GO:0005254

From wiki-pain
Jump to: navigation, search
Name chloride channel activity
Categary Function
Go Slim No
Go Link GO:0005254
Unique Molecular Interactions 106
Total Molecular Interactions 137
Total Single Events 1414
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chloride channel activity. They are ordered first by their pain relevance and then by number of times they were reported for chloride channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179445 Vta1 Positive_regulation of Gabrd 1 0.09 0 1.98
2 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
3 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
4 INT14827 Binding of Gabrd and Pag1 1 0.07 0.95 1.33
5 INT123260 Binding of Gabrg2 and Serpini1 1 0.02 0.63 1.16
6 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
7 INT123261 Gabrg2 Regulation of Serpini1 1 0.01 0.63 1.16
8 INT53847 Pag1 Regulation of Gabrd 1 0.01 1 1.08
9 INT53842 Abat Regulation of Gabrd 1 0.04 1 1.08
10 INT60948 Ltp Negative_regulation of Negative_regulation of Gabrd 1 0.02 0.07 1.03
11 INT81127 Binding of Gabrd and Abat 3 0.25 0 0.96
12 INT138862 ABCC2 Negative_regulation of ABCC4 1 0.63 0.24 0.9
13 INT292988 Negative_regulation of SGCG Positive_regulation of GABRB3 1 0.01 0.3 0.89
14 INT310348 Binding of Tspo and Gabrd 1 0.00 0.43 0.88
15 INT292990 SGCG Positive_regulation of Gene_expression of GABRB3 1 0.01 0.29 0.87
16 INT292989 SGCG Positive_regulation of GABRB3 1 0.01 0.29 0.87
17 INT271511 Binding of Phb2 and Glrb 1 0.04 1.7 0.84
18 INT13428 Gabrd Regulation of Localization of Sstr2 1 0.31 0 0.79
19 INT19577 Gabrg1 Negative_regulation of Got1 1 0.04 0.16 0.74
20 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67
21 INT343365 Acsf2 Negative_regulation of Gabrd 1 0.04 0 0.61
22 INT170833 Cftr Negative_regulation of Slc10a2 1 0.47 0.31 0.56
23 INT69291 Cftr Positive_regulation of Localization of Slc4a8 1 0.04 0.38 0.51
24 INT117482 CFTR Negative_regulation of THRB 1 0.01 0.15 0.51
25 INT205733 Gphn Regulation of Gene_expression of Gabrd 1 0.03 0.18 0.51
26 INT341623 Binding of CFTR and CTRC 1 0.35 1.22 0.46
27 INT341624 Binding of CFTR and PRSS1 1 0.39 1.01 0.45
28 INT67633 Binding of DST and Gabrd 1 0.03 0 0.41
29 INT103346 Abat Positive_regulation of Gabrd 1 0.20 0.08 0.4
30 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35
31 INT330794 Positive_regulation of Gabrd Positive_regulation of Localization of Bdnf 1 0.02 0.78 0.33
32 INT89013 Positive_regulation of Gabrd Positive_regulation of Pomc 1 0.21 0.18 0.29
33 INT310696 Tlr4 Positive_regulation of Positive_regulation of Cftr 1 0.16 0.74 0.28
34 INT182347 Binding of Glrb and Cd163 1 0.24 0.98 0.28
35 INT196695 Prkaca Positive_regulation of CFTR 1 0.46 0.13 0.27
36 INT274697 Binding of CFTR and Cftr 1 0.08 0.69 0.27
37 INT244034 Binding of Gabrg2 and Ubqln1 1 0.01 0.09 0.26
38 INT231797 Glrb Regulation of Negative_regulation of TNF 1 0.02 1.49 0.25
39 INT244047 Binding of Gabrg2 and Myoz1 1 0.00 0.19 0.23
40 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23
41 INT73969 Positive_regulation of Gabbr1 Regulation of Gabrd 1 0.01 0 0.23
42 INT170834 Cftr Regulation of Slc10a2 1 0.58 0.37 0.22
43 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21
44 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
45 INT196610 IFNG Negative_regulation of CFTR 1 0.17 0.21 0.19
