GO:0005244

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Name voltage-gated ion channel activity
Categary Function
Go Slim No
Go Link GO:0005244
Unique Molecular Interactions 473
Total Molecular Interactions 672
Total Single Events 6210
Pain Genes Associated 105

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for voltage-gated ion channel activity. They are ordered first by their pain relevance and then by number of times they were reported for voltage-gated ion channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
2 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
3 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
4 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
5 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27
6 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
7 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
8 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
9 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
10 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
11 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
12 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78
13 INT190981 Binding of Npy and Scn2a1 1 0.10 0 1.75
14 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
15 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
16 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
17 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
18 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
19 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
20 INT212662 KCNA1 Regulation of Localization of Cort 1 0.00 1.36 1.37
21 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
22 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
23 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
24 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
25 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
26 INT86090 SCN5A Negative_regulation of Positive_regulation of Abat 1 0.00 0 1.25
27 INT305408 Binding of KCNMA1 and ST8SIA2 1 0.01 0.09 1.24
28 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
29 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
30 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
31 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
32 INT350862 Hist1h1t Regulation of Kcnj5 1 0.02 1.35 1.22
33 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
34 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
35 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
36 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
37 INT212661 KCNA1 Positive_regulation of Scort1 1 0.00 0.91 1.03
38 INT86662 Ngf Regulation of SCN10A 1 0.27 1.24 0.99
39 INT65631 Ufm1 Positive_regulation of Kcna5 1 0.02 0 0.99
40 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98
41 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98
42 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
43 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
44 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
45 INT296283 Kcnip3 Regulation of Positive_regulation of Cysltr1 1 0.01 0.85 0.94
46 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
47 INT242621 Gdnf Positive_regulation of Gene_expression of Scn11a 1 0.05 0.12 0.88
48 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
49 INT285660 Cnrip1 Negative_regulation of Kcnk3 1 0.00 0.23 0.85
50 INT285656 Cnrip1 Negative_regulation of Kcnk3 1 0.00 0.23 0.85
51 INT140447 Ngf Regulation of Scn9a 1 0.69 0.16 0.84
