GO:0005219

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Name ryanodine-sensitive calcium-release channel activity
Categary Function
Go Slim No
Go Link GO:0005219
Unique Molecular Interactions 54
Total Molecular Interactions 72
Total Single Events 489
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ryanodine-sensitive calcium-release channel activity. They are ordered first by their pain relevance and then by number of times they were reported for ryanodine-sensitive calcium-release channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
2 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
3 INT149221 Binding of Ryr1 and Trpc3 5 0.40 0 0.37
4 INT311533 ROS1 Positive_regulation of Positive_regulation of RYR3 1 0.28 0.18 0.26
5 INT311532 ROS1 Regulation of RYR3 1 0.43 0.18 0.25
6 INT283373 Pcbd1 Regulation of RYR1 1 0.00 1.45 0.21
7 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
8 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13
9 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
10 INT351427 Binding of PIK3C3 and RYR1 1 0.00 0 0.11
11 INT149219 Binding of Ryr1 and Trpc1 1 0.35 0 0.11
12 INT225740 RYR1 Positive_regulation of Binding of Entpd1 1 0.08 0.08 0.1
13 INT265983 Homer1 Regulation of Ryr1 1 0.37 0.15 0.07
14 INT170517 Binding of Ryr1 and Qdpr 2 0.15 0.36 0.05
15 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
16 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
17 INT192046 Negative_regulation of Binding of RYR2 and Cbx5 1 0.01 1.12 0
18 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
19 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
20 INT266704 Binding of RYR1 and TRDN 1 0.34 0 0
21 INT316647 Ryr1 Regulation of Qdpr 1 0.19 0.68 0
22 INT192049 Negative_regulation of Binding of RYR2 and Cbx1 1 0.01 1.12 0
23 INT192045 Jup Positive_regulation of RYR2 1 0.11 0.29 0
24 INT283372 Binding of RYR1 and Pcbd1 1 0.00 0.28 0
25 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
26 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0
27 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
28 INT192047 Binding of RYR2 and Cbx1 1 0.01 1.12 0
29 INT192043 Binding of RYR2 and Cbx5 1 0.01 1.12 0
30 INT192048 Binding of DSP and Ryr2 1 0.24 1.1 0
31 INT271027 Binding of RYR1 and Car2 1 0.03 0.46 0
32 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0
33 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0
34 INT192042 Binding of Jup and Ryr2 1 0.17 1.09 0
35 INT266703 Binding of RYR1 and DIXDC1 1 0.26 0.1 0
36 INT296930 Casq1 Negative_regulation of RYR1 1 0.00 0.38 0
37 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ryanodine-sensitive calcium-release channel activity. They are ordered first by their pain relevance and then by number of times they were reported in ryanodine-sensitive calcium-release channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18393 Negative_regulation of Ryr1 15 0.43 3.63 7.57
2 INT59555 Binding of RYR1 39 0.42 8.65 4.92
3 INT18396 Positive_regulation of Ryr1 10 0.58 2.45 3.38
4 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26
5 INT18394 Regulation of Ryr1 6 0.60 0.28 3.26
6 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11
7 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04
8 INT11713 Localization of RYR1 22 0.76 10.42 1.64
9 INT55305 Regulation of RYR1 14 0.45 5.27 1.33
10 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
11 INT116831 Binding of Ryr1 11 0.47 0.12 0.9
12 INT38446 Localization of Ryr1 3 0.64 0.28 0.86
13 INT18395 Negative_regulation of Negative_regulation of Ryr1 1 0.00 0 0.59
14 INT15647 Regulation of Positive_regulation of RYR1 1 0.26 0.23 0.45
15 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44
16 INT80636 Positive_regulation of Localization of RYR1 2 0.47 0.78 0.29
17 INT311550 Positive_regulation of Positive_regulation of RYR3 1 0.33 0.18 0.26
18 INT311547 Positive_regulation of RYR3 1 0.45 0.17 0.26
19 INT59650 Regulation of Binding of RYR1 1 0.04 0 0.23
20 INT120216 Regulation of RYR2 2 0.28 1.03 0.22
21 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19
22 INT164519 Gene_expression of FKBP1A 2 0.39 0.22 0.19
23 INT60209 Transcription of RYR1 3 0.69 3.06 0.16
24 INT158175 Positive_regulation of Gene_expression of RYR1 2 0.48 1.35 0.13
25 INT293345 Negative_regulation of Binding of FKBP1A 1 0.02 0.19 0.13
26 INT170514 Gene_expression of Ryr1 4 0.49 0.56 0.12
27 INT165787 Positive_regulation of RYR2 2 0.23 1.3 0.11
28 INT299319 Localization of FKBP1A 1 0.44 0 0.09
29 INT192016 Localization of RYR2 5 0.25 4.18 0.05
30 INT192012 Binding of RYR2 2 0.30 3.61 0.05
31 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05
32 INT299313 Positive_regulation of Gene_expression of FKBP1A 1 0.29 0 0.05
33 INT271024 Negative_regulation of Binding of RYR1 3 0.05 1.07 0.04
34 INT316641 Positive_regulation of Localization of Ryr1 1 0.42 0 0.04
35 INT192023 Negative_regulation of RYR2 1 0.15 1.86 0.04
36 INT322462 Transcription of Ryr2 1 0.55 0.47 0.03
37 INT219581 Binding of Ryr2 2 0.27 4.54 0
38 INT219567 Phosphorylation of Ryr2 2 0.62 0.22 0
39 INT219566 Localization of Ryr2 1 0.45 0.49 0
40 INT211904 Negative_regulation of Localization of RYR1 1 0.37 0.64 0
41 INT322461 Negative_regulation of Transcription of Ryr2 1 0.45 0 0
42 INT219582 Positive_regulation of Phosphorylation of Ryr2 1 0.30 0.22 0
43 INT192020 Regulation of Localization of RYR2 1 0.15 0.27 0
44 INT80635 Regulation of Localization of RYR1 1 0.04 0.1 0
45 INT211903 Negative_regulation of Gene_expression of RYR1 1 0.37 0.06 0
46 INT297204 Regulation of Ryr2 1 0.08 0.3 0
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