GO:0005176

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Name ErbB-2 class receptor binding
Categary Function
Go Slim No
Go Link GO:0005176
Unique Molecular Interactions 82
Total Molecular Interactions 110
Total Single Events 782
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ErbB-2 class receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for ErbB-2 class receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
2 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
3 INT172982 Binding of MUC1 and MUC4 1 0.30 2.46 0.78
4 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
5 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
6 INT132168 PSG7 Positive_regulation of Muc4 1 0.00 0 0.34
7 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34
8 INT132167 PSG7 Positive_regulation of Gene_expression of Muc4 1 0.00 0 0.34
9 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
10 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
11 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
12 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27
13 INT141634 Binding of Alb and Nrg1 1 0.00 0.3 0.26
14 INT134522 Nrg1 Regulation of Gene_expression of Mpz 1 0.60 0.29 0.25
15 INT134523 Nrg1 Positive_regulation of Gene_expression of Mpz 1 0.49 0.32 0.23
16 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23
17 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
18 INT326834 Cdk5r2 Positive_regulation of Cdk5 1 0.02 0.96 0.21
19 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2
20 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
21 INT318211 MUC5AC Positive_regulation of Muc4 1 0.17 1.12 0.17
22 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17
23 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17
24 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
25 INT273233 Negative_regulation of Cdk5 Negative_regulation of Positive_regulation of Ltp 1 0.20 0.39 0.13
26 INT273239 Cdk5 Positive_regulation of Positive_regulation of GRIN1 1 0.51 0.37 0.12
27 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
28 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
29 INT273236 Cdk5 Positive_regulation of Car2 1 0.13 0.45 0.1
30 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
31 INT201751 Car2 Positive_regulation of Cdk5 1 0.00 0.67 0.09
32 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
33 INT341008 Nrg1 Regulation of Binding of Erbb4 1 0.04 0 0.09
34 INT221954 Binding of CDK5 and CDK5R2 1 0.02 0.36 0.09
35 INT247948 Positive_regulation of Cdk5r1 Positive_regulation of Cdk5 1 0.26 0.16 0.07
36 INT332329 Binding of Cdk5 and P2rx3 1 0.22 0.05 0.05
37 INT332331 Binding of Cdk5 and Rbm39 1 0.00 0.05 0.05
38 INT326830 Cdk5r1 Positive_regulation of Positive_regulation of Cdk5 1 0.09 0.16 0.04
39 INT341009 Nrg1 Positive_regulation of Gene_expression of Fabp7 1 0.10 0.49 0.04
40 INT231276 Erbb4 Positive_regulation of Nrg1 2 0.35 0.06 0.03
41 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03
42 INT221639 Fyn Positive_regulation of Phosphorylation of Cdk5 1 0.14 0.28 0.03
43 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03
44 INT221661 Sema3a Positive_regulation of Phosphorylation of Cdk5 1 0.19 0.28 0.03
45 INT332330 Cdk5 Negative_regulation of Pirt 1 0.00 0 0.03
46 INT231275 Erbb4 Positive_regulation of Gene_expression of Nrg1 1 0.35 0 0.03
