GO:0005243

Name gap junction channel activity Categary Function Go Slim No Go Link GO:0005243

Unique Molecular Interactions 36 Total Molecular Interactions 47 Total Single Events 707 Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for gap junction channel activity. They are ordered first by their pain relevance and then by number of times they were reported for gap junction channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT128404	Mapk1 Positive_regulation of Phosphorylation of Gja1	1	0.65	0.73	0.73
2	INT144129	Prkce Positive_regulation of Phosphorylation of Gja1	1	0.42	0.48	0.55
3	INT144128	Binding of Gja1 and Prkce	1	0.40	0.5	0.52
4	INT144130	Binding of Gja1 and Prkcg	1	0.48	0.5	0.52
5	INT221234	Gja3 Regulation of Binding of Ptpn2	1	0.08	0.58	0.18
6	INT270827	P2rx7 Positive_regulation of Localization of Panx1	1	0.41	0.18	0.13
7	INT270834	CBX1 Negative_regulation of Transcription of Panx1	1	0.06	0.13	0.1
8	INT270837	Negative_regulation of Panx1 Negative_regulation of Transcription of CBX1	1	0.07	0.13	0.1
9	INT252421	Gja1 Regulation of P2ry1	1	0.00	0.28	0.09
10	INT270833	Binding of CASP1 and Panx1	1	0.02	0.14	0.09
11	INT270824	Binding of P2rx7 and Panx1	1	0.34	0.15	0.09
12	INT270830	Panx1 Negative_regulation of CASP1	1	0.03	0.09	0.09
13	INT270832	Negative_regulation of Panx1 Negative_regulation of Gene_expression of CASP1	1	0.03	0.14	0.08
14	INT307666	Binding of Pmp22 and Gjb1	1	0.31	0.38	0.08
15	INT270829	P2rx7 Positive_regulation of Panx1	1	0.66	0.08	0.08
16	INT178084	EDNRA Positive_regulation of Phosphorylation of GJA1	1	0.10	0.88	0.06
17	INT178090	EDN1 Positive_regulation of Phosphorylation of GJA1	1	0.09	0.88	0.06
18	INT221245	Binding of Gja3 and Gopc	1	0.01	0	0.03
19	INT270831	Positive_regulation of Panx1 Positive_regulation of NLRP3	1	0.18	0.1	0
20	INT247820	Gjc1 Regulation of Gja5	1	0.08	1.24	0
21	INT221233	Positive_regulation of Binding of Gja3 and Gfm1	1	0.00	0	0
22	INT221239	Binding of Gja3 and Gfm1	1	0.00	0	0
23	INT270836	CBX1 Negative_regulation of Panx1	1	0.09	0	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for gap junction channel activity. They are ordered first by their pain relevance and then by number of times they were reported in gap junction channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT87775	Phosphorylation of Gja1	13	0.82	2.75	6.56
2	INT134821	Gene_expression of Gja3	8	0.77	7.45	4.44
3	INT87780	Gene_expression of Gja1	22	0.77	5.84	4.24
4	INT257683	Negative_regulation of Gene_expression of Gja3	1	0.58	2.63	2.78
5	INT87778	Positive_regulation of Gene_expression of Gja1	6	0.69	1.46	2.14
6	INT87779	Positive_regulation of Gja1	4	0.53	0.9	1.95
7	INT128030	Gene_expression of GJA1	23	0.75	7.81	1.88
8	INT87776	Positive_regulation of Phosphorylation of Gja1	3	0.62	0.71	1.86
9	INT134822	Gene_expression of Gja1	18	0.72	4.2	1
10	INT257685	Regulation of Gene_expression of Gja3	1	0.61	2.86	0.91
11	INT87777	Regulation of Gja1	1	0.62	0.76	0.81
12	INT143306	Positive_regulation of Gja1	3	0.50	0.42	0.75
13	INT178116	Phosphorylation of GJA1	7	0.80	4.09	0.74
14	INT128402	Negative_regulation of Phosphorylation of Gja1	1	0.58	0.73	0.73
15	INT152909	Regulation of Gene_expression of Gja1	1	0.61	0.46	0.69
16	INT221216	Localization of Gja3	12	0.65	3.65	0.67
17	INT87781	Regulation of Phosphorylation of Gja1	1	0.27	0	0.67
18	INT246207	Positive_regulation of GJA1	3	0.67	0.91	0.65
19	INT134819	Positive_regulation of Gene_expression of Gja3	3	0.50	1.68	0.63
