GO:0005201

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Name extracellular matrix structural constituent
Categary Function
Go Slim No
Go Link GO:0005201
Unique Molecular Interactions 395
Total Molecular Interactions 496
Total Single Events 5082
Pain Genes Associated 46

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for extracellular matrix structural constituent. They are ordered first by their pain relevance and then by number of times they were reported for extracellular matrix structural constituent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113550 Binding of FN1 and VTN 6 0.30 5.24 1.91
2 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
3 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
4 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
5 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
6 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
7 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12
8 INT282712 Binding of MUC5AC and Csf2 1 0.01 2.63 1.07
9 INT116777 Psma5 Positive_regulation of Binding of Fn1 1 0.01 1.24 1.06
10 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
11 INT114553 Binding of Trpv1 and Col4a4 1 0.01 0.44 1.03
12 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02
13 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
14 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
15 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
16 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
17 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
18 INT107698 FN1 Positive_regulation of Gene_expression of CPOX 1 0.13 0.26 0.84
19 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
20 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
21 INT172982 Binding of MUC1 and MUC4 1 0.30 2.46 0.78
22 INT113546 Binding of FN1 and ITGA3 1 0.03 2.12 0.77
23 INT170992 Binding of FN1 and MMRN1 3 0.01 2.13 0.73
24 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
25 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71
26 INT117677 Binding of MATN3 and OPRL1 1 0.26 0.07 0.68
27 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
28 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
29 INT117958 Col4a4 Regulation of Repin1 1 0.01 0.39 0.6
30 INT176340 CHI3L1 Positive_regulation of Localization of CSF2 1 0.11 1.86 0.55
31 INT176343 CHI3L1 Positive_regulation of Localization of CSF1 1 0.23 1.86 0.55
32 INT155254 Col4a4 Regulation of Rtn4 1 0.00 0 0.54
33 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
34 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52
35 INT62299 Binding of CD4 and SGCG 1 0.39 1.23 0.51
36 INT311963 Ifx Negative_regulation of FBN1 1 0.00 0.44 0.5
37 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47
38 INT65909 LAMB1 Positive_regulation of GANAB 1 0.00 0 0.45
39 INT248310 Crx Regulation of MATN3 1 0.07 0.65 0.45
40 INT296827 Binding of BGN and USE1 1 0.01 0 0.44
41 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42
42 INT107701 Negative_regulation of FN1 Positive_regulation of CPOX 1 0.11 0.13 0.42
43 INT248239 Binding of FN1 and SDC3 1 0.00 0.77 0.42
44 INT107696 FN1 Positive_regulation of CPOX 1 0.12 0.13 0.41
45 INT208461 Binding of CD4 and IL16 1 0.05 3.04 0.41
46 INT248236 Binding of FN1 and SDC1 1 0.00 0.76 0.41
47 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
48 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4
49 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4
50 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4
51 INT135015 MGP Negative_regulation of Cabin1 1 0.01 0.26 0.4
52 INT346150 Binding of ADM and FN1 1 0.10 0.93 0.39