46 INT287014 Gabrd Regulation of Ptn 1 0.10 0 0.18
47 INT267660 CFTR Regulation of Gene_expression of P2RX2 1 0.25 0.51 0.18
48 INT244038 Binding of Gabrg2 and Gabarap 1 0.08 0.24 0.18
49 INT196606 IFNG Positive_regulation of CFTR 1 0.16 0.45 0.16
50 INT196608 TNF Negative_regulation of CFTR 1 0.16 0.11 0.14
51 INT156057 UMOD Regulation of GABRG3 1 0.01 0.54 0.14
52 INT271513 Binding of Glrb and Spha2 1 0.16 0.18 0.13
53 INT328143 Gabrb3 Positive_regulation of Ube3a 1 0.56 0.99 0.11
54 INT328146 Gabrb3 Negative_regulation of Ube3a 1 0.48 0.99 0.11
55 INT73968 Gabbr1 Regulation of Gabrd 1 0.01 0 0.09
56 INT150446 Binding of Clcn1 and Scn4a 1 0.26 0.65 0.08
57 INT273947 Binding of Gabra1 and Mrvi1 1 0.00 0.94 0.07
58 INT273937 Binding of Crem and Gabra1 1 0.30 0.94 0.07
59 INT167271 Binding of Ezr and Clic5 1 0.54 0.07 0.06
60 INT271512 Binding of Glrb and Traf1 1 0.09 0.1 0.05
61 INT311296 Akt1 Positive_regulation of Gene_expression of Clcn1 1 0.11 0 0.05
62 INT244048 Binding of Gabrg2 and Gabarapl1 1 0.02 0.19 0.05
63 INT271510 Binding of Glrb and rs 1 0.00 0.26 0.05
64 INT244031 Binding of Gabrg2 and Nsf 1 0.04 0.19 0.05
65 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03
66 INT196639 Negative_regulation of NA Negative_regulation of Transcription of CFTR 1 0.02 0.63 0.03
67 INT213585 Binding of CFTR and FLNA 1 0.14 0.11 0.03
68 INT310694 Tlr4 Positive_regulation of Cftr 1 0.16 0.34 0.03
69 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0
70 INT308747 Binding of Cftr and Prkag1 1 0.02 0 0
71 INT311295 Gopc Positive_regulation of Gene_expression of Clcn1 1 0.07 0.29 0
72 INT235693 Binding of Clcn1 and Gab2 1 0.19 2.96 0
73 INT297560 Binding of HSD11B1 and APOL1 1 0.04 0.88 0
74 INT342378 Binding of Vdr and Best1 1 0.05 0.4 0
75 INT342383 Binding of Srp14 and Best1 1 0.00 0.56 0
76 INT289836 BEST1 Positive_regulation of Gene_expression of Car2 1 0.03 0.08 0
77 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0
78 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0
79 INT254432 Binding of Best1 and Sost 1 0.12 0.69 0
80 INT235697 Binding of Clcn1 and Syn1 1 0.00 0.48 0
81 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0
82 INT164624 Binding of SLCO2B1 and Positive_regulation of ABCC4 1 0.41 0.09 0
83 INT328141 Binding of Chrne and Gabrb3 1 0.41 0.08 0
84 INT235695 Gab2 Positive_regulation of Clcn1 1 0.20 0.52 0
85 INT235692 Clcn1 Positive_regulation of Binding of Alms1 1 0.05 0.9 0
86 INT164619 SLCO2B1 Positive_regulation of ABCC4 1 0.41 0.09 0
87 INT341728 Pth Positive_regulation of Best1 1 0.06 0.43 0
88 INT297558 Binding of APOL1 and SRA1 1 0.22 0.56 0
89 INT342386 Binding of CALCR and Best1 1 0.01 0.96 0
90 INT235696 Regulation of Binding of Clcn1 and Gab2 1 0.18 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for chloride channel activity. They are ordered first by their pain relevance and then by number of times they were reported in chloride channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25
2 INT51801 Gene_expression of Gabrd 64 0.72 19.17 22.61
3 INT11524 Negative_regulation of Gabrd 39 0.58 6.25 18.8
4 INT6807 Regulation of Gabrd 39 0.62 9.22 18.74
5 INT21132 Gene_expression of GABRB3 36 0.33 11.32 17.61
6 INT12444 Binding of Gabrd 26 0.48 4.7 11.23
7 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73
8 INT49315 Localization of Gabrd 17 0.63 2.32 7.95
