68 0.47 0.97
48 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
49 INT72380 Positive_regulation of Shc1 10 0.69 6.87 0.77
50 INT317733 Positive_regulation of Binding of Ngfr 1 0.18 0.51 0.71
51 INT133018 Regulation of Gene_expression of Ngfr 2 0.43 1.47 0.7
52 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64
53 INT191347 Regulation of Shc1 6 0.27 3.6 0.6
54 INT135666 Negative_regulation of Negative_regulation of Pik3r1 2 0.29 0.3 0.6
55 INT110002 Regulation of Positive_regulation of Plcg1 1 0.11 0.4 0.59
56 INT139929 Phosphorylation of Ngfr 3 0.58 1.67 0.57
57 INT118729 Regulation of Transcription of Ngfr 1 0.36 0.45 0.57
58 INT110393 Positive_regulation of Transcription of Ngfr 1 0.46 1 0.54
59 INT136679 Negative_regulation of Shc1 3 0.59 2.5 0.51
60 INT72379 Localization of Shc1 4 0.74 0.89 0.49
61 INT257756 Regulation of Gene_expression of SHC1 1 0.39 1.13 0.41
62 INT114740 Binding of GRB2 8 0.36 2.24 0.37
63 INT165518 Positive_regulation of Regulation of Ngfr 2 0.47 0.47 0.37
64 INT168766 Positive_regulation of Binding of Pik3r1 3 0.21 1.54 0.35
65 INT191211 Gene_expression of GRB2 5 0.62 0.96 0.32
66 INT212985 Negative_regulation of Positive_regulation of Pik3r1 3 0.19 3.28 0.3
67 INT185119 Regulation of Positive_regulation of Pik3r1 3 0.13 0.45 0.3
68 INT77634 Binding of Plcg1 1 0.07 0 0.27
69 INT240034 Phosphorylation of GRB2 3 0.79 1.79 0.25
70 INT297460 Regulation of Regulation of Ngfr 1 0.33 0.32 0.21
71 INT304145 Phosphorylation of Grb2 1 0.03 0.72 0.2
72 INT142137 Regulation of Phosphorylation of Plcg1 1 0.37 0.1 0.19
73 INT236698 Transcription of Pik3r1 1 0.15 1.3 0.18
74 INT142138 Positive_regulation of Plcg1 1 0.41 0 0.18
75 INT142140 Gene_expression of Plcg1 1 0.64 0 0.17
76 INT309653 Negative_regulation of Localization of Pik3r1 1 0.14 0.55 0.15
77 INT351894 Negative_regulation of SHC1 1 0.12 0.69 0.14
78 INT129082 Positive_regulation of Pik3r1 1 0.00 0.47 0.11
79 INT191353 Localization of SHC1 2 0.73 0.75 0.1
80 INT288190 Regulation of Localization of Pik3r1 1 0.04 0.07 0.1
81 INT297459 Protein_catabolism of Ngfr 1 0.21 0.5 0.1
82 INT291370 Phosphorylation of SHC1 1 0.14 0.57 0.1
83 INT308619 Regulation of Phosphorylation of Pik3r1 1 0.09 1.06 0.06
84 INT340308 Negative_regulation of Localization of Shc1 1 0.37 0 0.04
85 INT241405 Localization of Ngfr 2 0.56 0.4 0.03
86 INT340312 Regulation of Binding of Shc1 1 0.39 0.05 0.03
87 INT201644 Positive_regulation of Positive_regulation of Shc1 1 0.07 0.82 0.03
88 INT241402 Protein_catabolism of Ngfr 1 0.39 0 0.03
89 INT275931 Binding of Grb2 5 0.26 0 0
90 INT114742 Positive_regulation of GRB2 3 0.49 1.59 0
91 INT191352 Regulation of SHC1 2 0.14 1.46 0
92 INT223596 Positive_regulation of Gene_expression of GRB2 1 0.03 0.51 0
93 INT239161 Positive_regulation of Negative_regulation of Pik3r1 1 0.30 0.77 0
94 INT201591 Regulation of Grb2 1 0.20 1.18 0
95 INT193880 Regulation of Phosphorylation of Ngfr 1 0.02 0.25 0
96 INT275959 Localization of Grb2 1 0.51 0 0
97 INT201629 Negative_regulation of Positive_regulation of Ngfr 1 0.07 0.37 0
98 INT275932 Gene_expression of Grb2 1 0.53 0 0
99 INT176532 Binding of SHC1 1 0.36 1.3 0
100 INT191349 Transcription of Shc1 1 0.53 0.92 0
101 INT191348 Regulation of Transcription of Shc1 1 0.27 0.93 0
102 INT142139 Negative_regulation of Phosphorylation of Plcg1 1 0.48 0.07 0
103 INT142135 Positive_regulation of Phosphorylation of Plcg1 1 0.41 0.08 0
104 INT244929 Transcription of GRB2 1 0.47 0 0
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