52 INT54559 KCNMA1 Positive_regulation of Localization of TBXA2R 1 0.01 0.07 0.81
53 INT145646 Binding of Scn2a1 and Scn5a 1 0.36 0 0.76
54 INT336835 Binding of CACNG6 and Aia1 1 0.01 3.41 0.75
55 INT329120 Binding of KCNA1 and CNTNAP2 1 0.09 1.23 0.75
56 INT190986 Per1 Positive_regulation of Scn2a1 1 0.17 0 0.74
57 INT190979 Per2 Positive_regulation of Scn2a1 1 0.20 0 0.74
58 INT154193 Binding of KCNK2 and Mtap2 1 0.22 0.48 0.74
59 INT254030 Binding of Kcna6 and AIS 2 0.03 0 0.72
60 INT296289 Grin2a Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
61 INT296282 Grin2b Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
62 INT255337 Nav1 Positive_regulation of Kcnq2 1 0.09 0 0.71
63 INT190984 Binding of Scn2a1 and Gria1 1 0.03 0.08 0.71
64 INT255334 Nav1 Positive_regulation of Kcnq3 1 0.09 0 0.71
65 INT67887 SCN5A Negative_regulation of INA 1 0.02 0.13 0.71
66 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7
67 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
68 INT42780 Negative_regulation of Scn4a Negative_regulation of Positive_regulation of Prl 1 0.11 0 0.69
69 INT117217 Binding of Calca and Hcn2 1 0.25 0.17 0.68
70 INT255332 Binding of Kcna6 and Nav1 1 0.03 0 0.68
71 INT40180 Regulation of Binding of Oprl1 and Scn7a 1 0.02 0 0.67
72 INT240065 KCNIP3 Regulation of Transcription of PDYN 1 0.42 0.88 0.67
73 INT40179 Binding of Oprl1 and Scn7a 1 0.03 0 0.67
74 INT42779 Scn4a Positive_regulation of Localization of Gnrhr 1 0.10 0 0.66
75 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
76 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
77 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
78 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
79 INT253165 SCN10A Positive_regulation of OVGP1 1 0.06 1.34 0.61
80 INT28845 su Negative_regulation of Positive_regulation of Scn2a1 1 0.27 1.27 0.61
81 INT255319 Binding of Dpep1 and Kcnq2 1 0.01 0 0.6
82 INT64776 Binding of Oprm1 and Kcnj3 1 0.38 0 0.6
83 INT255320 Binding of Dpep1 and Kcnq3 1 0.01 0 0.6
84 INT190987 Abat Regulation of Scn2a1 1 0.03 0.07 0.59
85 INT240066 KCNIP3 Regulation of SLC8A3 1 0.39 0.73 0.59
86 INT240069 KCNIP3 Regulation of Gene_expression of PDYN 1 0.25 0.75 0.59
87 INT350859 Hist1h1t Regulation of Gene_expression of Kcnj5 1 0.02 0.37 0.59
88 INT240070 KCNIP3 Regulation of CA2 1 0.02 0.72 0.59
89 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
90 INT190988 Vip Positive_regulation of Gene_expression of Scn2a1 1 0.16 0.1 0.57
91 INT350861 Hist1h1t Positive_regulation of Gene_expression of Kcnj5 1 0.02 0.35 0.56
92 INT166863 Kcnj9 Regulation of Kcnj6 1 0.20 0 0.56
93 INT155898 Binding of KCNJ8 and MMD 1 0.09 0.39 0.53
94 INT271902 Binding of KCNK1 and Jun 1 0.12 0.08 0.53
95 INT166862 Kcnj6 Positive_regulation of Gene_expression of Oprd1 1 0.15 0 0.52
96 INT166864 Kcnj9 Positive_regulation of Gene_expression of Oprd1 1 0.07 0 0.52
97 INT85565 Oprd1 Regulation of KCNJ6 1 0.00 0 0.51
98 INT98117 Gdnf Regulation of SCN11A 1 0.05 0.39 0.5
99 INT350860 Hist1h1t Positive_regulation of Kcnj5 1 0.02 0.54 0.5
100 INT153897 Binding of KCNJ3 and Snx27 1 0.03 0.28 0.5
101 INT98116 Gdnf Regulation of SCN10A 1 0.03 0.39 0.5
102 INT80627 Binding of KCNIP3 and Dre 4 0.03 0.72 0.49
103 INT120834 Binding of CNTN1 and SCN3A 1 0.01 0.41 0.49
104 INT212659 KCNA1 Regulation of Cort 1 0.00 0.41 0.49
105 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
106 INT155958 Binding of Kcnk2 and Akap5 1 0.15 0.64 0.48
107 INT111244 Binding of BRS3 and SCN5A 1 0.00 0.72 0.48
108 INT207501 Scn7a Negative_regulation of Gene_expression of ap 1 0.01 0 0.46