9 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02
10 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97
11 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12
12 INT182338 Gene_expression of Glrb 11 0.51 14.26 5.1
13 INT89114 Binding of Cftr 13 0.37 11.29 4.99
14 INT6941 Positive_regulation of Positive_regulation of Gabrd 6 0.50 1.29 4.6
15 INT169756 Binding of CFTR 9 0.35 9.65 4.55
16 INT70739 Gene_expression of Gabrg2 11 0.75 4.15 4.18
17 INT48993 Positive_regulation of Cftr 17 0.57 6.02 4.12
18 INT89113 Regulation of Cftr 11 0.62 6.83 4.01
19 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79
20 INT183560 Binding of GABRB3 12 0.23 2.59 3.77
21 INT120596 Gene_expression of ABCC4 11 0.78 2.51 3.76
22 INT68791 Positive_regulation of Gene_expression of Gabrd 10 0.47 2.89 3.48
23 INT137049 Positive_regulation of Glrb 7 0.46 9.24 3.22
24 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14
25 INT244388 Regulation of Gene_expression of Gabrd 8 0.38 3.27 3.08
26 INT70738 Negative_regulation of Gabrg2 7 0.57 4 2.96
27 INT55824 Negative_regulation of Positive_regulation of Gabrd 5 0.59 1.56 2.88
28 INT163528 Gene_expression of Gabra1 3 0.74 0.75 2.73
29 INT292993 Positive_regulation of Gene_expression of GABRB3 4 0.17 0.9 2.63
30 INT69290 Localization of Cftr 11 0.75 3.69 2.52
31 INT292992 Negative_regulation of Gene_expression of GABRB3 3 0.15 0.78 2.41
32 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32
33 INT74361 Negative_regulation of Gabrb3 4 0.58 0.73 2.28
34 INT202522 Negative_regulation of Gene_expression of Cftr 11 0.57 5.9 2.24
35 INT21130 Positive_regulation of GABRB3 4 0.27 1.88 2.21
36 INT9429 Positive_regulation of Clcn1 18 0.58 10.03 2.07
37 INT124355 Negative_regulation of BEST1 11 0.19 6.13 2.04
38 INT166710 Positive_regulation of Gene_expression of CFTR 9 0.46 3.72 2.03
39 INT119891 Regulation of Gene_expression of Cftr 4 0.59 2.67 1.98
40 INT38268 Positive_regulation of BEST1 16 0.17 14.54 1.93
41 INT120595 Positive_regulation of ABCC4 3 0.51 2.83 1.91
42 INT151101 Regulation of CFTR 4 0.62 3.69 1.89
43 INT138863 Positive_regulation of Gene_expression of ABCC4 1 0.49 0.64 1.84
44 INT227759 Gene_expression of Best1 26 0.42 20.36 1.73
45 INT182334 Binding of Glrb 3 0.28 4.81 1.71
46 INT215636 Regulation of Localization of Gabrd 2 0.18 0.18 1.71
47 INT120598 Negative_regulation of ABCC4 4 0.59 0.49 1.6
48 INT19467 Localization of Clcn1 7 0.66 2.84 1.59
49 INT13176 Positive_regulation of Binding of Gabrd 3 0.38 0.73 1.55
50 INT114862 Gene_expression of BEST1 16 0.65 12.14 1.53
51 INT74360 Gene_expression of Gabrb3 2 0.77 3.85 1.49
52 INT16178 Gene_expression of Clcn1 20 0.69 8.67 1.46
53 INT152223 Binding of BEST1 10 0.29 6.67 1.46
54 INT121605 Transcription of Gabrd 2 0.19 0.37 1.46
55 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44
56 INT183557 Localization of GABRB3 3 0.46 1.01 1.34
57 INT137048 Regulation of Glrb 2 0.39 3.2 1.32
58 INT13530 Negative_regulation of GABRB3 4 0.17 1.48 1.31
59 INT19466 Negative_regulation of Clcn1 6 0.52 3.39 1.22
60 INT236435 Negative_regulation of Gene_expression of Gabrd 4 0.17 0.91 1.19
61 INT196675 Localization of CFTR 4 0.64 1.95 1.19
62 INT292991 Negative_regulation of Localization of GABRB3 2 0.13 0.44 1.18
63 INT95370 Phosphorylation of Gabrd 3 0.78 0.46 1.15