47 INT219352 CDK5 Negative_regulation of PAK1 1 0.22 0.72 0.03
48 INT334869 Nrg1 Positive_regulation of Phosphorylation of C3 1 0.08 0 0.03
49 INT221613 Binding of Cdk5 and Fyn 1 0.10 0.29 0.03
50 INT221617 Fyn Positive_regulation of Cdk5 1 0.13 0.28 0.03
51 INT341005 Binding of Vim and Nrg1 1 0.05 0.14 0
52 INT201734 Binding of Akt1 and Cdk5 1 0.01 0.31 0
53 INT201738 Positive_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
54 INT341013 Binding of Erbb3 and Nrg1 1 0.04 0.14 0
55 INT277860 MUC4 Negative_regulation of ERBB2 1 0.19 0.29 0
56 INT341023 PIK3CB Positive_regulation of Nrg1 1 0.03 0.06 0
57 INT341010 Nrg1 Positive_regulation of Regulation of Vim 1 0.07 0 0
58 INT341014 Positive_regulation of Binding of Erbb3 and Nrg1 1 0.06 0.14 0
59 INT201731 Negative_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
60 INT268446 Cdk5 Positive_regulation of Cdk5r1 1 0.02 0.58 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ErbB-2 class receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in ErbB-2 class receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
2 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
3 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45
4 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
5 INT103659 Gene_expression of Muc4 10 0.78 7.2 7.7
6 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95
7 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
8 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95
9 INT342801 Negative_regulation of Transcription of Muc4 1 0.04 0.82 4.56
10 INT15771 Gene_expression of Nrg1 34 0.67 3.16 4.11
11 INT148495 Regulation of Cdk5 6 0.58 5.42 3.95
12 INT196733 Gene_expression of Cdk5 25 0.76 18.25 2.64
13 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
14 INT148494 Binding of Cdk5 6 0.40 5.97 2.31
15 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3
16 INT139624 Transcription of Muc4 2 0.49 0.41 2.27
17 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
18 INT168983 Negative_regulation of Nrg1 11 0.43 3.4 2.03
19 INT148492 Positive_regulation of Binding of Cdk5 1 0.47 0.51 1.86
20 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
21 INT342804 Protein_catabolism of Muc4 1 0.06 0.43 1.73
22 INT105784 Binding of Nrg1 7 0.37 1.29 1.52
23 INT109222 Positive_regulation of Negative_regulation of Cdk5 2 0.50 0.23 1.39
24 INT158709 Negative_regulation of Phosphorylation of Cdk5 1 0.40 0 1.39
25 INT158056 Localization of Nrg1 13 0.79 3.11 1.28
26 INT172999 Positive_regulation of Gene_expression of MUC4 5 0.59 8.91 1.18
27 INT101994 Positive_regulation of Nrg1 10 0.50 1.24 1.05
28 INT273221 Positive_regulation of Negative_regulation of Cdk5 8 0.49 9.89 1.03
29 INT342806 Regulation of Muc4 1 0.06 0.64 1.01
30 INT203893 Positive_regulation of Gene_expression of Cdk5 2 0.49 7.12 0.92
31 INT138788 Positive_regulation of Gene_expression of Cdk5 1 0.49 0.44 0.91
32 INT127452 Positive_regulation of CDK5 5 0.32 1.88 0.87
33 INT203892 Positive_regulation of Positive_regulation of Cdk5 4 0.49 4.02 0.85
34 INT219358 Gene_expression of CDK5 9 0.58 5.65 0.81
35 INT138787 Positive_regulation of Positive_regulation of Cdk5 1 0.49 0.38 0.81
36 INT139846 Protein_catabolism of Nrg1 5 0.60 1.78 0.74
37 INT126736 Positive_regulation of Gene_expression of Nrg1 3 0.50 0.42 0.71
38 INT196790 Localization of Cdk5 6 0.74 2.6 0.67
39 INT100055 Transcription of MUC4 5 0.69 3.04 0.58