109 INT119598 H2-Ab1 Regulation of Scn4a 1 0.00 0.09 0.46
110 INT162954 Sema6a Regulation of Scn7a 1 0.10 0.55 0.46
111 INT101966 Pnoc Positive_regulation of Kcnj9 1 0.14 0.26 0.46
112 INT98119 Gdnf Regulation of SCN10A 1 0.01 0.34 0.45
113 INT98118 Gdnf Regulation of SCN11A 1 0.01 0.34 0.45
114 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
115 INT154592 Binding of Ntrk2 and Positive_regulation of Gene_expression of Kcna3 1 0.11 0.16 0.44
116 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
117 INT329122 Binding of KCNA1 and LGI1 1 0.08 0.29 0.43
118 INT29906 Binding of Scn4a and Ap2m1 1 0.09 0 0.43
119 INT296477 Binding of Cacng2 and Dlg4 1 0.04 0.22 0.42
120 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
121 INT53139 Binding of Htr1a and Kcnj3 1 0.37 0 0.42
122 INT127546 Gria1 Positive_regulation of Gene_expression of Kcnab3 1 0.02 0.35 0.42
123 INT297229 Binding of Kcnj8 and Abcc8 1 0.03 0 0.42
124 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
125 INT60456 SCN5A Regulation of Scn2a1 1 0.00 0 0.41
126 INT326942 Unc79 Regulation of Nalcn 1 0.20 0.08 0.41
127 INT99122 Binding of Cacna2d3 and DLL1 1 0.02 0 0.41
128 INT190977 Npy Regulation of Scn2a1 1 0.16 0 0.4
129 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
130 INT296296 Binding of Grin2b and Kcnip3 1 0.24 0 0.4
131 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
132 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
133 INT34786 KCNA1 Positive_regulation of Localization of PRL 1 0.05 0 0.4
134 INT296300 Binding of Grin1 and Kcnip3 1 0.18 0 0.4
135 INT296301 Binding of Grin2a and Kcnip3 1 0.27 0 0.4
136 INT215629 Binding of Kcnj5 and Fig4 1 0.00 0.37 0.39
137 INT98121 Ngf Regulation of SCN11A 1 0.07 0.29 0.39
138 INT98120 Ngf Regulation of SCN10A 1 0.04 0.29 0.39
139 INT190739 Adcyap1 Regulation of Gene_expression of Scn2a1 1 0.13 0 0.39
140 INT152431 Regulation of Ghrh Positive_regulation of Scn7a 1 0.02 0.17 0.38
141 INT306694 Nav1 Positive_regulation of Gene_expression of Scn7a 1 0.01 0.07 0.38
142 INT305405 Binding of KCNMA1 and ANTXR1 1 0.00 0.09 0.38
143 INT152427 Ghrh Positive_regulation of Scn7a 1 0.03 0.17 0.38
144 INT179207 KCNAB2 Regulation of Gene_expression of ATP1A4 1 0.00 1.25 0.37
145 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
146 INT334632 Binding of Kcna2 and Eae1 1 0.17 0.87 0.35
147 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
148 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
149 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
150 INT153896 Snx27 Regulation of KCNJ3 1 0.04 0.17 0.33
151 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33
152 INT140537 RGD1563588 Negative_regulation of Gene_expression of KCND2 1 0.31 0.09 0.32
153 INT147445 Pscs Positive_regulation of Gene_expression of CYBB 1 0.02 0.33 0.31
154 INT269064 Il6 Positive_regulation of Gene_expression of Cybb 1 0.75 0.79 0.31
155 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
156 INT156632 Prkaca Regulation of Scn10a 1 0.13 0.67 0.3
157 INT207503 Binding of Klkb1 and Scn7a 1 0.02 0 0.3
158 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
159 INT239783 Kcnip4 Positive_regulation of Gene_expression of Prh1 1 0.03 0.6 0.29
160 INT122311 Sst Regulation of Kcnk3 1 0.14 0.28 0.29
161 INT154194 Binding of KCNK2 and Akap5 1 0.08 0.19 0.29
162 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
163 INT77753 Abnormal Regulation of CACNA1S 1 0.00 0.78 0.28
164 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