64 INT163527 Positive_regulation of Gene_expression of Gabra1 1 0.31 0.16 1.15
65 INT215642 Regulation of Negative_regulation of Gabrd 2 0.07 0 1.14
66 INT22962 Gene_expression of FXYD1 2 0.58 3.32 1.12
67 INT215638 Negative_regulation of Localization of Gabrd 2 0.36 0.36 1.12
68 INT54505 Binding of Gabra1 2 0.35 0.45 1.1
69 INT138864 Binding of ABCC4 1 0.36 0.38 0.93
70 INT95372 Regulation of Phosphorylation of Gabrd 1 0.24 0.21 0.9
71 INT131757 Positive_regulation of Transcription of Gabrd 1 0.07 0.29 0.83
72 INT61290 Regulation of Phosphorylation of CFTR 1 0.44 0.25 0.81
73 INT274693 Positive_regulation of Gene_expression of Cftr 6 0.49 2.93 0.8
74 INT61291 Phosphorylation of CFTR 1 0.80 0.25 0.8
75 INT318278 Regulation of Gene_expression of GABRB3 1 0.14 0.47 0.77
76 INT182344 Positive_regulation of Gene_expression of Glrb 1 0.38 2.92 0.74
77 INT196682 Negative_regulation of Gene_expression of CFTR 6 0.34 1.96 0.73
78 INT151100 Negative_regulation of Positive_regulation of CFTR 1 0.43 1.11 0.73
79 INT37012 Binding of Clcn1 11 0.33 4.83 0.7
80 INT211972 Regulation of Best1 18 0.33 12.04 0.67
81 INT250351 Positive_regulation of Gene_expression of Best1 5 0.27 3.14 0.65
82 INT121610 Regulation of Transcription of Gabrd 1 0.10 0.08 0.64
83 INT151098 Positive_regulation of Positive_regulation of CFTR 2 0.50 0.9 0.63
84 INT182342 Regulation of Gene_expression of Glrb 1 0.34 1.12 0.63
85 INT344760 Gene_expression of GABRG3 1 0.36 0.41 0.62
86 INT74362 Regulation of Gabrb3 1 0.28 0 0.58
87 INT243940 Binding of Gabrg2 2 0.47 0.88 0.56
88 INT200980 Transcription of APOL1 1 0.67 0.84 0.54
89 INT201005 Gene_expression of APOL1 9 0.75 4.66 0.53
90 INT39251 Negative_regulation of Gabrg1 1 0.06 0 0.53
91 INT145269 Transcription of ABCC4 1 0.39 1.18 0.53
92 INT163526 Regulation of Gene_expression of Gabra1 1 0.16 0.16 0.52
93 INT86339 Positive_regulation of Gabrb3 1 0.14 0.14 0.51
94 INT148391 Positive_regulation of Gabrg2 3 0.45 0.31 0.5
95 INT245016 Transcription of GABRB3 1 0.17 0 0.47
96 INT292608 Positive_regulation of Regulation of GABRB3 1 0.05 1.58 0.45
97 INT161878 Negative_regulation of Gene_expression of Gabrg2 2 0.57 0.75 0.4
98 INT310689 Positive_regulation of Negative_regulation of Cftr 1 0.47 1.41 0.4
99 INT211968 Localization of Best1 11 0.40 9.33 0.38
100 INT226184 Protein_catabolism of Cftr 3 0.87 1.52 0.38
101 INT318270 Positive_regulation of Negative_regulation of GABRB3 1 0.11 0.09 0.36
102 INT247999 Negative_regulation of FXYD1 2 0.06 1.75 0.35
103 INT273027 Regulation of Negative_regulation of FXYD1 1 0.05 1.19 0.35
104 INT211971 Binding of Best1 16 0.22 7.73 0.33
105 INT70737 Transcription of Gabrg2 3 0.52 0.67 0.31
106 INT267666 Regulation of Localization of CFTR 1 0.22 0.39 0.3
107 INT120959 Protein_catabolism of CFTR 1 0.03 0.14 0.28
108 INT328133 Localization of Gabrb3 1 0.75 1.35 0.27
109 INT200986 Positive_regulation of Gene_expression of APOL1 1 0.36 0.26 0.26
110 INT318277 Phosphorylation of GABRB3 1 0.19 0.45 0.25
111 INT182333 Negative_regulation of Gene_expression of Glrb 1 0.28 1.04 0.25
112 INT247915 Regulation of Positive_regulation of Gabrg2 1 0.26 0.08 0.25
113 INT216403 Positive_regulation of Negative_regulation of Gabrd 1 0.20 0.47 0.24
114 INT196688 Positive_regulation of Binding of CFTR 1 0.26 0.33 0.24
115 INT200997 Regulation of Transcription of APOL1 1 0.32 0.23 0.24
116 INT201019 Localization of APOL1 3 0.66 1.29 0.23