53 INT266382 Binding of Col4a1 and Fn1 1 0.00 0.82 0.39
54 INT183924 Binding of CHI3L1 and HLA-E 1 0.08 0.9 0.39
55 INT346135 Positive_regulation of Binding of ADM and FN1 1 0.13 0.93 0.39
56 INT266397 Binding of Ager and Col4a1 1 0.00 0.81 0.38
57 INT200469 Binding of COL7A1 and COMP 1 0.04 0.91 0.38
58 INT113560 Negative_regulation of Binding of FN1 and PLAUR 1 0.26 0.87 0.37
59 INT113556 Binding of FN1 and PLAUR 1 0.22 0.81 0.37
60 INT273172 Negative_regulation of PDE4A Negative_regulation of Localization of CD4 1 0.11 0.74 0.37
61 INT113555 Negative_regulation of Binding of FN1 and VTN 1 0.23 0.87 0.37
62 INT296828 USE1 Regulation of Gene_expression of BGN 1 0.01 0.17 0.37
63 INT172023 Binding of FN1 and PRTN3 1 0.00 1.05 0.37
64 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37
65 INT226374 Negative_regulation of Binding of CD4 and IFNA1 1 0.03 0.66 0.37
66 INT296830 USE1 Regulation of BGN 1 0.00 0.17 0.37
67 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35
68 INT254393 Binding of FN1 and GSN 1 0.01 1.08 0.34
69 INT27030 HERPUD1 Regulation of CD4 1 0.41 0 0.34
70 INT188391 Binding of CD4 and HLA-DRB1 1 0.05 0.96 0.34
71 INT27037 HERPUD1 Regulation of Gene_expression of CD4 1 0.55 0 0.34
72 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
73 INT340616 COL4A4 Regulation of MMP9 1 0.12 0.95 0.32
74 INT44127 Agt Negative_regulation of DSPP 1 0.02 0 0.32
75 INT340615 COL4A4 Regulation of MMP2 1 0.11 0.95 0.32
76 INT278693 ERAL1 Positive_regulation of CD4 1 0.05 1.1 0.31
77 INT278692 ERAL1 Positive_regulation of Positive_regulation of CD4 1 0.05 1.1 0.31
78 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
79 INT15828 Ambp Regulation of Negative_regulation of Fn1 1 0.03 0 0.3
80 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
81 INT179838 Col3a1 Regulation of Negative_regulation of Il11 1 0.21 0 0.29
82 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29
83 INT83967 Binding of MGP and OPRD1 1 0.16 0 0.29
84 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
85 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
86 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
87 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
88 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
89 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
90 INT265831 BGN Positive_regulation of ADCY1 1 0.01 0.41 0.27
91 INT56892 Binding of MGP and Oprd1 1 0.05 0 0.27
92 INT265830 KNG1 Positive_regulation of Localization of BGN 1 0.02 0.33 0.27
93 INT249831 Binding of CHI3L1 and IL6 1 0.30 2.81 0.26
94 INT311950 FBN1 Positive_regulation of Gene_expression of PGF 1 0.00 0.15 0.26
95 INT20547 IL1B Positive_regulation of Gene_expression of FN1 1 0.29 0.06 0.26
96 INT20549 IL1B Positive_regulation of FN1 1 0.19 0.06 0.26
97 INT194670 CREB1 Regulation of Gene_expression of CD4 1 0.05 0.07 0.25
98 INT271446 Thy1 Regulation of Col1a1 1 0.05 0.61 0.25
99 INT20548 IL1B Regulation of Gene_expression of FN1 1 0.19 0.07 0.25
100 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24
101 INT172022 Binding of F13A1 and FN1 1 0.00 1.33 0.24
102 INT352081 Binding of CD4 and ADAM11 1 0.09 0.33 0.24
103 INT252784 ROS1 Positive_regulation of Gene_expression of COL1A1 1 0.05 1.86 0.24
104 INT266006 Binding of COL5A2 and SGCG 1 0.00 0.89 0.23
105 INT115875 Col5a1 Positive_regulation of Localization of Gcg 1 0.08 0 0.23
106 INT259623 Binding of Eln and Elane 1 0.02 1.38 0.23
107 INT225117 Foxm1 Regulation of Gene_expression of FN1 1 0.01 0.4 0.22
108 INT285639 Col3a1 Regulation of Tnfrsf12a 1 0.19 0.16 0.22
109 INT285640 Eln Regulation of Tnfrsf12a 1 0.14 0.16 0.22