165 INT122312 Prkaca Regulation of Kcnk3 1 0.13 0.28 0.28
166 INT26577 SCN5A Positive_regulation of co 1 0.00 0 0.27
167 INT190998 ADCYAP1 Positive_regulation of Scn2a1 1 0.07 0.45 0.27
168 INT141314 Gs Regulation of Kcnk4 1 0.19 0.64 0.27
169 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
170 INT281980 Scn9a Positive_regulation of MDK 1 0.06 0.24 0.26
171 INT169837 Sp1 Positive_regulation of Gene_expression of Kcnq3 1 0.04 0.08 0.26
172 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26
173 INT296450 Cacng2 Regulation of Gria2 1 0.13 0.24 0.26
174 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
175 INT281963 SCN11A Positive_regulation of MDK 1 0.12 0.24 0.26
176 INT169836 Sp1 Positive_regulation of Gene_expression of Kcnq2 1 0.05 0.08 0.26
177 INT215280 Siglec1 Regulation of Cybb 1 0.01 0.74 0.26
178 INT269060 Il6 Positive_regulation of Cybb 1 0.75 0.65 0.26
179 INT346745 Binding of Cacng2 and Grip2 1 0.01 0 0.25
180 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24
181 INT296470 Binding of Cacng2 and Myo18a 1 0.00 0.22 0.24
182 INT296467 Binding of Cacng2 and Gria1 1 0.12 0.25 0.23
183 INT326941 Nts Regulation of Nalcn 1 0.04 0.24 0.23
184 INT296464 Binding of Cacng2 and Tinagl1 1 0.06 0.25 0.23
185 INT328896 Scn2a1 Regulation of hb 1 0.02 0.27 0.23
186 INT274005 KCNK3 Positive_regulation of SYNM 1 0.06 0 0.23
187 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23
188 INT154594 Ntf5 Positive_regulation of Gene_expression of Kcna3 1 0.05 0.07 0.23
189 INT154590 Bdnf Positive_regulation of Gene_expression of Kcna3 1 0.07 0.07 0.23
190 INT296474 Binding of Cacng2 and Gria2 1 0.18 0.26 0.23
191 INT251452 Binding of Car1 and Kcnc1 1 0.11 0 0.22
192 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22
193 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
194 INT248182 Cxcl1 Regulation of Scn8a 1 0.05 0 0.22
195 INT139902 Kcne2 Positive_regulation of Gpr83 1 0.03 1.43 0.22
196 INT154591 Binding of Ntrk2 and Positive_regulation of Kcna3 1 0.11 0.08 0.22
197 INT355503 Positive_regulation of SCN10A Positive_regulation of Localization of NPY 1 0.17 1.32 0.22
198 INT339903 Binding of SCN5A and ZGLP1 1 0.01 0.18 0.22
199 INT80620 CA2 Regulation of KCNIP3 1 0.11 0.08 0.21
200 INT53902 Atp7b Positive_regulation of Scn7a 1 0.04 0 0.21

Single Events

The table below shows the top 100 pain related interactions that have been reported for voltage-gated ion channel activity. They are ordered first by their pain relevance and then by number of times they were reported in voltage-gated ion channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT85395 Gene_expression of Scn11a 62 0.78 17.97 26.89
4 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
5 INT48248 Gene_expression of Scn10a 38 0.78 19.3 25.05
6 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94
7 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73
8 INT89657 Gene_expression of Kcnj9 24 0.77 15.15 18.86
9 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88
10 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
11 INT78749 Gene_expression of SCN10A 25 0.75 9.23 16.5
12 INT48540 Gene_expression of Kcna5 37 0.77 14.04 16.07
13 INT49768 Positive_regulation of Kcnj5 58 0.41 11.89 16.02
14 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55
15 INT5430 Gene_expression of Scn8a 37 0.75 4.58 14.82
16 INT69311 Gene_expression of Scn10a 31 0.78 15.54 14.64
17 INT13752 Binding of Scn4a 24 0.36 5.68 14.16
18 INT99116 Binding of Cacna2d3 15 0.48 7.33 13.58
19 INT142941 Negative_regulation of Scn11a 14 0.43 12.2 13.38