117 INT356219 Binding of Gabrb3 1 0.29 1.25 0.23
118 INT260854 Negative_regulation of Binding of Gabrd 1 0.10 0.06 0.22
119 INT308734 Transcription of Cftr 1 0.68 0.75 0.2
120 INT282127 Regulation of Regulation of Best1 1 0.15 1.67 0.18
121 INT174812 Regulation of BEST1 3 0.07 2.4 0.17
122 INT183817 Localization of BEST1 6 0.26 5.22 0.16
123 INT318139 Regulation of Gene_expression of Gabrg2 1 0.44 0.87 0.16
124 INT213080 Gene_expression of Clic5 1 0.04 0.51 0.15
125 INT328139 Negative_regulation of Gene_expression of Gabrb3 1 0.43 0.1 0.15
126 INT196681 Negative_regulation of Localization of CFTR 1 0.34 0.18 0.15
127 INT200973 Negative_regulation of APOL1 1 0.14 0.18 0.15
128 INT120597 Negative_regulation of Negative_regulation of ABCC4 1 0.43 0.17 0.14
129 INT310692 Positive_regulation of Protein_catabolism of Cftr 1 0.44 0.46 0.12
130 INT201000 Positive_regulation of APOL1 2 0.45 0.66 0.1
131 INT196672 Positive_regulation of Localization of CFTR 1 0.41 0 0.1
132 INT167268 Positive_regulation of Clic5 1 0.44 0.15 0.1
133 INT200976 Positive_regulation of Transcription of APOL1 1 0.49 0.23 0.1
134 INT127244 Binding of APOL1 1 0.33 3.29 0.09
135 INT347555 Positive_regulation of Localization of Cftr 1 0.14 0.63 0.09
136 INT308732 Regulation of Transcription of Cftr 1 0.44 0.18 0.09
137 INT308735 Negative_regulation of Positive_regulation of Cftr 1 0.42 0.15 0.08
138 INT196673 Regulation of Gene_expression of CFTR 1 0.36 0.62 0.08
139 INT167269 Transcription of Clic5 1 0.72 0.07 0.07
140 INT200974 Negative_regulation of Transcription of APOL1 1 0.27 0.23 0.06
141 INT274694 Negative_regulation of Binding of Cftr 1 0.35 0.19 0.05
142 INT235683 Regulation of Clcn1 4 0.21 1.49 0.03
143 INT196683 Negative_regulation of Transcription of CFTR 1 0.22 0.61 0.03
144 INT196685 Transcription of CFTR 1 0.37 0.6 0.03
145 INT243921 Regulation of Gabrg2 1 0.08 0.18 0.03
146 INT272462 Transcription of Clcn1 4 0.63 1.21 0
147 INT227758 Positive_regulation of Localization of Best1 3 0.07 1.95 0
148 INT272476 Negative_regulation of Transcription of Clcn1 3 0.43 1.05 0
149 INT272461 Negative_regulation of Gene_expression of Clcn1 2 0.52 0.82 0
150 INT235684 Protein_catabolism of Clcn1 2 0.23 0.42 0
151 INT311279 Positive_regulation of Gene_expression of Clcn1 1 0.44 0.06 0
152 INT247997 Regulation of FXYD1 1 0.00 0.51 0
153 INT308731 Phosphorylation of Cftr 1 0.62 0 0
154 INT273026 Localization of FXYD1 1 0.08 1.53 0
155 INT328126 Positive_regulation of Gene_expression of Gabrb3 1 0.50 1.08 0
156 INT264147 Gene_expression of CLCN7 1 0.35 0.73 0
157 INT341725 Regulation of Positive_regulation of Best1 1 0.07 0.26 0
158 INT328138 Protein_catabolism of Gabrb3 1 0.88 0 0
159 INT63293 Negative_regulation of Negative_regulation of Gabrd 1 0.18 0 0
160 INT297583 Regulation of APOL1 1 0.40 0.57 0
161 INT311277 Regulation of Gene_expression of Clcn1 1 0.40 1 0
162 INT261772 Regulation of Positive_regulation of Gabrd 1 0.11 0.42 0
163 INT311280 Positive_regulation of Transcription of Clcn1 1 0.44 0.24 0
164 INT264145 Gene_expression of BSND 1 0.04 1.25 0
165 INT306780 Binding of FXYD1 1 0.36 0.31 0
166 INT327449 Positive_regulation of Negative_regulation of BEST1 1 0.09 0.93 0
167 INT335854 Negative_regulation of Localization of Best1 1 0.06 0.33 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox