GO:0005220

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Name inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Categary Function
Go Slim No
Go Link GO:0005220
Unique Molecular Interactions 120
Total Molecular Interactions 188
Total Single Events 1114
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. They are ordered first by their pain relevance and then by number of times they were reported for inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87
2 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
3 INT297490 Itpr3 Regulation of Ltp 1 0.02 0 0.7
4 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
5 INT237810 Itpr3 Positive_regulation of Localization of Car2 2 0.08 0.68 0.45
6 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
7 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
8 INT33713 Binding of ITPR3 and Trh 1 0.00 0.86 0.39
9 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27
10 INT247475 P2RY6 Positive_regulation of ITPR3 1 0.01 0.45 0.23
11 INT33714 Positive_regulation of Binding of ITPR3 and Trh 1 0.00 0.46 0.21
12 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
13 INT216601 Itpr3 Positive_regulation of Localization of Ca2 1 0.00 0.05 0.15
14 INT34451 Binding of Itpr3 and Ptprg 1 0.03 0 0.15
15 INT335459 ABCA1 Positive_regulation of ITPR3 1 0.00 0 0.15
16 INT350735 PRKDC Negative_regulation of ITPR3 1 0.01 0.16 0.11
17 INT292383 Binding of Itpr3 and Mrvi1 1 0.18 0 0.11
18 INT33712 Trh Positive_regulation of Localization of ITPR3 1 0.00 0.8 0.1
19 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09
20 INT249183 Binding of ITPR3 and GOPC 2 0.01 0.26 0.09
21 INT350220 Positive_regulation of HSPG2 Positive_regulation of Localization of ITPR3 1 0.05 0.09 0.09
22 INT350216 ITPR3 Regulation of Localization of TNIP3 1 0.01 0.08 0.09
23 INT350217 Positive_regulation of HSPG2 Positive_regulation of ITPR3 1 0.05 0.09 0.09
24 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
25 INT237820 Binding of Itpr3 and soc 1 0.02 0 0.09
26 INT208979 Binding of Itpr3 and Trpc3 1 0.00 0.33 0.09
27 INT237814 Itpr3 Positive_regulation of Localization of Tmie 1 0.01 0.68 0.08
28 INT350218 Positive_regulation of HSPG2 Positive_regulation of Gene_expression of ITPR3 1 0.04 0.09 0.08
29 INT237815 Binding of Itpr3 and Stim1 1 0.04 0 0.07
30 INT350219 ITPR3 Positive_regulation of CA2 1 0.22 0 0.05
31 INT34447 Ptprg Positive_regulation of Itpr3 1 0.04 0 0.05
32 INT208988 Binding of CALM1 and Itpr3 1 0.01 0.15 0.05
33 INT208982 Negative_regulation of Binding of Itpr3 and Trpc3 1 0.00 0.17 0.04
34 INT318073 Itpr3 Regulation of Ca2 1 0.01 0 0.03
35 INT249159 HSPG2 Positive_regulation of Gene_expression of ITPR3 2 0.01 0.06 0
36 INT279704 Binding of CIB1 and Positive_regulation of ITPR3 1 0.06 0.17 0
37 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0
38 INT292384 Itpr3 Regulation of Car2 1 0.07 0 0
39 INT31765 Positive_regulation of Binding of Itpr3 and Ca2 1 0.21 0 0
40 INT292387 Lrmp Regulation of Itpr3 1 0.45 0.31 0
41 INT162508 Binding of ITGA2B and ITPR1 1 0.02 0.05 0
42 INT292386 Binding of Itpr3 and Lrmp 1 0.41 0.67 0
43 INT292389 Binding of Itpr1 and Mrvi1 1 0.16 0.05 0
44 INT162510 Binding of ITPR1 and HPSE 1 0.02 0.05 0
45 INT249176 Binding of ITPR3 and TRPC1 1 0.02 0 0
46 INT249163 Binding of CISH and ITPR3 1 0.00 0.5 0
47 INT292385 Binding of Itpr1 and Lrmp 1 0.17 0.05 0
48 INT31766 Binding of Itpr3 and Ca2 1 0.16 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. They are ordered first by their pain relevance and then by number of times they were reported in inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT31761 Positive_regulation of Itpr3 32 0.58 5.95 8.22
2 INT36040 Localization of Itpr3 21 0.70 4.87 7.77
3 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
4 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
5 INT31762 Gene_expression of Itpr3 22 0.74 1.6 4.15
6 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
7 INT37180 Negative_regulation of Itpr3 6 0.51 1.43 3.27
8 INT54999 Regulation of Itpr3 6 0.24 0.18 3.11
9 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93
10 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41
11 INT37347 Positive_regulation of Itpr3 6 0.34 1.3 2.31
12 INT31763 Positive_regulation of Gene_expression of Itpr3 10 0.30 0.83 2.28
13 INT26335 Binding of ITPR3 22 0.18 3.3 2.27
14 INT63081 Localization of Itpr3 13 0.67 1.08 2.12
15 INT55000 Positive_regulation of Regulation of Itpr3 1 0.41 0 2.08
16 INT37181 Negative_regulation of Localization of Itpr3 3 0.37 0.83 1.97
17 INT95544 Negative_regulation of Itpr1 4 0.59 1.6 1.85
18 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68
19 INT31760 Negative_regulation of Itpr3 5 0.23 0.84 1.61
20 INT37346 Positive_regulation of Localization of Itpr3 3 0.47 0.45 1.59
21 INT235401 Negative_regulation of Gene_expression of ITPR3 4 0.20 1.69 1.24
22 INT243729 Localization of Itpr1 2 0.05 0.37 1.16
23 INT262550 Negative_regulation of Localization of Itpr1 1 0.03 0.37 1.09
24 INT37241 Negative_regulation of Localization of ITPR3 7 0.13 1.22 1.05
25 INT116829 Regulation of Itpr3 2 0.39 0 1.02
26 INT55243 Positive_regulation of Positive_regulation of Itpr3 4 0.58 0.89 0.95
27 INT151532 Regulation of Itpr1 2 0.01 0.63 0.83
28 INT116830 Binding of Itpr3 10 0.45 0.29 0.78
29 INT31764 Negative_regulation of Positive_regulation of Itpr3 4 0.25 0 0.77
30 INT75712 Gene_expression of Itpr1 3 0.59 1.89 0.77
31 INT62887 Regulation of Gene_expression of ITPR3 3 0.14 0.95 0.76
32 INT129797 Negative_regulation of Binding of ITPR3 3 0.14 0.58 0.75
33 INT26333 Positive_regulation of Localization of ITPR3 6 0.43 0.17 0.68
34 INT26336 Regulation of Localization of ITPR3 2 0.13 0.37 0.61
35 INT101274 Gene_expression of ITPR1 1 0.52 0.79 0.59
36 INT59819 Phosphorylation of ITPR3 2 0.06 0 0.54
37 INT64935 Negative_regulation of Regulation of Itpr3 1 0.26 0 0.49
38 INT63082 Binding of Itpr3 12 0.12 0.54 0.39
39 INT55577 Negative_regulation of Gene_expression of Itpr3 1 0.06 0 0.39
40 INT240951 Positive_regulation of Positive_regulation of Itpr3 1 0.03 0.06 0.33
41 INT33706 Regulation of ITPR3 6 0.28 0.46 0.3
42 INT55240 Regulation of Positive_regulation of Itpr3 1 0.52 0.48 0.28
43 INT149738 Regulation of Gene_expression of Itpr3 1 0.22 0.09 0.27
44 INT216609 Protein_catabolism of Itpr3 2 0.24 0.42 0.14
45 INT237797 Positive_regulation of Gene_expression of Itpr3 3 0.05 1.08 0.11
46 INT124453 Binding of Itpr1 1 0.33 0 0.11
47 INT281233 Positive_regulation of Protein_catabolism of Itpr3 1 0.11 0.16 0.08
48 INT272152 Positive_regulation of Positive_regulation of ITPR3 1 0.06 0 0.08
49 INT120506 Negative_regulation of Negative_regulation of ITPR3 1 0.01 0.08 0.08
50 INT281239 Negative_regulation of Protein_catabolism of Itpr3 1 0.10 0.16 0.07
51 INT216802 Positive_regulation of Localization of Itpr3 1 0.07 0 0.06
52 INT63083 Positive_regulation of Binding of Itpr3 2 0.11 0.16 0.04
53 INT33707 Positive_regulation of Transcription of ITPR3 1 0.01 0.27 0.04
54 INT33705 Transcription of ITPR3 1 0.02 0.27 0.04
55 INT249279 Regulation of Binding of ITPR3 1 0.03 0.44 0.04
56 INT249235 Positive_regulation of Binding of ITPR3 3 0.17 0.2 0.03
57 INT292373 Regulation of Gene_expression of Itpr3 1 0.57 0.14 0
58 INT292378 Regulation of Binding of Itpr3 1 0.25 0 0
59 INT292377 Regulation of Localization of Itpr3 1 0.37 0 0
60 INT281234 Negative_regulation of Binding of Itpr3 1 0.14 0 0
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