20 INT132335 Gene_expression of KCNA1 36 0.77 18.31 13.36
21 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24
22 INT90184 Gene_expression of KCNJ6 7 0.67 4.14 12.57
23 INT85214 Gene_expression of SCN11A 24 0.78 4.05 12.5
24 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
25 INT57882 Negative_regulation of Kcnj5 33 0.35 13.06 12.27
26 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27
27 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91
28 INT138639 Gene_expression of Hcn4 32 0.75 13.85 11.25
29 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
30 INT91932 Positive_regulation of Scn10a 18 0.67 10.39 10.9
31 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85
32 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82
33 INT65627 Negative_regulation of Kcna5 19 0.59 7.82 10.79
34 INT28843 Positive_regulation of Scn2a1 31 0.68 5.35 10.7
35 INT128906 Gene_expression of Kcnj5 35 0.43 7.48 10.33
36 INT43009 Gene_expression of Scn7a 45 0.68 7.85 10.29
37 INT83674 Negative_regulation of SCN10A 14 0.59 7.28 9.65
38 INT183000 Transcription of KCNIP3 4 0.62 12.89 9.59
39 INT62997 Gene_expression of Kcnj6 17 0.77 2.16 9.44
40 INT114998 Gene_expression of Kcna6 33 0.53 2.65 8.93
41 INT182995 Gene_expression of KCNIP3 19 0.69 13.28 8.81
42 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
43 INT74075 Negative_regulation of Kcna3 20 0.59 4.68 8.64
44 INT117212 Gene_expression of Hcn2 13 0.78 5.83 8.19
45 INT21502 Gene_expression of Scn4a 22 0.78 4.47 7.97
46 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95
47 INT20705 Positive_regulation of Scn4a 18 0.68 4.34 7.85
48 INT73323 Negative_regulation of Scn10a 13 0.58 5.77 7.85
49 INT91930 Gene_expression of Kcnab3 10 0.16 4.41 7.77
50 INT182976 Negative_regulation of KCNIP3 2 0.51 8.49 7.67
51 INT130272 Gene_expression of Kcna4 12 0.75 9.25 7.61
52 INT84162 Negative_regulation of KCNMA1 26 0.58 5.05 7.58
53 INT17028 Positive_regulation of Scn7a 35 0.41 9.83 7.44
54 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3
55 INT65630 Regulation of Kcna5 11 0.62 6.61 7.22
56 INT48542 Gene_expression of Kcna3 18 0.77 6.53 7.15
57 INT116428 Gene_expression of Cybb 68 0.76 35.81 7.07
58 INT17029 Regulation of Scn7a 23 0.45 3.89 7.02
59 INT101965 Positive_regulation of Kcnj9 8 0.31 1.64 6.87
60 INT110605 Gene_expression of KCNK2 24 0.78 5.71 6.85
61 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79
62 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
63 INT48541 Positive_regulation of Kcna5 12 0.69 5.51 6.35
64 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14
65 INT133971 Binding of Kcnip3 4 0.42 5.54 6.12
66 INT101008 Gene_expression of Scn5a 5 0.75 26.93 6.06
67 INT59671 Positive_regulation of Scn8a 7 0.39 1.88 5.92
68 INT85563 Positive_regulation of KCNJ6 6 0.50 0.4 5.89
69 INT90188 Positive_regulation of KCNJ3 7 0.67 0 5.84
70 INT760 Negative_regulation of Scn8a 11 0.42 1.65 5.6
71 INT124960 Regulation of Scn11a 9 0.52 8.39 5.49
72 INT13370 Negative_regulation of Scn4a 11 0.57 4.05 5.47
73 INT116434 Positive_regulation of Gene_expression of CYBB 27 0.62 16.24 5.42
74 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4
75 INT23598 Binding of SCN5A 32 0.40 16 5.35
76 INT30209 Localization of SCN5A 24 0.72 7.95 5.35
77 INT149217 Gene_expression of Kcnip3 2 0.63 6.31 5.26
78 INT20703 Regulation of Scn4a 5 0.35 0.38 5.17
79 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
80 INT73322 Transcription of Scn10a 8 0.69 5.35 4.99
81 INT240092 Negative_regulation of Gene_expression of KCNIP3 1 0.51 5.58 4.96
