GO:0005328

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Name neurotransmitter:sodium symporter activity
Categary Function
Go Slim No
Go Link GO:0005328
Unique Molecular Interactions 77
Total Molecular Interactions 110
Total Single Events 804
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neurotransmitter:sodium symporter activity. They are ordered first by their pain relevance and then by number of times they were reported for neurotransmitter:sodium symporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT172206 Binding of Slc6a3 and ADHD1 2 0.03 2.76 1.61
2 INT62481 Penk Negative_regulation of Slc6a7 2 0.60 0 1.5
3 INT124925 Negative_regulation of Slc6a1 Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
4 INT119713 Negative_regulation of Slc6a3 Positive_regulation of Cpu3 1 0.39 0.71 1.26
5 INT169768 Binding of Slc6a4 and Mir16-1 1 0.33 0 1.25
6 INT184919 Binding of da and Slc6a3 1 0.12 0.33 1.23
7 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
8 INT90561 Slc6a1 Negative_regulation of Abat 1 0.02 0.25 0.91
9 INT333303 Zic2 Regulation of Gene_expression of Slc6a4 1 0.60 0.47 0.91
10 INT153370 LBX1 Positive_regulation of Gene_expression of Slc6a5 1 0.02 0 0.88
11 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
12 INT62480 Binding of Penk and Slc6a7 1 0.32 0 0.87
13 INT62477 Penk Negative_regulation of Binding of Slc6a7 1 0.44 0 0.86
14 INT62479 Binding of Slc6a7 and Flvcr2 1 0.08 0 0.85
15 INT243024 Binding of Dcpp1 and Slc6a4 1 0.08 0.42 0.76
16 INT243025 Dcpp1 Regulation of Slc6a4 1 0.10 0.43 0.76
17 INT169769 Mir16-1 Regulation of Slc6a4 1 0.24 0 0.74
18 INT333296 Gtf3a Regulation of Gene_expression of Slc6a4 1 0.01 0 0.74
19 INT210144 Binding of Slc6a3 and Slc37a4 1 0.11 0.23 0.72
20 INT74727 Binding of Slc6a4 and Hpic1 1 0.00 0.49 0.68
21 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
22 INT333305 Zic2 Positive_regulation of Transcription of Slc6a4 1 0.68 0 0.66
23 INT144107 Binding of SLC6A2 and SLC6A4 1 0.00 0.18 0.62
24 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58
25 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 0.19 1.32 0.58
26 INT333302 Zic2 Positive_regulation of Slc6a4 1 0.68 0.11 0.57
27 INT137246 Slc6a14 Negative_regulation of Gene_expression of Fos 1 0.10 1.24 0.54
28 INT43075 Slc6a14 Regulation of Positive_regulation of Npr1 1 0.01 0 0.51
29 INT43076 Slc6a14 Regulation of Npr1 1 0.01 0 0.51
30 INT235870 Bdnf Regulation of Gene_expression of Slc6a4 1 0.09 0.77 0.5
31 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
32 INT184877 Negative_regulation of Binding of Slc6a3 and ADHD1 1 0.01 0.69 0.45
33 INT90642 Cpe Negative_regulation of Negative_regulation of Slc6a3 1 0.04 0 0.44
34 INT235869 Binding of Slc6a4 and Ppp2ca 1 0.04 0.21 0.31
35 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
36 INT235877 Prkaca Regulation of Transcription of Slc6a4 1 0.06 0.13 0.31
37 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
38 INT235874 Camk2a Positive_regulation of Slc6a4 1 0.11 0.14 0.28