40 INT127557 Positive_regulation of Phosphorylation of Cdk5 2 0.50 0.43 0.56
41 INT15770 Negative_regulation of Gene_expression of Nrg1 3 0.43 1.27 0.5
42 INT273218 Negative_regulation of Negative_regulation of Cdk5 1 0.42 3.06 0.37
43 INT221973 Negative_regulation of CDK5 4 0.57 2.26 0.36
44 INT334851 Positive_regulation of Localization of Nrg1 1 0.30 0.68 0.34
45 INT209537 Gene_expression of Muc4 16 0.74 6.54 0.31
46 INT326820 Negative_regulation of Positive_regulation of Cdk5 1 0.36 1.27 0.28
47 INT298972 Transcription of Cdk5 1 0.15 1.63 0.28
48 INT209534 Binding of Muc4 1 0.46 1.28 0.26
49 INT100057 Positive_regulation of MUC4 4 0.50 2.08 0.24
50 INT164788 Regulation of Gene_expression of Cdk5 1 0.27 0.31 0.24
51 INT219375 Localization of CDK5 4 0.52 2.8 0.19
52 INT221974 Phosphorylation of CDK5 1 0.56 0.99 0.19
53 INT273226 Negative_regulation of Gene_expression of Cdk5 2 0.42 0.79 0.17
54 INT157582 Regulation of Phosphorylation of Cdk5 1 0.26 0.25 0.16
55 INT221972 Regulation of CDK5 1 0.42 1.87 0.16
56 INT231261 Regulation of Nrg1 3 0.31 1.32 0.15
57 INT209518 Negative_regulation of Muc4 1 0.56 0.75 0.15
58 INT220571 Positive_regulation of Protein_catabolism of Nrg1 1 0.30 0.08 0.15
59 INT103658 Positive_regulation of Gene_expression of Muc4 2 0.69 1.45 0.12
60 INT326822 Negative_regulation of Phosphorylation of Cdk5 1 0.36 0.43 0.12
61 INT341559 Positive_regulation of Gene_expression of CDK5 1 0.23 0.25 0.11
62 INT201655 Negative_regulation of Binding of Cdk5 1 0.06 0.9 0.09
63 INT329735 Negative_regulation of Protein_catabolism of Nrg1 1 0.36 0.49 0.08
64 INT341567 Negative_regulation of Gene_expression of CDK5 1 0.27 0.24 0.07
65 INT219355 Binding of CDK5 3 0.35 2.02 0.06
66 INT334840 Positive_regulation of Phosphorylation of Nrg1 1 0.30 0 0.06
67 INT220593 Negative_regulation of Localization of Nrg1 1 0.26 0.07 0.04
68 INT209538 Positive_regulation of Gene_expression of Muc4 4 0.48 0.87 0.03
69 INT334841 Negative_regulation of Phosphorylation of Nrg1 1 0.26 0 0.03
70 INT340964 Positive_regulation of Negative_regulation of Nrg1 1 0.28 0.12 0.03
71 INT334845 Phosphorylation of Nrg1 1 0.49 0 0.03
72 INT172994 Regulation of MUC4 2 0.43 1.3 0
73 INT209529 Regulation of Gene_expression of Muc4 2 0.59 0.67 0
74 INT209530 Negative_regulation of Gene_expression of Muc4 1 0.56 0.38 0
75 INT100056 Binding of MUC4 1 0.37 0.35 0
76 INT257446 Localization of MUC4 1 0.60 0 0
77 INT209528 Positive_regulation of Muc4 1 0.48 0.24 0
78 INT100053 Positive_regulation of Positive_regulation of MUC4 1 0.50 0.24 0
79 INT340965 Negative_regulation of Binding of Nrg1 1 0.24 0 0
80 INT220588 Transcription of Nrg1 1 0.41 0.64 0
81 INT268444 Regulation of Positive_regulation of Cdk5 1 0.08 0.66 0
82 INT347578 Positive_regulation of Transcription of MUC4 1 0.47 0.08 0
83 INT139623 Regulation of Gene_expression of Muc4 1 0.41 0 0
84 INT340954 Positive_regulation of Positive_regulation of Nrg1 1 0.28 0 0
85 INT353616 Localization of Muc4 1 0.57 0.07 0
86 INT340974 Negative_regulation of Negative_regulation of Nrg1 1 0.24 0 0
87 INT209536 Positive_regulation of Negative_regulation of Muc4 1 0.67 0 0
88 INT173010 Regulation of Gene_expression of MUC4 1 0.43 0.82 0
89 INT209524 Regulation of Muc4 1 0.26 0.19 0
90 INT231271 Regulation of Localization of Nrg1 1 0.45 0 0
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