GO:0005247

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Name voltage-gated chloride channel activity
Categary Function
Go Slim No
Go Link GO:0005247
Unique Molecular Interactions 28
Total Molecular Interactions 42
Total Single Events 254
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for voltage-gated chloride channel activity. They are ordered first by their pain relevance and then by number of times they were reported for voltage-gated chloride channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
2 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
3 INT150446 Binding of Clcn1 and Scn4a 1 0.26 0.65 0.08
4 INT167271 Binding of Ezr and Clic5 1 0.54 0.07 0.06
5 INT311296 Akt1 Positive_regulation of Gene_expression of Clcn1 1 0.11 0 0.05
6 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03
7 INT311295 Gopc Positive_regulation of Gene_expression of Clcn1 1 0.07 0.29 0
8 INT235693 Binding of Clcn1 and Gab2 1 0.19 2.96 0
9 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
10 INT235697 Binding of Clcn1 and Syn1 1 0.00 0.48 0
11 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0
12 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0
13 INT235695 Gab2 Positive_regulation of Clcn1 1 0.20 0.52 0
14 INT235692 Clcn1 Positive_regulation of Binding of Alms1 1 0.05 0.9 0
15 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0
16 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0
17 INT235696 Regulation of Binding of Clcn1 and Gab2 1 0.18 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for voltage-gated chloride channel activity. They are ordered first by their pain relevance and then by number of times they were reported in voltage-gated chloride channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9429 Positive_regulation of Clcn1 18 0.58 10.03 2.07
2 INT19467 Localization of Clcn1 7 0.66 2.84 1.59
3 INT16178 Gene_expression of Clcn1 20 0.69 8.67 1.46
4 INT19466 Negative_regulation of Clcn1 6 0.52 3.39 1.22
5 INT37012 Binding of Clcn1 11 0.33 4.83 0.7
6 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
7 INT164753 Negative_regulation of Clcn5 2 0.58 5.13 0.2
8 INT213080 Gene_expression of Clic5 1 0.04 0.51 0.15
9 INT167268 Positive_regulation of Clic5 1 0.44 0.15 0.1
10 INT167269 Transcription of Clic5 1 0.72 0.07 0.07
11 INT286583 Localization of PKD2 1 0.35 0.17 0.06
12 INT261879 Binding of PKD2 3 0.13 2.59 0.05
13 INT235683 Regulation of Clcn1 4 0.21 1.49 0.03
14 INT272462 Transcription of Clcn1 4 0.63 1.21 0
15 INT272476 Negative_regulation of Transcription of Clcn1 3 0.43 1.05 0
16 INT272461 Negative_regulation of Gene_expression of Clcn1 2 0.52 0.82 0
17 INT241245 Negative_regulation of PKD2 2 0.42 2.35 0
18 INT235684 Protein_catabolism of Clcn1 2 0.23 0.42 0
19 INT311279 Positive_regulation of Gene_expression of Clcn1 1 0.44 0.06 0
20 INT340360 Positive_regulation of Clcn5 1 0.50 1.62 0
21 INT340365 Protein_catabolism of Clcn5 1 0.99 1.03 0
22 INT264147 Gene_expression of CLCN7 1 0.35 0.73 0
23 INT311277 Regulation of Gene_expression of Clcn1 1 0.40 1 0
24 INT340363 Regulation of Clcn5 1 0.45 0.85 0
25 INT232493 Negative_regulation of Positive_regulation of PKD2 1 0.23 0.61 0
26 INT261878 Negative_regulation of Binding of PKD2 1 0.14 0.6 0
27 INT311280 Positive_regulation of Transcription of Clcn1 1 0.44 0.24 0
28 INT232491 Positive_regulation of PKD2 1 0.27 0.56 0
29 INT340359 Binding of Clcn5 1 0.48 1.91 0
30 INT340372 Negative_regulation of Protein_catabolism of Clcn5 1 0.43 1.07 0
31 INT340361 Binding of Clcn4-2 1 0.30 0.82 0
32 INT340366 Gene_expression of Clcn5 1 0.77 4.8 0
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