39 INT277317 Binding of Celf1 and Slc6a11 1 0.19 0.06 0.26
40 INT224908 Binding of SLC6A7 and GAL 1 0.17 0.37 0.22
41 INT333298 Zic2 Regulation of Transcription of Slc6a4 1 0.44 0.09 0.2
42 INT300562 Binding of Slc6a3 and Datd 1 0.02 1.12 0.2
43 INT184868 Binding of Slc6a3 and Lmo1 1 0.02 0.72 0.19
44 INT75039 Slc6a14 Positive_regulation of Gene_expression of Mgst1 1 0.01 0.17 0.17
45 INT75030 Slc6a14 Positive_regulation of Gene_expression of Ephx1 1 0.01 0.17 0.17
46 INT75036 Slc6a14 Negative_regulation of Cyp11b1 1 0.00 0.17 0.17
47 INT349505 Ptpn2 Negative_regulation of Slc6a3 1 0.19 0.7 0.16
48 INT235883 Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
49 INT235879 Regulation of Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15
50 INT144027 Binding of Slc6a4 and Pdgfrb 1 0.23 0.25 0.14
51 INT277316 Upf1 Positive_regulation of Slc6a11 1 0.01 0.47 0.09
52 INT184920 Binding of Agtrap and Slc6a3 1 0.02 0.09 0.09
53 INT75033 Slc6a14 Negative_regulation of Gene_expression of Cyp11b1 1 0.00 0.08 0.08
54 INT277319 Gene_expression of Celf1 Positive_regulation of Positive_regulation of Slc6a11 1 0.24 0.08 0.08
55 INT277313 Negative_regulation of Mbnl1 Positive_regulation of Positive_regulation of Slc6a11 1 0.52 0.08 0.08
56 INT75031 Slc6a14 Positive_regulation of Ephx1 1 0.01 0.07 0.07
57 INT184917 Slc6a3 Positive_regulation of Agtrap 1 0.03 0.08 0.06
58 INT333304 Zic2 Positive_regulation of Gene_expression of Slc6a4 1 0.68 0.1 0.06
59 INT333297 Gtf3a Positive_regulation of Gene_expression of Slc6a4 1 0.01 0.1 0.06
60 INT321651 Binding of Slc6a3 and Uts2r 1 0.04 0.06 0.05
61 INT321652 Binding of Slc6a3 and Slc6a4 1 0.26 0.07 0.05
62 INT321654 Binding of Slc6a4 and Uts2r 1 0.05 0.07 0.05
63 INT333301 Binding of Slc6a4 and Zic2 1 0.47 0 0.03
64 INT333307 Gene_expression of Zic2 Positive_regulation of Gene_expression of Slc6a4 1 0.45 0.05 0.03
65 INT322236 Agt Regulation of Gene_expression of Slc6a4 1 0.42 0.63 0
66 INT322251 Slc6a4 Regulation of Gene_expression of Agtrap 1 0.43 0.63 0
67 INT322248 Slc6a4 Regulation of Gene_expression of Agt 1 0.42 0.63 0
68 INT277311 Mbnl1 Regulation of Gene_expression of Slc6a11 1 0.50 0.06 0
69 INT322238 Slc6a4 Regulation of Gene_expression of Ace 1 0.37 0.63 0
70 INT322256 Ace Regulation of Gene_expression of Slc6a4 1 0.37 0.63 0
71 INT141576 Slc6a14 Positive_regulation of Gene_expression of Tnf 1 0.05 0.07 0
72 INT333306 Ephb1 Regulation of Gene_expression of Slc6a4 1 0.19 0.21 0
73 INT333295 Gtf3a Positive_regulation of Slc6a4 1 0.01 0 0
74 INT322247 Slc6a4 Regulation of Gene_expression of Htr2a 1 0.13 0.63 0
75 INT333300 Positive_regulation of Zic2 Positive_regulation of Slc6a4 1 0.45 0 0
76 INT277314 Celf1 Regulation of Gene_expression of Slc6a11 1 0.23 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neurotransmitter:sodium symporter activity. They are ordered first by their pain relevance and then by number of times they were reported in neurotransmitter:sodium symporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01