110 INT318189 MUC5AC Regulation of Gene_expression of VEGFA 1 0.21 1.17 0.22
111 INT173558 CTSK Positive_regulation of Protein_catabolism of COL5A2 1 0.00 0.53 0.22
112 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21
113 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21
114 INT353285 Prdx2 Regulation of Gene_expression of Col1a2 1 0.02 0.73 0.21
115 INT225099 ZNF630 Positive_regulation of Gene_expression of COL1A1 1 0.00 0.17 0.2
116 INT137569 Comp Negative_regulation of Positive_regulation of Prl 1 0.23 0 0.2
117 INT279107 Binding of COMP and MATN3 1 0.41 1.43 0.2
118 INT137568 Comp Negative_regulation of Regulation of Prl 1 0.17 0 0.2
119 INT255516 Binding of COL5A2 and GP6 1 0.01 1.17 0.2
120 INT137570 Comp Negative_regulation of Prl 1 0.17 0 0.2
121 INT179683 Binding of Col7a1 and Eln 2 0.00 3.02 0.19
122 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
123 INT252821 Binding of CD4 and IL12A 1 0.02 1.36 0.19
124 INT188570 Negative_regulation of IRF6 Positive_regulation of CD4 1 0.04 0.19 0.19
125 INT79206 Binding of MGP and YY1 1 0.34 0 0.19
126 INT188573 IRF6 Positive_regulation of CD4 1 0.05 0.19 0.19
127 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18
128 INT274386 Binding of CD4 and ERVW-1 1 0.05 3.07 0.18
129 INT180560 Binding of COMP and CYP27A1 1 0.12 0.47 0.18
130 INT318211 MUC5AC Positive_regulation of Muc4 1 0.17 1.12 0.17
131 INT318188 MUC5AC Positive_regulation of MUC1 1 0.16 1.12 0.17
132 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17
133 INT47357 Binding of FN1 and ANGPTL5 1 0.20 0.48 0.16
134 INT271444 Binding of Lox and Eln 1 0.21 0.82 0.16
135 INT323803 NFAT5 Positive_regulation of Regulation of COL5A2 1 0.07 0.46 0.16
136 INT188569 Binding of CD4 and TLR4 1 0.16 0.34 0.16
137 INT185793 SPP1 Positive_regulation of COL1A2 1 0.16 0.33 0.16
138 INT323805 NFAT5 Regulation of COL5A2 1 0.07 0.46 0.16
139 INT56010 Binding of FN1 and FKBPL 1 0.00 0.54 0.15
140 INT56008 Binding of FN1 and PTDSS1 1 0.05 0.55 0.15
141 INT180566 Binding of COMP and DMD 1 0.02 0.72 0.15
142 INT249833 Binding of CHI3L1 and GOPC 1 0.06 1.11 0.15
143 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15
144 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 0.01 0.7 0.14
145 INT305001 Binding of ACAN and TNFAIP6 1 0.28 1.22 0.14
146 INT249829 CHI3L1 Positive_regulation of AKT1 1 0.47 0.69 0.14
147 INT309779 PTH Negative_regulation of Gene_expression of COL5A2 1 0.00 0.52 0.14
148 INT180960 Protein_catabolism of COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 0.00 0.59 0.14
149 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14
150 INT180963 COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 0.00 0.59 0.14
151 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14
152 INT318185 MUC5AC Positive_regulation of Gene_expression of MMP3 1 0.09 0.86 0.13
153 INT157602 Binding of COL1A1 and COL3A1 1 0.04 0 0.13
154 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12
155 INT289790 Binding of Col7a1 and Comp 1 0.14 1.2 0.12
156 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12
157 INT10731 NEUROD1 Regulation of CD4 1 0.42 1.3 0.12
158 INT10730 CD9 Regulation of CD4 1 0.42 1.3 0.12
159 INT118316 Col4a4 Positive_regulation of Localization of Cck 1 0.17 0.14 0.12
160 INT316813 Sparc Negative_regulation of Gene_expression of Col1a1 1 0.13 0.67 0.12
161 INT251295 Binding of CD4 and Regulation of ITIH4 1 0.11 0.24 0.11
162 INT266003 Binding of COL5A2 and DIO3 1 0.01 0.43 0.11
163 INT241748 CCR5 Regulation of CD4 1 0.21 0.39 0.11
164 INT189144 MTNR1B Positive_regulation of Gene_expression of CD4 1 0.01 0.35 0.11
165 INT323869 Binding of BMI1 and COL1A2 1 0.00 1.21 0.11
