GO:0005329

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Name dopamine transmembrane transporter activity
Categary Function
Go Slim No
Go Link GO:0005329
Unique Molecular Interactions 116
Total Molecular Interactions 233
Total Single Events 1639
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for dopamine transmembrane transporter activity. They are ordered first by their pain relevance and then by number of times they were reported for dopamine transmembrane transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
2 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
3 INT274372 Phc1 Negative_regulation of Slc6a3 1 0.06 0.47 1.99
4 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76
5 INT172206 Binding of Slc6a3 and ADHD1 2 0.03 2.76 1.61
6 INT100908 Slc6a3 Regulation of Positive_regulation of Etf1 1 0.05 0 1.41
7 INT119713 Negative_regulation of Slc6a3 Positive_regulation of Cpu3 1 0.39 0.71 1.26
8 INT184919 Binding of da and Slc6a3 1 0.12 0.33 1.23
9 INT52955 Binding of Slc6a3 and Pdpn 1 0.17 1.11 1.22
10 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
11 INT76256 Binding of Slc6a3 and Sigmar1 1 0.20 0 1.16
12 INT336559 SLC6A3 Positive_regulation of GOPC 1 0.08 1 1.15
13 INT321476 Binding of Slc6a3 and Slc6a2 1 0.01 0.41 1.14
14 INT321473 Binding of Slc6a3 and Ubqln1 1 0.00 0.41 1.13
15 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03
16 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
17 INT214370 Slc6a3 Regulation of Amph 1 0.14 0.44 0.82
18 INT210144 Binding of Slc6a3 and Slc37a4 1 0.11 0.23 0.72
19 INT148257 NR4A2 Regulation of Gene_expression of SLC6A3 1 0.60 0.4 0.59
20 INT336557 SLC6A3 Positive_regulation of Binding of GOPC 1 0.08 0.5 0.58
21 INT270935 Cpe Regulation of Phosphorylation of Slc6a3 1 0.31 0 0.57
22 INT270984 Slc6a3 Regulation of IGKC 1 0.02 0 0.53
23 INT270937 Cpe Regulation of Slc6a3 1 0.36 0 0.5
24 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48
25 INT184877 Negative_regulation of Binding of Slc6a3 and ADHD1 1 0.01 0.69 0.45
26 INT90642 Cpe Negative_regulation of Negative_regulation of Slc6a3 1 0.04 0 0.44
27 INT157451 Binding of Slc6a3 and Dbh 1 0.04 0.48 0.44
28 INT344104 Binding of Slc6a3 and Obfc1 1 0.00 0 0.43
29 INT190003 Binding of MVD and Slc6a3 1 0.13 0.19 0.37
30 INT270939 Gene_expression of Cpe Positive_regulation of Slc6a3 1 0.20 0 0.36
31 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35
32 INT102341 Binding of Slc6a3 and Flvcr2 2 0.06 0 0.34
33 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
34 INT102340 Binding of Slc6a3 and Sert1 1 0.18 0 0.34
35 INT111837 Binding of ABCB1 and SLC22A3 1 0.35 0 0.31
36 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
37 INT270954 Gene_expression of Cpe Positive_regulation of Gene_expression of Slc6a3 1 0.23 0 0.28
38 INT270955 Cpe Regulation of Gene_expression of Slc6a3 1 0.14 0 0.25
39 INT270951 Regulation of Binding of Slc6a3 and Cpe 1 0.23 0 0.25
40 INT214366 Ins1 Regulation of Slc6a3 1 0.11 0.09 0.25
41 INT270940 Negative_regulation of Binding of Slc6a3 and Cpe 1 0.25 0 0.23
42 INT270948 Cpe Regulation of Regulation of Slc6a3 1 0.14 0.28 0.23
43 INT201440 Negative_regulation of Ngf Positive_regulation of Slc6a3 1 0.10 0 0.2
44 INT270947 Cpe Negative_regulation of Phosphorylation of Slc6a3 1 0.25 0 0.2