2 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23
3 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84
4 INT93360 Gene_expression of Slc6a3 63 0.78 19.54 26.55
5 INT100096 Regulation of Slc6a4 24 0.62 7.25 12.28
6 INT93967 Binding of Slc6a3 22 0.48 6.81 10.74
7 INT90639 Positive_regulation of Slc6a3 25 0.61 10.95 10.41
8 INT146343 Regulation of Slc6a3 17 0.60 7.33 8.27
9 INT95317 Positive_regulation of Slc6a1 6 0.69 5.91 7.94
10 INT184845 Negative_regulation of Gene_expression of Slc6a3 13 0.59 3.25 7.79
11 INT15099 Gene_expression of Slc6a5 8 0.51 1.09 7.57
12 INT105528 Negative_regulation of Slc6a1 7 0.57 2.79 7.32
13 INT119651 Binding of Slc6a4 12 0.32 4.65 7.07
14 INT112211 Gene_expression of Slc6a1 8 0.78 4.48 6.86
15 INT112209 Positive_regulation of Gene_expression of Slc6a1 8 0.69 3.92 6.44
16 INT95313 Gene_expression of Slc6a1 6 0.76 3.96 6.14
17 INT119711 Positive_regulation of Slc6a4 16 0.69 4.44 5.21
18 INT112210 Regulation of Slc6a1 8 0.62 6.75 4.96
19 INT122675 Negative_regulation of Gene_expression of Slc6a4 14 0.59 6.4 4.69
20 INT90555 Negative_regulation of Slc6a1 5 0.58 2.78 4.12
21 INT103021 Transcription of Slc6a4 16 0.70 3.93 3.77
22 INT146342 Negative_regulation of Negative_regulation of Slc6a3 5 0.44 3.34 3.4
23 INT167547 Positive_regulation of Gene_expression of Slc6a3 8 0.46 3.33 3.03
24 INT124438 Regulation of Gene_expression of Slc6a4 9 0.62 3.5 2.97
25 INT159587 Localization of Slc6a5 3 0.36 2.55 2.58
26 INT153960 Negative_regulation of Gene_expression of Slc6a1 1 0.42 2.4 2.54
27 INT195431 Binding of SLC6A2 3 0.33 1.86 2.45
28 INT325972 Negative_regulation of Binding of Slc6a1 1 0.02 0.52 2.38
29 INT325975 Binding of Slc6a1 1 0.02 0.52 2.37
30 INT96210 Positive_regulation of SLC6A2 5 0.49 1.99 2.34
31 INT120726 Positive_regulation of Gene_expression of Slc6a4 4 0.68 0.51 2.34
32 INT62473 Gene_expression of Slc6a7 4 0.71 0 2.23
33 INT165668 Negative_regulation of Slc6a5 2 0.48 1.59 2.21
34 INT93965 Negative_regulation of Binding of Slc6a3 5 0.42 1.39 2.07
35 INT169552 Positive_regulation of Negative_regulation of Slc6a3 3 0.50 0.51 2.05
36 INT153363 Positive_regulation of Gene_expression of Slc6a5 3 0.14 0 2
37 INT195429 Regulation of Positive_regulation of SLC6A2 1 0.42 1.01 1.98
38 INT125974 Localization of Slc6a4 5 0.66 2.27 1.97
39 INT243017 Negative_regulation of Binding of Slc6a4 1 0.25 0.22 1.89
40 INT210140 Regulation of Gene_expression of Slc6a3 1 0.62 0.83 1.82
41 INT70173 Gene_expression of SLC6A2 6 0.65 5.26 1.76
42 INT198952 Localization of Slc6a3 3 0.75 0.68 1.62
43 INT277265 Gene_expression of Slc6a11 1 0.75 2.11 1.54
44 INT65979 Regulation of SLC6A2 5 0.04 1.46 1.45
45 INT62474 Binding of Slc6a7 2 0.48 0 1.44
46 INT62475 Positive_regulation of Gene_expression of Slc6a7 2 0.50 0 1.28
47 INT277268 Positive_regulation of Slc6a11 1 0.67 2.47 1.27
48 INT138347 Phosphorylation of Slc6a3 2 0.71 1.01 1.26
49 INT114200 Negative_regulation of Gene_expression of Slc6a1 1 0.38 0.41 1.18
50 INT95312 Regulation of Slc6a1 3 0.27 0.77 1.09