166 INT294445 KLK4 Negative_regulation of COL1A1 1 0.01 0 0.1
167 INT343862 Binding of FN1 and TLR4 1 0.05 0.89 0.1
168 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1
169 INT179869 COL1A1 Positive_regulation of SOCS3 1 0.04 0.99 0.1
170 INT318192 MUC5AC Negative_regulation of Gene_expression of VEGFA 1 0.20 0.98 0.1
171 INT343843 Binding of FN1 and IRF6 1 0.01 0.9 0.1
172 INT10745 Fn1 Regulation of PIF1 1 0.02 0.38 0.1
173 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1
174 INT279109 Binding of COL9A2 and MATN3 1 0.48 0.64 0.1
175 INT207459 LGALS3 Regulation of Gene_expression of COL1A2 1 0.06 0.21 0.1
176 INT260099 Binding of COMP and IL4 1 0.00 0.18 0.09
177 INT333099 Localization of IL2 Negative_regulation of Negative_regulation of CD4 1 0.14 0.8 0.09
178 INT292632 CD4 Positive_regulation of Gene_expression of IL9 1 0.24 0 0.09
179 INT333094 HIVEP1 Regulation of CD4 1 0.00 0.22 0.09
180 INT318210 MUC5AC Negative_regulation of Phosphorylation of Flt1 1 0.07 0.98 0.09
181 INT222984 TNF Positive_regulation of Positive_regulation of FN1 1 0.05 0.72 0.09
182 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09
183 INT294608 Binding of Serpinh1 and Col5a1 1 0.03 0.45 0.09
184 INT346304 Col2a1 Positive_regulation of Localization of PTGER2 1 0.00 0.18 0.09
185 INT333089 CD4 Positive_regulation of ERVW-1 1 0.05 0.07 0.08
186 INT58630 Calca Negative_regulation of Positive_regulation of COL1A1 1 0.02 0.23 0.08
187 INT336425 MGAT1 Positive_regulation of Gene_expression of COL5A2 1 0.00 0.4 0.08
188 INT342288 Binding of CD4 and HFE 1 0.01 1.26 0.08
189 INT15953 Binding of CD4 and IgG2a 1 0.54 0.38 0.08
190 INT323876 LEP Regulation of COL1A2 1 0.10 0.86 0.08
191 INT222983 TNF Positive_regulation of Positive_regulation of COL1A1 1 0.01 0.71 0.08
192 INT183768 Csf2 Regulation of CD4 1 0.37 0.52 0.08
193 INT249832 Binding of CHI3L1 and HRASLS 1 0.00 0.85 0.08
194 INT218710 MMP1 Regulation of Positive_regulation of Col1a1 1 0.00 0.15 0.07
195 INT333096 Binding of CD4 and IFN1@ 1 0.12 0.17 0.07
196 INT231434 FN1 Positive_regulation of Gene_expression of PDGFA 1 0.04 0.83 0.07
197 INT277053 Protein_catabolism of TIMP1 Positive_regulation of COL5A2 1 0.01 0.14 0.07
198 INT231436 FN1 Positive_regulation of Gene_expression of VEGFA 1 0.06 0.83 0.07
199 INT84622 Binding of RERE and KAL1 1 0.00 1.18 0.07
200 INT333092 Binding of CD4 and IL2 1 0.01 0.17 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for extracellular matrix structural constituent. They are ordered first by their pain relevance and then by number of times they were reported in extracellular matrix structural constituent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
2 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
3 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99
4 INT64051 Gene_expression of Col4a4 33 0.61 10.1 17.82
5 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15
6 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
7 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
8 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44
9 INT36287 Binding of CD4 96 0.47 58.93 11.88
10 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
11 INT16404 Regulation of CD4 54 0.61 33.05 10.29
12 INT82829 Gene_expression of COMP 104 0.78 57 9.81
13 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
14 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96
15 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51
16 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29
17 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03
18 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33
19 INT17049 Localization of CD4 57 0.75 35.33 6.89
20 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87
21 INT47127 Gene_expression of BGN 11 0.75 17.09 6.25
22 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2
23 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18
24 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98
25 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96
26 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85
27 INT13170 Gene_expression of Comp 25 0.74 8.68 5.62
28 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48
29 INT84561 Binding of COL1A2 18 0.47 11.76 5.09
30 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95
31 INT71528 Regulation of Col4a4 6 0.38 3.67 4.8
32 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
33 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43
34 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38
35 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32
36 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2
37 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15
38 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99
39 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
40 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87
41 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6
42 INT20936 Binding of MGP 13 0.40 3.55 3.59
43 INT59900 Binding of MATN3 13 0.42 17.19 3.59
44 INT185148 Negative_regulation of BGN 3 0.20 1.23 3.56
45 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55
46 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55
47 INT15827 Regulation of Fn1 8 0.54 4.67 3.47
48 INT49238 Protein_catabolism of COL1A2 30 0.97 15.64 3.45
49 INT118095 Regulation of COMP 7 0.43 9.69 3.33
50 INT81229 Binding of COL1A1 24 0.35 12.07 3.3
51 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19
52 INT36032 Gene_expression of Col3a1 23 0.72 10.55 3.18
53 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
54 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
55 INT61500 Binding of FN1 39 0.48 27.33 3.13
56 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
57 INT65916 Gene_expression of LAMB1 13 0.55 3.09 3.06
58 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
59 INT19293 Protein_catabolism of FN1 7 0.95 5.15 2.97
60 INT200470 Positive_regulation of Gene_expression of COMP 13 0.69 13.73 2.93
61 INT14448 Localization of COL5A2 34 0.67 17.35 2.85
62 INT71533 Positive_regulation of Gene_expression of Col4a4 5 0.42 2.04 2.85
63 INT259760 Localization of Fbn2 5 0.05 5.55 2.85
64 INT73836 Regulation of Comp 4 0.19 4.2 2.79
65 INT50268 Gene_expression of FBN1 13 0.65 10.73 2.72
66 INT125885 Positive_regulation of Gene_expression of CHI3L1 8 0.49 10.8 2.64
67 INT47128 Regulation of BGN 2 0.41 0.33 2.62
68 INT39005 Negative_regulation of FBN1 7 0.42 4.97 2.6
69 INT68091 Localization of COL1A1 19 0.66 9.13 2.56
70 INT259762 Positive_regulation of Fbn2 4 0.05 6.74 2.55
71 INT136093 Regulation of FBN1 10 0.14 4.39 2.52
72 INT71531 Positive_regulation of Col4a4 5 0.42 2.49 2.51
73 INT173592 Binding of COL5A2 32 0.33 9.14 2.48
74 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
75 INT71529 Localization of Col4a4 8 0.59 1.69 2.46
76 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45
77 INT52409 Positive_regulation of FBN1 8 0.40 7.28 2.41
78 INT71273 Positive_regulation of Comp 8 0.42 3.8 2.32
79 INT124862 Gene_expression of Col5a1 4 0.17 2.05 2.32
80 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3
81 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28
82 INT92835 Gene_expression of Col4a1 22 0.49 13.5 2.27
83 INT61684 Localization of COL1A2 20 0.73 9.31 2.26
84 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23
85 INT35380 Binding of Fn1 8 0.35 4.84 2.23
86 INT96467 Gene_expression of Lamb1 3 0.10 2.56 2.23
87 INT8052 Negative_regulation of COMP 46 0.58 13.73 2.22
88 INT184305 Gene_expression of Comp 53 0.77 31.66 2.2
89 INT289775 Negative_regulation of Comp 4 0.41 5.69 2.2
90 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18
91 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17
92 INT27437 Negative_regulation of Comp 5 0.24 2.8 2.15
93 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12
94 INT114551 Transcription of Col4a4 3 0.07 1.2 2.06
95 INT113717 Negative_regulation of Gene_expression of COL1A1 21 0.41 6.14 2.01
96 INT19114 Negative_regulation of MGP 2 0.32 0.15 2
97 INT173851 Localization of FN1 20 0.76 13.95 1.97
98 INT158022 Binding of CHI3L1 10 0.43 14.18 1.94
99 INT57272 Negative_regulation of Gene_expression of FN1 16 0.43 11.42 1.93
100 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
101 INT47129 Positive_regulation of BGN 4 0.46 2.29 1.93
102 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91
103 INT152155 Positive_regulation of Col1a2 7 0.56 10.18 1.89
104 INT179670 Protein_catabolism of Eln 3 0.19 6.16 1.84
105 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81
106 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78
107 INT222997 Positive_regulation of Localization of FN1 4 0.14 4.26 1.78
108 INT84375 Regulation of COL1A2 6 0.44 8.75 1.72
109 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64
110 INT248321 Regulation of Gene_expression of CHI3L1 2 0.44 10.73 1.64
111 INT59899 Regulation of MATN3 4 0.45 7.61 1.6
112 INT89244 Negative_regulation of Gene_expression of Col4a4 2 0.09 0.74 1.6
113 INT203116 Positive_regulation of ACAN 6 0.67 3.98 1.56
114 INT139317 Negative_regulation of Col1a2 8 0.41 7.17 1.54
115 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53
116 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
117 INT259766 Positive_regulation of Localization of Fbn2 1 0.03 3.09 1.51
118 INT254631 Positive_regulation of Lamb1 1 0.01 2.79 1.51
119 INT142719 Binding of Col1a1 7 0.34 5.83 1.47
120 INT135879 Localization of MATN3 12 0.80 10.31 1.44
121 INT32184 Negative_regulation of Col2a1 9 0.42 3.05 1.43
122 INT118097 Localization of COMP 18 0.70 9.99 1.42
123 INT62669 Positive_regulation of COL1A2 13 0.49 6.89 1.4
124 INT124212 Protein_catabolism of CHI3L1 3 0.21 3.48 1.4
125 INT174486 Regulation of Gene_expression of CD4 12 0.36 6.09 1.39
126 INT71847 Positive_regulation of Positive_regulation of Col3a1 2 0.33 0.61 1.39
127 INT198453 Negative_regulation of MUC5AC 12 0.58 12.96 1.38
128 INT20937 Regulation of MGP 4 0.43 0.62 1.37
129 INT22558 Gene_expression of COL3A1 10 0.78 7.22 1.36
130 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
131 INT54831 Regulation of Gene_expression of Col2a1 4 0.39 2.3 1.31
132 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3
133 INT68057 Negative_regulation of Binding of MGP 1 0.03 0 1.28
134 INT124861 Positive_regulation of Col5a1 2 0.09 0.75 1.27
135 INT14727 Regulation of FN1 13 0.45 5.95 1.26
136 INT145312 Localization of CHI3L1 8 0.78 12.71 1.26
137 INT71846 Regulation of Positive_regulation of Fn1 1 0.14 0.13 1.25
138 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24
139 INT184313 Positive_regulation of Comp 4 0.55 4.23 1.24
140 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
141 INT22235 Gene_expression of Eln 11 0.76 5.4 1.23
142 INT169023 Positive_regulation of MATN3 2 0.43 3.67 1.23
143 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