82 INT83671 Negative_regulation of SCN11A 6 0.57 2.6 4.91
83 INT87753 Transcription of Kcnab3 8 0.55 1.7 4.85
84 INT221226 Gene_expression of Kcnj8 23 0.58 1.69 4.84
85 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
86 INT90957 Positive_regulation of Kcnj9 6 0.69 2 4.79
87 INT95989 Positive_regulation of Kcnq2 9 0.68 2.58 4.75
88 INT86488 Gene_expression of Kcnc1 34 0.66 3.58 4.72
89 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66
90 INT281850 Binding of KCNJ6 1 0.37 0.93 4.57
91 INT131892 Localization of Kcna6 28 0.69 5.09 4.53
92 INT26054 Regulation of Gene_expression of Scn8a 7 0.08 2.86 4.49
93 INT77148 Gene_expression of Kcna1 20 0.73 4.08 4.46
94 INT20121 Negative_regulation of CYBB 34 0.54 15.5 4.44
95 INT8624 Positive_regulation of Scn11a 7 0.46 3.56 4.41
96 INT137810 Regulation of Kcnk2 5 0.62 3.52 4.4
97 INT35999 Positive_regulation of KCNAB2 6 0.65 5.12 4.31
98 INT6967 Regulation of KCNMA1 28 0.61 3.37 4.3
99 INT80626 Binding of KCNIP3 46 0.43 9.84 4.27
100 INT56159 Regulation of Scn2a1 17 0.51 3.23 4.27
101 INT86647 Localization of SCN10A 8 0.78 3.88 4.27
102 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
103 INT73114 Gene_expression of Kcnk3 32 0.77 1.57 4.03
104 INT52608 Gene_expression of Kcnj3 16 0.78 0.42 4.03
105 INT34790 Localization of KCNA1 4 0.43 11.34 3.99
106 INT97375 Positive_regulation of Gene_expression of Scn10a 5 0.67 2.92 3.98
107 INT107415 Regulation of Kcnj9 6 0.62 1 3.87
108 INT66473 Negative_regulation of Kcnj6 6 0.50 1.26 3.87
109 INT47992 Gene_expression of Scn8a 14 0.78 4.15 3.83
110 INT91931 Positive_regulation of Kcnab3 4 0.13 2.14 3.81
111 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
112 INT190722 Positive_regulation of Gene_expression of Scn2a1 15 0.36 0.5 3.78
113 INT28844 Negative_regulation of Scn2a1 15 0.37 3.84 3.65
114 INT29832 Negative_regulation of Scn7a 20 0.37 5.91 3.63
115 INT240080 Negative_regulation of Transcription of KCNIP3 1 0.51 4.34 3.61
116 INT268032 Regulation of Kcnj5 23 0.27 3.66 3.51
117 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47
118 INT46208 Negative_regulation of Scn10a 6 0.58 7.16 3.46
119 INT46691 Negative_regulation of SCN9A 5 0.50 1.37 3.44
120 INT48122 Regulation of Cacna1h 5 0.42 3 3.37
121 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
122 INT167913 Gene_expression of CACNA1C 3 0.75 0.38 3.34
123 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
124 INT11490 Binding of KCNMA1 13 0.37 3.61 3.32
125 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31
126 INT110608 Negative_regulation of KCNK2 10 0.59 0.91 3.26
127 INT142701 Gene_expression of Kcnj6 8 0.78 0.34 3.25
128 INT116917 Positive_regulation of KCNK2 9 0.68 1.02 3.24
129 INT85564 Negative_regulation of KCNJ6 6 0.25 0 3.24
130 INT100591 Regulation of Kcnip3 3 0.50 2.51 3.17
131 INT126116 Gene_expression of Kcna7 16 0.16 4.67 3.14
132 INT69313 Regulation of Scn10a 5 0.60 4.45 3.14
133 INT141038 Positive_regulation of Gene_expression of Hcn4 4 0.38 3.58 3.12
134 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11
135 INT113929 Negative_regulation of Kcnj9 4 0.30 0 3.11
136 INT118247 Positive_regulation of Positive_regulation of Scn4a 1 0.06 0.82 3.1
137 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
138 INT254018 Positive_regulation of Kcna6 10 0.34 0.56 3.03
139 INT162835 Positive_regulation of Cybb 38 0.68 16.09 3.02
140 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
141 INT109496 Gene_expression of KCNK3 9 0.78 0.59 3.02