51 INT147712 Regulation of Negative_regulation of Slc6a1 1 0.45 0 1.07
52 INT90558 Negative_regulation of Slc6a11 1 0.57 0.27 1.04
53 INT168784 Regulation of Positive_regulation of Slc6a1 1 0.45 0.87 1.01
54 INT152000 Regulation of Regulation of Slc6a3 1 0.44 0.68 0.99
55 INT129674 Regulation of Negative_regulation of Slc6a4 1 0.38 0.46 0.98
56 INT133215 Transcription of Slc6a3 4 0.67 1.59 0.95
57 INT106941 Positive_regulation of Negative_regulation of Slc6a1 1 0.15 0.28 0.94
58 INT93969 Positive_regulation of Binding of Slc6a3 1 0.41 0.62 0.94
59 INT138346 Positive_regulation of Phosphorylation of Slc6a3 1 0.17 1.24 0.93
60 INT131649 Positive_regulation of Negative_regulation of Slc6a4 2 0.44 0.32 0.91
61 INT286694 Positive_regulation of Localization of Slc6a4 1 0.26 0 0.9
62 INT210141 Positive_regulation of Localization of Slc6a3 1 0.50 0.35 0.8
63 INT162663 Negative_regulation of SLC6A2 4 0.05 0.41 0.78
64 INT243015 Regulation of Binding of Slc6a4 1 0.16 0.43 0.75
65 INT146344 Negative_regulation of Regulation of Slc6a3 2 0.32 1.17 0.7
66 INT82948 Negative_regulation of Slc6a7 1 0.37 0 0.64
67 INT277283 Positive_regulation of Gene_expression of Slc6a11 1 0.49 0.68 0.62
68 INT146345 Regulation of Binding of Slc6a3 1 0.34 0.22 0.61
69 INT90637 Negative_regulation of Positive_regulation of Slc6a3 1 0.41 0 0.6
70 INT184911 Regulation of Negative_regulation of Slc6a3 1 0.36 0.06 0.59
71 INT286687 Phosphorylation of Slc6a4 1 0.46 0 0.58
72 INT286690 Positive_regulation of Phosphorylation of Slc6a4 1 0.28 0 0.58
73 INT128952 Regulation of Slc6a5 3 0.37 1.23 0.45
74 INT309365 Transcription of Slc6a5 1 0.14 0.06 0.45
75 INT281468 Positive_regulation of Positive_regulation of Slc6a3 1 0.42 0.34 0.4
76 INT203495 Positive_regulation of Slc6a1 1 0.67 0.35 0.37
77 INT333278 Negative_regulation of Transcription of Slc6a4 2 0.37 0.56 0.36
78 INT277261 Regulation of Slc6a11 1 0.60 1.51 0.31
79 INT70172 Localization of SLC6A2 1 0.68 1.11 0.28
80 INT224913 Binding of SLC6A7 1 0.35 0.09 0.26
81 INT340198 Regulation of Transcription of Slc6a4 1 0.36 0.66 0.22
82 INT103022 Positive_regulation of Transcription of Slc6a4 2 0.44 0.52 0.21
83 INT349491 Negative_regulation of Transcription of Slc6a3 1 0.22 0.7 0.16
84 INT309360 Regulation of Transcription of Slc6a5 1 0.05 0.06 0.14
85 INT82947 Localization of Slc6a7 1 0.80 0 0.12
86 INT277274 Regulation of Gene_expression of Slc6a11 1 0.44 0.54 0.09
87 INT201444 Regulation of Regulation of SLC6A2 1 0.01 0.08 0.08
88 INT309364 Binding of Slc6a5 1 0.07 0 0.08
89 INT332749 Positive_regulation of Binding of Slc6a4 1 0.23 0.19 0.07
90 INT289047 Gene_expression of Slc6a14 1 0.21 0 0.06
91 INT95316 Positive_regulation of Gene_expression of Slc6a1 1 0.51 0 0.05
92 INT195746 Positive_regulation of Binding of SLC6A2 1 0.05 0.34 0.03
93 INT333286 Negative_regulation of Positive_regulation of Slc6a4 1 0.50 0 0
94 INT333280 Regulation of Localization of Slc6a4 1 0.38 0.18 0
95 INT195412 Localization of SLC6A7 1 0.73 0 0
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