45 INT300562 Binding of Slc6a3 and Datd 1 0.02 1.12 0.2
46 INT201443 Ngf Positive_regulation of Slc6a3 1 0.11 0 0.19
47 INT184868 Binding of Slc6a3 and Lmo1 1 0.02 0.72 0.19
48 INT349505 Ptpn2 Negative_regulation of Slc6a3 1 0.19 0.7 0.16
49 INT258761 Binding of Slc6a3 and ADHD1 1 0.03 0.51 0.12
50 INT184920 Binding of Agtrap and Slc6a3 1 0.02 0.09 0.09
51 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09
52 INT201446 GOPC Positive_regulation of Slc6a3 1 0.03 0.07 0.08
53 INT184917 Slc6a3 Positive_regulation of Agtrap 1 0.03 0.08 0.06
54 INT201439 Dlat Regulation of Localization of Slc6a3 1 0.04 0 0.06
55 INT321651 Binding of Slc6a3 and Uts2r 1 0.04 0.06 0.05
56 INT321652 Binding of Slc6a3 and Slc6a4 1 0.26 0.07 0.05
57 INT201445 ESR1 Regulation of Slc6a3 1 0.02 0.05 0.04
58 INT201442 Dlat Regulation of Slc6a3 1 0.04 0.18 0.04
59 INT270950 Binding of Slc6a3 and Tgfb1i1 1 0.02 0.23 0.04
60 INT270985 Binding of Slc6a3 and GSTK1 1 0.02 0.05 0.03
61 INT270956 Slc6a3 Positive_regulation of Cpe 1 0.29 0 0.03
62 INT270941 Slc6a3 Positive_regulation of Binding of Cpe 1 0.29 0 0.03
63 INT90319 Binding of Slc6a3 and Positive_regulation of Regulation of Oprl1 1 0.14 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for dopamine transmembrane transporter activity. They are ordered first by their pain relevance and then by number of times they were reported in dopamine transmembrane transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01
2 INT93360 Gene_expression of Slc6a3 63 0.78 19.54 26.55
3 INT80791 Gene_expression of Slc6a3 113 0.78 11.89 25.76
4 INT61825 Negative_regulation of Slc6a3 47 0.59 6.52 21.27
5 INT65214 Binding of Slc6a3 54 0.48 4.77 16.79
6 INT54356 Regulation of Slc6a3 48 0.58 5.86 15.24
7 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23
8 INT28458 Localization of Slc6a3 31 0.76 2.33 12.49
9 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41
10 INT93967 Binding of Slc6a3 22 0.48 6.81 10.74
11 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69
12 INT90639 Positive_regulation of Slc6a3 25 0.61 10.95 10.41
13 INT146343 Regulation of Slc6a3 17 0.60 7.33 8.27
14 INT28461 Positive_regulation of Localization of Slc6a3 8 0.41 0 8.24
15 INT184845 Negative_regulation of Gene_expression of Slc6a3 13 0.59 3.25 7.79
16 INT28457 Positive_regulation of Slc6a3 26 0.50 3.64 7.76
17 INT201438 Phosphorylation of Slc6a3 3 0.68 0.79 4.19
18 INT183479 Positive_regulation of Gene_expression of Slc6a3 16 0.57 0.91 4.13
19 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4
20 INT214362 Negative_regulation of Gene_expression of Slc6a3 7 0.41 1.58 3.67
21 INT146342 Negative_regulation of Negative_regulation of Slc6a3 5 0.44 3.34 3.4
22 INT122577 Regulation of SLC6A3 9 0.53 1.47 3.09
23 INT167547 Positive_regulation of Gene_expression of Slc6a3 8 0.46 3.33 3.03
24 INT54355 Transcription of Slc6a3 6 0.61 0.28 3.02
25 INT28460 Negative_regulation of Localization of Slc6a3 5 0.36 0.24 2.9
26 INT229111 Localization of SLC6A3 5 0.68 1.12 2.48
27 INT111584 Positive_regulation of Negative_regulation of Slc6a3 4 0.47 0.68 2.31
28 INT93965 Negative_regulation of Binding of Slc6a3 5 0.42 1.39 2.07
29 INT169552 Positive_regulation of Negative_regulation of Slc6a3 3 0.50 0.51 2.05
30 INT95461 Positive_regulation of Regulation of Slc6a3 3 0.47 0 1.95