142 INT65628 Regulation of Gene_expression of Kcna5 4 0.61 1.66 2.98
143 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
144 INT110609 Binding of KCNK2 3 0.48 0.25 2.88
145 INT144264 Gene_expression of KCNH1 6 0.65 17.69 2.83
146 INT100344 Regulation of Gene_expression of Scn11a 4 0.44 1.6 2.82
147 INT159770 Positive_regulation of Gene_expression of Hcn2 2 0.67 2.65 2.82
148 INT143551 Binding of KCNA1 13 0.46 8.81 2.81
149 INT131897 Phosphorylation of Kcna6 7 0.70 4.75 2.8
150 INT89834 Positive_regulation of SCN2A 8 0.49 1.89 2.77
151 INT65629 Positive_regulation of Gene_expression of Kcna5 5 0.69 2.48 2.76
152 INT116215 Transcription of Kcna5 6 0.53 3.62 2.75
153 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74
154 INT5757 Gene_expression of SCN4A 6 0.75 1.73 2.73
155 INT117648 Negative_regulation of Positive_regulation of Kcnj9 2 0.12 0.6 2.73
156 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
157 INT123795 Positive_regulation of KCNQ1 13 0.49 3.53 2.65
158 INT116216 Negative_regulation of Gene_expression of Kcna5 4 0.43 3.11 2.64
159 INT100743 Regulation of KCNH2 6 0.54 2.37 2.61
160 INT11485 Localization of KCNMA1 7 0.09 1.81 2.6
161 INT144840 Negative_regulation of Gene_expression of Kcna4 2 0.55 3.13 2.6
162 INT86602 Binding of KCNH2 14 0.36 4.65 2.58
163 INT62998 Regulation of Kcnj6 4 0.39 0.5 2.57
164 INT99800 Binding of Kcna5 4 0.47 0.96 2.55
165 INT104663 Positive_regulation of SCN9A 3 0.60 0.42 2.54
166 INT140200 Regulation of Cacna2d3 4 0.45 1.48 2.53
167 INT82730 Transcription of Scn10a 3 0.69 2.5 2.53
168 INT145946 Negative_regulation of Kcnk2 3 0.59 2.65 2.52
169 INT101964 Regulation of Kcnj9 4 0.31 0.37 2.46
170 INT13021 Positive_regulation of SCN4A 7 0.49 1.61 2.42
171 INT146458 Negative_regulation of Kcna4 3 0.40 3.44 2.42
172 INT136993 Positive_regulation of KCNJ2 3 0.35 3.61 2.42
173 INT131831 Negative_regulation of Kcnj9 2 0.43 0.66 2.42
174 INT29901 Localization of Scn4a 3 0.68 0.07 2.41
175 INT60156 Regulation of Kcnk3 7 0.42 2.47 2.4
176 INT13753 Transcription of Scn4a 4 0.70 0 2.39
177 INT17559 Localization of Scn7a 13 0.28 4.47 2.37
178 INT236490 Positive_regulation of SCN11A 2 0.48 0.91 2.37
179 INT107414 Positive_regulation of Gene_expression of Kcnj9 1 0.50 2.61 2.34
180 INT69481 Negative_regulation of Kcna1 5 0.28 0.38 2.33
181 INT11487 Positive_regulation of Localization of KCNMA1 4 0.06 1.5 2.31
182 INT80733 Binding of Scn2a1 11 0.30 1.09 2.3
183 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
184 INT144841 Regulation of Gene_expression of Kcna4 1 0.60 2.99 2.26
185 INT86483 Localization of SCN11A 4 0.78 1.25 2.23
186 INT116914 Gene_expression of KCNK4 4 0.71 0.82 2.23
187 INT19286 Negative_regulation of Cacna1c 11 0.46 5.12 2.22
188 INT48120 Positive_regulation of Cacna1h 5 0.34 1.2 2.22
189 INT70522 Binding of Kcna1 2 0.36 0.73 2.22
190 INT99119 Gene_expression of Cacna2d3 7 0.65 1.41 2.21
191 INT74486 Positive_regulation of SCN1A 4 0.67 1 2.2
192 INT95128 Positive_regulation of KCNA1 8 0.41 4.28 2.19
193 INT140400 Binding of Scn9a 4 0.36 3.59 2.15
194 INT73754 Regulation of Gene_expression of Scn10a 3 0.62 1.66 2.15
195 INT169533 Positive_regulation of Gene_expression of Cybb 16 0.68 8.62 2.14
196 INT100590 Negative_regulation of Kcnip3 5 0.58 2.39 2.13
197 INT46692 Binding of SCN9A 4 0.36 2.55 2.13
198 INT69690 Gene_expression of Scn9a 6 0.78 2.08 2.09
199 INT114562 Gene_expression of Kcnj9 6 0.76 0.56 2.08
200 INT9429 Positive_regulation of Clcn1 18 0.58 10.03 2.07
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