144 INT97909 Binding of COMP 13 0.37 5.98 1.22
145 INT145959 Negative_regulation of DSPP 19 0.57 2.75 1.21
146 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2
147 INT176463 Protein_catabolism of Col2a1 4 0.35 1.94 1.2
148 INT64049 Binding of Col4a4 5 0.29 0.8 1.19
149 INT333999 Protein_catabolism of Comp 1 0.72 1.77 1.19
150 INT172999 Positive_regulation of Gene_expression of MUC4 5 0.59 8.91 1.18
151 INT173004 Transcription of MUC5AC 2 0.56 1.33 1.18
152 INT36461 Regulation of Col4a1 10 0.26 5.43 1.17
153 INT156613 Positive_regulation of Positive_regulation of FN1 2 0.45 3.33 1.15
154 INT133870 Positive_regulation of Gene_expression of LAMB1 2 0.35 0.41 1.15
155 INT100051 Binding of MUC5AC 20 0.32 14.21 1.14
156 INT60766 Gene_expression of COL4A4 10 0.77 13.46 1.14
157 INT248309 Positive_regulation of Binding of MATN3 1 0.08 1.81 1.11
158 INT54043 Transcription of Fn1 3 0.61 1.59 1.1
159 INT101104 Positive_regulation of Gene_expression of COL1A2 12 0.69 5.87 1.09
160 INT219108 Negative_regulation of Gene_expression of MUC5AC 11 0.31 9.74 1.08
161 INT54835 Regulation of Col2a1 5 0.59 2.08 1.07
162 INT182285 Positive_regulation of Positive_regulation of COL5A2 2 0.13 0.37 1.07
163 INT15726 Negative_regulation of Gene_expression of Fn1 8 0.32 5.25 1.04
164 INT92988 Protein_catabolism of Eln 6 0.47 5.48 1.03
165 INT89243 Regulation of Gene_expression of Col4a4 2 0.02 0.91 1.03
166 INT84235 Positive_regulation of Col11a1 2 0.01 0.09 1.03
167 INT133102 Negative_regulation of Gene_expression of COL1A2 8 0.08 2.56 1.02
168 INT173852 Protein_catabolism of ACAN 3 0.64 1.65 1.01
169 INT254629 Regulation of Gene_expression of Lamb1 1 0.00 0.95 1
170 INT156614 Regulation of Gene_expression of COL1A1 6 0.33 2.51 0.99
171 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99
172 INT89128 Binding of DSPP 7 0.32 2.24 0.98
173 INT47130 Binding of BGN 3 0.33 0.33 0.97
174 INT129997 Protein_catabolism of Col1a1 5 0.96 3.43 0.96
175 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95
176 INT173014 Positive_regulation of Gene_expression of MUC5AC 10 0.45 4.82 0.94
177 INT155867 Transcription of COL1A2 8 0.69 2.9 0.94
178 INT264171 Positive_regulation of Positive_regulation of CD4 5 0.49 4.74 0.94
179 INT131844 Gene_expression of MATN3 12 0.78 9.65 0.92
180 INT78533 Localization of COL4A4 2 0.55 1.93 0.92
181 INT153618 Positive_regulation of KAL1 1 0.48 1.03 0.92
182 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91
183 INT95641 Regulation of Fbn1 3 0.45 3.67 0.91
184 INT204547 Positive_regulation of Gene_expression of Col1a2 2 0.04 2.08 0.91
185 INT118098 Protein_catabolism of COMP 5 0.66 2.76 0.9
186 INT289785 Negative_regulation of Gene_expression of Comp 4 0.37 3.14 0.88
187 INT102988 Regulation of CHI3L1 5 0.48 7.23 0.86
188 INT8888 Regulation of Col1a1 4 0.13 1.97 0.86
189 INT89361 Negative_regulation of Col4a4 3 0.04 1.01 0.86
190 INT124210 Negative_regulation of CHI3L1 7 0.12 4.39 0.85
191 INT266562 Gene_expression of Fbn2 1 0.05 0.93 0.84
192 INT266563 Positive_regulation of Gene_expression of Fbn2 1 0.04 0.93 0.84
193 INT44955 Negative_regulation of Eln 8 0.42 3.79 0.83
194 INT160918 Negative_regulation of Gene_expression of MGP 1 0.07 0 0.83
195 INT182180 Transcription of CHI3L1 1 0.67 1.94 0.82
196 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8
197 INT189249 Localization of BGN 2 0.08 2.14 0.8
198 INT189171 Positive_regulation of Localization of CD4 7 0.49 5.88 0.79
199 INT156612 Regulation of Gene_expression of FN1 7 0.43 4.44 0.79
200 INT39879 Positive_regulation of Gene_expression of Fn1 12 0.41 12.69 0.78
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