20	INT173793	Positive_regulation of Gja3	6	0.50	0.55	0.6
21	INT165816	Gene_expression of Gjb1	1	0.65	0.68	0.57
22	INT221197	Phosphorylation of Gja3	3	0.71	0.99	0.56
23	INT165817	Negative_regulation of Gjb1	1	0.36	0.72	0.56
24	INT270809	Gene_expression of Panx1	1	0.69	0.59	0.55
25	INT154837	Regulation of Gja1	2	0.45	1.42	0.53
26	INT257688	Negative_regulation of Gja3	1	0.58	1.15	0.5
27	INT134820	Positive_regulation of Gene_expression of Gja1	3	0.64	0.84	0.49
28	INT87774	Binding of Gja1	2	0.48	0.19	0.48
29	INT329831	Positive_regulation of Positive_regulation of GJA1	1	0.49	0.58	0.48
30	INT192937	Positive_regulation of Gene_expression of GJA1	4	0.67	0.4	0.44
31	INT221202	Binding of Gja3	3	0.32	1.18	0.42
32	INT270810	Localization of Panx1	1	0.67	0.33	0.34
33	INT270811	Negative_regulation of Panx1	1	0.52	0.4	0.27
34	INT132951	Regulation of GJA1	2	0.57	0.79	0.24
35	INT247021	Binding of GJA1	6	0.47	0.91	0.23
36	INT126761	Negative_regulation of Gja1	1	0.33	0.08	0.22
37	INT221194	Negative_regulation of Phosphorylation of Gja3	1	0.11	0.62	0.22
38	INT221204	Positive_regulation of Localization of Gja3	1	0.13	0.62	0.21
39	INT270812	Transcription of Panx1	1	0.54	0.26	0.19
40	INT270803	Negative_regulation of Transcription of Panx1	1	0.33	0.26	0.19
41	INT186146	Negative_regulation of GJA1	2	0.41	1.29	0.18
42	INT178124	Positive_regulation of Phosphorylation of GJA1	2	0.65	1.21	0.18
43	INT209185	Regulation of Phosphorylation of GJA1	2	0.44	0.09	0.14
44	INT157782	Regulation of Gja3	4	0.44	1.24	0.1
45	INT155667	Negative_regulation of Gene_expression of Gja1	3	0.42	1.16	0.1
46	INT209182	Regulation of Gene_expression of GJA1	1	0.57	0.09	0.09
47	INT270808	Positive_regulation of Gene_expression of Panx1	1	0.62	0.13	0.08
48	INT188177	Localization of GJA1	2	0.75	0.07	0.07
49	INT178132	Negative_regulation of Gene_expression of GJA1	2	0.35	0.84	0.07
50	INT209187	Positive_regulation of Localization of GJA1	1	0.65	0.07	0.07
51	INT247799	Gene_expression of Gja5	1	0.34	0.74	0.07
52	INT247810	Negative_regulation of Gene_expression of Gja5	1	0.26	0.74	0.07
53	INT270807	Positive_regulation of Localization of Panx1	1	0.39	0.05	0.06
54	INT247816	Localization of Gja5	1	0.41	0.74	0.05
55	INT257689	Negative_regulation of Gja1	1	0.37	0.58	0.05
56	INT221199	Positive_regulation of Positive_regulation of Gja3	1	0.13	0.08	0.05
57	INT228786	Regulation of Gene_expression of Gja1	2	0.29	0.49	0.04
58	INT270806	Positive_regulation of Panx1	1	0.62	0.3	0.04
59	INT228802	Negative_regulation of Gene_expression of Gja1	4	0.37	0.87	0.03
60	INT216569	Localization of Gja1	2	0.36	0.35	0.03
61	INT270801	Binding of Panx1	1	0.33	0	0.03
62	INT247800	Regulation of Gja5	1	0.23	2.48	0.03
63	INT257682	Negative_regulation of Localization of Gja3	1	0.37	0.09	0.03
64	INT247813	Localization of Gja1	2	0.45	0.47	0
65	INT247793	Regulation of Localization of Gja1	2	0.17	0.47	0
66	INT209190	Negative_regulation of Negative_regulation of GJA1	1	0.40	0	0
67	INT178112	Negative_regulation of Phosphorylation of GJA1	1	0.18	1.09	0
68	INT157781	Transcription of Gja3	1	0.67	0	0
69	INT270805	Positive_regulation of Positive_regulation of Panx1	1	0.45	0.13	0
70	INT247817	Positive_regulation of Gja5	1	0.24	0.32	0
71	INT270799	Negative_regulation of Positive_regulation of Panx1	1	0.33	0	0
72	INT270802	Negative_regulation of Gene_expression of Panx1	1	0.33	0	0
73	INT270804	Regulation of Panx1	1	0.35	0.06	0