31 INT77990 Protein_catabolism of Slc6a3 6 0.72 0.99 1.84
32 INT210140 Regulation of Gene_expression of Slc6a3 1 0.62 0.83 1.82
33 INT198952 Localization of Slc6a3 3 0.75 0.68 1.62
34 INT114808 Positive_regulation of Binding of SLC6A3 4 0.50 0.63 1.45
35 INT28456 Negative_regulation of Positive_regulation of Slc6a3 2 0.32 0 1.38
36 INT99930 Positive_regulation of Gene_expression of SLC6A3 4 0.43 0.08 1.34
37 INT229116 Negative_regulation of Localization of SLC6A3 1 0.22 0.17 1.31
38 INT148262 Negative_regulation of Gene_expression of SLC6A3 2 0.38 1.66 1.29
39 INT138347 Phosphorylation of Slc6a3 2 0.71 1.01 1.26
40 INT156390 Regulation of Gene_expression of Slc6a3 2 0.37 0.28 1.22
41 INT28459 Regulation of Positive_regulation of Slc6a3 1 0.34 0 1.17
42 INT152000 Regulation of Regulation of Slc6a3 1 0.44 0.68 0.99
43 INT133215 Transcription of Slc6a3 4 0.67 1.59 0.95
44 INT111838 Regulation of SLC22A3 1 0.38 0 0.94
45 INT93969 Positive_regulation of Binding of Slc6a3 1 0.41 0.62 0.94
46 INT138346 Positive_regulation of Phosphorylation of Slc6a3 1 0.17 1.24 0.93
47 INT148263 Transcription of SLC6A3 1 0.62 0.49 0.81
48 INT210141 Positive_regulation of Localization of Slc6a3 1 0.50 0.35 0.8
49 INT270962 Negative_regulation of Phosphorylation of Slc6a3 1 0.42 0 0.8
50 INT122578 Regulation of Gene_expression of SLC6A3 3 0.34 0.2 0.75
51 INT54354 Regulation of Transcription of Slc6a3 1 0.21 0.08 0.74
52 INT201436 Positive_regulation of Phosphorylation of Slc6a3 2 0.50 0.27 0.71
53 INT117369 Gene_expression of SLC22A3 3 0.59 0.22 0.7
54 INT146344 Negative_regulation of Regulation of Slc6a3 2 0.32 1.17 0.7
55 INT109468 Negative_regulation of SLC22A3 1 0.13 0.15 0.66
56 INT146345 Regulation of Binding of Slc6a3 1 0.34 0.22 0.61
57 INT90637 Negative_regulation of Positive_regulation of Slc6a3 1 0.41 0 0.6
58 INT184911 Regulation of Negative_regulation of Slc6a3 1 0.36 0.06 0.59
59 INT119054 Negative_regulation of Binding of SLC6A3 2 0.43 0 0.54
60 INT89215 Negative_regulation of Binding of Slc6a3 1 0.26 0.06 0.48
61 INT281468 Positive_regulation of Positive_regulation of Slc6a3 1 0.42 0.34 0.4
62 INT101780 Regulation of Regulation of Slc6a3 1 0.26 0 0.3
63 INT341786 Positive_regulation of Phosphorylation of SLC6A3 1 0.16 0.07 0.26
64 INT341782 Phosphorylation of SLC6A3 1 0.27 0.07 0.26
65 INT270965 Positive_regulation of Positive_regulation of Slc6a3 1 0.36 0 0.25
66 INT274009 Positive_regulation of Positive_regulation of SLC6A3 1 0.43 0.09 0.25
67 INT270963 Positive_regulation of Binding of Slc6a3 1 0.36 0 0.25
68 INT326598 Negative_regulation of Negative_regulation of SLC6A3 1 0.28 0.65 0.24
69 INT131262 Transcription of SLC22A3 1 0.03 0 0.16
70 INT349491 Negative_regulation of Transcription of Slc6a3 1 0.22 0.7 0.16
71 INT131267 Positive_regulation of Gene_expression of SLC22A3 1 0.02 0 0.16
72 INT270974 Negative_regulation of Protein_catabolism of Slc6a3 1 0.42 0 0.15
73 INT270976 Positive_regulation of Protein_catabolism of Slc6a3 1 0.34 0 0.15
74 INT270970 Regulation of Binding of Slc6a3 1 0.32 0.44 0.14
75 INT270973 Regulation of Protein_catabolism of Slc6a3 1 0.44 0 0.09
76 INT341783 Positive_regulation of Localization of SLC6A3 1 0.14 0.08 0.09
77 INT223292 Localization of SLC22A3 1 0.29 0.06 0
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